Publications by authors named "Christel Herold-Mende"

100Publications

Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma.

Cancers (Basel) 2020 Sep 10;12(9). Epub 2020 Sep 10.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg L-1526, Luxembourg.

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http://dx.doi.org/10.3390/cancers12092583DOI Listing
September 2020

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq.

J Vis Exp 2020 Aug 25(162). Epub 2020 Aug 25.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg;

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http://dx.doi.org/10.3791/61542DOI Listing
August 2020

TERT and DNMT1 expression predict sensitivity to decitabine in gliomas.

Neuro Oncol 2020 Sep 3. Epub 2020 Sep 3.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noaa207DOI Listing
September 2020

Large-Scale Drug Screening in Patient-Derived IDH Glioma Stem Cells Identifies Several Efficient Drugs among FDA-Approved Antineoplastic Agents.

Cells 2020 06 3;9(6). Epub 2020 Jun 3.

Department of Neurosurgery, Division of Experimental Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cells9061389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348988PMC
June 2020

Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas.

Acta Neuropathol Commun 2019 12 5;7(1):201. Epub 2019 Dec 5.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 460, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-019-0851-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896263PMC
December 2019

Functional role of miR-148a in oropharyngeal cancer: influence on pregnane X receptor and P-glycoprotein expression.

J Recept Signal Transduct Res 2019 Oct-Dec;39(5-6):451-459. Epub 2019 Nov 27.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1080/10799893.2019.1694541DOI Listing
June 2020

Microscopic brain invasion in meningiomas previously classified as WHO grade I is not associated with patient outcome.

J Neurooncol 2019 Dec 11;145(3):469-477. Epub 2019 Nov 11.

Department of Neurosurgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s11060-019-03312-xDOI Listing
December 2019

Serum very long-chain fatty acid-containing lipids predict response to immune checkpoint inhibitors in urological cancers.

Cancer Immunol Immunother 2019 Dec 7;68(12):2005-2014. Epub 2019 Nov 7.

Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-019-02428-3DOI Listing
December 2019

Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.

Acta Neuropathol Commun 2019 08 30;7(1):140. Epub 2019 Aug 30.

Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, INF 400, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-019-0793-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716845PMC
August 2019

Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation.

Int J Cancer 2020 03 11;146(5):1281-1292. Epub 2019 Oct 11.

Division of Chromatin Networks, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.32649DOI Listing
March 2020

Volumetric assessment of glioblastoma and its predictive value for survival.

Acta Neurochir (Wien) 2019 08 28;161(8):1723-1732. Epub 2019 Jun 28.

Department of Neurosurgery, University Medicine of Rostock, Schillingallee 35, 18055, Rostock, Germany.

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http://link.springer.com/10.1007/s00701-019-03966-6
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http://dx.doi.org/10.1007/s00701-019-03966-6DOI Listing
August 2019

Impact of post-surgical freezing delay on brain tumor metabolomics.

Metabolomics 2019 05 13;15(5):78. Epub 2019 May 13.

Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11306-019-1541-2DOI Listing
May 2019

Preclinical evaluation of peptide-based radiotracers for integrin αvβ6-positive pancreatic carcinoma.

Nuklearmedizin 2019 Aug 10;58(4):309-318. Epub 2019 May 10.

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0894-4127
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http://dx.doi.org/10.1055/a-0894-4127DOI Listing
August 2019

Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation.

Cell Metab 2019 08 2;30(2):274-289.e5. Epub 2019 May 2.

Department of Clinical Neurobiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.04.004DOI Listing
August 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 06 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
June 2019

Evolutionary Trajectories of IDH Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.

Cancer Cell 2019 04 21;35(4):692-704.e12. Epub 2019 Mar 21.

Division of Molecular Genetics, German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193010
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http://dx.doi.org/10.1016/j.ccell.2019.02.007DOI Listing
April 2019

PET/CT Imaging of NSCLC with a αβ Integrin-Targeting Peptide.

Mol Imaging Biol 2019 10;21(5):973-983

Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11307-018-1296-6DOI Listing
October 2019

Location-Dependent Patient Outcome and Recurrence Patterns in IDH1-Wildtype Glioblastoma.

Cancers (Basel) 2019 Jan 21;11(1). Epub 2019 Jan 21.

Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF 400, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cancers11010122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356480PMC
January 2019

N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.

Bioorg Chem 2019 03 4;84:418-433. Epub 2018 Dec 4.

School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.12.003DOI Listing
March 2019

Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma.

Head Neck 2018 12 20;40(12):2685-2694. Epub 2018 Nov 20.

Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hed.25515DOI Listing
December 2018

Micronucleus formation in human cancer cells is biased by chromosome size.

Genes Chromosomes Cancer 2019 06 17;58(6):392-395. Epub 2019 Jan 17.

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22707DOI Listing
June 2019

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma.

Int J Mol Sci 2018 Sep 25;19(10). Epub 2018 Sep 25.

Department of Neurosurgery, Division of Experimental Neurosurgery, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms19102903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212863PMC
September 2018

MetaboDiff: an R package for differential metabolomic analysis.

Bioinformatics 2018 10;34(19):3417-3418

Division of Experimental Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bty344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157071PMC
October 2018

Human papilloma virus (HPV) 18 proteins E6 and E7 up-regulate ABC transporters in oropharyngeal carcinoma. Involvement of the nonsense-mediated decay (NMD) pathway.

Cancer Lett 2018 08 30;428:69-76. Epub 2018 Apr 30.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183030
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http://dx.doi.org/10.1016/j.canlet.2018.04.036DOI Listing
August 2018

Clinical and immunological correlates of long term survival in glioblastoma.

Contemp Oncol (Pozn) 2018 Mar 5;22(1A):81-85. Epub 2018 Mar 5.

Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Warsaw, Poland.

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http://dx.doi.org/10.5114/wo.2018.73893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885076PMC
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.

Acta Neuropathol Commun 2018 03 2;6(1):21. Epub 2018 Mar 2.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-018-0523-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834865PMC
March 2018

When Immune Cells Turn Bad-Tumor-Associated Microglia/Macrophages in Glioma.

Int J Mol Sci 2018 Feb 1;19(2). Epub 2018 Feb 1.

Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms19020436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855658PMC
February 2018

Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma.

Oncoimmunology 2018 7;7(2):e1391972. Epub 2017 Nov 7.

Department of Oncology, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1204 Geneva 11, Switzerland and Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, 1205 Geneva Switzerland.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1
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http://dx.doi.org/10.1080/2162402X.2017.1391972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749651PMC
November 2017

Identification of Ligands and Translation to Clinical Applications.

J Nucl Med 2017 09;58(Suppl 2):27S-33S

Department of Radiopharmacy, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.2967/jnumed.116.186791DOI Listing
September 2017

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.

Cell Rep 2017 Aug;20(8):1906-1920

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.005DOI Listing
August 2017

Helping EGFR inhibition to block cancer.

Nat Neurosci 2017 07;20(8):1035-1037

Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nn.4605DOI Listing
July 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.

Neuro Oncol 2017 Nov;19(12):1607-1617

Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute and Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, Section of Pediatric Brain Tumors, University Hospital Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, Clinical Trial Center, Heidelberg, Germany; Division of Neurosurgical Research, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716199PMC
November 2017

Identification of a Novel ITGαβ-Binding Peptide Using Protein Separation and Phage Display.

Clin Cancer Res 2017 Aug 3;23(15):4170-4180. Epub 2017 May 3.

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3217DOI Listing
August 2017

Sensitivity and specificity of antibodies against HPV16 E6 and other early proteins for the detection of HPV16-driven oropharyngeal squamous cell carcinoma.

Int J Cancer 2017 06 4;140(12):2748-2757. Epub 2017 Apr 4.

Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.30697DOI Listing
June 2017

Radiogenomics of Glioblastoma: Machine Learning-based Classification of Molecular Characteristics by Using Multiparametric and Multiregional MR Imaging Features.

Radiology 2016 Dec 16;281(3):907-918. Epub 2016 Sep 16.

From the Department of Neuroradiology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany (P.K., S.B., O.E., M.B.); German Cancer Research Center (DKFZ), Department of Radiology, Heidelberg, Germany (D.B., H.P.S., A.R.); Department of Neurology, Medical University Innsbruck, Austria (M.N.); Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany (A.K., A.v.D., D.C.); German Cancer Consortium (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.K., A.v.D., D.C.); Division of Biostatistics, DKFZ, Heidelberg, Germany (M.S.); Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany (M.N., S.B., A.W., W.W.); Department of Radiation Oncology, University of Heidelberg Medical Center, Heidelberg, Germany (J.D.); Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.); Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany (C.H.M.); Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany (A.U.); Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (D.J., S.P.); German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (D.J., S.P.); Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany (S.P.); and German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany (W.W.).

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http://dx.doi.org/10.1148/radiol.2016161382DOI Listing
December 2016