Christian C Naus

Christian C Naus

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Christian C Naus

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Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.

J Exp Med 2019 Apr 14;216(4):916-935. Epub 2019 Mar 14.

Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1084/jem.20171452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446879PMC
April 2019

Connexins and pannexins in Alzheimer's disease.

Neurosci Lett 2019 03 8;695:100-105. Epub 2017 Sep 8.

Department of Cellular & Physiological Sciences, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2017.09.006DOI Listing
March 2019

Pannexin 2 Localizes at ER-Mitochondria Contact Sites.

Cancers (Basel) 2019 Mar 11;11(3). Epub 2019 Mar 11.

Department of Cellular and Physiological Sciences, The Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.3390/cancers11030343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468579PMC
March 2019

Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture.

J Cell Commun Signal 2018 Dec 16;12(4):723-730. Epub 2018 Jun 16.

Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1007/s12079-018-0469-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235776PMC
December 2018

GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.

Acta Neuropathol Commun 2018 12 21;6(1):144. Epub 2018 Dec 21.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1186/s40478-018-0642-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303945PMC
December 2018

Connexins and Disease.

Cold Spring Harb Perspect Biol 2018 09 4;10(9). Epub 2018 Sep 4.

Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11790.

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http://dx.doi.org/10.1101/cshperspect.a029348DOI Listing
September 2018

Matrix-assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in mice.

Rapid Commun Mass Spectrom 2018 Jun;32(12):951-958

Vulnerable Brain Laboratory, Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada, N6A 5C1.

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http://doi.wiley.com/10.1002/rcm.8115
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http://dx.doi.org/10.1002/rcm.8115DOI Listing
June 2018

Acute connexin43 temporal and spatial expression in response to ischemic stroke.

J Cell Commun Signal 2018 Mar 13;12(1):193-204. Epub 2017 Nov 13.

Department of Cellular and Physiological Sciences, Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1007/s12079-017-0430-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842192PMC
March 2018

An update on minding the gap in cancer.

Biochim Biophys Acta Biomembr 2018 Jan 24;1860(1):237-243. Epub 2017 Jun 24.

Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.06.015DOI Listing
January 2018

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Pharmacol Rev 2017 10;69(4):396-478

Physiology Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (L.L.); Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington (P.D.L.); Institute for Pharmacology, University of Leipzig, Leipzig, Germany (S.D.); Department of Pathology and Immunology, Department of Medical Specialization-Cardiology, University of Geneva, Geneva, Switzerland (B.R.K.); Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary (P.F.); Pharmahungary Group, Szeged, Hungary (P.F.); Department of Pediatrics, University of Chicago, Chicago, Illinois (E.C.B.); Department of Anatomy and Cell Biology, University of Western Ontario, Dental Science Building, London, Ontario, Canada (D.W.L.); Cellular and Physiological Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada (C.C.N.); Department of Ophthalmology and The New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (C.R.G.); and Physiologisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany (R.S.).

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http://dx.doi.org/10.1124/pr.115.012062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612248PMC
October 2017

SnapShot: Connexins and Disease.

Cell 2017 Sep;170(6):1260-1260.e1

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.cell.2017.08.034DOI Listing
September 2017

Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.

Oncotarget 2017 Jun;8(23):36973-36983

Department of Cellular and Physiological Sciences, The Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.18632/oncotarget.16937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514885PMC
June 2017

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target.

Front Cell Neurosci 2017 26;11:174. Epub 2017 Jun 26.

Center of Interdisciplinary Research in Biology, Collège de FranceParis, France.

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http://dx.doi.org/10.3389/fncel.2017.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483454PMC
June 2017

Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.

BMC Cell Biol 2017 01 17;18(Suppl 1). Epub 2017 Jan 17.

Department of Cellular & Physiological Sciences, Faculty of Medicine, Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://bmccellbiol.biomedcentral.com/articles/10.1186/s12860
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http://dx.doi.org/10.1186/s12860-016-0120-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267333PMC
January 2017

Gap junctions and cancer: communicating for 50 years.

Nat Rev Cancer 2016 12 21;16(12):775-788. Epub 2016 Oct 21.

Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1038/nrc.2016.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279857PMC
December 2016

The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes.

Oncotarget 2016 Nov;7(45):73055-73067

CellCOM-SB Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), CH-Universitario A Coruña (XXIAC), University of A Coruña, Servizo Galego de Saúde (SERGAS), Xubias de Arriba, 84 15006 A Coruña, Spain.

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http://dx.doi.org/10.18632/oncotarget.12197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341963PMC
November 2016

Bridging the gap to therapeutic strategies based on connexin/pannexin biology.

J Transl Med 2016 11 29;14(1):330. Epub 2016 Nov 29.

ICIRB, CNRS UMR7241/INSERM U1050, Collège de France, Paris Cedex 05, France.

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http://dx.doi.org/10.1186/s12967-016-1089-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129631PMC
November 2016

Pannexin 3 is required for late stage bone growth but not for initiation of ossification in avian embryos.

Dev Dyn 2016 09 25;245(9):913-24. Epub 2016 Jul 25.

Faculty of Dentistry, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/dvdy.24425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006391PMC
September 2016

Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43.

Cardiovasc Res 2016 Mar 13;109(3):385-96. Epub 2016 Jan 13.

Department of Pathology and Immunology, University of Geneva, CMU, F06.2747.a, Rue Michel-Servet 1, Geneva 1211, Switzerland Department of Medical Specialties-Cardiology, University of Geneva, Geneva 1211, Switzerland.

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https://cardiovascres.oxfordjournals.org/content/cardiovascr
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http://cardiovascres.oxfordjournals.org/lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/cvr/cvw004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752044PMC
March 2016

Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion.

Semin Cell Dev Biol 2016 Feb 17;50:59-66. Epub 2015 Dec 17.

Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.semcdb.2015.12.008DOI Listing
February 2016

Gerald M. Kidder - bridging the gap in cell and developmental biology.

Semin Cell Dev Biol 2016 Feb;50:1-3

Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1016/j.semcdb.2016.02.017DOI Listing
February 2016

Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

Oncotarget 2015 Nov;6(35):37185-99

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.5953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741923PMC
November 2015

Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function.

PLoS One 2014 2;9(7):e101546. Epub 2014 Jul 2.

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101546PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079510PMC
October 2015

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

Cell Mol Life Sci 2015 Aug 29;72(15):2823-51. Epub 2015 Jun 29.

Physiology Group, Department of Basic Medical Sciences, Ghent University, De Pintelaan 185 (Block B, 3rd floor), 9000, Ghent, Belgium,

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http://dx.doi.org/10.1007/s00018-015-1962-7DOI Listing
August 2015

Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers.

Glia 2015 Jul 2;63(7):1185-99. Epub 2015 Mar 2.

Laboratorio de Neurociencias, Departamento de Neurología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/glia.22808DOI Listing
July 2015

Gap junctions modulate glioma invasion by direct transfer of microRNA.

Oncotarget 2015 Jun;6(17):15566-77

Department of Cellular and Physiological Sciences, The Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, V6T1Z3, Canada.

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http://www.oncotarget.com/fulltext/3904
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558171PMC
http://dx.doi.org/10.18632/oncotarget.3904DOI Listing
June 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Reduction in gap junction intercellular communication promotes glioma migration.

Oncotarget 2015 May;6(13):11447-64

Department of Cellular & Physiological Sciences, Life Sciences Institute, The University of British Columbia, Vancouver, BC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484468PMC
http://dx.doi.org/10.18632/oncotarget.3407DOI Listing
May 2015

Comorbid rat model of ischemia and β-amyloid toxicity: striatal and cortical degeneration.

Brain Pathol 2015 Jan 19;25(1):24-32. Epub 2014 May 19.

CIHR Group on Vascular Cognitive Impairment, Department of Anatomy and Cell Biology, Western University, London, ON, Canada.

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http://dx.doi.org/10.1111/bpa.12149DOI Listing
January 2015

Podoplanin: a marker for reactive gliosis in gliomas and brain injury.

J Neuropathol Exp Neurol 2015 Jan;74(1):64-74

From the Department of Cellular and Physiological Sciences, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada (KK, MF-A, JFB, CCN, WCS); and Department of Molecular Biology and Graduate School of Biomedical Sciences, Rowan University School of Medicine, Stratford, New Jersey (HK, GSG).

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN
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http://dx.doi.org/10.1097/NEN.0000000000000150DOI Listing
January 2015

Pannexin 2 protein expression is not restricted to the CNS.

Front Cell Neurosci 2014 25;8:392. Epub 2014 Nov 25.

Department of Cellular and Physiological Sciences, The Life Science Institute, University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fncel.2014.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243559PMC
December 2014

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

Front Cell Neurosci 2014 21;8:306. Epub 2014 Oct 21.

Center for Interdisciplinary Research in Biology, Centre National de la Recherche Scientifique, Collège de France Paris, France.

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http://dx.doi.org/10.3389/fncel.2014.00306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204617PMC
November 2014

Comorbid Aβ toxicity and stroke: hippocampal atrophy, pathology, and cognitive deficit.

Neurobiol Aging 2014 Jul 8;35(7):1605-14. Epub 2014 Jan 8.

Department of Anatomy and Cell Biology, Canadian Institutes of Health Research Group on Vascular Cognitive Impairment, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.005DOI Listing
July 2014

Gap junctions in C. elegans.

Front Physiol 2014 11;5:40. Epub 2014 Feb 11.

Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia Vancouver, BC, Canada.

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http://journal.frontiersin.org/article/10.3389/fphys.2014.00
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http://dx.doi.org/10.3389/fphys.2014.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920094PMC
June 2014

The pannexins: past and present.

Front Physiol 2014 19;5:58. Epub 2014 Feb 19.

Department of Cellular and Physiological Science, Life Sciences Institute, University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fphys.2014.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928549PMC
June 2014

The role of the gap junction protein connexin43 in B lymphocyte motility and migration.

FEBS Lett 2014 Apr 28;588(8):1249-58. Epub 2014 Jan 28.

CELL and I(3) Research Groups, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada; Department of Zoology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.01.027DOI Listing
April 2014

Mutations of Cx43 that affect B cell spreading in response to BCR signaling.

Biol Open 2014 Mar 15;3(3):185-94. Epub 2014 Mar 15.

CELL and I-cubed (I) Research Groups, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1242/bio.20147328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001238PMC
March 2014

Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress.

J Biol Chem 2014 Jan 3;289(3):1345-54. Epub 2013 Dec 3.

From the Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, V6T 1Z3 Canada.

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http://dx.doi.org/10.1074/jbc.M113.508390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894319PMC
January 2014

Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.

Neuropharmacology 2013 Dec 18;75:539-48. Epub 2013 May 18.

Department of Cellular and Physiological Science, Life Science Institute, University of British Columbia, 2350 Health Science Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.05.002DOI Listing
December 2013

Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.

Neuropharmacology 2013 Dec 31;75:549-56. Epub 2013 May 31.

Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.05.003DOI Listing
December 2013

Oncogenic radiation abscopal effects in vivo: interrogating mouse skin.

Int J Radiat Oncol Biol Phys 2013 Aug 5;86(5):993-9. Epub 2013 Jun 5.

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Casaccia Research Centre, Rome, Italy.

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http://dx.doi.org/10.1016/j.ijrobp.2013.04.040DOI Listing
August 2013

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles.

Front Pharmacol 2013 17;4:88. Epub 2013 Jul 17.

Collège de France, Center for Interdisciplinary Research in Biology/Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241/Institut National de la Santé et de la Recherche Médicale U1050 Paris, France ; University Pierre et Marie Curie Paris, France ; MEMOLIFE Laboratory of Excellence and Paris Science Lettre Research University Paris, France.

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http://dx.doi.org/10.3389/fphar.2013.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713369PMC
July 2013

Role of gap junction protein connexin43 in astrogliosis induced by brain injury.

PLoS One 2012 23;7(10):e47311. Epub 2012 Oct 23.

Department of Cellular and Physiological Sciences, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047311PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479098PMC
April 2013

Connexin multi-site phosphorylation: mass spectrometry-based proteomics fills the gap.

Biochim Biophys Acta 2013 Jan 6;1828(1):23-34. Epub 2012 Mar 6.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.bbamem.2012.02.028DOI Listing
January 2013

Gap junction proteins on the move: connexins, the cytoskeleton and migration.

Biochim Biophys Acta 2013 Jan 18;1828(1):94-108. Epub 2012 May 18.

Department of Zoology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.bbamem.2012.05.014DOI Listing
January 2013

Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control.

J Proteome Res 2012 Dec 8;11(12):6134-46. Epub 2012 Nov 8.

Department of Biochemistry and Molecular Biology, Centre for High-Throughput Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia, V6T 1Z3, Canada.

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http://dx.doi.org/10.1021/pr300790hDOI Listing
December 2012

Pannexin 1 ohnologs in the teleost lineage.

J Membr Biol 2012 Aug 26;245(8):483-93. Epub 2012 Aug 26.

Department of Cellular and Physiological Science, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00232-012-9497-4DOI Listing
August 2012

RF-Cloning.org: an online tool for the design of restriction-free cloning projects.

Nucleic Acids Res 2012 Jul 8;40(Web Server issue):W209-13. Epub 2012 May 8.

Department of Cellular and Physiological Science, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

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http://dx.doi.org/10.1093/nar/gks396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394257PMC
July 2012

Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton.

J Biol Chem 2012 Mar 20;287(11):8407-16. Epub 2012 Jan 20.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, Rhode Island 02912, USA.

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http://dx.doi.org/10.1074/jbc.M111.306522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318751PMC
March 2012

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes.

J Bone Miner Res 2011 Dec;26(12):2911-22

Department of Cellular and Physiological Science, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/jbmr.509DOI Listing
December 2011

Pannexin channels are not gap junction hemichannels.

Channels (Austin) 2011 May-Jun;5(3):193-7. Epub 2011 May 1.

National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704572PMC
http://dx.doi.org/10.4161/chan.5.3.15765DOI Listing
October 2011

The gap junction protein Cx43 regulates B-lymphocyte spreading and adhesion.

J Cell Sci 2011 Aug 12;124(Pt 15):2611-21. Epub 2011 Jul 12.

CELL and I³ Research Group, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.089532
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http://dx.doi.org/10.1242/jcs.089532DOI Listing
August 2011

Temporary sequestration of potassium by mitochondria in astrocytes.

J Biol Chem 2010 Oct 28;285(41):31107-19. Epub 2010 Jul 28.

Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.082073
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http://dx.doi.org/10.1074/jbc.M109.082073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951184PMC
October 2010

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective.

Mol Cell Neurosci 2010 Sep;45(1):37-46

INSERM U840, Collège de France, 11 Place Marcelin Berthelot, 75231 Paris, Cedex 05, France.

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http://dx.doi.org/10.1016/j.mcn.2010.05.007DOI Listing
September 2010

Implications and challenges of connexin connections to cancer.

Nat Rev Cancer 2010 06;10(6):435-41

Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T-1Z3, Canada.

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http://dx.doi.org/10.1038/nrc2841DOI Listing
June 2010

The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells.

J Cell Biochem 2010 Jun;110(3):589-97

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS-UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France.

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http://dx.doi.org/10.1002/jcb.22554DOI Listing
June 2010

Gap junction hemichannels contribute to the generation of diarrhoea during infectious enteric disease.

Gut 2010 Feb 14;59(2):218-26. Epub 2009 Oct 14.

Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1136/gut.2008.170464DOI Listing
February 2010

The connexin43 C-terminal region mediates neuroprotection during stroke.

J Neuropathol Exp Neurol 2010 Feb;69(2):196-206

Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Canada.

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http://dx.doi.org/10.1097/NEN.0b013e3181cd44dfDOI Listing
February 2010

Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization.

J Biol Chem 2009 Oct 25;284(43):29935-44. Epub 2009 Aug 25.

Department of Cellular and Physiological Sciences and The Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada.

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http://dx.doi.org/10.1074/jbc.M109.042630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785622PMC
October 2009

Conformational maturation and post-ER multisubunit assembly of gap junction proteins.

Mol Biol Cell 2009 May 18;20(9):2451-63. Epub 2009 Mar 18.

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1091/mbc.e09-01-0062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675624PMC
May 2009

Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration.

J Neurosci 2009 Feb;29(7):2009-21

Department of Cellular and Physiological Sciences, The Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5025-08.2
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http://dx.doi.org/10.1523/JNEUROSCI.5025-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666339PMC
February 2009

Dose-dependent differential upregulation of CCN1/Cyr61 and CCN3/NOV by the gap junction protein Connexin43 in glioma cells.

J Cell Biochem 2008 Apr;103(6):1772-82

Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/jcb.21571DOI Listing
April 2008

Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth.

J Biol Chem 2008 Mar 17;283(10):6546-60. Epub 2007 Dec 17.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1074/jbc.M709065200DOI Listing
March 2008

Tissue microarray analysis of connexin expression and its prognostic significance in human breast cancer.

Cancer Lett 2007 Oct 20;255(2):284-94. Epub 2007 Jun 20.

Department of Cellular & Physiological Sciences, The University of British Columbia, BC, Canada V6T 1Z3.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350700216
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http://dx.doi.org/10.1016/j.canlet.2007.05.001DOI Listing
October 2007

Expression of connexins in embryonic mouse neocortical development.

J Comp Neurol 2007 Sep;504(3):298-313

Department of Cellular & Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

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http://dx.doi.org/10.1002/cne.21426DOI Listing
September 2007

Tumor-suppressive effects of pannexin 1 in C6 glioma cells.

Cancer Res 2007 Feb;67(4):1545-54

Departments of Cellular and Physiological Sciences and Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1396DOI Listing
February 2007

Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells.

Carcinogenesis 2007 Jan 15;28(1):93-100. Epub 2006 Jun 15.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/carcin/bgl106DOI Listing
January 2007

Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor.

Mol Biol Cell 2007 Jan 1;18(1):34-46. Epub 2006 Nov 1.

Department of Physiology and Pathophysiology, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1091/mbc.e06-03-0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751325PMC
January 2007

Connexin over-expression differentially suppresses glioma growth and contributes to the bystander effect following HSV-thymidine kinase gene therapy.

Cell Commun Adhes 2006 Jan-Apr;13(1-2):79-92

Department of Anatomy & Cell Biology, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1080/15419060600631771DOI Listing
August 2006

Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP.

J Biol Chem 2006 Jul 26;281(30):20920-31. Epub 2006 May 26.

Department of Psychiatry, The University of Western Ontario, London, Canada.

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http://dx.doi.org/10.1074/jbc.M600026200DOI Listing
July 2006

Establishment of an apoptosis-sensitive rat mammary carcinoma cell line with a mutation in the DNA-binding region of p53.

Cancer Lett 2006 Feb;232(2):279-88

Second Department of Surgery, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0001, Japan.

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http://dx.doi.org/10.1016/j.canlet.2005.02.043DOI Listing
February 2006

Intracellular calcium changes trigger connexin 32 hemichannel opening.

EMBO J 2006 Jan 8;25(1):34-44. Epub 2005 Dec 8.

Department of Physiology and Pathophysiology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/sj.emboj.7600908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356351PMC
January 2006

General anesthetics attenuate gap junction coupling in P19 cell line.

J Neurosci Res 2005 Sep;81(5):746-52

University Health Network, Toronto Western Research Institute, Division of Cellular and Molecular Biology, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jnr.20577DOI Listing
September 2005

Nontransformed cells can normalize gap junctional communication with transformed cells.

Biochem Biophys Res Commun 2005 Jul;333(1):174-9

Department of Physiology and Biophysics, School of Medicine, Basic Science Tower L6, Health Science Complex, State University of New York at Stony Brook, 11794-8661, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.05.104DOI Listing
July 2005

Neuroprotective role of astrocytic gap junctions in ischemic stroke.

Cell Commun Adhes 2003 Jul-Dec;10(4-6):413-7

Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1080/cac.10.4-6.413.417DOI Listing
November 2004

Ethanol inhibits gap-junctional coupling between P19 cells.

Alcohol Clin Exp Res 2004 Sep;28(9):1284-90

Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/01.alc.0000139705.17646.baDOI Listing
September 2004

CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.

J Biol Chem 2004 Aug 21;279(35):36943-50. Epub 2004 Jun 21.

Department of Anatomy and Cell Biology, University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada.

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http://dx.doi.org/10.1074/jbc.M403952200DOI Listing
August 2004

Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes.

Am J Pathol 2004 Jun;164(6):2067-75

Department of Anatomy and Cell Biology, the University of British Columbia, Vancouver, British Columbia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615756PMC
http://dx.doi.org/10.1016/S0002-9440(10)63765-0DOI Listing
June 2004

Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells.

Carcinogenesis 2004 Apr 4;25(4):473-82. Epub 2003 Dec 4.

Department of Cell Biology, Beijing Institute for Cancer Research, Beijing University School of Oncology, Da-Hong-Luo-Chang Street, Western District, Beijing 100034, People's Republic of China.

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http://dx.doi.org/10.1093/carcin/bgh036DOI Listing
April 2004

Gap junctions and neurological disorders of the central nervous system.

Biochim Biophys Acta 2004 Mar;1662(1-2):149-58

Department of Anatomy and Cell Biology, University of British Columbia, 313-2177 Wesbrook Mall, Vancouver BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.bbamem.2004.01.009DOI Listing
March 2004

Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity.

Cancer Res 2004 Feb;64(4):1347-58

Department of Physiology and Biophysics, School of Medicine, Health Sciences Complex, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-2558DOI Listing
February 2004

Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia.

Stroke 2003 Aug 3;34(8):1987-93. Epub 2003 Jul 3.

Department of Anatomy and Cell Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1161/01.STR.0000079814.72027.34DOI Listing
August 2003

Epileptiform activity in hippocampal slice cultures exposed chronically to bicuculline: increased gap junctional function and expression.

J Neurochem 2003 Aug;86(3):687-99

Bloorview Epilepsy Research Laboratory, Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01893.xDOI Listing
August 2003

Changes in neuronal migration in neocortex of connexin43 null mutant mice.

J Neuropathol Exp Neurol 2003 Mar;62(3):304-14

Department of Pathology and Applied Neurobiology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1093/jnen/62.3.304DOI Listing
March 2003

Gap junctions and neuronal injury: protectants or executioners?

Neuroscientist 2003 Feb;9(1):5-9

The Hospital for Sick Children, Brain and Behaviour Program, Division of Neurology, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1073858402239586DOI Listing
February 2003

Ciliary neurotrophic factor (CNTF) in combination with its soluble receptor (CNTFRalpha) increases connexin43 expression and suppresses growth of C6 glioma cells.

Cancer Res 2002 Jun;62(12):3544-8

Department of Anatomy and Cell Biology, The University of Western Ontario, London, N6A 5C1, Canada.

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June 2002

Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels.

J Biol Chem 2002 Mar 14;277(12):10482-8. Epub 2002 Jan 14.

Loma Linda University School of Medicine, Loma Linda, California 92350, USA.

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http://dx.doi.org/10.1074/jbc.M109902200DOI Listing
March 2002

Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures.

J Neuropathol Exp Neurol 2002 Feb;61(2):132-41

Department of Anatomy & Cell Biology, The University of Western Ontario, London, Canada.

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http://dx.doi.org/10.1093/jnen/61.2.132DOI Listing
February 2002

Gap junctions and tumour progression.

Can J Physiol Pharmacol 2002 Feb;80(2):136-41

Department of Anatomy and Cell Biology, The University of Western Ontario, London, Canada.

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http://dx.doi.org/10.1139/y02-009DOI Listing
February 2002