Publications by authors named "Chongzhi Zang"

43Publications

U2af1 is required for survival and function of hematopoietic stem/progenitor cells.

Leukemia 2021 Jan 7. Epub 2021 Jan 7.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

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January 2021

Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements.

iScience 2020 Sep 1;23(9):101518. Epub 2020 Sep 1.

Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, USA. Electronic address:

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September 2020

Ectopic Tcf1 expression instills a stem-like program in exhausted CD8 T cells to enhance viral and tumor immunity.

Cell Mol Immunol 2020 Apr 27. Epub 2020 Apr 27.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, 07110, USA.

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April 2020

An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding.

Sci Rep 2020 03 16;10(1):4844. Epub 2020 Mar 16.

Department of Biochemistry & Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

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March 2020

Nickel-induced transcriptional changes persist  post exposure through epigenetic reprogramming.

Epigenetics Chromatin 2019 12 19;12(1):75. Epub 2019 Dec 19.

Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10010, USA.

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December 2019

Deciphering essential cistromes using genome-wide CRISPR screens.

Proc Natl Acad Sci U S A 2019 12 14;116(50):25186-25195. Epub 2019 Nov 14.

Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215;

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December 2019

YY1 is a cis-regulator in the organoid models of high mammographic density.

Bioinformatics 2020 03;36(6):1663-1667

Department of Electrical and Biomedical Engineering, University of Nevada, Reno, NV 22908, USA.

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March 2020

Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth.

Exp Cell Res 2019 09 26;382(2):111485. Epub 2019 Jun 26.

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, AL, 35294, United States; Department of Biochemistry and Molecular Genetics, Charlottesville, VA, 22908, USA. Electronic address:

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September 2019

Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1.

Mol Carcinog 2018 06 24;57(6):794-806. Epub 2018 Mar 24.

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York.

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June 2018

Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions.

Nucleic Acids Res 2018 01;46(2):e9

Biochemistry and Molecular Genetics Department, University of Virginia, Charlottesville, Virginia, USA.

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January 2018

Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer.

Cancer Res 2017 11;77(21):e19-e22

Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.

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November 2017

Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse.

Nucleic Acids Res 2017 01 26;45(D1):D658-D662. Epub 2016 Oct 26.

Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China

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January 2017

Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles.

Genome Res 2016 10 27;26(10):1417-1429. Epub 2016 Jul 27.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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October 2016

NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.

Sci Rep 2016 07 26;6:30255. Epub 2016 Jul 26.

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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July 2016

High-dimensional genomic data bias correction and data integration using MANCIE.

Nat Commun 2016 Apr 13;7:11305. Epub 2016 Apr 13.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA.

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April 2016

Integrative Analysis Reveals the Transcriptional Collaboration between EZH2 and E2F1 in the Regulation of Cancer-Related Gene Expression.

Mol Cancer Res 2016 Feb 9;14(2):163-172. Epub 2015 Dec 9.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, MA 02115, USA.

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February 2016

Network analysis of gene essentiality in functional genomics experiments.

Genome Biol 2015 Oct 30;16:239. Epub 2015 Oct 30.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.

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October 2015

The role of Notch receptors in transcriptional regulation.

J Cell Physiol 2015 May;230(5):982-8

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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May 2015

Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.

Genes Dev 2014 Aug;28(16):1827-39

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA

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August 2014

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):705-10. Epub 2013 Dec 27.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

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January 2014

Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification.

Nat Methods 2014 Jan 8;11(1):73-78. Epub 2013 Dec 8.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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January 2014

Target analysis by integration of transcriptome and ChIP-seq data with BETA.

Nat Protoc 2013 Dec 21;8(12):2502-15. Epub 2013 Nov 21.

Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, China.

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December 2013

Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.

PLoS Genet 2012 12;8(4):e1002649. Epub 2012 Apr 12.

Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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September 2012

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.

Cell 2009 Sep 20;138(5):1019-31. Epub 2009 Aug 20.

Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2009

H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.

Nat Genet 2009 Aug 26;41(8):941-5. Epub 2009 Jul 26.

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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August 2009

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data.

Bioinformatics 2009 Aug 8;25(15):1952-8. Epub 2009 Jun 8.

Department of Physics, The George Washington University, Washington, DC 20052, USA.

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August 2009

Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation.

Cell Stem Cell 2009 Jan;4(1):80-93

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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January 2009

Combinatorial patterns of histone acetylations and methylations in the human genome.

Nat Genet 2008 Jul 15;40(7):897-903. Epub 2008 Jun 15.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.

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July 2008