Publications by authors named "Chrishan Samuel"

100Publications

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1.

Front Pharmacol 2020 4;11:1201. Epub 2020 Aug 4.

Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fphar.2020.01201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417934PMC
August 2020

Serelaxin and the AT Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil.

ACS Pharmacol Transl Sci 2020 Feb 23;3(1):76-87. Epub 2020 Jan 23.

Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, and Department of Physiology, Monash University, Clayton, Victoria 3800 Australia.

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http://dx.doi.org/10.1021/acsptsci.9b00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088889PMC
February 2020

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis.

Pharmacol Ther 2020 05 22;209:107511. Epub 2020 Feb 22.

Cardiovascular Disease Theme, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2020.107511DOI Listing
May 2020

Inflammasomes-A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia.

Int J Mol Sci 2020 Feb 19;21(4). Epub 2020 Feb 19.

Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Victoria 3168, Australia.

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http://dx.doi.org/10.3390/ijms21041406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073120PMC
February 2020

Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity.

J Immunol Res 2019 11;2019:1278301. Epub 2019 Nov 11.

Cardiovascular Disease Program, Biomedicine Discovery Institute & Department of Pharmacology, Monash University, VIC 3800, Australia.

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http://dx.doi.org/10.1155/2019/1278301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877990PMC
April 2020

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis.

Exp Lung Res 2019 Nov - Dec;45(9-10):310-322. Epub 2019 Nov 25.

Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1080/01902148.2019.1695019DOI Listing
May 2020

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts.

FASEB J 2019 12 5;33(12):14717-14733. Epub 2019 Nov 5.

Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1096/fj.201901079RRDOI Listing
December 2019

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction.

Am J Physiol Renal Physiol 2019 09 3;317(3):F606-F615. Epub 2019 Jul 3.

Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1152/ajprenal.00262.2019DOI Listing
September 2019

The Use of Live Cell Imaging and Automated Image Analysis to Assist With Determining Optimal Parameters for Angiogenic Assay .

Front Cell Dev Biol 2019 10;7:45. Epub 2019 Apr 10.

Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fcell.2019.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468051PMC
April 2019

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease.

Br J Pharmacol 2019 07 7;176(13):2195-2208. Epub 2019 May 7.

Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1111/bph.14666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555854PMC
July 2019

Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis.

J Gastroenterol Hepatol 2019 Aug 2;34(8):1441-1449. Epub 2019 Apr 2.

Centre for Inflammatory Disease, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/jgh.14643DOI Listing
August 2019

Relaxin and fibrosis: Emerging targets, challenges, and future directions.

Mol Cell Endocrinol 2019 05 14;487:66-74. Epub 2019 Feb 14.

Cardiovascular Disease Theme, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC, Australia; Central Clinical School, Monash University, Prahran, VIC, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03037207193004
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http://dx.doi.org/10.1016/j.mce.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475456PMC
May 2019

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid.

FASEB J 2019 05 15;33(5):6402-6411. Epub 2019 Feb 15.

Monash Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1096/fj.201802307RDOI Listing
May 2019

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity.

Endocr Connect 2019 Mar;8(3):203-216

Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1530/EC-18-0535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391900PMC
March 2019

Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways.

Mol Cell Endocrinol 2019 05 17;487:59-65. Epub 2019 Jan 17.

Research Service, VA Nebraska-Western Iowa Health Care System, Departments of Internal Medicine and Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384500PMC
May 2019

Understanding relaxin signalling at the cellular level.

Mol Cell Endocrinol 2019 05 25;487:24-33. Epub 2018 Dec 25.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03037207183037
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http://dx.doi.org/10.1016/j.mce.2018.12.017DOI Listing
May 2019

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice.

Respir Res 2018 06 8;19(1):114. Epub 2018 Jun 8.

Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.

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http://dx.doi.org/10.1186/s12931-018-0816-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994120PMC
June 2018

Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases.

Pharmacol Ther 2018 07 12;187:61-70. Epub 2018 Feb 12.

Biomedicine Discovery Institute, Monash University, Melbourne, Australia; Department of Pharmacology, School of Biomedical Sciences, Monash University, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.02.004DOI Listing
July 2018

Endothelial Progenitor Cells and Vascular Health in Dialysis Patients.

Kidney Int Rep 2018 Jan 18;3(1):205-211. Epub 2017 Sep 18.

Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S24680249173039
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http://dx.doi.org/10.1016/j.ekir.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762957PMC
January 2018

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis.

Front Pharmacol 2017 14;8:824. Epub 2017 Nov 14.

Department of Nephrology, Royal Melbourne Hospital, Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fphar.2017.00824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694437PMC
November 2017

Relaxin contributes to the regulation of arterial pressure in adult female mice.

Clin Sci (Lond) 2017 Dec 28;131(23):2795-2805. Epub 2017 Nov 28.

Cardiovascular Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia

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http://dx.doi.org/10.1042/CS20171225DOI Listing
December 2017

Anti-fibrotic Potential of AT Receptor Agonists.

Front Pharmacol 2017 31;8:564. Epub 2017 Aug 31.

Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute, Monash University, ClaytonVIC, Australia.

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http://dx.doi.org/10.3389/fphar.2017.00564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583590PMC
August 2017

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

Sci Rep 2017 06 7;7(1):2968. Epub 2017 Jun 7.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.

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http://dx.doi.org/10.1038/s41598-017-02916-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462828PMC
June 2017

Inhibition of the K3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model.

Am J Respir Cell Mol Biol 2017 04;56(4):539-550

1 Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1165/rcmb.2016-0092OCDOI Listing
April 2017

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.

Pharmacol Res 2017 02 13;116:77-86. Epub 2016 Dec 13.

Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Australia; Department of Surgery, School of Clinical Sciences, Monash Health, Clayton, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.12.015DOI Listing
February 2017

Promise and Limitations of Relaxin-based Therapies in Chronic Fibrotic Lung Diseases.

Am J Respir Crit Care Med 2016 12;194(11):1434-1435

1 Monash University Melbourne, Victoria, Australia and.

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http://dx.doi.org/10.1164/rccm.201606-1256LEDOI Listing
December 2016

Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-Mediated Airway Relaxation.

Front Pharmacol 2016 27;7:406. Epub 2016 Oct 27.

Biomedicine Discovery Institute and Department of Pharmacology, Monash University, ClaytonVIC, Australia; Department of Pharmacology, Lung Health Research Centre, The University of Melbourne, ParkvilleVIC, Australia.

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http://dx.doi.org/10.3389/fphar.2016.00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081476PMC
October 2016

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease.

Clin Sci (Lond) 2016 12 19;130(23):2151-2165. Epub 2016 Sep 19.

Fibrosis Laboratory, Cardiovascular Disease Program, Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia

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http://dx.doi.org/10.1042/CS20160328DOI Listing
December 2016

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction.

Life Sci 2016 Aug 29;158:130-6. Epub 2016 Jun 29.

Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2016.06.022DOI Listing
August 2016

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate.

Front Pharmacol 2016 31;7:91. Epub 2016 Mar 31.

Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fphar.2016.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815292PMC
April 2016

Antifibrotic Actions of Serelaxin - New Roles for an Old Player.

Trends Pharmacol Sci 2016 06 17;37(6):485-497. Epub 2016 Mar 17.

Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.tips.2016.02.007DOI Listing
June 2016

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections.

Methods Mol Biol 2016 ;1397:279-289

Epigenomic Medicine, Baker IDI Heart & Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.1007/978-1-4939-3353-2_19DOI Listing
October 2016

Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease.

Stem Cell Res 2015 Nov 25;15(3):495-505. Epub 2015 Sep 25.

Fibrosis Laboratory, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.09.007DOI Listing
November 2015

Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension.

Hypertension 2015 Nov 8;66(5):1023-33. Epub 2015 Sep 8.

From the Cardiovascular Disease Program, Biomedicine Discovery Institute (C.T.C., C.G.S., M.L., D.F., M.M.K., H.D., H.A.K., S.M.K., C.V.L., A.V., C.S.S., G.R.D.), Department of Pharmacology (C.T.C., C.G.S., M.L., D.F., H.D., H.A.K., S.M.K., C.V.L., A.V., C.S.S., G.R.D.), Department of Surgery, Monash Health (C.G.S., G.R.D.), Department of Physiology (M.M.K.), Australian Regenerative Medicine Institute (E.S.), and Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School (P.T., B.-H.T.), Monash University, Clayton Victoria, Australia; Atherothrombosis and Vascular Laboratory (K.P.) and Vascular Biology and Atherosclerosis Laboratory (T.S.K., A.B.), Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; British Heart Foundation Centre for Excellence, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (T.J.G.); and Department of Internal Medicine, Jagiellonian University, Cracow, Poland (T.J.G).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05779DOI Listing
November 2015

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis.

BMC Pulm Med 2015 Jul 31;15:81. Epub 2015 Jul 31.

Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1186/s12890-015-0071-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521476PMC
July 2015

Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity.

J Am Coll Cardiol 2015 Jul;66(1):1-11

Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia. Electronic address:

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http://content.onlinejacc.org/data/Journals/JAC/934191/04058
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http://linkinghub.elsevier.com/retrieve/pii/S073510971502194
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http://dx.doi.org/10.1016/j.jacc.2015.04.058DOI Listing
July 2015

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability.

Biomed Res Int 2015 22;2015:731852. Epub 2015 Jan 22.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia ; School of Chemistry, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.1155/2015/731852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317577PMC
November 2015

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep.

Exp Lung Res 2015 Apr 22;41(3):115-34. Epub 2014 Dec 22.

1Faculty of Veterinary Science, The University of Melbourne , Parkville, Victoria , Australia.

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http://dx.doi.org/10.3109/01902148.2014.985806DOI Listing
April 2015

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy.

FASEB J 2015 Feb 13;29(2):540-53. Epub 2014 Nov 13.

*Department of Anatomy and Developmental Biology and Department of Pharmacology, Monash University, Clayton, Victoria, Australia; Department of Medicine, University of Melbourne, St. Vincent's Hospital, Melbourne, Australia; and Australia Regenerative Medicine Institute (ARMI) and Monash University, Clayton, Victoria, Australia

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http://dx.doi.org/10.1096/fj.14-254789DOI Listing
February 2015

Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma.

Lab Invest 2014 Dec 29;94(12):1326-39. Epub 2014 Sep 29.

Fibrosis Laboratory, Department of Pharmacology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.1038/labinvest.2014.119DOI Listing
December 2014

Qualitative and quantitative analysis of fibrosis in the kidney.

Nephrology (Carlton) 2014 Nov;19(11):721-6

Department of Nephrology, Royal Melbourne Hospital (RMH), Melbourne, Victoria, Australia; Department of Medicine, Royal Melbourne Hospital (RMH), Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/nep.12321DOI Listing
November 2014

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury.

Am J Physiol Renal Physiol 2014 May 12;306(10):F1222-35. Epub 2014 Mar 12.

Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia;

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http://dx.doi.org/10.1152/ajprenal.00675.2013DOI Listing
May 2014

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis.

Pharmacol Ther 2014 Mar 25;141(3):250-60. Epub 2013 Oct 25.

Fibrosis Laboratory, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2013.10.008DOI Listing
March 2014

Therapeutic effects of serelaxin in acute heart failure.

Circ J 2014 23;78(3):542-52. Epub 2014 Jan 23.

Baker IDI Heart and Diabetes Institute, Monash University.

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http://dx.doi.org/10.1253/circj.cj-14-0014DOI Listing
December 2014

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.

Kidney Int 2014 Jul 15;86(1):75-85. Epub 2014 Jan 15.

1] Florey Institute of Neuroscience and Mental Health, Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia [2] Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC, Australia [3] Department of Pharmacology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.1038/ki.2013.518DOI Listing
July 2014

Mechanistic insights into the contribution of epithelial damage to airway remodeling. Novel therapeutic targets for asthma.

Am J Respir Cell Mol Biol 2014 Jan;50(1):180-92

1 Department of Allergy and Immune Disorders, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1165/rcmb.2013-0008OCDOI Listing
January 2014

Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study.

PLoS One 2013 1;8(8):e69299. Epub 2013 Aug 1.

School of Medicine and Pharmacology, University of Western Australia and Royal Perth Hospital, Perth, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069299PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731305PMC
March 2014

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes.

Protein Pept Lett 2013 Sep;20(9):1029-38

Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.2174/0929866511320090009DOI Listing
September 2013

Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation.

Heart Rhythm 2013 Jan 1;10(1):90-100. Epub 2012 Sep 1.

Centre for Heart Rhythm Disorders, Discipline of Medicine, University of Adelaide and Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.hrthm.2012.08.043DOI Listing
January 2013

Human relaxin-2: historical perspectives and role in cancer biology.

Amino Acids 2012 Sep 2;43(3):1131-40. Epub 2012 Aug 2.

Florey Neuroscience Institutes, University of Melbourne, Melbourne, VIC 3010, Australia.

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http://link.springer.com/10.1007/s00726-012-1375-y
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http://dx.doi.org/10.1007/s00726-012-1375-yDOI Listing
September 2012

Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease.

Clin Sci (Lond) 2013 Jan;124(1):41-51

Department of Allergy and Immune Disorders, Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1042/CS20120024DOI Listing
January 2013

Trefoil factor-2 reverses airway remodeling changes in allergic airways disease.

Am J Respir Cell Mol Biol 2013 Jan 31;48(1):135-44. Epub 2012 May 31.

Department of Allergy and Immune Disorders, Murdoch Children's Research Institute Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1165/rcmb.2011-0320OCDOI Listing
January 2013

The regulation of fibrosis in airway remodeling in asthma.

Mol Cell Endocrinol 2012 Apr 14;351(2):167-75. Epub 2012 Jan 14.

Department of Allergy and Immunology, Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne 3052, Australia.

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http://dx.doi.org/10.1016/j.mce.2012.01.007DOI Listing
April 2012

Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size.

Endocrinology 2012 Jan 25;153(1):188-99. Epub 2011 Oct 25.

Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1210/en.2011-1311DOI Listing
January 2012

Relaxin regulates myofibroblast contractility and protects against lung fibrosis.

Am J Pathol 2011 Dec 6;179(6):2751-65. Epub 2011 Oct 6.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260800PMC
December 2011

Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease.

Nephrol Dial Transplant 2012 Mar 8;27(3):906-12. Epub 2011 Sep 8.

Department of Nephrology, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1093/ndt/gfr495DOI Listing
March 2012

The minimal active structure of human relaxin-2.

J Biol Chem 2011 Oct 30;286(43):37555-65. Epub 2011 Aug 30.

Florey Neuroscience Institutes, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1074/jbc.M111.282194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199501PMC
October 2011

H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.

Biochemistry 2011 Mar 31;50(8):1368-75. Epub 2011 Jan 31.

Howard Florey Institute, School of Chemistry, and Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1021/bi1013968DOI Listing
March 2011

Relaxin remodels fibrotic healing following myocardial infarction.

Lab Invest 2011 May 10;91(5):675-90. Epub 2011 Jan 10.

Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://www.nature.com/articles/labinvest2010198
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http://dx.doi.org/10.1038/labinvest.2010.198DOI Listing
May 2011

The relaxin peptide family--structure, function and clinical applications.

Protein Pept Lett 2011 Mar;18(3):220-9

Florey Neuroscience Institutes, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/092986611794578396DOI Listing
March 2011

Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis.

Endocrinology 2010 Oct 8;151(10):4938-48. Epub 2010 Sep 8.

Howard Florey Institute, The University of Melbourne, and Department of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1210/en.2010-0286DOI Listing
October 2010

Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair.

Am J Respir Crit Care Med 2010 Sep 3;182(5):643-51. Epub 2010 Jun 3.

F.R.A.C.P. School of Medicine and Pharmacology, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201001-0014O
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http://dx.doi.org/10.1164/rccm.201001-0014OCDOI Listing
September 2010

Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl₄-treated mice.

Cell Transplant 2010 4;19(9):1157-68. Epub 2010 May 4.

Centre for Reproduction & Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.3727/096368910X504496DOI Listing
May 2011

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist.

Amino Acids 2010 Jul 31;39(2):409-16. Epub 2009 Dec 31.

Florey Neuroscience Institutes, University of Melbourne, Melbourne, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s00726-009-0454-1DOI Listing
July 2010

Lectin histochemistry for light and electron microscopy.

Methods Mol Biol 2010 ;611:103-14

Department of Nephrology, The Royal Melbourne Hospital, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-60327-345-9_8DOI Listing
February 2010

Cardiovascular effects of relaxin: from basic science to clinical therapy.

Nat Rev Cardiol 2010 Jan 24;7(1):48-58. Epub 2009 Nov 24.

Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Vic 3008, Australia.

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http://dx.doi.org/10.1038/nrcardio.2009.198DOI Listing
January 2010

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy.

Proteomics Clin Appl 2009 Oct 4;3(10):1211-24. Epub 2009 Aug 4.

Howard Florey Institute, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/prca.200900021DOI Listing
October 2009

Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury.

Am J Pathol 2009 Jul 4;175(1):303-13. Epub 2009 Jun 4.

Department of Medicine, Monash Immunology and Stem Cell Laboratories, School of Biomedical Sciences, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.2353/ajpath.2009.080629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708816PMC
July 2009

Role of relaxin in regulation of fibrosis in the lung.

Ann N Y Acad Sci 2009 Apr;1160:342-7

Allergy and Immune Disorders, Murdoch Children's Research Institute, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1749-6632.2008.03825.xDOI Listing
April 2009

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation.

Ann N Y Acad Sci 2009 Apr;1160:294-9

Department of Biochemistry and Molecular Biology, Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1749-6632.2008.03823.xDOI Listing
April 2009

Relaxin: an endogenous renoprotective factor?

Ann N Y Acad Sci 2009 Apr;1160:289-93

Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1749-6632.2008.03795.xDOI Listing
April 2009

Reversal of cardiac fibrosis and related dysfunction by relaxin.

Ann N Y Acad Sci 2009 Apr;1160:278-84

Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1749-6632.2008.03780.xDOI Listing
April 2009

Structure and activity in the relaxin family of peptides.

Ann N Y Acad Sci 2009 Apr;1160:5-10

Department of Biochemistry and Molecular Biology, Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1749-6632.2009.03955.xDOI Listing
April 2009

Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease.

Endocrinology 2009 Jun 12;150(6):2692-9. Epub 2009 Feb 12.

Departments of Allergy and Immunology, The Royal Children's Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1210/en.2008-1457DOI Listing
June 2009

Determination of collagen content, concentration, and sub-types in kidney tissue.

Methods Mol Biol 2009 ;466:223-35

Howard Florey Institute, The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1007/978-1-59745-352-3_16DOI Listing
February 2009

SELDI-TOF mass spectrometry-based protein profiling of kidney tissue.

Methods Mol Biol 2009 ;466:237-49

Howard Florey Institute, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1007/978-1-59745-352-3_17DOI Listing
February 2009

Relaxin and the progression of kidney disease.

Curr Opin Nephrol Hypertens 2009 Jan;18(1):9-14

Howard Florey Institute, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/MNH.0b013e32831b7096DOI Listing
January 2009

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2.

FASEB J 2009 Apr 10;23(4):1219-29. Epub 2008 Dec 10.

Howard Florey Institute, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1096/fj.08-120857DOI Listing
April 2009

Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease.

Endocrinology 2009 Mar 30;150(3):1495-502. Epub 2008 Oct 30.

Department of Biochemistry and Molecular Biology, Howard Florey Institute , University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1210/en.2008-1062DOI Listing
March 2009

Relaxin family peptide receptors--from orphans to therapeutic targets.

Drug Discov Today 2008 Aug 6;13(15-16):640-51. Epub 2008 Jun 6.

Department of Pharmacology, Monash University, Clayton, 3800 Vic, Australia.

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http://dx.doi.org/10.1016/j.drudis.2008.04.002DOI Listing
August 2008

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy.

Endocrinology 2008 Jul 3;149(7):3286-93. Epub 2008 Apr 3.

Howard Florey Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1210/en.2008-0250DOI Listing
July 2008

Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction.

Clin Sci (Lond) 2008 Aug;115(3):99-106

Baker Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Melbourne, VIC 3004, Australia.

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http://dx.doi.org/10.1042/CS20070365DOI Listing
August 2008