Choon Kiat Ong

Choon Kiat Ong

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Choon Kiat Ong

Publications by authors named "Choon Kiat Ong"

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41Publications

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Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma.

Leukemia 2019 Jun 13;33(6):1451-1462. Epub 2018 Dec 13.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

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http://dx.doi.org/10.1038/s41375-018-0324-5DOI Listing
June 2019

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Cancer Cell 2019 Jun 23;35(6):932-947.e8. Epub 2019 May 23.

Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China; Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.04.007DOI Listing
June 2019

Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL).

J Hematol Oncol 2019 Mar 15;12(1):28. Epub 2019 Mar 15.

Division of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.

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http://dx.doi.org/10.1186/s13045-019-0717-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420729PMC
March 2019

Effect of Ang-2-VEGF-A Bispecific Antibody in Renal Cell Carcinoma.

Cancer Invest 2015 26;33(8):378-86. Epub 2015 Jun 26.

a Laboratory of Cancer Epigenome , National Cancer Centre Singapore , Singapore.

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http://dx.doi.org/10.3109/07357907.2015.1047505DOI Listing
April 2016

Fumarate Hydratase-deficient Cell Line NCCFH1 as a New In Vitro Model of Hereditary Papillary Renal Cell Carcinoma Type 2.

Anticancer Res 2015 Dec;35(12):6639-53

Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Republic of Singapore Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore

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December 2015

Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.

Eur Urol 2015 Jul 14;68(1):77-83. Epub 2015 Jan 14.

Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore; Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.12.040DOI Listing
July 2015

Pathogenesis of cholangiocarcinoma: From genetics to signalling pathways.

Best Pract Res Clin Gastroenterol 2015 Apr 17;29(2):233-44. Epub 2015 Feb 17.

Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bpg.2015.02.002DOI Listing
April 2015

Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.

J Clin Endocrinol Metab 2015 Feb 11;100(2):E360-4. Epub 2014 Nov 11.

Laboratory of Cancer Epigenome (W.Y., H.L.H., A.G., D.H., S.L.P., C.K.O., B.T.T.), Division of Medical Sciences, National Cancer Centre Singapore, 169610 Singapore; Division of Cancer and Stem Cell Biology (W.Y., J.R.M., H.L.H., D.H., S.L.P., C.K.O., S.G.R., P.T., B.T.T.), Duke-National University of Singapore Graduate Medical School, 169857 Singapore; National University of Singapore Graduate School for Integrative Sciences and Engineering (W.Y.), 117456 Singapore; Academic Endocrine Unit, Nuffield Department of Clinical Medicine (M.S., P.N., R.V.T.), Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, OX3 7LJ Oxford, United Kingdom; Department of Pathology (R.v.E., D.R., T.v.W., H.M.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Molecular Endocrinology Group, Molecular Pathobiology Research Centre Unit (U.I.P.M.) (B.C.) of the Portuguese Institute of Oncology from Lisbon Francisco Gentil (IPOLFG) and Chronic Diseases Research Centre (CEDOC), Faculty of Medical Sciences (FCM), New University of Lisbon (UNL), 1099-023 Lisbon, Portugal; Genome Institute of Singapore (P.T.), 138672 Singapore; and Cancer Science Institute of Singapore (P.T., B.T.T.), National University of Singapore, 117599 Singapore.

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http://dx.doi.org/10.1210/jc.2014-3238DOI Listing
February 2015

Inhibition of placental growth factor in renal cell carcinoma.

Anticancer Res 2015 Jan;35(1):531-41

Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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January 2015

The NF1 gene revisited - from bench to bedside.

Oncotarget 2014 Aug;5(15):5873-92

Cancer Therapeutics Laboratory, Centre for Personalised Cancer Medicine, University of Adelaide, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171599PMC
http://dx.doi.org/10.18632/oncotarget.2194DOI Listing
August 2014

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

Nat Genet 2014 Aug 20;46(8):877-80. Epub 2014 Jul 20.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore. [3] Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3037DOI Listing
August 2014

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.

Nat Genet 2013 Dec 3;45(12):1474-8. Epub 2013 Nov 3.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore. [3] Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. [4].

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http://www.nature.com/articles/ng.2806
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http://dx.doi.org/10.1038/ng.2806DOI Listing
December 2013

Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma.

Cancer Res 2012 Sep 17;72(17):4361-71. Epub 2012 Jul 17.

Laboratories of Cancer Genetics, Cytogenetics, and Computational Biology, Van Andel Research Institute; Department of Urology, Spectrum Health Hospital, Grand Rapids, MI 49503, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-2330DOI Listing
September 2012

Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.

Cancer Res 2011 Apr 2;71(8):3162-72. Epub 2011 Feb 2.

State Key Laboratory of Oncology in South China, Departments of Pathology and Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-10-3557DOI Listing
April 2011

Structural characterization of three novel rat OKL38 transcripts, their tissue distributions, and their regulation by human chorionic gonadotropin.

Endocrinology 2004 Oct 24;145(10):4763-74. Epub 2004 Jun 24.

Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, 11 Hospital Drive, Singapore 169610.

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http://dx.doi.org/10.1210/en.2004-0446DOI Listing
October 2004

Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44.

Oncogene 2004 Jul;23(33):5707-18

Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Singapore.

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http://dx.doi.org/10.1038/sj.onc.1207754DOI Listing
July 2004

Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis.

J Biol Chem 2004 Jan 21;279(1):743-54. Epub 2003 Oct 21.

Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Center, Singapore 169610.

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http://dx.doi.org/10.1074/jbc.M308668200DOI Listing
January 2004