Chiung-Tong Chen

Chiung-Tong Chen

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Chiung-Tong Chen

Publications by authors named "Chiung-Tong Chen"

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Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System.

Sci Rep 2020 Feb 18;10(1):2838. Epub 2020 Feb 18.

National Institute of Cancer Research, National Health Research Institutes, Miaoli, County, Taiwan.

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http://dx.doi.org/10.1038/s41598-020-59813-7DOI Listing
February 2020

Citronellol Induces Necroptosis of Human Lung Cancer Cells TNF-α Pathway and Reactive Oxygen Species Accumulation.

In Vivo 2019 Jul-Aug;33(4):1193-1201

Institute of Biochemistry, College of Life Science, National Chung Hsing University, Taichung, Taiwan, R.O.C.

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http://dx.doi.org/10.21873/invivo.11590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689369PMC
December 2019

A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses.

Antiviral Res 2019 Dec 23;172:104636. Epub 2019 Oct 23.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No.35, Keyan Road, Zhunan Town, Miaoli, 35053, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2019.104636DOI Listing
December 2019

Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1.

Phytomedicine 2019 Sep 6;62:152946. Epub 2019 May 6.

Division of Basic Chinese Medicine,National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan, ROC; Ph.D Program for the Clinical Drug Discovery from Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.152946DOI Listing
September 2019

A Dengue Virus Type 2 (DENV-2) NS4B-Interacting Host Factor, SERP1, Reduces DENV-2 Production by Suppressing Viral RNA Replication.

Viruses 2019 Aug 27;11(9). Epub 2019 Aug 27.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan.

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http://dx.doi.org/10.3390/v11090787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783944PMC
August 2019

Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates.

J Med Chem 2019 Jul 20;62(13):6047-6062. Epub 2019 Jun 20.

Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , Miaoli 35053 , Taiwan , ROC.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00173DOI Listing
July 2019

CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma.

J Cell Physiol 2019 Jun 20;234(6):9118-9129. Epub 2018 Oct 20.

Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan.

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http://dx.doi.org/10.1002/jcp.27589DOI Listing
June 2019

A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus.

Eur J Med Chem 2019 Apr 6;167:245-268. Epub 2019 Feb 6.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.02.016DOI Listing
April 2019

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.

Eur J Med Chem 2019 Apr 2;167:312-323. Epub 2019 Feb 2.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan, ROC; School of Pharmacy, National Cheng Kung University, Tainan, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.063DOI Listing
April 2019

Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors.

Bioorg Chem 2019 03 7;83:520-525. Epub 2018 Nov 7.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.006DOI Listing
March 2019

Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A.

J Gen Virol 2019 03 1;100(3):457-470. Epub 2019 Feb 1.

1​Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, PR China.

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http://dx.doi.org/10.1099/jgv.0.001227DOI Listing
March 2019

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems.

Adv Drug Deliv Rev 2019 01 6;139:71-82. Epub 2018 Dec 6.

Department of Chemical Engineering, Institute of Biomedical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2018.12.001DOI Listing
January 2019

CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways.

J Food Drug Anal 2019 01 25;27(1):184-194. Epub 2018 Oct 25.

Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10219498183016
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http://dx.doi.org/10.1016/j.jfda.2018.09.008DOI Listing
January 2019

An Intestinal "Transformers"-like Nanocarrier System for Enhancing the Oral Bioavailability of Poorly Water-Soluble Drugs.

ACS Nano 2018 07 6;12(7):6389-6397. Epub 2018 Jun 6.

Department of Chemical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters , National Tsing Hua University , Hsinchu 30013 , Taiwan (ROC).

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http://pubs.acs.org/doi/10.1021/acsnano.8b00470
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http://dx.doi.org/10.1021/acsnano.8b00470DOI Listing
July 2018

Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2.

Eur J Med Chem 2018 Jan 10;143:611-620. Epub 2017 Nov 10.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli 35053, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.11.019DOI Listing
January 2018

Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.

Free Radic Biol Med 2017 12 5;113:505-518. Epub 2017 Nov 5.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan; Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Graduate Program for Aging, China Medical University, Taichung 40402, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849173115
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http://dx.doi.org/10.1016/j.freeradbiomed.2017.10.375DOI Listing
December 2017

Targeting Tumor Associated Phosphatidylserine with New Zinc Dipicolylamine-Based Drug Conjugates.

Bioconjug Chem 2017 07 19;28(7):1878-1892. Epub 2017 Jun 19.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes , Miaoli 35053, Taiwan, ROC.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00225DOI Listing
July 2017

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways.

Sci Rep 2017 07 7;7(1):4862. Epub 2017 Jul 7.

Department of Biomedical Sciences and Engineering; Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.

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http://dx.doi.org/10.1038/s41598-017-05072-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501807PMC
July 2017

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.

Anesthesiology 2017 05;126(5):952-966

From the Institute of Biotechnology and Pharmaceutical Research (P.-K.C., S.-H.U., L.-C.O., T.-K.Y., W.-T.C., H.-F.C., S.-C.C., M.-F.C., C.-T.C., C.S., S.-H.Y.) and Center for Neuropsychiatric Research (P.-L.T.), National Health Research Institutes, Zhunan, Taiwan; Department of Pharmacology, Medical School University of Minnesota, Minneapolis, Minnesota (P.-Y.L., H.H.L.); and the Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan (J.-Y.C., S.-H.Y.).

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http://Insights.ovid.com/crossref?an=00000542-201705000-0003
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http://dx.doi.org/10.1097/ALN.0000000000001568DOI Listing
May 2017

BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia.

Mol Cancer Ther 2016 10 10;15(10):2323-2333. Epub 2016 Aug 10.

National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-1006DOI Listing
October 2016

N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors.

Bioorg Med Chem 2016 05 30;24(10):2242-50. Epub 2016 Mar 30.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.03.058DOI Listing
May 2016

Self-assembling bubble carriers for oral protein delivery.

Biomaterials 2015 Sep 20;64:115-24. Epub 2015 Jun 20.

Department of Chemical Engineering and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.06.035DOI Listing
September 2015

Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.

Eur J Med Chem 2015 Jul 9;100:151-61. Epub 2015 May 9.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.05.008DOI Listing
July 2015

Stem cell mobilizers targeting chemokine receptor CXCR4: renoprotective application in acute kidney injury.

J Med Chem 2015 Mar 2;58(5):2315-25. Epub 2015 Mar 2.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes , Miaoli, Miaoli County 35053, Taiwan R.O.C.

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http://dx.doi.org/10.1021/jm501769rDOI Listing
March 2015

Effects of Dipeptidyl Peptidase-4 Inhibition with MK-0431 on Syngeneic Mouse Islet Transplantation.

Int J Endocrinol 2014 4;2014:795283. Epub 2014 Aug 4.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 35053, Taiwan.

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http://dx.doi.org/10.1155/2014/795283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138783PMC
August 2014

Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles.

Biomaterials 2014 Apr 27;35(11):3641-9. Epub 2014 Jan 27.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.01.020DOI Listing
April 2014

Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats.

J Control Release 2013 Dec 21;172(2):513-22. Epub 2013 May 21.

Department of Chemical Engineering/Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.jconrel.2013.05.006DOI Listing
December 2013

BPR0C305, an orally active microtubule-disrupting anticancer agent.

Anticancer Drugs 2013 Nov;24(10):1047-57

aDivision of Medicinal Chemistry, National Research Institute of Chinese Medicine bInstitute of Biophotonics, National Yang Ming University, Taipei cInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.

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http://dx.doi.org/10.1097/CAD.0000000000000014DOI Listing
November 2013

In vivo imaging of brain infarct with the novel fluorescent probe PSVue 794 in a rat middle cerebral artery occlusion-reperfusion model.

Mol Imaging 2013 Jan-Feb;12(1):8-16

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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July 2013

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

J Med Chem 2013 Jul 28;56(13):5247-60. Epub 2013 Jun 28.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes , 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, ROC.

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http://dx.doi.org/10.1021/jm4006059DOI Listing
July 2013

Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence.

J Microbiol 2013 Jun 28;51(3):345-51. Epub 2013 Jun 28.

Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan.

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http://dx.doi.org/10.1007/s12275-013-2577-zDOI Listing
June 2013

H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cells.

Antioxid Redox Signal 2013 May 20;18(15):1895-905. Epub 2012 Dec 20.

Regenerative Medicine Research Group, Institute of Cellular and System Medicine ICSM, National Health Research Institute NHRI, Zhunan 350, Taiwan.

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http://dx.doi.org/10.1089/ars.2012.4692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624695PMC
May 2013

Effects of pH on molecular mechanisms of chitosan-integrin interactions and resulting tight-junction disruptions.

Biomaterials 2013 Jan 24;34(3):784-93. Epub 2012 Oct 24.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.biomaterials.2012.09.082DOI Listing
January 2013

Putative tumor metastasis-associated genes in human gastric cancer.

Int J Oncol 2012 Sep 31;41(3):1068-84. Epub 2012 May 31.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/ijo.2012.1502DOI Listing
September 2012

Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan.

Biomaterials 2012 Sep 7;33(26):6254-63. Epub 2012 Jun 7.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, ROC.

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http://dx.doi.org/10.1016/j.biomaterials.2012.05.013DOI Listing
September 2012

HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy.

Clin Cancer Res 2012 Sep 18;18(17):4691-701. Epub 2012 Jul 18.

Institute of Biomedical Sciences, Bioinformatics Program, Taiwan.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0633DOI Listing
September 2012

Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors.

Eur J Med Chem 2012 Sep 4;55:32-8. Epub 2012 Jul 4.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan.

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http://dx.doi.org/10.1016/j.ejmech.2012.06.053DOI Listing
September 2012

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

Bioorg Med Chem Lett 2012 Jul 7;22(14):4654-9. Epub 2012 Jun 7.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Town, Miaoli Country 350, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.bmcl.2012.05.116DOI Listing
July 2012

R432 is a key residue for the multiple functions of Ndt80p in Candida albicans.

Cell Mol Life Sci 2012 Mar 16;69(6):1011-23. Epub 2011 Oct 16.

Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.

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http://dx.doi.org/10.1007/s00018-011-0849-5DOI Listing
March 2012

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.

Invest New Drugs 2012 Feb 2;30(1):164-75. Epub 2010 Oct 2.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 35053, Taiwan.

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http://dx.doi.org/10.1007/s10637-010-9547-7DOI Listing
February 2012

Discovery of novel stem cell mobilizers that target the CXCR4 receptor.

ChemMedChem 2012 Feb 20;7(2):209-12. Epub 2011 Dec 20.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan, ROC.

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http://dx.doi.org/10.1002/cmdc.201100525DOI Listing
February 2012

Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins.

Biomaterials 2011 Nov 8;32(33):8712-21. Epub 2011 Sep 8.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.biomaterials.2011.07.086DOI Listing
November 2011

Antiproliferative effects of N-heterocyclic indolyl glyoxylamide derivatives on human lung cancer cells.

Anticancer Res 2011 Oct;31(10):3407-15

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Linong St. Sec. 2, Beitou District, 112 Taipei, Taiwan, R.O.C.

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October 2011

Immune response and pathophysiological features of Klebsiella pneumoniae liver abscesses in an animal model.

Lab Invest 2011 Jul 4;91(7):1029-39. Epub 2011 Apr 4.

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taiwan, ROC.

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http://www.nature.com/articles/labinvest201152
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http://dx.doi.org/10.1038/labinvest.2011.52DOI Listing
July 2011

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

Bioorg Med Chem 2011 Jul 13;19(14):4173-82. Epub 2011 Jun 13.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Town, Miaoli Country 350, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.bmc.2011.06.016DOI Listing
July 2011

Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4.

J Agric Food Chem 2011 May 5;59(9):4644-8. Epub 2011 Apr 5.

School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/jf104786tDOI Listing
May 2011

Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening.

J Med Chem 2010 Dec 19;53(24):8770-4. Epub 2010 Nov 19.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/jm101080vDOI Listing
December 2010

Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae?

PLoS One 2010 Nov 30;5(11):e15005. Epub 2010 Nov 30.

Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, and Institute of Clinical Medicine, School of Medicine, Naitonal Yang-Ming University, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994827PMC
November 2010

Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type.

Cancer Chemother Pharmacol 2010 Sep 1;66(4):773-83. Epub 2010 Jan 1.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli, Taiwan.

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http://dx.doi.org/10.1007/s00280-009-1222-3DOI Listing
September 2010

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

Anticancer Res 2010 Jul;30(7):2813-22

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 35053, Taiwan, R.O.C.

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http://ar.iiarjournals.org/content/30/7/2813.full.pdf
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July 2010

Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice.

Obesity (Silver Spring) 2010 Mar 3;18(3):463-9. Epub 2009 Sep 3.

Department of Physiology, College of Medicine, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/oby.2009.273DOI Listing
March 2010

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.

Pharmacol Res 2010 Feb 28;61(2):108-15. Epub 2009 Jul 28.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.

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http://dx.doi.org/10.1016/j.phrs.2009.07.005DOI Listing
February 2010

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

J Med Chem 2009 Aug;52(15):4941-5

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/jm900060sDOI Listing
August 2009

Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes.

Food Chem Toxicol 2009 Jul 3;47(7):1703-9. Epub 2009 May 3.

Department of Nutrition, China Medical University, 91, Hsueh-Shih Road, Taichung City 404, Taiwan.

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http://dx.doi.org/10.1016/j.fct.2009.04.030DOI Listing
July 2009

In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery.

Biomaterials 2009 Apr 26;30(12):2329-39. Epub 2009 Jan 26.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.biomaterials.2008.12.066DOI Listing
April 2009

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

Bioorg Med Chem Lett 2009 Apr 21;19(7):1908-12. Epub 2009 Feb 21.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Town, Miaoli Country 350, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.061DOI Listing
April 2009

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.

Bioorg Med Chem 2009 Mar 20;17(6):2388-99. Epub 2009 Feb 20.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Town, Miaoli Country 350, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.bmc.2009.02.020DOI Listing
March 2009

Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10).

Cancer Lett 2008 Nov 22;271(2):294-305. Epub 2008 Jul 22.

Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.

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http://dx.doi.org/10.1016/j.canlet.2008.06.016DOI Listing
November 2008

Human breast tumor cells express multimodal imaging reporter genes.

Mol Imaging Biol 2008 Sep 17;10(5):253-63. Epub 2008 Jun 17.

Division of Medical Engineering Research, National Health Research Institutes, R1-1027, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China.

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http://dx.doi.org/10.1007/s11307-008-0147-2DOI Listing
September 2008

Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.

Int J Pharm 2008 Jul 16;359(1-2):174-81. Epub 2008 Apr 16.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 35053, Taiwan.

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http://dx.doi.org/10.1016/j.ijpharm.2008.04.013DOI Listing
July 2008

Decreased expression of UK114 is related to the differentiation status of human hepatocellular carcinoma.

Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):535-42

Division of Molecular and Genomic Medicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, [corrected] Republic of China.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0506DOI Listing
March 2008

Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet.

J Ethnopharmacol 2008 Feb 13;116(1):49-57. Epub 2007 Nov 13.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.jep.2007.10.043DOI Listing
February 2008

Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.

Drug Metab Dispos 2007 Jul 2;35(7):1042-9. Epub 2007 Apr 2.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan, Republic of China.

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http://dx.doi.org/10.1124/dmd.106.014597DOI Listing
July 2007

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.

Bioorg Med Chem Lett 2007 Mar 12;17(5):1274-9. Epub 2006 Dec 12.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.bmcl.2006.12.019DOI Listing
March 2007

Effects of paclitaxel and doxorubicin in histocultures of hepatocelular carcinomas.

J Biomed Sci 2007 Mar 6;14(2):233-44. Epub 2007 Jan 6.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli, 35053, Taiwan.

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http://dx.doi.org/10.1007/s11373-006-9141-3DOI Listing
March 2007

Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Feb 26;846(1-2):162-8. Epub 2006 Sep 26.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.jchromb.2006.08.040DOI Listing
February 2007

Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery.

Biomacromolecules 2007 Jan;8(1):146-52

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/bm0607776DOI Listing
January 2007

The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.

Life Sci 2006 Nov 23;79(26):2432-40. Epub 2006 Aug 23.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.lfs.2006.08.016DOI Listing
November 2006

Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control.

J Clin Endocrinol Metab 2006 Aug 23;91(8):3084-7. Epub 2006 May 23.

Department of Internal Medicine, Tri-Service General Hospital, #325 Section 2 Cheng-Kung Road, Neihu, Taipei 114, Taiwan, Republic of China.

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http://dx.doi.org/10.1210/jc.2005-2749DOI Listing
August 2006

Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system against cultured HepG2 cells.

Bioconjug Chem 2006 Mar-Apr;17(2):291-9

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.

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http://dx.doi.org/10.1021/bc0502107DOI Listing
July 2006

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

Bioorg Med Chem Lett 2006 Jun 11;16(12):3268-72. Epub 2006 Apr 11.

Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.bmcl.2006.03.037DOI Listing
June 2006

Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system for the treatment of liver cancer.

Biomaterials 2006 Mar 22;27(9):2051-9. Epub 2005 Nov 22.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.biomaterials.2005.10.027DOI Listing
March 2006