Chris Brightling

Chris Brightling

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Chris Brightling

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Resistome analyses of sputum from COPD and healthy subjects reveals bacterial load-related prevalence of target genes.

Authors:
Mohammadali Yavari Ramsheh Koirobi Haldar Mona Bafadhel Leena George Robert C Free Catherine John Nicola F Reeve Loems Ziegler-Heitbrock Ivo Gut Dave Singh Vijay Mistry Martin D Tobin Marco R Oggioni Chris Brightling Michael R Barer

Thorax 2019 Nov 7. Epub 2019 Nov 7.

Department of Respiratory Sciences, University of Leicester, Leicester, UK

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http://dx.doi.org/10.1136/thoraxjnl-2019-213485DOI Listing
November 2019

Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline.

Authors:
Fernando Holguin Juan Carlos Cardet Kian Fan Chung Sarah Diver Diogenes S Ferreira Anne Fitzpatrick Mina Gaga Liz Kellermeyer Sandhya Khurana Shandra Knight Vanessa M McDonald Rebecca L Morgan Victor E Ortega David Rigau Padmaja Subbarao Thomy Tonia Ian M Adcock Eugene R Bleecker Chris Brightling Louis-Philippe Boulet Michael Cabana Mario Castro Pascal Chanez Adnan Custovic Ratko Djukanovic Urs Frey Betty Frankemolle Peter Gibson Dominique Hamerlijnck Nizar Jarjour Satoshi Konno Huahao Shen Cathy Vitary Andy Bush

Eur Respir J 2019 Sep 26. Epub 2019 Sep 26.

Department of Paediatrics, National Heart & Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1183/13993003.00588-2019DOI Listing
September 2019

Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum.

Authors:
Michael A Ghebre Pee Hwee Pang Dhananjay Desai Beverley Hargadon Chris Newby Joanne Woods Laura Rapley Suzanne E Cohen Athula Herath Erol A Gaillard Richard D May Chris E Brightling

BMC Pulm Med 2019 Aug 8;19(1):144. Epub 2019 Aug 8.

Institute for Lung Health NIHR Leicester Biomedical Research Centre Department of Respiratory Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, LE3 9QP, UK.

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http://dx.doi.org/10.1186/s12890-019-0906-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688375PMC
August 2019

Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma.

Authors:
Alex J Bell Brody H Foy Matthew Richardson Amisha Singapuri Evgeny Mirkes Maarten van den Berge David Kay Chris Brightling Alexander N Gorban Craig J Galbán Salman Siddiqui

J Allergy Clin Immunol 2019 Jul 22;144(1):83-93. Epub 2019 Jan 22.

NIHR Respiratory Biomedical Research Centre (BRC), Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.01.014DOI Listing
July 2019

Breath analysis by two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection - Method optimisation and integration within a large-scale clinical study.

Authors:
Michael J Wilde Rebecca L Cordell Dahlia Salman Bo Zhao Wadah Ibrahim Luke Bryant Dorota Ruszkiewicz Amisha Singapuri Robert C Free Erol A Gaillard Caroline Beardsmore C L Paul Thomas Chris E Brightling Salman Siddiqui Paul S Monks

J Chromatogr A 2019 Jun 5;1594:160-172. Epub 2019 Feb 5.

Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491496PMC
June 2019

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study.

Authors:
Dirkje S Postma Chris Brightling Simonetta Baldi Maarten Van den Berge Leonardo M Fabbri Alessandra Gagnatelli Alberto Papi Thys Van der Molen Klaus F Rabe Salman Siddiqui Dave Singh Gabriele Nicolini Monica Kraft

Lancet Respir Med 2019 May 12;7(5):402-416. Epub 2019 Mar 12.

University of Arizona College of Medicine, Department of Medicine, Tucson, AZ, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22132600193004
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http://dx.doi.org/10.1016/S2213-2600(19)30049-9DOI Listing
May 2019

Mepolizumab does not alter the blood basophil count in severe asthma.

Authors:
Adam Kelvin Alec Wright Sarah Diver Jamie McCarthy Andrew Marvin Marcia Soares Tracy Thornton Michelle Bourne Michelle Craner Helen Evans Sarah Edwards Sarah Glover Liesl Carr Sarah Parker Salman Siddiqui David Cousins Chris Brightling

Allergy 2019 May 20. Epub 2019 May 20.

Department of Respiratory Sciences, University of Leicester, Leicester, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13879
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http://dx.doi.org/10.1111/all.13879DOI Listing
May 2019

Exacerbations of severe asthma in patients treated with mepolizumab.

Authors:
Rahul Shrimanker Ian D Pavord Steve Yancey Liam G Heaney Ruth H Green Peter Bradding Beverley Hargadon Chris E Brightling Andrew J Wardlaw Pranabashis Haldar

Eur Respir J 2018 12 13;52(6). Epub 2018 Dec 13.

Dept of Respiratory Medicine, Allergy and Thoracic Surgery and NIHR BRC Respiratory Theme, Glenfield Hospital, University of Leicester, Leicester, UK.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01127
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http://dx.doi.org/10.1183/13993003.01127-2018DOI Listing
December 2018

ERS Clinical Research Collaborations: underpinning research excellence.

Authors:
Chris Brightling Celine Genton Werner Bill Tobias Welte Mina Gaga Elise Heuvelin Guy Brusselle

Eur Respir J 2018 09 15;52(3). Epub 2018 Sep 15.

Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1183/13993003.01534-2018DOI Listing
September 2018

Urgent need for pragmatic trial platforms in severe asthma.

Authors:
Charles Pilette Chris Brightling Denis Lacombe Guy Brusselle

Lancet Respir Med 2018 08;6(8):581-583

Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Departments of Epidemiology and Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30291-1DOI Listing
August 2018

Modelling the effect of gravity on inert-gas washout outputs.

Authors:
Brody H Foy Sherif Gonem Chris Brightling Salman Siddiqui David Kay

Physiol Rep 2018 05;6(10):e13709

Department of Computer Science, University of Oxford, Oxford, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.14814/phy2.13709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974727PMC
May 2018

Big asthma data: getting bigger and more beautiful?

Authors:
Sarah Diver Chris E Brightling

Thorax 2018 04 29;73(4):311-312. Epub 2017 Dec 29.

Department of Infection, Immunity and Inflammation, Leicester NIHR BRC, Institute for Lung Health, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2017-211148DOI Listing
April 2018

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

Authors:
Kathryn G Welsh Karine Rousseau Gemma Fisher Luke R Bonser Peter Bradding Chris E Brightling David J Thornton Erol A Gaillard

Chest 2017 10 14;152(4):771-779. Epub 2017 Jul 14.

Institute for Lung Health, National Institute for Health Research Leicester Biomedical Research Centre, and Department of Infection Immunity and Inflammation, University of Leicester, and University Hospitals Leicester, Children's Hospital, Leicester, England. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624091PMC
October 2017

Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics.

Authors:
Michael A Ghebre Dhananjay Desai Amisha Singapuri Joanne Woods Laura Rapley Suzanne Cohen Athula Herath Andrew J Wardlaw Catherine H Pashley Richard May Chris E Brightling

Allergy Asthma Immunol Res 2017 Mar;9(2):177-181

Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

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http://dx.doi.org/10.4168/aair.2017.9.2.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266110PMC
March 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.

Authors:
Andrew Skeggs Tricia McKeever Lelia Duley Eleanor Mitchell Lucy Bradshaw Kevin Mortimer Samantha Walker Steve Parrott Andrew Wilson Ian Pavord Chris Brightling Mike Thomas David Price Graham Devereux Bernard Higgins Tim Harrison Rebecca Haydock

Trials 2016 10 13;17(1):499. Epub 2016 Oct 13.

Nottingham Clinical Trials Unit (NCTU), Nottingham Health Science Partners, C Floor, South Block, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1186/s13063-016-1608-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064792PMC
October 2016

Novel imaging approaches in adult asthma and their clinical potential.

Authors:
Ruth Hartley Simonetta Baldi Chris Brightling Sumit Gupta

Expert Rev Clin Immunol 2015 7;11(10):1147-62. Epub 2015 Aug 7.

a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.

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http://dx.doi.org/10.1586/1744666X.2015.1072049DOI Listing
June 2016

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Authors:
Victoria E Jackson Ioanna Ntalla Ian Sayers Richard Morris Peter Whincup Juan-Pablo Casas Antoinette Amuzu Minkyoung Choi Caroline Dale Meena Kumari Jorgen Engmann Noor Kalsheker Sally Chappell Tamar Guetta-Baranes Tricia M McKeever Colin N A Palmer Roger Tavendale John W Holloway Avan A Sayer Elaine M Dennison Cyrus Cooper Mona Bafadhel Bethan Barker Chris Brightling Charlotte E Bolton Michelle E John Stuart G Parker Miriam F Moffat Andrew J Wardlaw Martin J Connolly David J Porteous Blair H Smith Sandosh Padmanabhan Lynne Hocking Kathleen E Stirrups Panos Deloukas David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Thorax 2016 06 25;71(6):501-9. Epub 2016 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2015-207876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893124PMC
June 2016

Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study.

Authors:
Ruth A Hartley Bethan L Barker Chris Newby Mini Pakkal Simonetta Baldi Radhika Kajekar Richard Kay Marie Laurencin Richard P Marshall Ana R Sousa Harsukh Parmar Salman Siddiqui Sumit Gupta Chris E Brightling

J Allergy Clin Immunol 2016 05 19;137(5):1413-1422.e12. Epub 2016 Mar 19.

Department of Infection, Inflammation and Immunity and Health Sciences, Institute for Lung Health, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852952PMC
May 2016

Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry.

Authors:
Joan Sweeney Chris C Patterson Andrew Menzies-Gow Rob M Niven Adel H Mansur Christine Bucknall Rekha Chaudhuri David Price Chris E Brightling Liam G Heaney

Thorax 2016 Apr 27;71(4):339-46. Epub 2016 Jan 27.

Centre for Infection and Immunity, Queen's University of Belfast, Belfast, UK.

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http://thorax.bmj.com/content/early/2016/01/27/thoraxjnl-201
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http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2015-2076
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http://dx.doi.org/10.1136/thoraxjnl-2015-207630DOI Listing
April 2016

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Authors:
Liam G Heaney Ratko Djukanovic Ashley Woodcock Samantha Walker John G Matthews Ian D Pavord Peter Bradding Robert Niven Chris E Brightling Rekha Chaudhuri Joseph R Arron David F Choy Douglas Cowan Adel Mansur Andrew Menzies-Gow Ian Adcock Kian F Chung Chris Corrigan Peter Coyle Timothy Harrison Sebastian Johnston Peter Howarth James Lordan Ian Sabroe Jeannette Bigler Dirk Smith Matthew Catley Richard May Lisa Pierre Chris Stevenson Glenn Crater Frank Keane Richard W Costello Val Hudson David Supple Tim Hardman

Thorax 2016 Feb 23;71(2):187-9. Epub 2015 Jul 23.

Niche Science & Technology, Richmond, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2015-207326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752622PMC
February 2016

Comparison of CT-based Lobar Ventilation with 3He MR Imaging Ventilation Measurements.

Authors:
Bilal A Tahir Cedric Van Holsbeke Rob H Ireland Andrew J Swift Felix C Horn Helen Marshall John C Kenworthy Juan Parra-Robles Ruth Hartley Richard Kay Chris E Brightling Jan De Backer Wim Vos Jim M Wild

Radiology 2016 Feb 28;278(2):585-92. Epub 2015 Aug 28.

From the Academic Units of Academic Radiology (B.A.T., A.J.S., F.C.H., H.M., J.C.K., J.P.R., J.M.W.) and Clinical Oncology (B.A.T., R.H.I.), University of Sheffield, C Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, England; Fluidda, Kontich, Belgium (C.V.H., J.D.B., W.V.); Institute for Lung Health, University of Leicester, Leicester, England (R.H., C.E.B.); Novartis, Basel, Switzerland (R.K.); and INSIGNEO Institute of In-silico Medicine, Sheffield, England (A.J.S., J.M.W.).

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http://dx.doi.org/10.1148/radiol.2015142278DOI Listing
February 2016

Dynamic flow characteristics in normal and asthmatic lungs.

Authors:
Minsuok Kim Rafel Bordas Wim Vos Ruth A Hartley Chris E Brightling David Kay Vicente Grau Kelly S Burrowes

Int J Numer Method Biomed Eng 2015 Dec 25;31(12). Epub 2015 Jun 25.

Department of Computer Science, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/cnm.2730
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http://dx.doi.org/10.1002/cnm.2730DOI Listing
December 2015

Dedicated severe asthma services improve health-care use and quality of life.

Authors:
David Gibeon Liam G Heaney Chris E Brightling Rob Niven Adel H Mansur Rekha Chaudhuri Christine E Bucknall Andrew N Menzies-Gow

Chest 2015 Oct;148(4):870-876

Royal Brompton Hospital, London, England. Electronic address:

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http://dx.doi.org/10.1378/chest.14-3056DOI Listing
October 2015

Toll-like receptor 9 dependent interferon-α release is impaired in severe asthma but is not associated with exacerbation frequency.

Authors:
Adam K A Wright Vijay Mistry Matthew Richardson Maria Shelley Tracy Thornton Sarah Terry Bethan Barker Mona Bafadhel Chris Brightling

Immunobiology 2015 Jul 22;220(7):859-64. Epub 2015 Jan 22.

Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust, Leicestershire, UK; Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01712985150000
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http://dx.doi.org/10.1016/j.imbio.2015.01.005DOI Listing
July 2015

Unmet needs for the assessment of small airways dysfunction in asthma: introduction to the ATLANTIS study.

Authors:
Dirkje S Postma Chris Brightling Leo Fabbri Thys van der Molen Gabriele Nicolini Alberto Papi Klaus F Rabe Salman Siddiqui Dave Singh Maarten van den Berge Monica Kraft

Eur Respir J 2015 Jun;45(6):1534-8

Dept of Medicine, University of Arizona Health Sciences Center, Tucson, AZ, USA.

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http://dx.doi.org/10.1183/09031936.00214314DOI Listing
June 2015

Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease.

Authors:
Osama Eltboli Vijay Mistry Bethan Barker Chris E Brightling

Respirology 2015 May 27;20(4):667-70. Epub 2015 Jan 27.

Institute for Lung Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK; Department of Medicine, Faculty of Medicine, Benghazi University, Benghazi, Libya.

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http://dx.doi.org/10.1111/resp.12475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833195PMC
May 2015

The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry.

Authors:
Stephen O'Neill Joan Sweeney Chris C Patterson Andrew Menzies-Gow Rob Niven Adel H Mansur Christine Bucknall Rekha Chaudhuri Neil C Thomson Chris E Brightling Ciaran O'Neill Liam G Heaney

Thorax 2015 Apr 10;70(4):376-8. Epub 2014 Jun 10.

Centre for Infection and Immunity, Queen's University of Belfast, Belfast, UK.

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http://thorax.bmj.com/content/early/2014/06/10/thoraxjnl-201
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http://thorax.bmj.com/cgi/doi/10.1136/thoraxjnl-2013-204114
Publisher Site
http://dx.doi.org/10.1136/thoraxjnl-2013-204114DOI Listing
April 2015

Statistical cluster analysis of the British Thoracic Society Severe refractory Asthma Registry: clinical outcomes and phenotype stability.

Authors:
Chris Newby Liam G Heaney Andrew Menzies-Gow Rob M Niven Adel Mansur Christine Bucknall Rekha Chaudhuri John Thompson Paul Burton Chris Brightling

PLoS One 2014 24;9(7):e102987. Epub 2014 Jul 24.

Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102987PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109965PMC
April 2015

Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

Authors:
Michael A Ghebre Mona Bafadhel Dhananjay Desai Suzanne E Cohen Paul Newbold Laura Rapley Jo Woods Paul Rugman Ian D Pavord Chris Newby Paul R Burton Richard D May Chris E Brightling

J Allergy Clin Immunol 2015 Jan 13;135(1):63-72. Epub 2014 Aug 13.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospitals of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282726PMC
January 2015

Eosinophilic inflammation in COPD: prevalence and clinical characteristics.

Authors:
Dave Singh Umme Kolsum Chris E Brightling Nicholas Locantore Alvar Agusti Ruth Tal-Singer

Eur Respir J 2014 Dec 16;44(6):1697-700. Epub 2014 Oct 16.

GlaxoSmithKline, Research and Development, King of Prussia, PA, USA.

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http://dx.doi.org/10.1183/09031936.00162414DOI Listing
December 2014

Computational modeling of the obstructive lung diseases asthma and COPD.

Authors:
Kelly Suzanne Burrowes Tom Doel Chris Brightling

J Transl Med 2014 Nov 28;12 Suppl 2:S5. Epub 2014 Nov 28.

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http://dx.doi.org/10.1186/1479-5876-12-S2-S5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255909PMC
November 2014

Reply: Elevated sputum IL-5 and submucosal eosinophilia in obese individuals with severe asthma.

Authors:
Dhananjay Desai Chris E Brightling

Am J Respir Crit Care Med 2014 May;189(10):1285-6

1 University of Leicester Leicester, United Kingdom and.

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http://dx.doi.org/10.1164/rccm.201402-0294LEDOI Listing
May 2014

Reply: Role of primary necrosis/lysis of submucosal eosinophils in obese individuals with asthma.

Authors:
Chris E Brightling Dhananjay Desai

Am J Respir Crit Care Med 2013 Dec;188(12):1468-9

1 University of Leicester Leicester, United Kingdom and University Hospitals of Leicester NHS Trust Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201305-0996LEDOI Listing
December 2013

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

Authors:
Dhananjay Desai Christopher Newby Fiona A Symon Pranabashis Haldar Sachil Shah Sumit Gupta Mona Bafadhel Amisha Singapuri Salman Siddiqui Joanne Woods Athula Herath Ian K Anderson Peter Bradding Ruth Green Nita Kulkarni Ian Pavord Richard P Marshall Ana R Sousa Richard D May Andrew J Wardlaw Chris E Brightling

Am J Respir Crit Care Med 2013 Sep;188(6):657-63

1 Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201208-1470OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826183PMC
September 2013

A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children.

Authors:
Aristea Binia Nicole Van Stiphout Liming Liang Sven Michel Pankaj K Bhavsar K Fan Chung Chris E Brightling Peter J Barnes Michael Kabesch Andrew Bush William O C Cookson Miriam F Moffatt

Hum Mutat 2013 Aug 20;34(8):1131-9. Epub 2013 May 20.

Molecular Genetics and Genomics Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1002/humu.22340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296222PMC
August 2013

Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI.

Authors:
David Gibeon Kannangara Batuwita Michelle Osmond Liam G Heaney Chris E Brightling Rob Niven Adel Mansur Rekha Chaudhuri Christine E Bucknall Anthony Rowe Yike Guo Pankaj K Bhavsar Kian Fan Chung Andrew Menzies-Gow

Chest 2013 Feb;143(2):406-414

Royal Brompton Hospital, London, England. Electronic address:

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http://dx.doi.org/10.1378/chest.12-0872DOI Listing
February 2013

The EvA study: aims and strategy.

Authors:
Loems Ziegler-Heitbrock Marion Frankenberger Irene Heimbeck Dorothe Burggraf Matthias Wjst Karl Häussinger Chris Brightling Sumit Gupta David Parr Deepak Subramanian Dave Singh Umme Kolsum Piera Boschetto Alfredo Potena Dorota Gorecka Adam Nowinski Imre Barta Balazs Döme Janos Strausz Timm Greulich Claus Vogelmeier Robert Bals Jens M Hohlfeld Tobias Welte Per Venge Ivo Gut Anne Boland Robert Olaso Jörg Hager Pieter Hiemstra Klaus F Rabe Martina Unmüssig Joachim Müller-Quernheim Antje Prasse

Eur Respir J 2012 Oct 22;40(4):823-9. Epub 2012 Mar 22.

EvA Study Center, Helmholtz Zentrum Muenchen and Asklepios-Klinik, Gauting, Germany.

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http://dx.doi.org/10.1183/09031936.00142811DOI Listing
October 2012

Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry.

Authors:
Joan Sweeney Chris E Brightling Andrew Menzies-Gow Robert Niven Chris C Patterson Liam G Heaney

Thorax 2012 Aug 11;67(8):754-6. Epub 2012 May 11.

Centre for Infection and Immunity, Queen's University of Belfast, Lisburn Road, Belfast, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2012-201869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402747PMC
August 2012

Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.

Authors:
Amanda Sutcliffe Fay Hollins Edith Gomez Ruth Saunders Camille Doe Marcus Cooke R A John Challiss Chris E Brightling

Am J Respir Crit Care Med 2012 Feb 22;185(3):267-74. Epub 2011 Nov 22.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201107-1281OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402550PMC
February 2012

Functional KCa3.1 K+ channels are required for human fibrocyte migration.

Authors:
Glenn Cruse Shailendra R Singh S Mark Duffy Camille Doe Ruth Saunders Chris E Brightling Peter Bradding

J Allergy Clin Immunol 2011 Dec 27;128(6):1303-1309.e2. Epub 2011 Aug 27.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2011.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526791PMC
December 2011

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.

Authors:
Amanda L Tatler Alison E John Lisa Jolly Anthony Habgood Jo Porte Chris Brightling Alan J Knox Linhua Pang Dean Sheppard Xiaozhu Huang Gisli Jenkins

J Immunol 2011 Dec 24;187(11):6094-107. Epub 2011 Oct 24.

Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1003507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242066PMC
December 2011

Eosinophils best marker of steroid response.

Authors:
Neil Martin Chris E Brightling Ian D Pavord

Thorax 2011 Aug 23;66(8):730; author reply 730-1. Epub 2010 Sep 23.

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http://dx.doi.org/10.1136/thx.2010.144592DOI Listing
August 2011

Systems medicine and integrated care to combat chronic noncommunicable diseases.

Authors:
Jean Bousquet Josep M Anto Peter J Sterk Ian M Adcock Kian Fan Chung Josep Roca Alvar Agusti Chris Brightling Anne Cambon-Thomsen Alfredo Cesario Sonia Abdelhak Stylianos E Antonarakis Antoine Avignon Andrea Ballabio Eugenio Baraldi Alexander Baranov Thomas Bieber Joël Bockaert Samir Brahmachari Christian Brambilla Jacques Bringer Michel Dauzat Ingemar Ernberg Leonardo Fabbri Philippe Froguel David Galas Takashi Gojobori Peter Hunter Christian Jorgensen Francine Kauffmann Philippe Kourilsky Marek L Kowalski Doron Lancet Claude Le Pen Jacques Mallet Bongani Mayosi Jacques Mercier Andres Metspalu Joseph H Nadeau Grégory Ninot Denis Noble Mehmet Oztürk Susanna Palkonen Christian Préfaut Klaus Rabe Eric Renard Richard G Roberts Boleslav Samolinski Holger J Schünemann Hans-Uwe Simon Marcelo Bento Soares Giulio Superti-Furga Jesper Tegner Sergio Verjovski-Almeida Peter Wellstead Olaf Wolkenhauer Emiel Wouters Rudi Balling Anthony J Brookes Dominique Charron Christophe Pison Zhu Chen Leroy Hood Charles Auffray

Genome Med 2011 Jul 6;3(7):43. Epub 2011 Jul 6.

Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France.

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http://dx.doi.org/10.1186/gm259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221551PMC
July 2011

Chromosome 17q21 SNP and severe asthma.

Authors:
Aristea Binia Nadia Khorasani Pankaj K Bhavsar Ian Adcock Chris E Brightling K Fan Chung William O C Cookson Miriam F Moffatt

J Hum Genet 2011 Jan 28;56(1):97-8. Epub 2010 Oct 28.

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http://dx.doi.org/10.1038/jhg.2010.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027598PMC
January 2011

Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma.

Authors:
Jean Bousquet Eva Mantzouranis Alvaro A Cruz Nadia Aït-Khaled Carlos E Baena-Cagnani Eugene R Bleecker Chris E Brightling Peter Burney Andrew Bush William W Busse Thomas B Casale Moira Chan-Yeung Rongchang Chen Badrul Chowdhury Kian Fan Chung Ronald Dahl Jeffrey M Drazen Leonardo M Fabbri Stephen T Holgate Francine Kauffmann Tari Haahtela Nikolaï Khaltaev James P Kiley Mohammad R Masjedi Yousser Mohammad Paul O'Byrne Martyn R Partridge Klaus F Rabe Alkis Togias Christiaan van Weel Sally Wenzel Nanshan Zhong Torsten Zuberbier

J Allergy Clin Immunol 2010 Nov;126(5):926-38

University Hospital, Hôpital Arnaud de Villeneuve, Montpellier, France.

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http://dx.doi.org/10.1016/j.jaci.2010.07.019DOI Listing
November 2010

Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry.

Authors:
Liam G Heaney Chris E Brightling Andrew Menzies-Gow Michael Stevenson Rob M Niven

Thorax 2010 Sep;65(9):787-94

Centre for Infection and Immunity, Queen's University of Belfast, Level 8, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, UK.

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http://dx.doi.org/10.1136/thx.2010.137414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975949PMC
September 2010

Mannitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness.

Authors:
Amisha Singapuri Sue McKenna Chris E Brightling Peter Bradding

Respirology 2010 Apr 24;15(3):510-5. Epub 2010 Feb 24.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/j.1440-1843.2010.01712.xDOI Listing
April 2010

Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis.

Authors:
Dhan Desai Chris Brightling

Otolaryngol Clin North Am 2010 Feb;43(1):123-30, x

Department of Infection, Inflammation, and Immunity, University of Leicester, Institute for Lung Health, Glenfield Hospital, UK.

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http://dx.doi.org/10.1016/j.otc.2009.11.006DOI Listing
February 2010

Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors.

Authors:
Adam K A Wright Satish Rao Simon Range Christiane Eder Thomas P J Hofer Marion Frankenberger Lester Kobzik Chris Brightling Jonathan Grigg Loems Ziegler-Heitbrock

J Leukoc Biol 2009 Sep 29;86(3):479-89. Epub 2009 Apr 29.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

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http://doi.wiley.com/10.1189/jlb.1108699
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September 2009

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration.

Authors:
S Mark Duffy Glenn Cruse Sarah L Cockerill Chris E Brightling Peter Bradding

Eur J Immunol 2008 Sep;38(9):2548-56

The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK.

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http://doi.wiley.com/10.1002/eji.200738106
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http://dx.doi.org/10.1002/eji.200738106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699428PMC
September 2008

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.

Authors:
Malcolm C Shepherd S Mark Duffy Trudi Harris Glenn Cruse Michael Schuliga Chris E Brightling Craig B Neylon Peter Bradding Alastair G Stewart

Am J Respir Cell Mol Biol 2007 Nov 21;37(5):525-31. Epub 2007 Jun 21.

Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2006-0358OC
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November 2007

The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.

Authors:
Dominick E Shaw Mike A Berry Mike Thomas Ruth H Green Chris E Brightling Andrew J Wardlaw Ian D Pavord

Am J Respir Crit Care Med 2007 Aug 11;176(3):231-7. Epub 2007 May 11.

Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200610-1427OCDOI Listing
August 2007

Mast cell infiltration of airway smooth muscle in asthma.

Authors:
Peter Bradding Chris Brightling

Respir Med 2007 May 15;101(5):1045; author reply 1046-7. Epub 2007 Feb 15.

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http://dx.doi.org/10.1016/j.rmed.2007.01.004DOI Listing
May 2007

Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma.

Authors:
Kugathasan Mutalithas Joanne Croudace Cristina Guillen Salman Siddiqui David Thickett Andrew Wardlaw David Lammas Chris Brightling

J Allergy Clin Immunol 2007 May 2;119(5):1274-6. Epub 2007 Apr 2.

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http://dx.doi.org/10.1016/j.jaci.2007.02.021DOI Listing
May 2007

The reclassification of asthma based on subphenotypes.

Authors:
Ruth H Green Chris E Brightling Peter Bradding

Curr Opin Allergy Clin Immunol 2007 Feb;7(1):43-50

Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester, UK.

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http://dx.doi.org/10.1097/ACI.0b013e3280118a32DOI Listing
February 2007

The influence of age on induced sputum differential cell counts in normal subjects.

Authors:
Rebecca A Thomas Ruth H Green Chris E Brightling Surinder S Birring Debbie Parker Andrew J Wardlaw Ian D Pavord

Chest 2004 Dec;126(6):1811-4

Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.

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http://dx.doi.org/10.1378/chest.126.6.1811DOI Listing
December 2004