Publications by authors named "Chong Jiang"

49 Publications

Identification of a New Genetic Clade of Cowpea Mild Mottle Virus and Characterization of Its Interaction With Soybean Mosaic Virus in Co-infected Soybean.

Front Microbiol 2021 8;12:650773. Epub 2021 Apr 8.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Plant Virology, Ningbo University, Ningbo, China.

Cowpea mild mottle virus (CPMMV; genus ) can be a destructive pathogen of soybean but there is little information about its distribution on soybean in China. Here, we collected soybean plants with virus-like symptoms from 11 fields widely scattered within China, and used high-throughput sequencing to determine their virome. Most samples (8/11) were co-infected by the well-studied potyvirus soybean mosaic virus (SMV) and CPMMV, and the remaining three samples were singly infected with CPMMV. The near-complete genome sequences of the 11 CPMMV isolates were determined and phylogenetic analysis showed that they constituted a new genetic clade. One recombination event was detected among the CPMMV sequences, and the isolate CPMMV_JL_CC was identified as recombinant. In mechanical inoculation assays, co-infection by CPMMV and SMV resulted in an enhancement of disease symptoms, but decreased the expression level of the genomic RNAs and CP of CPMMV, without significantly affecting SMV accumulation. The interaction between these viruses needs further investigation.
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http://dx.doi.org/10.3389/fmicb.2021.650773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060446PMC
April 2021

Understanding the complex environmental management through a len of food-water-ecosystem nexus: Insights from an ecosystem restoration hotspot in dryland.

Sci Total Environ 2021 Apr 15;783:147029. Epub 2021 Apr 15.

Guangdong Open Laboratory of Geospatial Information Technology and Application, Guangzhou Institute of Geography, Guangdong Academy of Sciences, Guangzhou 510070, PR China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, PR China.

The Ecosystem Restoration Project (ERP) is a critical and urgent practice to achieve the land degradation neutrality (LDN) targets. However, an insufficient understanding of the balance between contrasting sectors of the food-water-ecosystem nexus results in ineffectiveness in supporting complex environmental management (CEM), leading to undesirable ERP failures. The Ordos Plateau case identified the nexus evolution and the non-linear interactions between sectors, which were expected to support adaptive strategy formulations for CEM and achieve win-win outcomes. Revegetation in drylands substantially boosted ecosystem restoration, alleviating soil erosion. However, the excessive reliance on returning cropland to woodland and grassland has caused a significant loss of arable and grazing land. During the initial period of ERPs, this exacerbated decline in grain and meat productivity. In addition, aggressive revegetation activities have also reduced runoff yield and depleted soil water resources. Water scarcity is recognized as the most challenging issue in dryland ecosystem restoration, heavily influencing the interactions between sectors and threatening the long-term sustainability of ERPs. To accommodate for regional water carrying capacity, ERPs should adopt and properly allocate the use of suitable plant species with a proven anti-drought capability and high survival ratios without additional human interventions. In addition, the evolution regimes, driving factors, critical thresholds, and complex feedbacks between the nexus sectors should be fully understood to address the water resources constraints and reconcile trade-offs. This would enable the prevention of ecosystem shifts to undesirable failures and inform timely and cost-effective CEM to achieve the LDN targets.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147029DOI Listing
April 2021

Sustained remission of multi-line relapsed extranodal NK/T-cell lymphoma, nasal type, following sintilimab and chidamide: A case report.

Medicine (Baltimore) 2021 Mar;100(10):e24824

Department of Hematology.

Introduction: There is currently no optimal treatment modality for refractory or relapsed Extranodal NK/T-cell lymphoma, nasal type (ENKTL). In recent years, programmed cell death protein 1 (PD-1)/programmed cell - ligand 1 pathway blockade and histone deacetylase inhibitors have emerged as promising strategies for refractory or relapsed ENKTL. Accumulating evidence has shown that therapeutic effects of anti-PD-1 antibody could be enhanced by histone deacetylase inhibitors.

Patient Concerns: A 52-year-old male patient was diagnosed with stage I ENKTL by biopsy on February 2010.

Diagnosis: positron emission tomography-computed tomography (PET-CT) and biopsy were used to diagnose relapsed ENKTL in 2014.

Interventions: The patient was treated with radiotherapy and six cycles of etoposide, prednisone, vincristine (Oncovin), cyclophosphamide and doxorubicin hydrochloride and achieved complete remission (CR) by PET-CT in August 2010. In November 2014, the patient was diagnosed with relapsed stage IV ENKTL and was treated with six cycles of alternative chemotherapy with the regimen of steroid (dexamethasone), methotrexate, ifosfamide, L-asparaginase, and etoposide and pegaspargase plus Gemcitabine, Oxaliplatin along with radiotherapy. The patient achieved remission and was placed on thalidomide maintenance treatment. Upon suspicion of relapse suggested by PET-CT, Autologous stem cell transplant was performed after BCNU, etoposide, Ara-C, and melphalan preconditioning on February 2016. Following relapse again in December 2016, the lesions of left femur were treated with radiotherapy and he received anti-PD-1 antibody. He was treated with 4 cycles of pegaspargase plus Gemcitabine, Oxaliplatin on August 2017. The patient's condition improved. He received maintenance and consolidation therapy including lenalidomide, radiotherapy of the right nasal cavity and paranasal sinuses and antigen-specific reactive T cell infusions. PET-CT imaging showed there was high metabolic activity signal in the distal end of right femoral on August 2018 and the treatment regimen was adjusted to radiotherapy of the distal end of right femoral and systemic treatment of PD-1 antibody Sintilimab and chidamide 30 mg. After 5 months post-treatment, biopsy of nasopharynx showed no lymphoma cells. The patient continued the treatment of Sintilimab and chidamide 20 mg.

Outcomes: PET-CT imaging showed his lesions obtained remission after 8 months post-treatment.

Conclusion: Thus, combination of sintilimab and chidamide can be used to treat relapsed ENKTL following treatment failure from chemo-, radio-, and immuno-therapy. A clinical trial has been launched.
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http://dx.doi.org/10.1097/MD.0000000000024824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969288PMC
March 2021

Win-win-win pathway for ecological restoration by balancing hydrological, ecological, and agricultural dimensions: Contrasting lessons from highly eroded agroforestry.

Sci Total Environ 2021 Jun 6;774:145140. Epub 2021 Feb 6.

Guangdong Open Laboratory of Geospatial Information Technology and Application, Guangzhou Institute of Geography, Guangdong Academy of Sciences, Guangzhou 510070, PR China; Key Lab of Guangdong for Utilization of Remote Sensing and Geographical Information System, Guangzhou 510070, PR China.

Ecological restoration projects (ERP) can effectively reverse ecosystem degradation. However, some ERPs have failed to restore ecosystems under environmental constraints, and they were unable to achieve the desired ecological and economic benefits. To achieve a win-win-win target that balances the hydrological, ecological, and agricultural dimensions, we introduced the contrasting lessons from hotspots of ecosystem restoration in the arid Loess Plateau (LP) and the humid Karst Plateau (KP) in China, and discussed a novel strategy for coordinating ecosystem restoration, water and food security, and residents' livelihoods. The biophysical models and related statistical records showed that aggressive ERPs and soil and water conservation projects (SWCPs) significantly promoted vegetation restoration and reduced soil erosion and sediment yield in both areas. However, excessive afforestation in the arid LP exhausted water resources and threatened ecosystem sustainability. The accelerated replacement of cropland since 1999 in the LP aggravated cropland shortage which led to carbon sequestration and grain productivity declines in the initial years. However, the construction of terrace and check-dam fields and improvements in the conditions of agricultural production reconciled the cropland shortage and stabilized food security. The positive involvement of stakeholders in ERPs effectively minimized land degradation through economic development and the improved livelihoods of local residents. Therefore, based on the evidence from the KP and LP, the proposed win-win-win strategy is potentially applicable in other global regions that suffer from land degradation. This strategy can achieve considerable success if the planners have a good understanding of local environmental conditions as well as the social and economic needs of residents affected by ERPs.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145140DOI Listing
June 2021

synthesis of hierarchical NiCo-MOF@NiCo(OH) heterostructures for enhanced pseudocapacitor and oxygen evolution reaction performances.

Dalton Trans 2021 Mar;50(8):3060-3066

College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, 443002, P. R. China.

Integrating the merits of different components to construct heterostructures for energy storage and conversion has attracted intensive attention. Herein, taking advantage of bimetallic MOFs and transition bimetal hydroxide, we have successfully used nanoflower-like Ni1-xCox(OH)2 as both the precursor and template to in situ construct three dimensional (3D) NiCo-MOF@Ni1-xCox(OH)2 (denoted as MOF@TMH) hierarchical heterostructures. Benefiting from the optimized composition with hierarchical heterostructures assembled by ultrathin nanosheets, MOF@TMH-2 possesses rich effective active sites and high electrochemical reactivity, delivering superior pseudocapacitor performance with a specific capacitance of 1855.3 F g-1 at 2 A g-1 and good rate performance. Besides, MOF@TMH-2 also exhibits excellent OER activity with small overpotentials of 193 mV and 310 mV at 10 and 100 mA cm-2, respectively.
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http://dx.doi.org/10.1039/d0dt03872eDOI Listing
March 2021

Exploring soil erosion trajectories and their divergent responses to driving factors: a model-based contrasting study in highly eroded mountain areas.

Environ Sci Pollut Res Int 2021 Mar 20;28(12):14720-14738. Epub 2020 Nov 20.

Guangdong Open Laboratory of Geospatial Information Technology and Application, Guangzhou Institute of Geography, Guangdong Academy of Sciences, Guangzhou, 510070, People's Republic of China.

Soil erosion threatens environmental sustainability worldwide. Exploring the trajectories of soil erosion and associated drivers is of great significance for combating land degradation. This study selected the highly eroded Loess Plateau (LP) and Karst Plateau (KP) as contrasting regions to monitor soil erosion dynamics. Monitoring was performed by applying the Revised Universal Soil Loss Equation based on a GIS platform and multi-source input data to investigate associated drivers. The results established that soil erosion in both regions was substantially reduced by ecological restoration projects and significant land use/cover conversions. Landscape and geomorphological variables were found to be the dominant factors controlling soil erosion in the LP and KP, as they influenced land use patches and geomorphological patterns, respectively. The correlations between fragmentation metric indices and soil erosion indicated that the appropriately intensive fragmentation in the LP could mitigate or prevent soil erosion by disturbing its formation and transportation and ultimately positively influenced soil erosion control. Geomorphological patterns were also determinative factors, particularly for the KP, where almost all geomorphological variables were significantly correlated with the erosion modulus. Owing to the peculiar landform and landscape conditions in karst areas and loess hilly-gully areas, geomorphological and landscape variables should be considered when determining the main factors affecting soil erosion processes and integrated into the forecasting model to improve the accuracy of the simulation. The findings of this study are expected to (i) improve the efficacy of soil erosion control and (ii) promote the sustainable planning and management of land and soil resources.
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http://dx.doi.org/10.1007/s11356-020-11703-1DOI Listing
March 2021

Occurrence of Soybean Yellow Common Mosaic Virus in Soybean in China Showing Yellow Common Mosaic Disease.

Plant Dis 2020 Nov 17. Epub 2020 Nov 17.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Plant Virology, Ningbo University, Fenghua road 818, Ningbo, Zhejiang, China, 315211;

Soybean yellow common mosaic virus (SYCMV), a positive sense ssRNA virus classified in the genus Sobemovirus, was first reported and characterized in Korea (Nam et al., 2012). Currently, its only known host is soybean (Nam et al., 2012) on which it causes bright yellow mosaic and crinkling of the leaves (Lim et al., 2016). During a field survey in July 2019, bright yellow mosaic and mild crinkling symptoms were observed on soybean leaves (cv. Zhonghuang 13) in the Hubei province of China. To identify the possible pathogen(s) associated to the disease symptoms, leaves from five symptomatic plants were collected, pooled and total RNA was extracted using TRIzol® Reagent (Invitrogen, CA, USA). 10 μg of the total RNA was purified via magnetic beads (Thermo Fischer Scientific, USA) and a TruSeq RNA Sample Prep Kit (Illumina, San Diego, CA, USA) was then used to construct an RNA sequencing library. Transcriptome sequencing was performed on an Illumina HiSeq 4000 (LC Sciences, USA). The average insert size for the paired-end library was 300 ± 50 bp. After quality control, a total of 47.5 million clean reads were obtained and assembled using the Trinity software (version 2.8.5). The assembled contigs were searched against NCBI virus RefSeqs (ftp://ftp.ncbi.nlm.nih.gov/refseq/release/viral) by the BLASTx algorithm with a cutoff E value of ≤10-5. 12 contigs sized from 3,421 to 4,093 bp were found to share a sequence identity of 77.5%-94.1% with SYCMV isolates from Japan (LC332541) and South Korea (JF495127.1). No other virus matches were identified. The largest contig (4,093 bp, MT816507) covers 99% of the expected complete genome of SYCMV (4,121 bp, KX096577). To verify the accuracy of the sequence assembled, RT-PCR-Sanger sequencing was performed on a single field plant sample using primers designed for SYCMV (Forward, 5'-GAACAAAGAGTCTGGATCTT-3'; Reverse, 5'-TCCTTCCAAAACCTCGCGGG-3'). The sequence of the amplicon (3854 bp, MT997092) exhibited an identity of 99.9% to the HTS-derived SYCMV contig sequence. Phylogenetic analysis of the amplicon sequence revealed that the SYCMV isolate from China formed a distinct branch in the tree (Fig. S1). Sap from symptomatic field plants was used to mechanically inoculate two soybean cultivars (Jiunong 9 and Kefeng 1, 10 plants per cultivar), and leaves inoculated with phosphate buffer saline (PBS, 0.01 M, pH 7.5) served as a control (3 plants per cultivar). All but the control plants developed systemic bright yellow mosaic symptoms 10 days after inoculation (Fig. S2A). The infection of the soybean plants with SYCMV was confirmed by RT-PCR with the newly designed primers for SYCMV (Forward, 5'- CCTACAGGCATTGGTTTCGT-3'; Reverse, 5'-CGTGAGGTTCTTGCTTCACA-3', anticipated amplicon size: 2,210 bp) (Fig. S2B) and by amplicon sequencing (100% sequence identity with MT9979092). In addition, the infection was further confirmed by immuno-blotting using an antibody against SYCMV coat protein (synthesized by GenScript, USA) (Fig. S2C). Together, the results demonstrate that SYCMV is the causal agent of the bright yellow mosaic symptoms in soybean observed in the field. To the best of our knowledge, this is the first report of SYCMV on soybean in China. These findings shall not only alert local growers to a potential new threat to soybean production in their region, but also provide new insights on the transmission, epidemiology and pathological properties of SYCMV in China.
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http://dx.doi.org/10.1094/PDIS-08-20-1738-PDNDOI Listing
November 2020

Will Baseline Total Lesion Glycolysis Play a Role in Improving the Prognostic Value of the NCCN-IPI in Primary Gastric Diffuse Large B-Cell Lymphoma Patients Treated With the R-CHOP Regimen?

Clin Nucl Med 2021 Jan;46(1):1-7

From the Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School.

Purpose: The aim was to explore whether baseline total lesion glycolysis (TLG) can improve the prognostic value of the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) in primary gastric diffuse large B-cell lymphoma (PG-DLBCL) patients treated with an R-CHOP-like regimen.

Materials And Methods: Ninety-four PG-DLBCL patients who underwent baseline PET/CT between July 2010 and May 2019 were included in this retrospective study. FDG-avid lesions in each patient were segmented to calculate the SUVmax, total metabolic tumor volume (TMTV), and TLG. Progression-free survival (PFS) and overall survival (OS) were used as end points to evaluate prognosis.

Results: During the follow-up period of 5 to 108 months (35.3 ± 23.5 months), high TLG and a high NCCN-IPI were significantly associated with poor PFS and OS. Total lesion glycolysis and the NCCN-IPI were independent predictors of PFS and OS. Patients were stratified into 3 groups according to the combination of TLG and the NCCN-IPI for PFS (P < 0.001) and OS (P < 0.001): high-risk group (TLG > 1159.1 and NCCN-IPI 4-8) (PFS and OS, 57.7% and 61.5%, respectively, n = 42), intermediate-risk group (TLG > 1159.1 or NCCN-IPI 4-8) (PFS and OS, both 76.9%, n = 26), and low-risk group (TLG ≤ 1159.1 and NCCN-IPI 0-3) (PFS and OS, 97.6% and 100.0%, respectively, n = 26).

Conclusions: Both TLG and the NCCN-IPI are independent predictors of PG-DLBCL patient survival. Moreover, the combination of TLG and the NCCN-IPI improved patient risk stratification and might help personalize therapeutic regimens.
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http://dx.doi.org/10.1097/RLU.0000000000003378DOI Listing
January 2021

Value of F-FDG PET/CT for prognostic stratification in patients with primary intestinal diffuse large B cell lymphoma treated with an R-CHOP-like regimen.

Ann Nucl Med 2020 Dec 15;34(12):911-919. Epub 2020 Oct 15.

Department of Hematology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Purpose: The prognostic value of F-FDG PET/CT for primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) patients has not been determined. This prompted us to explore the value of F-FDG PET/CT for prognostic stratification in patients with PI-DLBCL treated with an R-CHOP-like regimen.

Materials And Methods: Seventy-three PI-DLBCL patients who underwent baseline PET/CT between January 2010 and May 2019 were included in this retrospective study. Total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) were computed using the 41% SUV thresholding method. Progression-free survival (PFS) and overall survival (OS) were used as endpoints to evaluate prognosis.

Results: During the follow-up period of 3-117 months (29.0 ± 25.5 months), high TLG, non-germinal center B-cell-like (non-GCB) and high National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) were significantly associated with inferior PFS and OS. TLG, cell-of-origin and NCCN-IPI were independent predictors of PFS, and both TLG and NCCN-IPI were independent predictors of OS. The grading system was based on the number of risk factors (high TLG, non-GCB, high NCCN-IPI) and patients were divided into 4 risk groups (PFS: χ = 33.858, P < 0.001; OS: χ = 29.435, P < 0.001): low-risk group (none of the 3 risk factors, 18 patients); low-intermediate risk group (1 risk factor, 24 patients); high-intermediate risk group (2 risk factors, 16 patients); and high-risk group (all 3 risk factors, 15 patients).

Conclusions: High TLG, non-GCB and high NCCN-IPI can identify a subset of PI-DLBCL patients with inferior survival outcomes. Furthermore, the grading system can identify PI-DLBCL patient groups with markedly different prognoses, which might contribute to the adjustment of the therapeutic regime.
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http://dx.doi.org/10.1007/s12149-020-01536-wDOI Listing
December 2020

Baseline total metabolic tumor volume combined with international peripheral T-cell lymphoma project may improve prognostic stratification for patients with peripheral T-cell lymphoma (PTCL).

EJNMMI Res 2020 Sep 23;10(1):110. Epub 2020 Sep 23.

Department of Hematology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Purpose: The aim of this study was to explore the prognostic value of total metabolic tumor volume (TMTV) at baseline F-FDG PET/CT in patients diagnosed with peripheral T-cell lymphoma (PTCL).

Materials And Methods: Eighty-four newly diagnosed PTCL patients who underwent baseline F-FDG PET/CT prior to treatment between March 2009 and January 2019 were enrolled in this retrospective study. The FDG-avid lesions in each patient were segmented using semiautomated software to calculate the maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG) values using the boundaries of voxels presenting with the 41% SUVmax threshold method. Progression-free survival (PFS) and overall survival (OS) were used as end points to evaluate patient prognosis. The log-rank test and Cox regression analyses were used to evaluate PFS and OS.

Results: ROC curve analysis indicated an ideal TMTV cut-off value of 228.8 cm. During the 4-131 months (29.2 ± 28.5 months) follow-up period, high TMTV was significantly associated with worse PFS and OS. TMTV and the international peripheral T-cell lymphoma project score (IPTCLP) were independent predictors of PFS and OS with multivariate analysis. The combination of TMTV and the IPTCLP may provide significantly better risk substratification in PFS and OS of PTCL patients.

Conclusions: Both TMTV and IPTCLP are independent predictors of PTCL patient survival outcomes. Moreover, the combination of TMTV and IPTCLP improved patient risk stratification and may contribute to personalized therapeutic regimens.
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http://dx.doi.org/10.1186/s13550-020-00698-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511502PMC
September 2020

Texture Analysis Improves the Value of Pretreatment F-FDG PET/CT in Predicting Interim Response of Primary Gastrointestinal Diffuse Large B-Cell Lymphoma.

Contrast Media Mol Imaging 2020 21;2020:2981585. Epub 2020 Aug 21.

Department of Nuclear Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China.

Objectives: To explore the application of pretreatment F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) texture analysis (TA) in predicting the interim response of primary gastrointestinal diffuse large B-cell lymphoma (PGIL-DLBCL).

Methods: Pretreatment F-FDG PET/CT images of 30 PGIL-DLBCL patients were studied retrospectively. The interim response was evaluated after 3-4 cycles of chemotherapy. The complete response (CR) rates in patients with different clinicopathological characteristics were compared by Fisher's exact test. The differences in the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and texture features between the CR and non-CR groups were compared by the Mann-Whitney test. Feature selection was performed according to the results of the Mann-Whitney test and feature categories. The predictive efficacies of the SUVmax, MTV, and the selected texture features were assessed by receiver operating characteristic (ROC) analysis. A prediction probability was generated by binary logistic regression analysis.

Results: The SUVmax, MTV, some first-order texture features, volume, and entropy were significantly higher in the non-CR group. The energy was significantly lower in the non-CR group. The SUVmax, volume, and entropy were excellent predictors of the interim response, and the areas under the curves (AUCs) were 0.850, 0.805, and 0.800, respectively. The CR rate was significantly lower in patients with intestinal involvement. The prediction probability generated from the combination of the SUVmax, entropy, volume, and intestinal involvement had a higher AUC (0.915) than all single parameters.

Conclusions: TA has potential in improving the value of pretreatment PET/CT in predicting the interim response of PGIL-DLBCL. However, prospective studies with large sample sizes and validation analyses are needed to confirm the current results.
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http://dx.doi.org/10.1155/2020/2981585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463417PMC
August 2020

Ecological restoration is not sufficient for reconciling the trade-off between soil retention and water yield: A contrasting study from catchment governance perspective.

Sci Total Environ 2021 Feb 2;754:142139. Epub 2020 Sep 2.

Guangdong Open Laboratory of Geospatial Information Technology and Application, Guangzhou Institute of Geography, Guangzhou 510070, PR China; Key Lab of Guangdong for Utilization of Remote Sensing and Geographical Information System, Guangzhou 510070, PR China. Electronic address:

Ecological restoration program (ERP) is widely recognized as an effective measure to combat land degradation and improve environmental quality. However, inappropriate ERPs lead to trade-offs between soil retention and water yield as well as conflicts of soil and water resources between the midstream and the downstream of catchment. This study aims to assess the efficiency of ERPs in soil erosion control and identify the trade-offs between soil retention and water yield through the lens of runoff and sediment regimes in contrasting catchments of the Loess Plateau (LP) and the Karst Plateau (KP). Although favorable climate and rapid vegetation restoration substantially reduced water erosion in both these areas, the hydrological responses were not the same because of climate differences. In the arid LP, water and energy variables correlated closely with vegetation cover. Excessive afforestation programs in drylands increased vegetation transpiration and soil evaporation, further exhausting soil water resources, and eventually causing water yield reduction. However, soil and water conservation programs (SWCPs) in the humid KP reduced sediment yield substantially, and the runoff remained stable. Significant runoff reduction in the midstream of the Yellow River aggravated water scarcity and threatened the downstream water demand. Meanwhile, sediment load decline in the LP and the KP impacted sediment deposition in the downstream and estuary formation. From the perspective of integrated catchment governance, human interventions including ERP and SWCP should be more sustainable and consider not only the target process at the local scale (intracoupling effect), but also unprecedented non-target process at the regional scale (telecoupling effect). In addition, it should allow for the supply-demand balance of competing soil and water resources to achieve the coordinated development of resources, environment, and production.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142139DOI Listing
February 2021

Unfolding the effectiveness of ecological restoration programs in combating land degradation: Achievements, causes, and implications.

Sci Total Environ 2020 Dec 10;748:141552. Epub 2020 Aug 10.

Guangdong Open Laboratory of Geospatial Information Technology and Application, Guangzhou Institute of Geography, Guangzhou 510070, PR China; Key Lab of Guangdong for Utilization of Remote Sensing and Geographical Information System, Guangzhou 510070, PR China.

Land degradation is one of the most serious environmental problems worldwide. To combat land degradation, China has implemented a series of ecological restoration programs (ERPs). This study selected the northern dryland of China as a case study to examine the efficiency of ERPs, and the response of soil loss to afforestation efforts and climatic conditions was discussed using the principles from the ecological theory of non-linear ecosystem dynamics. Owing to the combined impacts of declining wind speed and rapid vegetation restoration, the soil erosion for the entire region was substantially reduced from 1990 to 2015. However, the rainfall fluctuated considerably, particularly for the period from the late 1990s to early 2000s. Several drought events to some extent inhibited vegetation growth and further offset afforestation efforts, resulting in degradations in vegetation structure and soil retention function, which have been aggravating soil erosion since 2005. In certain representative sandstorm areas, limited increase in rainfall was not enough to promote vegetation growth, and therefore the vegetation cover did not present increasing trends and, in some cases, even declined significantly. The responses in terms of land degradation to climatic conditions and afforestation efforts behaved in a non-linear dynamic manner, providing essential insights into appropriate timings, climate-induced windows of opportunity, and risk in recovering and sustaining ecosystems, and eventually moving towards the land degradation neutrality (LDN) target. The climate-induced windows of opportunity and risk are critical in identifying the time for starting human interventions to mitigate and halt land degradation. Meanwhile, effective investment actions should be taken according to existing environmental conditions and critical thresholds, to achieve LDN at minimum risk and cost.
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http://dx.doi.org/10.1016/j.scitotenv.2020.141552DOI Listing
December 2020

Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR.

Int J Mol Sci 2020 Jul 8;21(14). Epub 2020 Jul 8.

Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France.

Cystic Fibrosis is a lethal monogenic autosomal recessive disease linked to mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. The most frequent mutation is the deletion of phenylalanine at position 508 of the protein. This F508del-CFTR mutation leads to misfolded protein that is detected by the quality control machinery within the endoplasmic reticulum and targeted for destruction by the proteasome. Modulating quality control proteins as molecular chaperones is a promising strategy for attenuating the degradation and stabilizing the mutant CFTR at the plasma membrane. Among the molecular chaperones, the small heat shock protein HspB1 and HspB4 were shown to promote degradation of F508del-CFTR. Here, we investigated the impact of HspB5 expression and phosphorylation on transport to the plasma membrane, function and stability of F508del-CFTR. We show that a phosphomimetic form of HspB5 increases the transport to the plasma membrane, function and stability of F508del-CFTR. These activities are further enhanced in presence of therapeutic drugs currently used for the treatment of cystic fibrosis (VX-770/Ivacaftor, VX-770+VX-809/Orkambi). Overall, this study highlights the beneficial effects of a phosphorylated form of HspB5 on F508del-CFTR rescue and its therapeutic potential in cystic fibrosis.
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http://dx.doi.org/10.3390/ijms21144844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402320PMC
July 2020

Phylogeography of (Lepidoptera: Lasiocampidae): Population differentiation and last glacial maximum survival.

Ecol Evol 2019 Jul 19;9(13):7480-7496. Epub 2019 Jun 19.

College of Life Sciences Capital Normal University Beijing China.

Although the Masson pine moth, , is one of the most destructive forest pest insects and is an endemic condition in China, we still do not fully understand the patterns of how its distribution range varies in response to Quaternary climatic oscillations. Here, we sequenced one maternally inherited mitochondrial gene () and biparentally inherited nuclear data ( and ) among 23 natural populations across the entire range of the species in China. A total of 51 mitotypes and 38 ribotypes were separately obtained using mtDNA and data. Furthermore, significant phylogeographical structure ( > ,  < 0.01) were detected. The spatial distribution of mitotypes implied that two distinct groups existed in the species: one in the southwest distribution, including 10 locations, and the other located in the northeast region of China. It is suggested, therefore, that each group was derived from ancestors that occupied different isolated refugia during previous periods, possibly last glacial maximum. Mismatch distribution and Bayesian population dynamics analysis suggested the population size underwent sudden expansion, which is consistent with the results of ecological niche modeling. As a typical phytophagous insect, the history of population expansion was in accordance with the host plants, providing abundant food resources and habitat. Intraspecific success rate of barcoding identification was lower than interspecific ones, indicating a level of difficulty in barcoding individuals from different populations. However, it still provides an early insight into the pattern of genetic diversity within a species.

Open Research Badges: This article has been awarded an Open Data and Open Materials. All materials and data are publicly accessible via the Open Science Framework at https://doi.org/10.5061/dryad.2df87g2. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
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http://dx.doi.org/10.1002/ece3.5278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635939PMC
July 2019

Stable Bimetal-MOF Ultrathin Nanosheets for Pseudocapacitors with Enhanced Performance.

Inorg Chem 2019 Aug 25;58(15):9543-9547. Epub 2019 Jul 25.

College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials , China Three Gorges University , Yichang 443002 , P. R. China.

Exploring high-performance metal-organic frameworks (MOFs) for pseudocapacitors is quite meaningful for energy storage. Herein a bimetal NiCo-MOF with ultrathin thickness was prepared via a simple hydrothermal method, which shows excellent electrochemical performance with specific capacitances of 1945.83 and 1700.40 F/g at current densities of 0.5 and 1 A/g, respectively, while maintaining good stability. X-ray photoelectron spectroscopy and X-ray absorption near-edge spectroscopy spectra unravel that the strong coupling between Ni and Co species enhances the valence state of Ni in the ultrathin nanosheets, which facilitates the charge transfer during the electrochemical reaction and results in greatly improved pseudocapacitive reactivity. This work provides guidance on the promising prospect of MOF materials for pseudocapacitor applications.
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http://dx.doi.org/10.1021/acs.inorgchem.9b00937DOI Listing
August 2019

Analysis of vertically loaded piles considering crushing characteristics of crushed stones.

PLoS One 2019 11;14(7):e0219003. Epub 2019 Jul 11.

School of Resources and Safety Engineering, Central South University, Changsha, Hunan, China.

In this paper, a method was developed to assess the vertical response of piles considering crushing characteristics. A load transfer model of a pile is built and the relationship between the crushing characteristics and load transfer function of a pile was analyzed. Based on the analysis results, the transfer equation of load function considering the crushing characteristics was derived using the finite difference method. The ideal side resistance and the load transfer mechanism of a pile can be obtained by the transfer equation of load function. The predicted response of piles with the proposed method is in good agreement with the response observed in some pile tests reported in the literature. Further study was conducted to discuss the effect of the parameters related to the load transfer model considering crushing characteristics on the load-settlement response of a single pile.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622475PMC
March 2020

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1.

Cell Rep 2019 05;27(6):1886-1896.e6

Program in Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Biochemistry Department, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1). Here we show that the Na/K/2Cl cotransporter NKCC1 (SLC12A2), a known regulator of cell volume, is present in complex with LAT1. We further show that NKCC1 depletion or deletion enhances LAT1 activity, as well as activation of Akt and Erk, leading to activation of mTORC1 in cells, colonic organoids, and mouse colon. Moreover, NKCC1 depletion reduces intracellular Na concentration and cell volume (size) and mass and stimulates cell proliferation. NKCC1, therefore, suppresses mTORC1 by inhibiting its key activating signaling pathways. Importantly, by linking ion transport and cell volume regulation to mTORC1 function, NKCC1 provides a long-sought link connecting cell volume (size) to cell mass regulation.
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http://dx.doi.org/10.1016/j.celrep.2019.04.034DOI Listing
May 2019

Biomimetic Moth-eye Nanofabrication: Enhanced Antireflection with Superior Self-cleaning Characteristic.

Sci Rep 2018 04 3;8(1):5438. Epub 2018 Apr 3.

College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

Sub-wavelength antireflection moth-eye structures were fabricated with Nickel mold using Roll-to-Plate (R2P) ultraviolet nanoimprint lithography (UV-NIL) on transparent polycarbonate (PC) substrates. Samples with well replicated patterns established an average reflection of 1.21% in the visible light range, 380 to 760 nm, at normal incidence. An excellent antireflection property of a wide range of incidence angles was shown with the average reflection below 4% at 50°. Compared with the unpatterned ultraviolet-curable resin coating, the resulting sub-wavelength moth-eye structure also exhibited increased hydrophobicity in addition to antireflection. This R2P method is especially suitable for large-area product preparation and the biomimetic moth-eye structure with multiple performances can be applied to optical devices such as display screens, solar cells, or light emitting diodes.
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http://dx.doi.org/10.1038/s41598-018-23771-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883013PMC
April 2018

Prognostic value of baseline, interim and end-of-treatment 18F-FDG PET/CT parameters in extranodal natural killer/T-cell lymphoma: A meta-analysis.

PLoS One 2018 20;13(3):e0194435. Epub 2018 Mar 20.

Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Methods: We searched the PubMed, EMBASE, Cochrane Library and Medline databases for eligible articles. SUVmax, MTV, and TLG on B-PET/CT, DS on I-PET/CT and DS on E-PET/CT were regarded as efficacy data. Combined hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were estimated using RevMan 5.3 software.

Results: Nine trials with a total of 535 ENKTL patients were included. SUVmax, MTV and TLG on B-PET/CT were significantly associated with PFS with HRs of 2.78 (95%CI 1.54-5.03), 3.61 (95%CI 1.96-6.65) and 5.62 (95%CI 1.94-16.33), respectively, and with OS with HRs of 4.78 (95%CI 2.29-9.96), 3.20 (95%CI 1.55-6.60) and 7.76 (95%CI 1.79-33.58), respectively. For the DS on I-PET/CT, the HRs for PFS and OS were 5.15 (95%CI 2.71-9.80) and 5.80 (95%CI 2.28-14.73), respectively. Similarly, the DS on E-PET/CT was a significant predictor of PFS and OS with HRs of 3.65 (95%CI 2.13-6.26) and 3.32 (95%CI 1.79-6.15), respectively.

Conclusion: Our results suggest that SUVmax, MTV, TLG on B-PET/CT, DS on I-PET/CT and DS on E-PET/CT may be significant prognostic indicators for PFS and OS in ENKTL patients. Moreover, TLG tends to be superior to SUVmax and MTV on B-PET/CT for predicting survival of ENKTL patients. Therefore, response monitoring and prognostication assessments based on multiple PET/CT parameters should be considered in the management of ENKTL patients.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194435PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860776PMC
July 2018

Simultaneous pulmonary and inferior vena cava tumor thromboembolism secondary to retroperitoneal pleomorphic liposarcoma.

Hell J Nucl Med 2018 Jan-Apr;21(1):74-76. Epub 2018 Mar 20.

Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

Retroperitoneal pleomorphic liposarcoma (RPLS) is the least common but the most aggressive subtype of liposarcoma. We herein report a case of tumor embolism (TE) to the inferior vena cava (IVC) and pulmonary arteries in a 54 years old woman with RPLS. The case suggests that fusion fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) can accurately detect occult TE. It also illustrates the usefulness of computed tomography (CT) and high F-FDG uptake by PET/CT imaging for diagnosing such findings as filling defect in the veins and beaded pulmonary arteries as TE. To our knowledge, this is the first reported case of simultaneous pulmonary and inferior vena cava thromboembolism secondary to RPLS. And occult TE from RPLS has not been reported previously by F-FDG PET/CT.
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http://dx.doi.org/10.1967/s002449910709DOI Listing
June 2018

The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations: a case report.

Medicine (Baltimore) 2017 Dec;96(50):e9171

Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center Emergency Department Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Rationale: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could reveal potential lymph node involvement and assisted locating sample sites for pathological examinations.

Patient Concerns: Help choose the right treatment strategies for patients. To better stage immature ovarian teratomas with 18F-FDG PET/CT when lymphatic metastasis is suspected while lymph node biopsy results are negative.

Diagnoses: The ultimate pathological diagnosis was left ovarian cancer, an immature teratoma (IMT) Grade 1.

Interventions: Surgery was the initial treatment option. Chemotherapy (BEP scheme: Bleomycin 30 mg d1, 7 + Etoposide 100mg d1-6 + Cisplatin 50mg d1-3) was then administered.

Outcomes: The post-operational pathological examination additionally showed a small number of tumor cells in para-aortic lymph nodes. The end-of-treatment disclosed no recurrent tumors and serum levels of AFP (2.9 ng/mL), hCG (0.12 mIU/L), and CA-125 (11.4 IU/mL) were normal.

Lessons: 18F-FDG PET/CT successfully detected lymphatic metastasis when lymph node biopsy results were negative, which would be of great significance in detecting metastasis and monitoring reoccurrence of ovarian immature teratomas.
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http://dx.doi.org/10.1097/MD.0000000000009171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815738PMC
December 2017

Contrast-enhanced ultrasound in the therapeutic assessment of diffuse large B-cell lymphoma: A case report.

Oncol Lett 2017 Oct 16;14(4):4593-4598. Epub 2017 Aug 16.

Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Contrast-enhanced computed tomography (CECT) has been extensively used in the restaging and assessment of treatment response for diffuse large B-cell lymphoma (DLBCL). However, CECT does not provide information regarding the specific functionality of lesions. A patient (56 years old, female) was previously admitted to the present institution, with bilateral cervical masses. Following numerous cycles of chemotherapy, a stable disease status was confirmed using CECT. In conjunction with CECT imaging results, contrast-enhanced ultrasound (CEUS) demonstrated important semi-functional information regarding blood perfusion, during the revision of treatment assessment. F-fluoro-2-deoxyglucose (FDG)-positron emission tomography-computed tomography imaging demonstrated no increase in FDG uptake of the same tumor lesion, consistent with the results of CEUS. CEUS exhibited the potential to present complementary results to CECT, in the therapeutic assessment of DLBCL, which, to the best of our knowledge, has not previously been reported.
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http://dx.doi.org/10.3892/ol.2017.6758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649538PMC
October 2017

Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma: a retrospective study.

Nucl Med Commun 2017 Nov;38(11):937-947

Departments of aNuclear Medicine bOncology, West China Hospital, Sichuan University, Chengdu, China cDepartment of Radiology, Santa Clara Valley Medical Center, Stanford University, San Jose, California, USA.

Purpose: The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Project (IHP) criteria, the Deauville five-point scale (5-PS), and standardized uptake value (SUV)-based assessment.

Patients And Methods: Fifty-nine patients diagnosed with ENKTL were enrolled. Each patient underwent three F-FDG PET/CT scans: (i) baseline, (ii) after two to four cycles of chemotherapy (early response assessment), and (iii) at the end of treatment (evaluation of the final response). Post-therapy F-FDG PET/CT results were determined on the basis of IHP criteria, 5-PS, and change in the maximum F-FDG uptake (ΔSUVmax). IHP criteria, 5-PS, and ΔSUVmax were then examined for their ability to predict progression-free survival (PFS) and overall survival (OS).

Results: Over a median follow-up of 25 months, 5-PS and ΔSUVmax were significant predictors of PFS and OS. After multivariate analysis, 5-PS could predict PFS (P=0.008) and OS (P=0.002) independently. ΔSUVmax was found to be an independent predictor of PFS (P=0.019), but not OS, and had a lower accuracy and positive predictive value than 5-PS.

Conclusion: Post-therapy PET/CT analysis using the 5-PS is more able to predict survival than analysis with IHP or [INCREMENT]SUVmax in ENKTL patients.
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http://dx.doi.org/10.1097/MNM.0000000000000731DOI Listing
November 2017

Targeted Imaging of Tumor-Associated Macrophages by Cyanine 7-Labeled Mannose in Xenograft Tumors.

Mol Imaging 2017 01;16:1536012116689499

1 Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

Mannose receptor is considered as a hallmark of M2-oriented tumor-associated macrophages (TAMs), but its utility in TAMs was rarely reported. Therefore, deoxymannose (DM), a high-affinity ligand of mannose receptor, was labeled with near-infrared dye cyanine 7 (Cy7), and its feasibility of targeted imaging on TAMs was evaluated in vitro and in vivo. The Cy7-DM was synthesized, and its binding affinity with induced TAMs in vitro, whole-body imaging in xenograft tumor mouse model in vivo, and the cellular localization in dissected tissues were evaluated. We demonstrated a high uptake of Cy7-DM by induced M2 macrophages and TAMs in tumor tissues. In vivo near-infrared live imaging visualized abundant TAMs in tumor lesions instead of inflammatory sites by Cy7-DM imaging, and the quantity of Cy7-DM signals in tumors was significantly higher than that shown in inflammatory sites from 1 to 8 hours of imaging. Our results suggest that mannose could rapidly and specifically target TAMs and is a promising candidate for targeted diagnosis of tumor with rich TAMs.
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http://dx.doi.org/10.1177/1536012116689499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470129PMC
January 2017

Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice.

J Cyst Fibros 2017 Nov 20;16(6):671-680. Epub 2017 May 20.

Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.

Background: Epithelial sodium channel (ENaC, Scnn1) hyperactivity in the lung leads to airway surface dehydration and mucus accumulation in cystic fibrosis (CF) patients and in mice with CF-like lung disease.

Methods: We identified several potent ENaC specific antisense oligonucleotides (ASOs) and tested them by inhalation in mouse models of CF-like lung disease.

Results: The inhaled ASOs distributed into lung airway epithelial cells and decreased ENaC expression by inducing RNase H1-dependent degradation of the targeted Scnn1a mRNA. Aerosol delivered ENaC ASO down-regulated mucus marker expression and ameliorated goblet cell metaplasia, inflammation, and airway hyper-responsiveness. Lack of systemic activity of ASOs delivered via the aerosol route ensures the safety of this approach.

Conclusions: Our results demonstrate that antisense inhibition of ENaC in airway epithelial cells could be an effective and safe approach for the prevention and reversal of lung symptoms in CF and potentially other inflammatory diseases of the lung.
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http://dx.doi.org/10.1016/j.jcf.2017.05.003DOI Listing
November 2017

The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon.

J Biol Chem 2017 02 13;292(8):3137-3145. Epub 2017 Jan 13.

Hospital for Sick Children and University of Toronto, Toronto, Ontario M5G 0A4, Canada. Electronic address:

The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds to and regulates stability of the epithelial Na channel (ENaC) in salt-absorbing epithelia in the kidney, lung, and other tissues. Its role in the distal colon, which also absorbs salt and fluid and expresses ENaC, is unknown. Using a conditional knock-out approach to knock out in mice intestinal epithelium ( ; ) we show here that depletion leads to a higher steady-state short circuit current (Isc) in mouse distal colon tissue relative to controls. This higher Isc was partially reduced by the addition of apical amiloride and strongly reduced by basolateral bumetanide as well as by depletion of basolateral Cl, suggesting that Na/K/2Cl (NKCC1/SLC12A2) co-transporter and ENaC are targets of Nedd4L in the colon. In accordance, NKCC1 (and γENaC) protein abundance in the colon of the Nedd4L knock-out animals was increased, indicating that Nedd4L normally suppresses these proteins. However, we did not observe co-immunoprecipitation between Nedd4L and NKCC1, suggesting that Nedd4L indirectly suppresses NKCC1 expression. Low salt diet resulted in a strong increase in β and γ (but not α) ENaC mRNA and protein expression and ENaC activity. Although salt restriction also increased NKCC1 protein and mRNA abundance, it did not lead to its elevated activity (Isc). These results identify NKCC1 as a novel target for Nedd4L-mediated down-regulation , which modulates ion and fluid transport in the distal colon together with ENaC.
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http://dx.doi.org/10.1074/jbc.M116.770065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336150PMC
February 2017

The early diagnosis of testicular natural killer/t-cell lymphoma.

Hell J Nucl Med 2016 Sep-Dec;19(3):275-277. Epub 2016 Nov 8.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy. No. 17, section 3, Renmin Road South, Chengdu, Sichuan 610041, China.

Testicular natural killer/T-cell lymphoma is a rare aggressive extranodal lymphoma associated with Epstein-Barr virus infection. Time to diagnose is crucial as the disease is rapidly progressive and fatal. Early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/T-cell lymphoma. However, no reports have described the results of imaging studies. In this paper, contrast-enhanced ultrasonography (CEUS), fluorine-18-fuorodexoyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) and tumor biopsies were all diagnostic of testicular natural killer/T-cell lymphoma. The CEUS showed a clear hyperenhancement which strongly indicted malignant tumor. In conclusion, in our study, CEUS as a first line easy test, may help physicians to make an early diagnosis of the very rare case of testicular T-lymphoma.
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http://dx.doi.org/10.1967/s002449910412DOI Listing
June 2017

A pulmonary chondromatous hamartoma resembling multiple metastases in the (18)F-FDG PET/CT scan.

Hell J Nucl Med 2016 May-Aug;19(2):176-8. Epub 2016 Jun 22.

Department of Nuclear Medicine, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, Sichuan 610000, P.R. China.

Multiple pulmonary hamartomas (PH) occur rarely, are mostly seen in females, and are usually leiomyomatous hamartomas. Here, we report an extremely rare case of a 30 years old male patient diagnosed as multiple pulmonary chondromatous hamartomas. He was admitted on May 2015 to our hospital for a 3 months history of cough. Multiple nodules in the right lung were detected on chest X-rays during a routine checkup 9 months ago and in a subsequent chest computed tomography (CT). However, he abandoned medical follow-up because he was asymptomatic. Nine months later, rare and atypical CT findings with progression were observed during this visit so that pulmonary metastases from an unknown primary tumor was suspected. Positron emission tomography/computed tomography (PET/CT) scan showed mild fluorine-18 fluorodeoxyglucose ((18)F-FDG) uptake in the lesions and no abnormal foci in any other part of his body. A posterolateral thoracotomy was performed. Pathologic features were consistent with those of pulmonary chondromatous hamartomas.
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http://dx.doi.org/10.1967/s002449910376DOI Listing
September 2016

Effect of ecological restoration and climate change on ecosystems: a case study in the Three-Rivers Headwater Region, China.

Environ Monit Assess 2016 Jun 30;188(6):382. Epub 2016 May 30.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, People's Republic of China.

The Three-Rivers Headwater Region (TRHR) is the headwater of the Yangtze River Basin (YARB), Yellow River Basin (YRB), and Lancang River Basin (LRB); it is known as China's 'Water Tower' owing to its important supply of freshwater. In order to assess ecosystem changes in the TRHR during 2000-2012, we systematically and comprehensively evaluated a combination of model simulation results and actual observational data. The results showed the following: (1) Ecosystem pattern was relatively stable during 2000-2010, with a slight decrease in farmland and desert areas, and a slight increase in grassland and wetland/water-body areas. (2) A warmer and wetter climate, and ecological engineering, caused the vegetation cover and productivity to significantly improve. (3) Precipitation was the main controlling factor for streamflow. A significant increase in precipitation during 2000-2012 resulted in an obvious increase in annual and seasonal streamflow. Glacier melting also contributed to the streamflow increase. (4) The total amount of soil conservation increased slightly from 2000 to 2012. The increase in precipitation caused rainfall erosivity to increase, which enhanced the intensity of soil erosion. The decrease in wind speed decreased wind erosion and the frequency of sandstorms. (5) The overall habitat quality in the TRHR was stable between 2000 and 2010, and the spatial pattern exhibited obvious heterogeneity. In some counties that included nature reserves, habitat quality was slightly higher in 2010 than in 2000, which reflected the effectiveness of the ecological restoration. Overall, the aforementioned ecosystem changes are the combined results of ecological restoration and climate change, and they are likely a local and temporary improvement, rather than a comprehensive and fundamental change. Therefore, more investments and efforts are needed to preserve natural ecosystems.
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http://dx.doi.org/10.1007/s10661-016-5368-2DOI Listing
June 2016