Chris Boshoff

Chris Boshoff

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Chris Boshoff

Publications by authors named "Chris Boshoff"

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Kidney cancer: The next decade.

J Exp Med 2018 10 14;215(10):2477-2479. Epub 2018 Sep 14.

Pfizer Inc., New York, NY

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http://dx.doi.org/10.1084/jem.20181617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170181PMC
October 2018

The biology and management of non-small cell lung cancer.

Nature 2018 01;553(7689):446-454

Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nature25183DOI Listing
January 2018

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment.

Clin Cancer Res 2015 Jul 4;21(13):2905-10. Epub 2015 May 4.

Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, California.

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http://clincancerres.aacrjournals.org/content/early/2015/05/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-0816DOI Listing
July 2015

Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.

PLoS Pathog 2014 Sep 25;10(9):e1004400. Epub 2014 Sep 25.

UCL Cancer Institute, Research Department of Cancer Biology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1004400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177984PMC
September 2014

APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.

Cell Rep 2014 Jun 5;7(6):1833-41. Epub 2014 Jun 5.

Department of Oncology, UCL Cancer Institute, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.012DOI Listing
June 2014

Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.

Stem Cells 2013 Oct;31(10):2061-72

Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1002/stem.1472DOI Listing
October 2013

Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogramming.

Trends Cell Biol 2013 Sep 17;23(9):421-32. Epub 2013 May 17.

UCL Cancer Institute, 72 Huntley Street, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.tcb.2013.04.001DOI Listing
September 2013

Integrated virus-host methylome analysis in head and neck squamous cell carcinoma.

Epigenetics 2013 Sep 18;8(9):953-61. Epub 2013 Jul 18.

Medical Genomics; UCL Cancer Institute; University College London; London, UK.

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http://dx.doi.org/10.4161/epi.25614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883772PMC
September 2013

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

J Invest Dermatol 2013 Jul 30;133(7):1768-76. Epub 2013 Jan 30.

Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/jid.2013.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682392PMC
July 2013

Redefining KSHV latency.

Cell Host Microbe 2013 Apr;13(4):373-4

Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Huntley Street, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.chom.2013.04.003DOI Listing
April 2013

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.

Blood 2012 Dec 18;120(25):5063-72. Epub 2012 Oct 18.

Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2012-04-423004DOI Listing
December 2012

Ephrin receptor: a door to KSHV infection.

Authors:
Chris Boshoff

Nat Med 2012 Jun 6;18(6):861-3. Epub 2012 Jun 6.

UCL Cancer Institute, University College London, London.

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http://dx.doi.org/10.1038/nm.2803DOI Listing
June 2012

Focal adhesion kinase is required for KSHV vGPCR signaling.

Mol Carcinog 2012 Apr 2;51(4):339-51. Epub 2011 May 2.

The Department of Medicine, The University of Minnesota, Minneapolis, Minnesota; The Center for Infectious Diseases and Microbiology Translational Research, The University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/mc.20790DOI Listing
April 2012

Unraveling virus-induced lymphomagenesis.

Authors:
Chris Boshoff

J Clin Invest 2011 Mar 21;121(3):838-41. Epub 2011 Feb 21.

UCL Cancer Institute, University College London, London, United Kingdom.

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http://www.jci.org/articles/view/46499
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http://dx.doi.org/10.1172/JCI46499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046640PMC
March 2011

Cancer epigenome.

Adv Genet 2010 ;70:247-76

UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1016/B978-0-12-380866-0.60009-5DOI Listing
November 2010

In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylation.

Carcinogenesis 2010 Oct 13;31(10):1854-62. Epub 2010 May 13.

CRUK Viral Oncology Group, UCL Cancer Institute, University College London, 72 Huntley Street, WC1E 6BT, UK.

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http://dx.doi.org/10.1093/carcin/bgq080DOI Listing
October 2010

Kaposi's sarcoma and its associated herpesvirus.

Nat Rev Cancer 2010 Oct;10(10):707-19

Viral Oncology Program, Developmental Center for AIDS Research, and Department of Microbiology & Immunology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1,550 NW 10th Avenue, 109 Papanicolau Building, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/nrc2888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721662PMC
October 2010

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator.

Nat Cell Biol 2010 May 25;12(5):513-9. Epub 2010 Apr 25.

Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London WC1E 6BT, U.K.

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http://dx.doi.org/10.1038/ncb2054DOI Listing
May 2010

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Genes Dev 2010 Jan;24(2):195-205

Cancer Research UK Viral Oncology Group, University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1101/gad.553410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807354PMC
January 2010

KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.

PLoS Pathog 2009 Oct 9;5(10):e1000616. Epub 2009 Oct 9.

Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1000616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751827PMC
October 2009

Targeting EGFR in head and neck cancer: a decade of progress.

Nat Clin Pract Oncol 2009 Mar;6(3):123

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http://dx.doi.org/10.1038/ncponc1328DOI Listing
March 2009

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.

Mol Cancer Ther 2009 Jan;8(1):249-60

Cancer Research UK Viral Oncology Group, University College London Cancer Institute, Paul O'Gorman Building, 74 Huntley Street, London, United Kingdom WC1E 6BT.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0636DOI Listing
January 2009

Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus.

Cell Host Microbe 2008 Nov;4(5):470-83

Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Paul O'Gorman Building, Huntley Street, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.chom.2008.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698447PMC
November 2008

Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.

Mol Cell 2008 Jun;30(5):620-31

Institute of Structural and Molecular Biology, School of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1016/j.molcel.2008.04.029DOI Listing
June 2008

KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.

Blood 2008 May 16;111(9):4731-40. Epub 2008 Jan 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1182/blood-2007-09-110544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343603PMC
May 2008

Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.

Cancer Res 2007 May;67(9):4042-51

Cancer Research U.K. Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3321DOI Listing
May 2007

Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells.

Blood 2007 Feb 17;109(4):1550-8. Epub 2006 Oct 17.

Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, UK.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-05-02
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http://dx.doi.org/10.1182/blood-2006-05-024034DOI Listing
February 2007

Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells.

Nat Methods 2007 Feb 14;4(2):153-9. Epub 2007 Jan 14.

Biological and Medicinal Chemistry Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1038/nmeth997DOI Listing
February 2007

Kaposi sarcoma as a model of oncogenesis and cancer treatment.

Expert Rev Anticancer Ther 2007 Feb;7(2):211-20

Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, London, UK.

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http://dx.doi.org/10.1586/14737140.7.2.211DOI Listing
February 2007

Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

Skeletal Radiol 2007 Jan 30;36(1):59-65. Epub 2006 Jun 30.

Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK.

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http://dx.doi.org/10.1007/s00256-006-0167-4DOI Listing
January 2007

A molecular map of mesenchymal tumors.

Genome Biol 2005 26;6(9):R76. Epub 2005 Aug 26.

Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2005-6-9-r76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242211PMC
July 2006

Lentiviral manipulation of gene expression in human adult and embryonic stem cells.

Tissue Eng 2006 Jul;12(7):1741-51

Wolfson Institute of Biomedical Research, University College, London, United Kingdom.

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http://dx.doi.org/10.1089/ten.2006.12.1741DOI Listing
July 2006

KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.

Blood 2006 Jan 8;107(1):277-84. Epub 2005 Sep 8.

Division of International Medicine and Infectious Diseases, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2005-06-2350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895347PMC
January 2006

Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala.

Mol Cancer Ther 2005 Dec;4(12):2008-15

Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0070DOI Listing
December 2005

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

EMBO J 2005 Sep 11;24(17):3104-16. Epub 2005 Aug 11.

Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201355PMC
September 2005

Linking Kaposi virus to cancer-associated cytokines.

Trends Mol Med 2005 Jul;11(7):309-12

Institute of Microbiology and Immunology, National Yang-Ming University, No. 155 Sec 2 Li-Nong Street, Taipei 112, Taiwan.

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http://dx.doi.org/10.1016/j.molmed.2005.06.002DOI Listing
July 2005

Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA.

Blood 2005 Mar 30;105(6):2510-8. Epub 2004 Nov 30.

Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London, United Kingdom WC1E 6BT.

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http://dx.doi.org/10.1182/blood-2004-08-3052DOI Listing
March 2005

LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.

Proc Natl Acad Sci U S A 2004 Nov 12;101(47):16531-6. Epub 2004 Nov 12.

Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0407123101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534532PMC
November 2004

Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Nat Genet 2004 Jul 27;36(7):687-93. Epub 2004 Jun 27.

Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK.

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http://www.nature.com/articles/ng1384
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http://dx.doi.org/10.1038/ng1384DOI Listing
July 2004

Distinct cellular origins of primary effusion lymphoma with and without EBV infection.

Leuk Res 2004 Apr;28(4):333-8

Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK.

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http://dx.doi.org/10.1016/j.leukres.2003.08.003DOI Listing
April 2004

Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia.

AIDS 2004 Feb;18(3):485-93

Wolfson Institute for Biomedical Research and the Department of Sexually Transmitted Diseases, University College London, London, UK.

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http://dx.doi.org/10.1097/00002030-200402200-00015DOI Listing
February 2004

RNA interference: a potential tool against Kaposi's sarcoma-associated herpesvirus.

Curr Opin Infect Dis 2003 Dec;16(6):593-600

Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK.

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http://dx.doi.org/10.1097/00001432-200312000-00013DOI Listing
December 2003

KSHV vFLIP binds to IKK-gamma to activate IKK.

J Cell Sci 2003 Sep 30;116(Pt 18):3721-8. Epub 2003 Jul 30.

Department of Immunology and Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland St, London W1T 2AH, UK.

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http://dx.doi.org/10.1242/jcs.00691DOI Listing
September 2003

Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile.

Proc Natl Acad Sci U S A 2003 Sep 18;100(18):10399-404. Epub 2003 Aug 18.

Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1630810100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193573PMC
September 2003

Viral coinfections among African children infected with human immunodeficiency virus type 1.

Clin Infect Dis 2003 Apr 19;36(7):922-4. Epub 2003 Mar 19.

Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1086/368207DOI Listing
April 2003

Kaposi virus scores cancer coup.

Authors:
Chris Boshoff

Nat Med 2003 Mar;9(3):261-2

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http://dx.doi.org/10.1038/nm0303-261DOI Listing
March 2003

Kaposi's sarcoma biology.

Authors:
Chris Boshoff

IUBMB Life 2002 Apr-May;53(4-5):259-61

Wolfson Institute for Biomedical Research, University College London, United Kingdom.

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http://dx.doi.org/10.1080/15216540212645DOI Listing
January 2003

Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.

EMBO J 2002 Jun;21(11):2602-15

The Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1093/emboj/21.11.2602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126038PMC
June 2002

AIDS-related malignancies.

Nat Rev Cancer 2002 May;2(5):373-82

Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK.

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http://dx.doi.org/10.1038/nrc797DOI Listing
May 2002

The molecular pathology of Kaposi's sarcoma-associated herpesvirus.

Biochim Biophys Acta 2002 Mar;1602(1):1-22

Wohl Virion Centre, Windeyer Institute for Medical Research, Cleveland Street, UCL (University College London), London, UK.

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http://dx.doi.org/10.1016/s0304-419x(01)00040-3DOI Listing
March 2002

Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism.

J Clin Virol 2002 Jan;23(3):119-48

Molecular Virology Laboratories, Department of Oncology, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB 3M09, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/s1386-6532(01)00205-0DOI Listing
January 2002

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.

J Virol 2002 Jan;76(2):802-16

The CRC Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom WC1E 6BT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136811PMC
http://dx.doi.org/10.1128/jvi.76.2.802-816.2002DOI Listing
January 2002