Christer Betsholtz

Christer Betsholtz

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Christer Betsholtz

Publications by authors named "Christer Betsholtz"

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100Publications

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Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes.

EMBO Rep 2019 Nov 16;20(11):e48070. Epub 2019 Oct 16.

Integrated Cardio Metabolic Centre (ICMC), Huddinge, Sweden.

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http://dx.doi.org/10.15252/embr.201948070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831996PMC
November 2019

Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing.

Cardiovasc Res 2019 Oct;115(12):1705-1715

Pathology Department, CARIM School for Cardiovascular Diseases, MUMC Maastricht, P. Debyelaan 25, Maastricht, the Netherlands.

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https://academic.oup.com/cardiovascres/article/115/12/1705/5
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http://dx.doi.org/10.1093/cvr/cvz185DOI Listing
October 2019

Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse.

J Steroid Biochem Mol Biol 2019 Sep 18;195:105475. Epub 2019 Sep 18.

Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, Wales, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.105475DOI Listing
September 2019

Single-Cell mRNA Sequencing of the Mouse Brain Vasculature.

Methods Mol Biol 2018 ;1846:309-324

Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Huddinge, Sweden.

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http://dx.doi.org/10.1007/978-1-4939-8712-2_21DOI Listing
May 2019

CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.

Circ Res 2019 Apr;124(8):1240-1252

From the Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (M.C., B.L., K.A., A.Á.-A., A.A.T., E.D., C. Betsholtz, K.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31430
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http://dx.doi.org/10.1161/CIRCRESAHA.118.314300DOI Listing
April 2019

PDGF-B Is Required for Development of the Glymphatic System.

Cell Rep 2019 Mar;26(11):2955-2969.e3

Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA; Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, 221 84 Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447074PMC
March 2019

Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour.

Vascul Pharmacol 2019 01 10;112:8-16. Epub 2018 Nov 10.

Biozentrum der Universität Basel, Klingelbergstrasse 50/70, CH-4053 Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15371891183019
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http://dx.doi.org/10.1016/j.vph.2018.11.002DOI Listing
January 2019

Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling.

Development 2019 01 25;146(2). Epub 2019 Jan 25.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.

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http://dev.biologists.org/lookup/doi/10.1242/dev.165589
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http://dx.doi.org/10.1242/dev.165589DOI Listing
January 2019

Rate of small-molecular drug transport across the blood-brain barrier in a pericyte-deficient state.

Eur J Pharm Sci 2018 Nov 9;124:182-187. Epub 2018 Aug 9.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183037
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http://dx.doi.org/10.1016/j.ejps.2018.08.009DOI Listing
November 2018

Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier.

Eur J Pharm Sci 2018 Sep 20;122:77-84. Epub 2018 Jun 20.

Translational PKPD Group, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2018.06.018DOI Listing
September 2018

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.

Development 2018 07 2;145(13). Epub 2018 Jul 2.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden

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http://dx.doi.org/10.1242/dev.161182DOI Listing
July 2018

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events.

Nat Commun 2018 07 16;9(1):2746. Epub 2018 Jul 16.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Dag Hammarskjöldsv. 20, 751 85, Uppsala, Sweden.

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http://dx.doi.org/10.1038/s41467-018-04929-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048163PMC
July 2018

Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2018 04 6;314(4):L593-L605. Epub 2017 Dec 6.

Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1152/ajplung.00054.2017DOI Listing
April 2018

PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung.

Development 2018 04 10;145(7). Epub 2018 Apr 10.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden

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http://dx.doi.org/10.1242/dev.161976DOI Listing
April 2018

Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice.

J Cereb Blood Flow Metab 2018 03 9;38(3):456-468. Epub 2017 Mar 9.

1 Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://journals.sagepub.com/doi/10.1177/0271678X17697720
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http://dx.doi.org/10.1177/0271678X17697720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851136PMC
March 2018

Cell-cell signaling in blood vessel development and function.

EMBO Mol Med 2018 03;10(3)

Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Huddinge, Sweden.

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http://dx.doi.org/10.15252/emmm.201708610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840538PMC
March 2018

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.

Development 2017 10 29;144(19):3590-3601. Epub 2017 Aug 29.

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Scheeles Väg 2, SE171 77 Stockholm, Sweden

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http://dx.doi.org/10.1242/dev.147967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665477PMC
October 2017

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

Cell Rep 2017 Aug;20(8):1755-1764

Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK; Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Laboratory of Stem Cells and Neuroregeneration, Institute of Anatomy, Histology and Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile; Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574064PMC
August 2017

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

Nat Cell Biol 2017 Jun 22;19(6):639-652. Epub 2017 May 22.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/ncb3534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467724PMC
June 2017

Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung.

Physiol Rep 2017 Mar;5(6)

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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http://dx.doi.org/10.14814/phy2.13092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371545PMC
March 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.

Cell Stem Cell 2016 12 13;19(6):738-751. Epub 2016 Oct 13.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA; Department of Dermatology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135565PMC
December 2016

PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice.

Exp Cell Res 2016 Dec 2;349(2):282-290. Epub 2016 Nov 2.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.10.022DOI Listing
December 2016

Analysis of the brain mural cell transcriptome.

Sci Rep 2016 10 11;6:35108. Epub 2016 Oct 11.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1038/srep35108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057134PMC
October 2016

Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype.

PLoS One 2016 31;11(3):e0152276. Epub 2016 Mar 31.

Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152276PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816573PMC
August 2016

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Science 2016 Aug;353(6301):827-30

Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York , NY 10029, USA. Clinical Gene Networks AB, Jungfrugatan 10, 114 44 Stockholm, Sweden. Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Ravila 19, 50411, Tartu, Estonia. Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aad6970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534139PMC
August 2016

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.

Sci Rep 2016 05 6;6:25658. Epub 2016 May 6.

Roche Pharma Research and Early Development (pRED), Neurodegeneration and Regeneration, Roche Innovation Center Basel, Switzerland.

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http://dx.doi.org/10.1038/srep25658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858719PMC
May 2016

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex.

Biol Open 2016 Apr 15;5(4):461-74. Epub 2016 Apr 15.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 751 85, Sweden.

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http://dx.doi.org/10.1242/bio.017368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890675PMC
April 2016

Age-dependent modulation of vascular niches for haematopoietic stem cells.

Nature 2016 Apr 13;532(7599):380-4. Epub 2016 Apr 13.

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/nature17638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035541PMC
April 2016

Vascular biology: Transcriptional control of endothelial energy.

Nature 2016 Jan 6;529(7585):160-1. Epub 2016 Jan 6.

Department of Immunology, Genetics and Pathology at Uppsala University, and the Department of Medical Biochemistry and Biophysics at the Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nature16866DOI Listing
January 2016

NEURODEVELOPMENT. Oligodendrocytes follow blood vessel trails in the brain.

Science 2016 Jan;351(6271):341-2

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aaf1139DOI Listing
January 2016

Knockdown of Tmem234 in zebrafish results in proteinuria.

Am J Physiol Renal Physiol 2015 Dec 16;309(11):F955-66. Epub 2015 Sep 16.

KI/AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden;

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http://dx.doi.org/10.1152/ajprenal.00525.2014DOI Listing
December 2015

Establishment and Dysfunction of the Blood-Brain Barrier.

Cell 2015 Nov;163(5):1064-1078

Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655822PMC
November 2015

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.

Nat Commun 2014 ;5:3195

1] Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm SE-171 77, Sweden [2] Cardiovascular and Metabolic Disorders Program, Duke-NUS, Singapore City 169857, Singapore.

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http://dx.doi.org/10.1038/ncomms4195DOI Listing
October 2015

Characterization of platelet-derived growth factor-A expression in mouse tissues using a lacZ knock-in approach.

PLoS One 2014 28;9(8):e105477. Epub 2014 Aug 28.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105477PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148317PMC
October 2015

Increased flux of the plant sterols campesterol and sitosterol across a disrupted blood brain barrier.

Steroids 2015 Jul 12;99(Pt B):183-8. Epub 2015 Feb 12.

Institute for Clinical Chemistry and Clinical Pharmacology, University Clinics Bonn, 53105 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.02.005DOI Listing
July 2015

Lipid transport and human brain development.

Nat Genet 2015 Jul;47(7):699-701

Vascular Biology Program, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/ng.3348DOI Listing
July 2015

Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq.

Science 2015 Mar 19;347(6226):1138-42. Epub 2015 Feb 19.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aaa1934DOI Listing
March 2015

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Cell Rep 2015 Mar 12;10(10):1708-1721. Epub 2015 Mar 12.

The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.026DOI Listing
March 2015

Notch3 is necessary for blood vessel integrity in the central nervous system.

Arterioscler Thromb Vasc Biol 2015 Feb 4;35(2):409-20. Epub 2014 Dec 4.

From the Department of Cell and Molecular Biology (T.H., S.J., U.L.) and Department of Medical Biochemistry and Biophysics, Division of Vascular Biology (C.B., E.R.), Karolinska Institute, Stockholm, Sweden; Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden (A.K., L.H., E.R., M.A.M., C.B.); EM Unit, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden (B.R.J.); and Octapharma AB, Stockholm, Sweden (E.W.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304849DOI Listing
February 2015

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.

J Am Soc Nephrol 2014 Dec 22;25(12):2764-77. Epub 2014 May 22.

Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, and Cardiovascular & Metabolic Disorders Program, Duke-NUS, Singapore

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http://dx.doi.org/10.1681/ASN.2012080823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243338PMC
December 2014

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.

PLoS One 2013 20;8(12):e83133. Epub 2013 Dec 20.

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083133PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869763PMC
October 2014

Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis.

Arterioscler Thromb Vasc Biol 2014 Sep 12;34(9):2068-77. Epub 2014 Jun 12.

From the Division of Cardiovascular Genomics (M.M.S., H.A.T., H.F.A., A.R., C.C., J.S., J.L.M.B.), Division of Vascular Biology, Department of Medical Biochemistry and Biophysics (M.M.S., H.A.T., J.J.H., C.N., H.F.A., A.R., C.C., C.B., J.S., J.L.M.B.), Computational Medicine Unit, Department of Medicine Solna, Center of Molecular Medicine (M.M.S.), and Department of Environmental Medicine (B.G., K.L., U.d.F.), Karolinska Institutet, Solna, Sweden; Clinical Gene Networks AB, Karolinska Science Park, Solna, Sweden (M.M.S., A.R., J.L.M.B.); Division of Cardiovascular Genomics, Department of Pathological Anatomy and Forensic Medicine, University of Tartu, Tartu, Estonia (R.K.J., A.R., J.L.M.B.); Cardiovascular Genetics and Genomics, Department of Medicine Solna, Karolinska Institutet, Solna, Sweden (A.S., A.H.); Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia (A.R.); Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Clinical Research Center, Skåne University Hospital, Malmö, Sweden (O.M.); Department of Cardiothoracic Surgery and Anesthesiology and Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institutet, Sweden (T.I.); School of Life Sciences-LifeNet, Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg im Breisgau, Germany (T.M.); The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom (T.M.); and Institute for Genomics and Multi-Scale Biology, Mount Sinai School of Medicine, New York, NY (E.E.S., J.L.M.B.).

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September 2014

Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.

J Biol Chem 2014 Aug 27;289(34):23712-22. Epub 2014 Jun 27.

From the Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital, Karolinska Institute, Huddinge, Stockholm 141 86, Sweden,

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http://www.jbc.org/cgi/doi/10.1074/jbc.M114.556159
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156098PMC
August 2014

PDGF, pericytes and the pathogenesis of idiopathic basal ganglia calcification (IBGC).

Brain Pathol 2014 Jul;24(4):387-95

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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July 2014

Physiology: Double function at the blood-brain barrier.

Nature 2014 May 14;509(7501):432-3. Epub 2014 May 14.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden, and the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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May 2014

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Nat Med 2013 Dec 10;19(12):1617-24. Epub 2013 Nov 10.

1] Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA. [2] Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nm.3282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855865PMC
December 2013

Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.

Mol Cell Biol 2013 Oct 12;33(20):4030-40. Epub 2013 Aug 12.

Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00749-13
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811674PMC
October 2013

Correction: The importance of microglia in the development of the vasculature in the central nervous system.

Vasc Cell 2013 Jun 25;5(1):12. Epub 2013 Jun 25.

Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm 17177, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695819PMC
June 2013

Endocytosis regulates VEGF signalling during angiogenesis.

Nat Cell Biol 2013 Mar;15(3):233-5

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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March 2013

The importance of microglia in the development of the vasculature in the central nervous system.

Vasc Cell 2013 Feb 19;5(1). Epub 2013 Feb 19.

Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583711PMC
February 2013

Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.

Kidney Int 2013 Jan 22;83(1):63-71. Epub 2012 Aug 22.

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/ki.2012.321DOI Listing
January 2013

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Nature 2012 May 16;485(7399):512-6. Epub 2012 May 16.

Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047116PMC
May 2012

Getting to know the cast - cellular interactions and signaling at the neurovascular unit.

Curr Pharm Des 2011 ;17(26):2750-4

Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77, Stockholm, Sweden.

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March 2012

Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.

Am J Pathol 2012 Mar 9;180(3):1136-44. Epub 2012 Jan 9.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349890PMC
March 2012

Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

Dev Dyn 2011 Dec;240(12):2646-56

Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden.

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December 2011

Pdlim2 is a novel actin-regulating protein of podocyte foot processes.

Kidney Int 2011 Nov 3;80(10):1045-54. Epub 2011 Aug 3.

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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November 2011

Glcci1 deficiency leads to proteinuria.

J Am Soc Nephrol 2011 Nov 23;22(11):2037-46. Epub 2011 Sep 23.

Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279996PMC
November 2011

Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria.

Nephron Exp Nephrol 2011 24;118(3):e39-48. Epub 2010 Dec 24.

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000320382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031148PMC
October 2011

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

Dev Cell 2011 Aug;21(2):193-215

Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.devcel.2011.07.001DOI Listing
August 2011

Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology.

Curr Opin Nephrol Hypertens 2011 Jul;20(4):416-24

Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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July 2011

Podocin-green fluorescence protein allows visualization and functional analysis of podocytes.

J Am Soc Nephrol 2011 Jun 12;22(6):1019-23. Epub 2011 May 12.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374364PMC
June 2011