Publications by authors named "Chris Barnes"

100Publications

Nonacog beta pegol (N9-GP) in hemophilia B: First report on safety and efficacy in previously untreated and minimally treated patients.

Res Pract Thromb Haemost 2020 Oct 29;4(7):1101-1113. Epub 2020 Jul 29.

Children's Hospital Los Angeles University of Southern California Keck School of Medicine Los Angeles CA USA.

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October 2020

Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite.

Drug Metab Dispos 2020 12 25;48(12):1312-1320. Epub 2020 Sep 25.

Theravance Biopharma US, Inc., South San Francisco, California (D.L.B., S.Y., S.S.H., P.-J.C., C.N.B., M.T.B).

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December 2020

Evolutionary dynamics of neoantigens in growing tumors.

Nat Genet 2020 10 14;52(10):1057-1066. Epub 2020 Sep 14.

Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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October 2020

FlopR: An Open Source Software Package for Calibration and Normalization of Plate Reader and Flow Cytometry Data.

ACS Synth Biol 2020 09 1;9(9):2258-2266. Epub 2020 Sep 1.

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K.

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September 2020

From Microbial Communities to Distributed Computing Systems.

Front Bioeng Biotechnol 2020 22;8:834. Epub 2020 Jul 22.

Department of Cell and Developmental Biology, University College London, London, United Kingdom.

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July 2020

Development of a fluorine-18 radiolabelled fluorescent chalcone: evaluated for detecting glycogen.

EJNMMI Radiopharm Chem 2020 Jun 23;5(1):17. Epub 2020 Jun 23.

Comprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK.

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June 2020

Peak Inspiratory Flows: Defining Repeatability Limits and a Predictive Equation for Different Inhalers.

Chest 2020 Oct 25;158(4):1413-1419. Epub 2020 Apr 25.

Theravance Biopharma US, Inc., South San Francisco, CA. Electronic address:

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October 2020

Deep reinforcement learning for the control of microbial co-cultures in bioreactors.

PLoS Comput Biol 2020 04 10;16(4):e1007783. Epub 2020 Apr 10.

Department of Cell and Developmental Biology, University College London, London, United Kingdom.

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April 2020

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.

Elife 2020 Mar 30;9. Epub 2020 Mar 30.

Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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March 2020

Clinical translation of F-fluoropivalate - a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers.

Eur J Nucl Med Mol Imaging 2020 Oct 2;47(11):2549-2561. Epub 2020 Mar 2.

Department of Surgery and Cancer, Imperial College London, GN1 Commonwealth Building, Hammersmith Hospital, DuCane Rd, London, W12 0NN, UK.

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October 2020

Clinical Experience with Telavancin: Real-World Results from the Telavancin Observational Use Registry (TOUR™).

Drugs Real World Outcomes 2019 Dec;6(4):183-191

Theravance Biopharma US, Inc., 901 Gateway Blvd, South San Francisco, CA, 94080, USA.

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December 2019

Detecting Changes in the Intestinal Environment Using an Engineered Bacterial Biosensor.

ACS Synth Biol 2019 12 8;8(12):2620-2628. Epub 2019 Nov 8.

Department of Cell and Developmental Biology , University College London , London WC1E 6BT , United Kingdom.

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December 2019

Pharmacokinetics and safety of revefenacin in subjects with impaired renal or hepatic function.

Int J Chron Obstruct Pulmon Dis 2019 8;14:2305-2318. Epub 2019 Oct 8.

Department of Drug Metabolism and Pharmacokinetics, Theravance Biopharma US, Inc., South San Francisco, CA, USA.

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April 2020

Two New Plasmid Post-segregational Killing Mechanisms for the Implementation of Synthetic Gene Networks in Escherichia coli.

iScience 2019 Apr 22;14:323-334. Epub 2019 Mar 22.

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK. Electronic address:

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April 2019

Development and Evaluation of an F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression.

Mol Pharm 2019 05 3;16(5):2106-2117. Epub 2019 Apr 3.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , Hammersmith Hospital Campus, Du Cane Road , London W12 0NN , U.K.

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May 2019

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

EJNMMI Res 2019 Feb 19;9(1):18. Epub 2019 Feb 19.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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February 2019

Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology.

Processes (Basel) 2018 Sep;6(9):167

Department of Cell and Developmental Biology, UCL, London WC1E 6BT, UK.

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September 2018

Reply to 'Neutral tumor evolution?'

Nat Genet 2018 12;50(12):1633-1637

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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December 2018

Reply to 'Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution'.

Nat Genet 2018 12;50(12):1624-1626

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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December 2018

2018 American Society of Consultant Pharmacists Annual Meeting & Exhibition.

Authors:
Mary Bridgeman Donna Prete Nicole Rolston Daniel Abazia Marc Sturgill Laura Finn Deborah Summers Marketa Marvanova Paul Henkel Jayson Thompson Mark Dewey Daniel Friesner Marketa Marvanova Carolyn Alessi Lourdes Cuellar Lisa Yamagishi Christine O'Neil Olivia Erickson Kelly Mazzei Khalid Kamal Nicole Early Brian Bainter Laura Hanson Emily Schmitz Amanda Loomis Marissa Norberto Anne Hume Marsha Meyer Romilla Batra Denise Likar Susan Enguidanos Catherine Liu Brian Kotansky Ann Fisher Christine M Ruby Jennifer Pruskowski Siti Nurhana Abdul Karim Belinda Soon Wei Yong Carolyn Alessi Lourdes Cuellar Patricia Slattum Ericka Crouse Jeffrey Delafuente Krista Donohoe Kelechi Ogbonna Emily Peron Kacie Powers Elvin Price Kristin Zimmerman Sarah Rahim Tracey Gendron Patricia Slattum Krista Donohoe Clarissa Cho Kristin Zimmerman Ericka Crouse Emily Peron Kacie Powers Elvin Price Patricia Slattum Krista Donohoe Lindsay Elliott Candace Minter Mary Morin Leisa Marshall Gregg Stevens Charles Cordaro Matthew Hill Kayla Nagy Kelly Reilly Kroustos Kristen Finley Sobota Rebecca Mahan Trista Bailey Kara Ioannou Diana Mansour Tristan Thompson Kristel Chatellier Amanda Schwenk Christine Ruby Tsuhua Susan Chen Shilun Li Marian James Maria Spilios Andrea Leschak Alexander Levine Stephanie Forgette Nneka Oluigbo Doreen Szollosi Dzifa Avalime Salome Bwayo Weaver Mary Maneno Earl Ettienne Julia Yunkyung Yi Laura Hart Shelly Gray Stephanie Ozalas Kayla Miller Rohini Dave Jacqueline Bork Janetta Emmelhainz Kaylee Adams Joshua Postolski Matthew Willoughby Elizabeth Feldman Kelly Braham Christopher Miller Deena Barbagallo Robert Seabury John Noviasky Carolyn Alessi Lourdes Cuellar Jayvir Dabhi Donna Bartlett Tham Le Linda Simoni-Wastila Aida Kuzucan Linda Simoni-Wastila Tham Le Siyeon Park Linda Simoni-Wastila Tham Le Siyeon Park Michelle Choi Linda Simoni-Wastila Siyeon Park Tham Le Michelle Choi Linda Simoni-Wastila Bilal Khokhar Michelle Choi Tham Le Linda Simoni-Wastila Peter Brody Mary Hejna Jessica Mason Miranda Graham Jessica Micceri Roksolana Lypska Bryan Quinn Henry Wilson Robert Wahler Marissa Aloyo Vanessa Tomm Angela Hill Alan Obringer Kirsten Butterfoss Julia Blak Rebecca Balcer Jenna Boza Amanda Foster Ehtesham Shafique Casondra Kleven Patricia Wigle Bethanne Brown Carolyn Alessi Lourdes Cuellar Kristin Meyer Wendy Mobley-Bukstein Hemlata Singh Emelia Perez Alaa-Eldin Mira William Kuehner Lou Czechowski Heather Cook Nicole Brandt Janee Parson Rachyl Fornaro Nicole Brandt Kimberly Claeys Barbara Zarowitz Daniel Mansour Chelsea McFadden Sierra Simpkins Folarin Ojowa Abigail Klutts Sarah Holmes Everett Smith Jr Reba Cornman Kelly Doran Barbara Resnick Nicole Brandt Chinasa Umeozulu Anne Williams Nicole Brandt George Hennawi Danielle Thomas Dawn Knudsen Gerber Kristin Meyer Kriti Sharma Catherine Cooke Amy Howard Rebecca Chater Abbie Vogler Nicole Brandt Kaitlyn Kennett-Hayes Laura Elliott John Engelbert Emily Hargrave Chynna Bambico Kripali Patel Cynthia Warriner Patricia Slattum Nihar R Desai Christopher G Rowan Paula Alvarez Jeanene Fogli Robert D Toto Nihar R Desai Paula Alvarez Jeanene Fogli Pamala Reed Mary Kay Owens John F Greden Anthony J Rothschild Shannon Zandy Michael Thase Boadie W Dunlop Charles DeBattista Charles R Conway Brent P Forester Francis M Mondimore Richard C Shelton James Li Alexa Gilbert Lindsey Burns Michael Jablonski Bryan Dechairo Sagar Parikh James Donohue Gregory Feldman Sanjay Sethi Chris Barnes Srikanth Pendyala David Bourdet Gary Ferguson Chris Barnes Srikanth Pendyala Glenn Crater Jeanene Fogli Martha Mayo Coleman Gross John Miyawa Reyn Ono Steven Woods Dahlia Garza Natalie Panov Jeanene Fogli Edmund Moran Vijay Sabesan James Wertman Kenley Ngim

Consult Pharm 2017 Oct;33(10):572-608

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October 2017

Reply to 'Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data'.

Nat Genet 2018 12;50(12):1628-1630

Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, the Institute of Cancer Research, London, UK.

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December 2018

Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity.

Cell Syst 2018 07;7(1):5-16

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK; UCL Genetics Institute, University College London, London WC1E 6BT, UK. Electronic address:

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July 2018

Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data.

Nat Genet 2018 09;50(9):1342

Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK.

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September 2018

Perspectives of applied collaborative sport science research within professional team sports.

Eur J Sport Sci 2019 Mar 14;19(2):147-155. Epub 2018 Jul 14.

i Sport, Health and Exercise Science , University of Hull , Hull , UK.

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March 2019

Quantification of subclonal selection in cancer from bulk sequencing data.

Nat Genet 2018 06 28;50(6):895-903. Epub 2018 May 28.

Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK.

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June 2018

Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.

Cell Syst 2018 Apr 21;6(4):521-530.e3. Epub 2018 Mar 21.

Department of Mathematics, University College London, Gower Street, WC1E 6BT London, UK.

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April 2018

Optimization of prophylaxis for hemophilia A.

PLoS One 2018 15;13(2):e0192783. Epub 2018 Feb 15.

University of Sydney, Camperdown, NSW, Australia.

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April 2018

The boy with the ruddy face: An approach to polycythaemia presenting in childhood.

J Paediatr Child Health 2018 Apr 29;54(4):453-456. Epub 2017 Dec 29.

Department of Haematology, Royal Children's Hospital, Melbourne, Victoria, Australia.

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April 2018

Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures.

Nat Genet 2017 08;49(9):1289-1291

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

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August 2017

Catch my drift? Making sense of genomic intra-tumour heterogeneity.

Biochim Biophys Acta Rev Cancer 2017 Apr 7;1867(2):95-100. Epub 2017 Jan 7.

Evolution and Cancer Laboratory, Barts Cancer Institute, Charterhouse Sq, Queen Mary University of London, EC1M 6BQ, UK. Electronic address:

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April 2017

A computational method for the investigation of multistable systems and its application to genetic switches.

BMC Syst Biol 2016 12 7;10(1):130. Epub 2016 Dec 7.

Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.

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December 2016

Mechanistic Modelling and Bayesian Inference Elucidates the Variable Dynamics of Double-Strand Break Repair.

PLoS Comput Biol 2016 Oct 14;12(10):e1005131. Epub 2016 Oct 14.

Department of Cell and Developmental Biology, University College London, London, England.

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October 2016

Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling.

Cell Rep 2016 06 2;15(11):2524-35. Epub 2016 Jun 2.

Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London SW7 2AZ, UK; Institute of Chemical Biology, Imperial College London, London SW7 2AZ, UK. Electronic address:

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June 2016

A Statistical Approach Reveals Designs for the Most Robust Stochastic Gene Oscillators.

ACS Synth Biol 2016 06 17;5(6):459-70. Epub 2016 Feb 17.

Department of Cell and Developmental Biology, ‡Department of Mathematics, and ¶Department of Genetics, Evolution and Environment, University College London , London, WC1E 6BT, U.K.

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June 2016

Identification of neutral tumor evolution across cancer types.

Nat Genet 2016 Mar 18;48(3):238-244. Epub 2016 Jan 18.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, SM2 5NG, UK.

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March 2016

Congenital Methemoglobinemia Type II-Clinical Improvement with Short-Term Methylene Blue Treatment.

Pediatr Blood Cancer 2016 Mar 17;63(3):558-60. Epub 2015 Nov 17.

Department of Haematology, Royal Children's Hospital, Murdoch Children's Research Institute, Parkville, Melbourne, Australia.

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March 2016

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.

Nat Commun 2015 Apr 2;6:6709. Epub 2015 Apr 2.

MRC-National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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April 2015

Evolution of match performance parameters for various playing positions in the English Premier League.

Hum Mov Sci 2015 Feb 18;39:1-11. Epub 2014 Nov 18.

Carnegie School of Sport, Leeds Beckett University, UK. Electronic address:

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February 2015

Benchmarking the management of children with haemophilia in Australia.

J Paediatr Child Health 2014 Dec;50(12):1032-3

Haematology, Royal Children's Hospital, Melbourne, Victoria, Australia.

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December 2014

A theoretical framework for the regulation of Shh morphogen-controlled gene expression.

Development 2014 Oct;141(20):3868-78

MRC-National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK

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October 2014

Directional collective cell migration emerges as a property of cell interactions.

PLoS One 2014 2;9(9):e104969. Epub 2014 Sep 2.

Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom; Department of Mathematics, University College London, London, United Kingdom.

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May 2015

Model selection in systems biology depends on experimental design.

PLoS Comput Biol 2014 Jun 12;10(6):e1003650. Epub 2014 Jun 12.

Centre for Integrative Systems Biology at Imperial College London, London, United Kingdom.

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June 2014

Outpatient versus inpatient IV antibiotic management for pediatric oncology patients with low risk febrile neutropenia: a randomised trial.

Pediatr Blood Cancer 2014 Aug 6;61(8):1427-33. Epub 2014 Mar 6.

Children's Cancer Centre, The Royal Children's Hospital, Parkville, Victoria, Australia.

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August 2014

A framework for parameter estimation and model selection from experimental data in systems biology using approximate Bayesian computation.

Nat Protoc 2014 Feb 23;9(2):439-56. Epub 2014 Jan 23.

1] Department of Life Sciences, Centre for Integrative Systems Biology and Bioinformatics, Imperial College, London, UK. [2] Institute of Chemical Biology, Imperial College, London, UK.

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February 2014

From EHRs to Linked Data: representing and mining encounter data for clinical expertise evaluation.

AMIA Jt Summits Transl Sci Proc 2013 18;2013:165. Epub 2013 Mar 18.

OHSU Library and Department of Medical Informatics, Oregon Health & Science University, Portland, OR.

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December 2013

Reduced burden of very large and rare CNVs in bipolar affective disorder.

Bipolar Disord 2013 Dec 16;15(8):893-8. Epub 2013 Oct 16.

MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff.

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December 2013

On optimality of kernels for approximate Bayesian computation using sequential Monte Carlo.

Stat Appl Genet Mol Biol 2013 Mar 26;12(1):87-107. Epub 2013 Mar 26.

Imperial College London, London, UK.

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March 2013

Central venous access device-related infections in patients with haemophilia.

J Paediatr Child Health 2013 Mar 26;49(3):242-5. Epub 2013 Feb 26.

Henry Ekert Haemophilia Treatment Centre, Royal Children's Hospital, Melbourne, Victoria, Australia.

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March 2013

Applying decision tree induction for identification of important attributes in one-versus-one player interactions: a hockey exemplar.

J Sports Sci 2013 15;31(10):1031-7. Epub 2013 Feb 15.

Australian Institute of Sport, Performance Research, Canberra, Australia.

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December 2013

Bayesian design strategies for synthetic biology.

Interface Focus 2011 Dec 5;1(6):895-908. Epub 2011 Oct 5.

Centre for Integrative Systems Biology and Bioinformatics, Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK.

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December 2011

Hospitalisations for sickle-cell disease in an Australian paediatric population.

J Paediatr Child Health 2013 Jan 2;49(1):68-71. Epub 2012 Dec 2.

Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.

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January 2013

Importance of pharmacokinetics in the management of hemophilia.

Authors:
Chris Barnes

Pediatr Blood Cancer 2013 25;60 Suppl 1:S27-9. Epub 2012 Oct 25.

Henry Ekert Hemophilia Treatment Centre, Royal Children's Hospital, Parkville, Melbourne, Australia.

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January 2013

The Department of Health-supported genetic counsellor training post scheme in England: a unique initiative?

J Community Genet 2012 Oct 31;3(4):297-302. Epub 2012 May 31.

Genetic Counsellor Training Post Panel, Association of Genetic Nurses and Counsellors, 46 Park Hill, Carshalton Beeches, Surrey, SM5 3RU, UK,

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October 2012

Off-label use of recombinant factor VIIa in pediatric patients.

Pediatrics 2012 Jun 28;129(6):e1533-40. Epub 2012 May 28.

Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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June 2012

Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation.

Integr Biol (Camb) 2012 Mar 10;4(3):335-345. Epub 2012 Feb 10.

Centre for Integrative Systems Biology and Bioinformatics, Division of Molecular Biosciences, Department of Life Sciences, Imperial College London, London, UK.

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March 2012

Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia.

Schizophr Res 2012 Mar 29;135(1-3):1-7. Epub 2011 Nov 29.

MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

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March 2012

Bayesian design of synthetic biological systems.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15190-5. Epub 2011 Aug 29.

Center for Bioinformatics, Division of Molecular Biosciences, Institute of Mathematical Sciences, Imperial College London, London SW7 2AZ, United Kingdom.

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September 2011

Cytotoxicity and physicochemical properties of hafnium oxide nanoparticles.

Chemosphere 2011 Sep 24;84(10):1401-7. Epub 2011 May 24.

Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ 85721, USA.

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September 2011

Prospective audit of patients with haemophilia: bleeding episodes and management.

J Paediatr Child Health 2012 Feb 12;48(2):177-9. Epub 2011 May 12.

Department of Orthopaedics, Austin Hospital, Melbourne, Victoria, Australia.

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February 2012

Computational design approaches and tools for synthetic biology.

Integr Biol (Camb) 2011 Feb 24;3(2):97-108. Epub 2011 Jan 24.

Centre for Synthetic Biology and Innovation, Imperial College London, London, UK.

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February 2011

GPU accelerated biochemical network simulation.

Bioinformatics 2011 Mar 11;27(6):874-6. Epub 2011 Jan 11.

Institute of Mathematical Sciences, Imperial College London, London, UK.

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March 2011