Publications by authors named "Chou-Long Huang"

90Publications

WNK1 regulates uterine homeostasis and its ability to support pregnancy.

JCI Insight 2020 Nov 19;5(22). Epub 2020 Nov 19.

Reproductive and Developmental Biology Laboratory and.

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http://dx.doi.org/10.1172/jci.insight.141832DOI Listing
November 2020

WNK1-OSR1/SPAK KINASE CASCADE IS IMPORTANT FOR ANGIOGENESIS.

Trans Am Clin Climatol Assoc 2020 ;131:140-146

IOWA CITY, IOWA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358493PMC
January 2020

Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles.

PLoS One 2020 5;15(3):e0229799. Epub 2020 Mar 5.

Division of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229799PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058344PMC
June 2020

WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis.

Cancers (Basel) 2020 Mar 2;12(3). Epub 2020 Mar 2.

Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.

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http://dx.doi.org/10.3390/cancers12030575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139507PMC
March 2020

Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII?

Proc Natl Acad Sci U S A 2019 08 1;116(33):16175-16176. Epub 2019 Aug 1.

Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan;

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http://dx.doi.org/10.1073/pnas.1910215116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697869PMC
August 2019

Soluble klotho regulates TRPC6 calcium signaling lipid rafts, independent of the FGFR-FGF23 pathway.

FASEB J 2019 08 7;33(8):9182-9193. Epub 2019 May 7.

Division of Nephrology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA; and.

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http://dx.doi.org/10.1096/fj.201900321RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662984PMC
August 2019

WNK4 kinase is a physiological intracellular chloride sensor.

Proc Natl Acad Sci U S A 2019 03 14;116(10):4502-4507. Epub 2019 Feb 14.

Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan;

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http://dx.doi.org/10.1073/pnas.1817220116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410802PMC
March 2019

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.

Proc Natl Acad Sci U S A 2018 04 26;115(15):3840-3845. Epub 2018 Mar 26.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1802339115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899495PMC
April 2018

Differential roles of WNK4 in regulation of NCC in vivo.

Am J Physiol Renal Physiol 2018 05 31;314(5):F999-F1007. Epub 2018 Jan 31.

Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center , Dallas, Texas.

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http://dx.doi.org/10.1152/ajprenal.00177.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031911PMC
May 2018

New Insights into the Mechanism of Action of Soluble Klotho.

Front Endocrinol (Lausanne) 2017 17;8:323. Epub 2017 Nov 17.

Department of Internal Medicine, Division of Nephrology and Hypertension, University of Iowa Carver College of Medicine, Iowa City, IA, United States.

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http://dx.doi.org/10.3389/fendo.2017.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715364PMC
November 2017

Functional severity of CLCNKB mutations correlates with phenotypes in patients with classic Bartter's syndrome.

J Physiol 2017 08 27;595(16):5573-5586. Epub 2017 Jun 27.

Department of Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan.

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http://dx.doi.org/10.1113/JP274344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556149PMC
August 2017

Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho.

FASEB J 2017 08 25;31(8):3574-3586. Epub 2017 Apr 25.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Texas, USA;

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http://dx.doi.org/10.1096/fj.201700043RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503716PMC
August 2017

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.

Kidney Int 2017 04 12;91(4):830-841. Epub 2016 Dec 12.

Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357448PMC
April 2017

High dietary phosphate intake induces hypertension and augments exercise pressor reflex function in rats.

Am J Physiol Regul Integr Comp Physiol 2016 07 11;311(1):R39-48. Epub 2016 May 11.

Cardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas; Hypertension Section, University of Texas Southwestern Medical Center, Dallas, Texas; Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas

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http://dx.doi.org/10.1152/ajpregu.00124.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967233PMC
July 2016

Hypertension: the missing WNKs.

Am J Physiol Renal Physiol 2016 07 23;311(1):F16-27. Epub 2016 Mar 23.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and

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http://dx.doi.org/10.1152/ajprenal.00358.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967160PMC
July 2016

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):2994-9. Epub 2016 Feb 29.

Department of Internal Medicine, Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://dx.doi.org/10.1073/pnas.1601860113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801257PMC
March 2016

Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function.

Am J Physiol Regul Integr Comp Physiol 2015 Oct 29;309(7):R747-56. Epub 2015 Jul 29.

Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas; and

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http://dx.doi.org/10.1152/ajpregu.00148.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666928PMC
October 2015

A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter.

Pflugers Arch 2015 Nov 24;467(11):2235-41. Epub 2015 Apr 24.

Department of Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s00424-015-1708-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601926PMC
November 2015

STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb.

Am J Physiol Renal Physiol 2015 Mar 4;308(5):F437-43. Epub 2014 Dec 4.

Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas;

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http://dx.doi.org/10.1152/ajprenal.00493.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346744PMC
March 2015

Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate.

J Am Soc Nephrol 2015 May 4;26(5):1150-60. Epub 2014 Dec 4.

Division of Nephrology, Department of Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas; and

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http://dx.doi.org/10.1681/ASN.2014040325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413766PMC
May 2015

Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms.

J Biol Chem 2014 Dec 5;289(52):35849-57. Epub 2014 Nov 5.

Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390

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http://dx.doi.org/10.1074/jbc.M114.616649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276853PMC
December 2014

Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance.

J Clin Endocrinol Metab 2015 Jan;100(1):E155-63

Department of Medicine (C.-J.C., C.-C.S., S.-H.L.), Division of Nephrology; Department of Surgery (S.-T.W.), Division of Urology; Deparment of Pathology (Y.-C.L.), Tri-Service General Hospital; Graduate Institute of Life Science (C.-C.S., S.-H.L.); and Department and Graduate Institute of Microbiology and Immunology (H.-K.S.), National Defense Medical Center, Taipei 114, Taiwan; and Department of Medicine (C.-L.H.), Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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http://dx.doi.org/10.1210/jc.2014-3009DOI Listing
January 2015

Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.

PLoS One 2014 29;9(8):e106129. Epub 2014 Aug 29.

Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, ROC; College of Life Science and Institute of Bioinformatics and Structural Biology, National Tsing-Hua University, Hsinchu, Taiwan, ROC; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.

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https://ir.nctu.edu.tw/bitstream/11536/25046/1/0003411275001
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http://dx.plos.org/10.1371/journal.pone.0106129
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106129PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149531PMC
November 2015

An acetate switch regulates stress erythropoiesis.

Nat Med 2014 Sep 10;20(9):1018-26. Epub 2014 Aug 10.

1] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Medicine, VA North Texas Health Care System, Dallas, Texas, USA. [3].

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http://dx.doi.org/10.1038/nm.3587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159437PMC
September 2014

Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.

J Biol Chem 2014 Sep 1;289(38):26131-42. Epub 2014 Aug 1.

From the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856

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http://dx.doi.org/10.1074/jbc.M114.577767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176205PMC
September 2014

Inward-rectifying potassium channelopathies: new insights into disorders of sodium and potassium homeostasis.

Pediatr Nephrol 2015 Mar 6;30(3):373-83. Epub 2014 Jun 6.

Department of Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan.

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http://link.springer.com/10.1007/s00467-014-2764-0
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http://dx.doi.org/10.1007/s00467-014-2764-0DOI Listing
March 2015

Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization.

Biochim Biophys Acta 2013 Dec 31;1833(12):3046-3053. Epub 2013 Aug 31.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889130031
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http://dx.doi.org/10.1016/j.bbamcr.2013.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932323PMC
December 2013

Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis.

Semin Nephrol 2013 May;33(3):237-47

Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8859, USA.

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http://dx.doi.org/10.1016/j.semnephrol.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131448PMC
May 2013

Acquired hypocalciuric hypercalcemia in a patient with CKD.

Am J Kidney Dis 2013 Dec 27;62(6):1151-4. Epub 2013 Jun 27.

Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2013.04.023DOI Listing
December 2013

Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease.

Curr Opin Nephrol Hypertens 2013 Jul;22(4):452-8

Department of Internal Medicine, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1097/MNH.0b013e328362483aDOI Listing
July 2013

Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.

Kidney Int 2013 Jul 6;84(1):130-7. Epub 2013 Mar 6.

Division of Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538155592
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http://dx.doi.org/10.1038/ki.2013.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700562PMC
July 2013

WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.

J Biol Chem 2013 Mar 5;288(12):8566-74. Epub 2013 Feb 5.

Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1074/jbc.M113.451575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605675PMC
March 2013

Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.

Am J Physiol Renal Physiol 2013 Feb 28;304(4):F397-402. Epub 2012 Nov 28.

Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1152/ajprenal.00589.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566501PMC
February 2013

The Drosophila NKCC Ncc69 is required for normal renal tubule function.

Am J Physiol Cell Physiol 2012 Oct 22;303(8):C883-94. Epub 2012 Aug 22.

Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1152/ajpcell.00201.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774093PMC
October 2012

Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb.

Am J Physiol Renal Physiol 2012 Sep 11;303(5):F667-73. Epub 2012 Jul 11.

Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1152/ajprenal.00290.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468497PMC
September 2012

Mechanism of thyrotoxic periodic paralysis.

J Am Soc Nephrol 2012 Jun 29;23(6):985-8. Epub 2012 Mar 29.

Division of Nephrology, Department of Medicine, Tri-Service General Hospital, No. 325 Section 2 Cheng-Kung Road, Taipei, Taiwan, Republic of China.

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http://dx.doi.org/10.1681/ASN.2012010046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358768PMC
June 2012

Regulation of ion channels by secreted Klotho.

Authors:
Chou-Long Huang

Adv Exp Med Biol 2012 ;728:100-6

Department of Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/978-1-4614-0887-1_7DOI Listing
April 2012

WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling.

Curr Biol 2011 Dec 23;21(23):1979-87. Epub 2011 Nov 23.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cub.2011.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237931PMC
December 2011

Association of urinary sodium/potassium ratio with blood pressure: sex and racial differences.

Clin J Am Soc Nephrol 2012 Feb 23;7(2):315-22. Epub 2011 Nov 23.

Renal Section, Medical Service, Veterans Affairs North Texas Health Care System, Dallas, TX 75216-7167, USA.

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http://dx.doi.org/10.2215/CJN.02060311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280031PMC
February 2012

The mechanism of hypocalciuria with NaCl cotransporter inhibition.

Nat Rev Nephrol 2011 09 27;7(11):669-74. Epub 2011 Sep 27.

Department of Medicine, VA North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, 4500 South Lancaster Road, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1038/nrneph.2011.138DOI Listing
September 2011

Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis.

J Biol Chem 2011 Aug 10;286(31):27425-35. Epub 2011 Jun 10.

Department of Medicine, Division of Nephrology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.249656
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http://dx.doi.org/10.1074/jbc.M111.249656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149336PMC
August 2011

Klotho: a novel regulator of calcium and phosphorus homeostasis.

Pflugers Arch 2011 Aug 29;462(2):185-93. Epub 2011 Mar 29.

Department of Internal Medicine, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1007/s00424-011-0950-5DOI Listing
August 2011

Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.

J Am Soc Nephrol 2011 Mar 25;22(3):460-71. Epub 2011 Feb 25.

Department of Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1681/ASN.2010060681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060440PMC
March 2011

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.

J Clin Invest 2011 Mar 7;121(3):956-65. Epub 2011 Feb 7.

The Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA.

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http://www.jci.org/articles/view/43475
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http://dx.doi.org/10.1172/JCI43475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049373PMC
March 2011

Recent advances in distal tubular potassium handling.

Am J Physiol Renal Physiol 2011 Apr 26;300(4):F821-7. Epub 2011 Jan 26.

Division of Nephrology, Department of Medicine, UT, USA.

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http://dx.doi.org/10.1152/ajprenal.00742.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074996PMC
April 2011

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.

Hum Mol Genet 2011 Mar 2;20(5):855-66. Epub 2010 Dec 2.

Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1093/hmg/ddq525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033178PMC
March 2011

Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1.

J Biol Chem 2011 Jan 17;286(3):1828-35. Epub 2010 Nov 17.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M110.160390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023478PMC
January 2011

An emerging role for SPAK in NCC, NKCC, and blood pressure regulation.

J Am Soc Nephrol 2010 Nov 7;21(11):1812-4. Epub 2010 Oct 7.

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http://dx.doi.org/10.1681/ASN.2010090926DOI Listing
November 2010

Regulation of ion channels by secreted Klotho: mechanisms and implications.

Authors:
Chou-Long Huang

Kidney Int 2010 May 10;77(10):855-60. Epub 2010 Mar 10.

Department of Medicine, UT Southwestern Medical Center, Dallas, Texas,

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http://dx.doi.org/10.1038/ki.2010.73DOI Listing
May 2010

WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C.

J Biol Chem 2010 Feb 8;285(9):6604-11. Epub 2010 Jan 8.

Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1074/jbc.M109.056044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825456PMC
February 2010

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.

Am J Pathol 2009 Sep 30;175(3):1315-27. Epub 2009 Jul 30.

Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.2353/ajpath.2009.090094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731149PMC
September 2009

Distal potassium handling based on flow modulation of maxi-K channel activity.

Curr Opin Nephrol Hypertens 2009 Jul;18(4):350-5

Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1097/MNH.0b013e32832c75d8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151167PMC
July 2009

Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.

Mol Pharmacol 2009 Jul 6;76(1):38-46. Epub 2009 Apr 6.

Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1124/mol.109.055780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701452PMC
July 2009

Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.

J Biol Chem 2009 May 25;284(18):12198-206. Epub 2009 Feb 25.

Department of Medicine (Division of Nephrology), University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1074/jbc.M806551200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673288PMC
May 2009

Mechanism of regulation of renal ion transport by WNK kinases.

Curr Opin Nephrol Hypertens 2008 Sep;17(5):519-25

Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1097/MNH.0b013e32830dd580DOI Listing
September 2008

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.

Proc Natl Acad Sci U S A 2008 Jul 7;105(28):9805-10. Epub 2008 Jul 7.

Departments of Medicine and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0803223105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474477PMC
July 2008

Domains of WNK1 kinase in the regulation of ROMK1.

Am J Physiol Renal Physiol 2008 Aug 11;295(2):F438-45. Epub 2008 Jun 11.

Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1152/ajprenal.90287.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519181PMC
August 2008

Mechanism of urinary calcium regulation by urinary magnesium and pH.

J Am Soc Nephrol 2008 Aug 30;19(8):1530-7. Epub 2008 Apr 30.

Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1681/ASN.2007091038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488265PMC
August 2008

Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5.

Am J Physiol Renal Physiol 2008 May 27;294(5):F1212-21. Epub 2008 Feb 27.

Department of Medicine (Division of Nephrology), UT Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1152/ajprenal.00007.2008DOI Listing
May 2008

WNK kinases and essential hypertension.

Curr Opin Nephrol Hypertens 2008 Mar;17(2):133-7

Department of Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1097/MNH.0b013e3282f4e4fdDOI Listing
March 2008

WNKs: protein kinases with a unique kinase domain.

Exp Mol Med 2007 Oct;39(5):565-73

Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/emm.2007.62DOI Listing
October 2007

Regulation of TRPV5 single-channel activity by intracellular pH.

J Membr Biol 2007 Dec 15;220(1-3):79-85. Epub 2007 Nov 15.

Division of Nephrology and Charles & Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1007/s00232-007-9076-2DOI Listing
December 2007

Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension.

Nat Clin Pract Nephrol 2007 Nov;3(11):623-30

Division of Nephrology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1038/ncpneph0638DOI Listing
November 2007

Complex roles of PIP2 in the regulation of ion channels and transporters.

Authors:
Chou-Long Huang

Am J Physiol Renal Physiol 2007 Dec 10;293(6):F1761-5. Epub 2007 Oct 10.

UT Southwestern Medical Center, Dept. of Medicine, 5323 Harry Hines Blvd., Dallas, TX 75390-8856, USA.

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http://www.physiology.org/doi/10.1152/ajprenal.00400.2007
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December 2007

Mechanism of hypokalemia in magnesium deficiency.

J Am Soc Nephrol 2007 Oct 5;18(10):2649-52. Epub 2007 Sep 5.

UT Southwestern Medical Center, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1681/ASN.2007070792DOI Listing
October 2007

Intersectin links WNK kinases to endocytosis of ROMK1.

J Clin Invest 2007 Apr 22;117(4):1078-87. Epub 2007 Mar 22.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1172/JCI30087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821066PMC
April 2007

On the role of pore helix in regulation of TRPV5 by extracellular protons.

J Membr Biol 2006 28;212(3):191-8. Epub 2007 Feb 28.

Department of Biochemistry and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Kangwondo, 220-701, Republic of Korea.

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http://dx.doi.org/10.1007/s00232-006-0023-4DOI Listing
August 2007

Probing the effects of phosphoinositides on ion channels.

Authors:
Chou-Long Huang

Methods Mol Biol 2006 ;337:81-7

Department of Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1385/1-59745-095-2:81DOI Listing
December 2006

Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.

Pediatr Nephrol 2006 Sep 9;21(9):1231-6. Epub 2006 May 9.

Department of Medicine, Room J5-104, MC-8856, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-8856, USA.

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http://dx.doi.org/10.1007/s00467-006-0106-6DOI Listing
September 2006

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Proc Natl Acad Sci U S A 2006 Jan 20;103(5):1615-20. Epub 2006 Jan 20.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1073/pnas.0510609103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360592PMC
January 2006

PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+.

J Gen Physiol 2005 Nov 17;126(5):439-51. Epub 2005 Oct 17.

Department of Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1085/jgp.200509314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266600PMC
November 2005

Conformational changes of pore helix coupled to gating of TRPV5 by protons.

EMBO J 2005 Sep 25;24(18):3224-34. Epub 2005 Aug 25.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224685PMC
September 2005

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.

J Biol Chem 2005 Oct 4;280(40):34218-23. Epub 2005 Aug 4.

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M505735200DOI Listing
October 2005

WNK1 activates SGK1 to regulate the epithelial sodium channel.

Proc Natl Acad Sci U S A 2005 Jul 8;102(29):10315-20. Epub 2005 Jul 8.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1073/pnas.0504422102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177404PMC
July 2005

Inhibition of ROMK potassium channel by syntaxin 1A.

Am J Physiol Renal Physiol 2005 Feb 28;288(2):F284-9. Epub 2004 Sep 28.

Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8856, USA.

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http://ajprenal.physiology.org/content/ajprenal/288/2/F284.f
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http://dx.doi.org/10.1152/ajprenal.00320.2004DOI Listing
February 2005

The transient receptor potential superfamily of ion channels.

Authors:
Chou-Long Huang

J Am Soc Nephrol 2004 Jul;15(7):1690-9

Division of Nephrology, Department of Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1097/01.asn.0000129115.69395.65DOI Listing
July 2004

The N-terminal extracellular domain is required for polycystin-1-dependent channel activity.

J Biol Chem 2004 Jun 1;279(24):25582-9. Epub 2004 Apr 1.

Division of Nephrology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M402829200DOI Listing
June 2004

Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH.

J Biol Chem 2003 Dec 2;278(51):51044-52. Epub 2003 Oct 2.

Center for Mineral Metabolism and Clinical Research and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, 75390-8856, USA.

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http://dx.doi.org/10.1074/jbc.M306326200DOI Listing
December 2003

Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct.

Am J Physiol Renal Physiol 2003 Dec 2;285(6):F1179-87. Epub 2003 Sep 2.

Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8856, USA.

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http://dx.doi.org/10.1152/ajprenal.00150.2003DOI Listing
December 2003

Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism.

J Biol Chem 2003 May 3;278(19):16852-6. Epub 2003 Mar 3.

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1074/jbc.M300619200DOI Listing
May 2003

Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles.

Am J Physiol Renal Physiol 2002 Oct;283(4):F630-9

Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75390-8856, USA.

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http://dx.doi.org/10.1152/ajprenal.00378.2001DOI Listing
October 2002

Structural determinants and specificities for ROMK1-phosphoinositide interaction.

Am J Physiol Renal Physiol 2002 May;282(5):F826-34

Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA.

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http://dx.doi.org/10.1152/ajprenal.00300.2001DOI Listing
May 2002