Chris B Schaffer

Chris B Schaffer

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Chris B Schaffer

Publications by authors named "Chris B Schaffer"

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Increasing cerebral blood flow improves cognition into late stages in Alzheimer's disease mice.

J Cereb Blood Flow Metab 2019 Sep 7:271678X19873658. Epub 2019 Sep 7.

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

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http://dx.doi.org/10.1177/0271678X19873658DOI Listing
September 2019

Surgical preparations, labeling strategies, and optical techniques for cell-resolved, in vivo imaging in the mouse spinal cord.

Exp Neurol 2019 Aug 13;318:192-204. Epub 2019 May 13.

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588420PMC
August 2019

Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells.

J Cereb Blood Flow Metab 2019 May 23;39(5):886-900. Epub 2017 Nov 23.

1 Optics Division, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1177/0271678X17743877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501506PMC
May 2019

Aspirin treatment does not increase microhemorrhage size in young or aged mice.

PLoS One 2019 4;14(1):e0204295. Epub 2019 Jan 4.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204295PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319729PMC
January 2019

In Vivo Femtosecond Laser Subsurface Cortical Microtransections Attenuate Acute Rat Focal Seizures.

Cereb Cortex 2018 Sep 6. Epub 2018 Sep 6.

Department of Neurological Surgery, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY, USA.

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http://dx.doi.org/10.1093/cercor/bhy210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644864PMC
September 2018

Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation.

Stroke 2018 07 29;49(7):1719-1726. Epub 2018 May 29.

From the Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY (S.J.A., N.N., C.B.S.)

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http://dx.doi.org/10.1161/STROKEAHA.117.020461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019563PMC
July 2018

Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers.

Struct Dyn 2016 Sep 29;3(5):054301. Epub 2016 Aug 29.

School of Applied and Engineering Physics, Cornell University , Ithaca, New York 14853, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010557PMC
http://dx.doi.org/10.1063/1.4961971DOI Listing
September 2016

Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.

PLoS One 2015 25;10(11):e0142326. Epub 2015 Nov 25.

Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Rd., Ithaca, NY 14853, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142326PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659663PMC
June 2016

The origin and implementation of the Broadening Experiences in Scientific Training programs: an NIH common fund initiative.

FASEB J 2016 Feb 2;30(2):507-14. Epub 2015 Oct 2.

*Health System, University of California, Davis, Sacramento, California, USA; The Graduate School, Wayne State University, Detroit, Michigan, USA; Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA; University of California, San Francisco, San Francisco, California, USA; Graduate School, University of Colorado, Anschutz Medical Campus, University of Colorado, Denver, Colorado, USA; Division of Program Coordination, Planning, and Strategic Initiatives, National Institutes of Health, Bethesda, Maryland, USA; Biomedical Research Education and Training and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; **Department of Microbiology and Immunology and Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA; and Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, USA

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http://www.nihbest.org/wp-content/uploads/2015/10/FASEB2015.
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http://www.fasebj.org/cgi/doi/10.1096/fj.15-276139
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http://dx.doi.org/10.1096/fj.15-276139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188226PMC
February 2016

TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer.

J Control Release 2016 Feb 28;223:215-223. Epub 2015 Dec 28.

Meinig School of Biomedical Engineering, Cornell University, 526 N. Campus Rd, Weill Hall, Ithaca, NY 14853, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.12.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724502PMC
February 2016

Characterization of blood flow in the mouse dorsal spinal venous system before and after dorsal spinal vein occlusion.

J Cereb Blood Flow Metab 2015 Mar 31;35(4):667-75. Epub 2015 Mar 31.

Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420886PMC
March 2015

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

Proc Natl Acad Sci U S A 2014 Dec 2;111(50):18007-12. Epub 2014 Dec 2.

Laboratory for Accelerated Vascular Research, Department of Surgery, Division of Vascular Surgery, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1415316111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273347PMC
December 2014

A procedure for implanting a spinal chamber for longitudinal in vivo imaging of the mouse spinal cord.

J Vis Exp 2014 Dec 3(94). Epub 2014 Dec 3.

Department of Biomedical Engineering, Cornell University;

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http://dx.doi.org/10.3791/52196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396935PMC
December 2014

Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage.

PLoS One 2013 28;8(5):e65663. Epub 2013 May 28.

Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065663PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665593PMC
January 2014

TRAIL-coated leukocytes that kill cancer cells in the circulation.

Proc Natl Acad Sci U S A 2014 Jan 6;111(3):930-5. Epub 2014 Jan 6.

Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853.

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http://dx.doi.org/10.1073/pnas.1316312111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903223PMC
January 2014

Optoporation and genetic manipulation of cells using femtosecond laser pulses.

Biophys J 2013 Aug;105(4):862-71

Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

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http://dx.doi.org/10.1016/j.bpj.2013.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752125PMC
August 2013

Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain.

Stroke 2013 Jun;44(6 Suppl 1):S90-2

Department of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.

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http://dx.doi.org/10.1161/STROKEAHA.112.679621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862170PMC
June 2013

Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies.

Lancet Neurol 2013 Apr 18;12(4):394-405. Epub 2013 Mar 18.

Department of Neurology, Johann Wolfgang Goethe-University, 60526 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/S1474-4422(13)70049-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702044PMC
April 2013

Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals.

PLoS One 2012 26;7(6):e38590. Epub 2012 Jun 26.

Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, Department of Surgery, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038590PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383695PMC
March 2013

three-photon microscopy of subcortical structures within an intact mouse brain.

Nat Photonics 2013 Mar;7(3)

School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1038/nphoton.2012.336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864872PMC
March 2013

Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain.

J Cereb Blood Flow Metab 2012 Jul 1;32(7):1277-309. Epub 2012 Feb 1.

Department of Physics, University of California at San Diego, La Jolla, CA 92093-0374, USA.

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http://dx.doi.org/10.1038/jcbfm.2011.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390800PMC
July 2012

Estimating brain microvascular blood flows from partial two-photon microscopy data by computation with a circuit model.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:174-7

Department of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6089922DOI Listing
June 2012

Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex.

Ann Biomed Eng 2012 Feb 19;40(2):292-303. Epub 2011 Oct 19.

School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s10439-011-0440-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288849PMC
February 2012

Notch4 normalization reduces blood vessel size in arteriovenous malformations.

Sci Transl Med 2012 Jan;4(117):117ra8

Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320799PMC
January 2012

Chronic in vivo imaging in the mouse spinal cord using an implanted chamber.

Nat Methods 2012 Jan 22;9(3):297-302. Epub 2012 Jan 22.

Department of Physics, Cornell University, Ithaca, New York, USA.

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http://www.nature.com/articles/nmeth.1856
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http://dx.doi.org/10.1038/nmeth.1856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429123PMC
January 2012

Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries.

J Cereb Blood Flow Metab 2011 Nov 29;31(11):2243-54. Epub 2011 Jun 29.

Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1038/jcbfm.2011.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210348PMC
November 2011

Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus.

J Neurosci 2011 Sep;31(37):13292-300

Department of Neurological Surgery, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2597-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191875PMC
September 2011

Sub-surface, micrometer-scale incisions produced in rodent cortex using tightly-focused femtosecond laser pulses.

Lasers Surg Med 2011 Jul;43(5):382-91

Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1002/lsm.21054DOI Listing
July 2011

Optically quantified cerebral blood flow.

J Cereb Blood Flow Metab 2011 Jun 2;31(6):1337-8. Epub 2011 Mar 2.

Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1038/jcbfm.2011.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130320PMC
June 2011

Optical tools to produce and study small strokes in animal models.

Authors:
Chris B Schaffer

Conf Proc IEEE Eng Med Biol Soc 2010 ;2010:3377-8

Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1109/IEMBS.2010.5627919DOI Listing
April 2011

In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy.

Biophys J 2011 Mar;100(5):1362-71

Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

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http://dx.doi.org/10.1016/j.bpj.2011.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043202PMC
March 2011

Limitations of collateral flow after occlusion of a single cortical penetrating arteriole.

J Cereb Blood Flow Metab 2010 Dec 15;30(12):1914-27. Epub 2010 Sep 15.

Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

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http://dx.doi.org/10.1038/jcbfm.2010.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002886PMC
December 2010

Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects.

Am J Physiol Heart Circ Physiol 2010 Nov 13;299(5):H1728-35. Epub 2010 Aug 13.

Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1152/ajpheart.00495.2010DOI Listing
November 2010

Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery.

Biomed Microdevices 2009 Aug;11(4):915-24

School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s10544-009-9308-6DOI Listing
August 2009

Deep tissue multiphoton microscopy using longer wavelength excitation.

Opt Express 2009 Aug;17(16):13354-64

School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1364/oe.17.013354DOI Listing
August 2009

Penetrating arterioles are a bottleneck in the perfusion of neocortex.

Proc Natl Acad Sci U S A 2007 Jan 26;104(1):365-70. Epub 2006 Dec 26.

Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0609551104
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http://dx.doi.org/10.1073/pnas.0609551104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1765467PMC
January 2007

Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm.

J Chem Phys 2007 Jan;126(2):025102

Department of Physics, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1063/1.2404678DOI Listing
January 2007

Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor.

Mech Chem Biosyst 2005 ;2(1):17-25

Department of Physics, Harvard University, USA.

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June 2006

Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke.

Nat Methods 2006 Feb;3(2):99-108

Department of Physics, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nmeth844DOI Listing
February 2006

All-optical histology using ultrashort laser pulses.

Neuron 2003 Jul;39(1):27-41

Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/s0896-6273(03)00370-2DOI Listing
July 2003