Choukri Ben Mamoun

Choukri Ben Mamoun

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Choukri Ben Mamoun

Publications by authors named "Choukri Ben Mamoun"

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Efficient Single-Gene and Gene Family Editing in the Apicomplexan Parasite Using CRISPR-Cas9.

Front Bioeng Biotechnol 2020 25;8:128. Epub 2020 Feb 25.

Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.

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http://dx.doi.org/10.3389/fbioe.2020.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052334PMC
February 2020

Crystal structures of lactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.

FASEB J 2019 Dec 4;33(12):13669-13682. Epub 2019 Oct 4.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

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http://dx.doi.org/10.1096/fj.201901259RDOI Listing
December 2019

The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.

J Biol Chem 2019 Oct 13;294(40):14757-14767. Epub 2019 Aug 13.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA119.009791
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http://dx.doi.org/10.1074/jbc.RA119.009791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779428PMC
October 2019

Evidence for vesicle-mediated antigen export by the human pathogen .

Life Sci Alliance 2019 06 13;2(3). Epub 2019 Jun 13.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA

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http://dx.doi.org/10.26508/lsa.201900382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572159PMC
June 2019

Stable transfection of Eimeria necatrix through nucleofection of second generation merozoites.

Mol Biochem Parasitol 2019 03 15;228:1-5. Epub 2019 Jan 15.

State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, 100193, China; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2019.01.002DOI Listing
March 2019

Selection and identification of a precocious line of Eimeria intestinalis with enlarged oocysts and deletion of one generation of schizogony.

Parasitol Res 2019 Mar 29;118(3):969-976. Epub 2019 Jan 29.

State Key Laboratory for Agrobiotechnology, Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, National Animal Protozoa Laboratory and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

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http://dx.doi.org/10.1007/s00436-018-06199-1DOI Listing
March 2019

Insights into the evolution and drug susceptibility of Babesia duncani from the sequence of its mitochondrial and apicoplast genomes.

Int J Parasitol 2019 02 31;49(2):105-113. Epub 2018 Aug 31.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395566PMC
February 2019

A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.

Int J Parasitol 2019 02 24;49(2):115-125. Epub 2018 Oct 24.

Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183023
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http://dx.doi.org/10.1016/j.ijpara.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406021PMC
February 2019

Role of phospholipid synthesis in the development and differentiation of malaria parasites in the blood.

J Biol Chem 2018 11 4;293(45):17308-17316. Epub 2018 Oct 4.

From the Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06520 and

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http://dx.doi.org/10.1074/jbc.R118.003213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231132PMC
November 2018

BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection.

J Clin Microbiol 2018 10 25;56(10). Epub 2018 Sep 25.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA

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http://dx.doi.org/10.1128/JCM.00067-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156295PMC
October 2018

A novel fluorescence assay for measuring phosphatidylserine decarboxylase catalysis.

J Biol Chem 2018 02 15;293(5):1493-1503. Epub 2017 Dec 15.

From the Basic Science Section, Department of Medicine, National Jewish Health, Denver, Colorado 80206,

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http://dx.doi.org/10.1074/jbc.RA117.000525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798280PMC
February 2018

A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A. Evidence for a structural revision.

Chem Sci 2017 Jul 4;8(7):4867-4871. Epub 2017 May 4.

Department of Chemistry , Yale University , New Haven , CT 06520 , USA . Email:

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http://dx.doi.org/10.1039/c7sc01127jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603897PMC
July 2017

Antimalarial Properties of Simplified Kalihinol Analogues.

ACS Med Chem Lett 2017 Mar 16;8(3):355-360. Epub 2017 Feb 16.

Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346982PMC
March 2017

Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii.

Antimicrob Agents Chemother 2017 02 24;61(2). Epub 2017 Jan 24.

Division of Infectious Diseases, Oregon Health & Science University, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.01866-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278733PMC
February 2017

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening.

Mol Microbiol 2016 Mar 22;99(6):999-1014. Epub 2015 Dec 22.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, 15 York St., New Haven, CT 06520, USA.

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http://dx.doi.org/10.1111/mmi.13280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898484PMC
March 2016

Subtelomere organization in the genome of the microsporidian Encephalitozoon cuniculi: patterns of repeated sequences and physicochemical signatures.

BMC Genomics 2016 Jan 7;17:34. Epub 2016 Jan 7.

Institut de Recherche en Cancérologie de Montpellier, IRCM - INSERM U1194 & Université de Montpellier & ICM, Institut régional du Cancer Montpellier, Campus Val d'Aurelle, 34298, Montpellier cedex 5, France.

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http://dx.doi.org/10.1186/s12864-015-1920-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704409PMC
January 2016

Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum.

Proc Natl Acad Sci U S A 2015 Sep 8;112(38):11935-40. Epub 2015 Sep 8.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1515864112
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http://dx.doi.org/10.1073/pnas.1515864112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586866PMC
September 2015

Sequence and annotation of the apicoplast genome of the human pathogen Babesia microti.

PLoS One 2014 3;9(10):e107939. Epub 2014 Oct 3.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184790PMC
July 2015

Babesiosis.

Infect Dis Clin North Am 2015 Jun;29(2):357-70

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA; Departments of Internal Medicine and Pediatrics, Yale School of Medicine, 15 York Street, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.idc.2015.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458703PMC
June 2015

From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE.

J Biol Chem 2015 Apr 26;290(17):10972-80. Epub 2015 Feb 26.

From the Department of Medicine, Basic Science Section, National Jewish Health, Denver, Colorado 80206,

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http://dx.doi.org/10.1074/jbc.M115.642413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409258PMC
April 2015

Plasmodium yoelii vitamin B5 pantothenate transporter candidate is essential for parasite transmission to the mosquito.

Sci Rep 2014 Jul 11;4:5665. Epub 2014 Jul 11.

Tulane University, Department of Tropical Medicine, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1038/srep05665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092334PMC
July 2014

Quantitative PCR for detection of Babesia microti in Ixodes scapularis ticks and in human blood.

Vector Borne Zoonotic Dis 2013 Nov 9;13(11):784-90. Epub 2013 Oct 9.

1 Department of Epidemiology and Public Health, Yale School of Public Health , New Haven, Connecticut.

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http://dx.doi.org/10.1089/vbz.2011.0935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822370PMC
November 2013

Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells.

PLoS One 2013 6;8(2):e55584. Epub 2013 Feb 6.

Division of Parasitology, Department of Microbiology, New York University School of Medicine, New York, New York, United State of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055584PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565962PMC
August 2013

(1)H, (13)C, and (15)N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum.

Biomol NMR Assign 2013 Apr 6;7(1):17-20. Epub 2012 Mar 6.

Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 6030-3305, USA.

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http://dx.doi.org/10.1007/s12104-012-9372-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882757PMC
April 2013

Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.

J Virol 2012 Nov 29;86(22):12053-68. Epub 2012 Aug 29.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1128/JVI.01970-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486471PMC
November 2012

Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6235-40. Epub 2012 Apr 2.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.1203516109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341008PMC
April 2012

PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity.

J Biol Chem 2011 Aug 25;286(33):28940-7. Epub 2011 Jun 25.

Research Unit on BioActive Molecules, Departament de Química Biomèdica, Instituto de Química Avanzada de Cataluña IQAC, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.

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http://www.jbc.org/content/286/33/28940.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M111.268946
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.268946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190701PMC
August 2011

Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.

FEMS Microbiol Rev 2011 Jul 10;35(4):609-19. Epub 2011 Mar 10.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510-3221, USA.

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http://dx.doi.org/10.1111/j.1574-6976.2011.00267.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107886PMC
July 2011

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus.

Mol Biochem Parasitol 2010 Jul 21;172(1):9-18. Epub 2010 Mar 21.

Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016668511000060
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http://dx.doi.org/10.1016/j.molbiopara.2010.03.009DOI Listing
July 2010

Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.

Drug Dev Res 2010 Feb;71(1):44-55

Section of Infectious Disease, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ddr.20347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886290PMC
February 2010

Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay.

BMC Biochem 2010 Jan 19;11. Epub 2010 Jan 19.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, 333 Cedar St., New Haven 06052, USA.

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http://dx.doi.org/10.1186/1471-2091-11-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824672PMC
January 2010

Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum.

Mol Biochem Parasitol 2008 Oct 3;161(2):130-9. Epub 2008 Jul 3.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2008.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612043PMC
October 2008

Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum.

Eukaryot Cell 2008 Aug 20;7(8):1231-7. Epub 2008 Jun 20.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1128/EC.00159-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519781PMC
August 2008

Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum.

J Biol Chem 2008 Mar 4;283(12):7894-900. Epub 2008 Jan 4.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Framington, CT 06030, USA.

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http://dx.doi.org/10.1074/jbc.M709869200DOI Listing
March 2008

Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

BMC Clin Pharmacol 2007 Oct 23;7:13. Epub 2007 Oct 23.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030-3301, USA.

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http://dx.doi.org/10.1186/1472-6904-7-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213633PMC
October 2007

Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase.

Eukaryot Cell 2007 Sep 20;6(9):1618-24. Epub 2007 Jul 20.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030-3301, USA.

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http://ec.asm.org/lookup/doi/10.1128/EC.00229-07
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http://dx.doi.org/10.1128/EC.00229-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043360PMC
September 2007

Purification of components of the translation elongation factor complex of Plasmodium falciparum by tandem affinity purification.

Eukaryot Cell 2007 Apr 16;6(4):584-91. Epub 2007 Feb 16.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3301, USA.

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http://dx.doi.org/10.1128/EC.00376-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865644PMC
April 2007

Amino acids mediate colony and cell differentiation in the fungal pathogen Candida parapsilosis.

Microbiology 2006 Oct;152(Pt 10):2885-94

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030-3301, USA.

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http://mic.microbiologyresearch.org/content/journal/micro/10
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http://dx.doi.org/10.1099/mic.0.29180-0DOI Listing
October 2006

Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.

J Biol Chem 2006 Jul 16;281(30):21305-11. Epub 2006 May 16.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, 06030-3301, USA.

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http://dx.doi.org/10.1074/jbc.M603260200DOI Listing
July 2006

The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.

Proc Natl Acad Sci U S A 2006 Jun 2;103(24):9286-91. Epub 2006 Jun 2.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030-3301, USA.

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http://dx.doi.org/10.1073/pnas.0602590103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482602PMC
June 2006

Leishmania major expresses a single dihydroxyacetone phosphate acyltransferase localized in the glycosome, important for rapid growth and survival at high cell density and essential for virulence.

J Biol Chem 2006 Mar 19;281(12):7952-9. Epub 2006 Jan 19.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3301, USA.

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http://dx.doi.org/10.1074/jbc.M512911200DOI Listing
March 2006

The initial step of glycerolipid metabolism in Leishmania major promastigotes involves a single glycerol-3-phosphate acyltransferase enzyme important for the synthesis of triacylglycerol but not essential for virulence.

Mol Microbiol 2005 May;56(3):800-10

Center for Microbial Pathogenesis, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04579.xDOI Listing
May 2005

In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway.

J Biol Chem 2005 Apr 21;280(13):12461-6. Epub 2005 Jan 21.

Center for Microbial Pathogenesis and Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1074/jbc.M414626200DOI Listing
April 2005

Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae.

Antimicrob Agents Chemother 2004 Aug;48(8):2816-24

Dynamique Moleculaire des Interactions Membranaires, CNRS UMR 5539, Universite Montpellier II, France.

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http://dx.doi.org/10.1128/AAC.48.8.2816-2824.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478495PMC
August 2004

A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation.

Proc Natl Acad Sci U S A 2004 Apr 8;101(16):6206-11. Epub 2004 Apr 8.

Center for Microbial Pathogenesis and Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030-3710, USA.

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http://dx.doi.org/10.1073/pnas.0307742101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395947PMC
April 2004

The Plasmodium falciparum PfGatp is an endoplasmic reticulum membrane protein important for the initial step of malarial glycerolipid synthesis.

J Biol Chem 2004 Mar 10;279(10):9222-32. Epub 2003 Dec 10.

Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1074/jbc.M310502200DOI Listing
March 2004

Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis.

Eukaryot Cell 2004 Feb;3(1):135-43

Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329513PMC
http://dx.doi.org/10.1128/ec.3.1.135-143.2004DOI Listing
February 2004

Reexamining the role of choline transporter-like (Ctlp) proteins in choline transport.

Neurochem Res 2004 Feb;29(2):461-7

Center for Microbial Pathogenesis, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1023/b:nere.0000013752.43906.e5DOI Listing
February 2004

Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p.

J Biol Chem 2003 Oct 18;278(40):38723-30. Epub 2003 Jul 18.

Center for Microbial Pathogenesis and the Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3710, USA.

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http://dx.doi.org/10.1074/jbc.M303008200DOI Listing
October 2003

Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs.

Mol Biochem Parasitol 2002 Nov-Dec;125(1-2):127-34

Department of Pathology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/s0166-6851(02)00220-7DOI Listing
March 2003

Genetic manipulation of the pathogenic yeast Candida parapsilosis.

Curr Genet 2002 Oct 20;42(1):27-35. Epub 2002 Sep 20.

Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-1, 84215 Bratislava, Slovakia.

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http://link.springer.com/content/pdf/10.1007/s00294-002-0326
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http://dx.doi.org/10.1007/s00294-002-0326-7DOI Listing
October 2002