Chris Brightling

Chris Brightling

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Chris Brightling

Chris Brightling

Publications by authors named "Chris Brightling"

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Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum.

BMC Pulm Med 2019 Aug 8;19(1):144. Epub 2019 Aug 8.

Institute for Lung Health NIHR Leicester Biomedical Research Centre Department of Respiratory Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, LE3 9QP, UK.

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http://dx.doi.org/10.1186/s12890-019-0906-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688375PMC
August 2019

Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma.

J Allergy Clin Immunol 2019 Jul 22;144(1):83-93. Epub 2019 Jan 22.

NIHR Respiratory Biomedical Research Centre (BRC), Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.01.014DOI Listing
July 2019

Exacerbations of severe asthma in patients treated with mepolizumab.

Eur Respir J 2018 12 13;52(6). Epub 2018 Dec 13.

Dept of Respiratory Medicine, Allergy and Thoracic Surgery and NIHR BRC Respiratory Theme, Glenfield Hospital, University of Leicester, Leicester, UK.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01127
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http://dx.doi.org/10.1183/13993003.01127-2018DOI Listing
December 2018

ERS Clinical Research Collaborations: underpinning research excellence.

Eur Respir J 2018 09 15;52(3). Epub 2018 Sep 15.

Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1183/13993003.01534-2018DOI Listing
September 2018

Urgent need for pragmatic trial platforms in severe asthma.

Lancet Respir Med 2018 08;6(8):581-583

Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Departments of Epidemiology and Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30291-1DOI Listing
August 2018

Modelling the effect of gravity on inert-gas washout outputs.

Physiol Rep 2018 05;6(10):e13709

Department of Computer Science, University of Oxford, Oxford, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.14814/phy2.13709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974727PMC
May 2018

Big asthma data: getting bigger and more beautiful?

Thorax 2018 04 29;73(4):311-312. Epub 2017 Dec 29.

Department of Infection, Immunity and Inflammation, Leicester NIHR BRC, Institute for Lung Health, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2017-211148DOI Listing
April 2018

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

Chest 2017 10 14;152(4):771-779. Epub 2017 Jul 14.

Institute for Lung Health, National Institute for Health Research Leicester Biomedical Research Centre, and Department of Infection Immunity and Inflammation, University of Leicester, and University Hospitals Leicester, Children's Hospital, Leicester, England. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624091PMC
October 2017

Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics.

Allergy Asthma Immunol Res 2017 Mar;9(2):177-181

Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

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http://dx.doi.org/10.4168/aair.2017.9.2.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266110PMC
March 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

Novel imaging approaches in adult asthma and their clinical potential.

Expert Rev Clin Immunol 2015 7;11(10):1147-62. Epub 2015 Aug 7.

a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.

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http://dx.doi.org/10.1586/1744666X.2015.1072049DOI Listing
June 2016

Comparison of CT-based Lobar Ventilation with 3He MR Imaging Ventilation Measurements.

Radiology 2016 Feb 28;278(2):585-92. Epub 2015 Aug 28.

From the Academic Units of Academic Radiology (B.A.T., A.J.S., F.C.H., H.M., J.C.K., J.P.R., J.M.W.) and Clinical Oncology (B.A.T., R.H.I.), University of Sheffield, C Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, England; Fluidda, Kontich, Belgium (C.V.H., J.D.B., W.V.); Institute for Lung Health, University of Leicester, Leicester, England (R.H., C.E.B.); Novartis, Basel, Switzerland (R.K.); and INSIGNEO Institute of In-silico Medicine, Sheffield, England (A.J.S., J.M.W.).

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http://dx.doi.org/10.1148/radiol.2015142278DOI Listing
February 2016

Dynamic flow characteristics in normal and asthmatic lungs.

Int J Numer Method Biomed Eng 2015 Dec 25;31(12). Epub 2015 Jun 25.

Department of Computer Science, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/cnm.2730
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http://dx.doi.org/10.1002/cnm.2730DOI Listing
December 2015

Toll-like receptor 9 dependent interferon-α release is impaired in severe asthma but is not associated with exacerbation frequency.

Immunobiology 2015 Jul 22;220(7):859-64. Epub 2015 Jan 22.

Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust, Leicestershire, UK; Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01712985150000
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http://dx.doi.org/10.1016/j.imbio.2015.01.005DOI Listing
July 2015

Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease.

Respirology 2015 May 27;20(4):667-70. Epub 2015 Jan 27.

Institute for Lung Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK; Department of Medicine, Faculty of Medicine, Benghazi University, Benghazi, Libya.

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http://dx.doi.org/10.1111/resp.12475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833195PMC
May 2015

Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2015 Jan 13;135(1):63-72. Epub 2014 Aug 13.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospitals of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282726PMC
January 2015

Eosinophilic inflammation in COPD: prevalence and clinical characteristics.

Eur Respir J 2014 Dec 16;44(6):1697-700. Epub 2014 Oct 16.

GlaxoSmithKline, Research and Development, King of Prussia, PA, USA.

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http://dx.doi.org/10.1183/09031936.00162414DOI Listing
December 2014

Reply: Elevated sputum IL-5 and submucosal eosinophilia in obese individuals with severe asthma.

Am J Respir Crit Care Med 2014 May;189(10):1285-6

1 University of Leicester Leicester, United Kingdom and.

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http://dx.doi.org/10.1164/rccm.201402-0294LEDOI Listing
May 2014

Reply: Role of primary necrosis/lysis of submucosal eosinophils in obese individuals with asthma.

Am J Respir Crit Care Med 2013 Dec;188(12):1468-9

1 University of Leicester Leicester, United Kingdom and University Hospitals of Leicester NHS Trust Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201305-0996LEDOI Listing
December 2013

Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.

Am J Respir Crit Care Med 2012 Feb 22;185(3):267-74. Epub 2011 Nov 22.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201107-1281OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402550PMC
February 2012

Functional KCa3.1 K+ channels are required for human fibrocyte migration.

J Allergy Clin Immunol 2011 Dec 27;128(6):1303-1309.e2. Epub 2011 Aug 27.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2011.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526791PMC
December 2011

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.

J Immunol 2011 Dec 24;187(11):6094-107. Epub 2011 Oct 24.

Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1003507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242066PMC
December 2011

Eosinophils best marker of steroid response.

Thorax 2011 Aug 23;66(8):730; author reply 730-1. Epub 2010 Sep 23.

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http://dx.doi.org/10.1136/thx.2010.144592DOI Listing
August 2011

Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry.

Thorax 2010 Sep;65(9):787-94

Centre for Infection and Immunity, Queen's University of Belfast, Level 8, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, UK.

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http://dx.doi.org/10.1136/thx.2010.137414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975949PMC
September 2010

Mannitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness.

Respirology 2010 Apr 24;15(3):510-5. Epub 2010 Feb 24.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/j.1440-1843.2010.01712.xDOI Listing
April 2010

Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis.

Otolaryngol Clin North Am 2010 Feb;43(1):123-30, x

Department of Infection, Inflammation, and Immunity, University of Leicester, Institute for Lung Health, Glenfield Hospital, UK.

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http://dx.doi.org/10.1016/j.otc.2009.11.006DOI Listing
February 2010

Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors.

J Leukoc Biol 2009 Sep 29;86(3):479-89. Epub 2009 Apr 29.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

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http://doi.wiley.com/10.1189/jlb.1108699
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http://dx.doi.org/10.1189/jlb.1108699DOI Listing
September 2009

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration.

Eur J Immunol 2008 Sep;38(9):2548-56

The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK.

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http://doi.wiley.com/10.1002/eji.200738106
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http://dx.doi.org/10.1002/eji.200738106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699428PMC
September 2008

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.

Am J Respir Cell Mol Biol 2007 Nov 21;37(5):525-31. Epub 2007 Jun 21.

Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2006-0358OC
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http://dx.doi.org/10.1165/rcmb.2006-0358OCDOI Listing
November 2007

The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.

Am J Respir Crit Care Med 2007 Aug 11;176(3):231-7. Epub 2007 May 11.

Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200610-1427OCDOI Listing
August 2007

Mast cell infiltration of airway smooth muscle in asthma.

Respir Med 2007 May 15;101(5):1045; author reply 1046-7. Epub 2007 Feb 15.

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http://dx.doi.org/10.1016/j.rmed.2007.01.004DOI Listing
May 2007

The reclassification of asthma based on subphenotypes.

Curr Opin Allergy Clin Immunol 2007 Feb;7(1):43-50

Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester, UK.

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http://dx.doi.org/10.1097/ACI.0b013e3280118a32DOI Listing
February 2007

The influence of age on induced sputum differential cell counts in normal subjects.

Chest 2004 Dec;126(6):1811-4

Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.

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http://dx.doi.org/10.1378/chest.126.6.1811DOI Listing
December 2004