Ching-Hua Lu

Ching-Hua Lu

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Ching-Hua Lu

Ching-Hua Lu

Publications by authors named "Ching-Hua Lu"

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20Publications

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Plasma pNfH levels differentiate SBMA from ALS.

J Neurol Neurosurg Psychiatry 2019 Oct 1. Epub 2019 Oct 1.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK

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http://dx.doi.org/10.1136/jnnp-2019-320624DOI Listing
October 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy.

Neurology 2019 Mar 20;92(11):e1205-e1211. Epub 2019 Feb 20.

From the Institute of Neurology (V.L., O.J.Z., L.Z., C.H., M.F., C.-H.L., B.M., H.Z., A.H., L.G., M.H., P.F.), University College London Institute of Neurology, Queen Square, London; Blizard Institute (V.L., A.M.), Queen Mary, University of London, UK; Department of Neurosciences (G.Q., I.M., C.B., G.S.), University of Padova, Italy; Department of Neurology (C.-H.L.), China Medical University Hospital, Taiwan; Basildon Hospital (K.A.), UK; Department of Physiology, Anatomy and Genetics (C.R.), University of Oxford; UK Dementia Research Institute at UCL (H.Z., A.H.), London, UK; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital; and the Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000007097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511101PMC
March 2019

Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis.

Mol Neurodegener 2018 11 7;13(1):60. Epub 2018 Nov 7.

Neuroscience and Trauma Centre, Blizard Institute, Barts and The School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, City of London, Greater London, E1 2AT, UK.

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https://molecularneurodegeneration.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13024-018-0292-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223075PMC
November 2018

Idarucizumab-facilitated intravenous thrombolysis in acute stroke with dabigatran: Two cases with hemorrhagic transformation.

J Neurol Sci 2018 05 14;388:155-157. Epub 2018 Mar 14.

Department of Neurology, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Department of BioMedical Engineering, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X183014
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http://dx.doi.org/10.1016/j.jns.2018.03.021DOI Listing
May 2018

Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Aug 1;3(4):e244. Epub 2016 Jun 1.

Centre for Neuroscience & Trauma (C.L., F.O., J.K., A.M.) and Centre of Primary Care and Public Health (V.G.), Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; Sobell Department of Motor Neuroscience and Movement Disorders (C.L., P.F., L.G.), MRC Centre for Neuromuscular Diseases (P.F., L.G.), MRC Unit for Lifelong Health and Ageing (N.S.), Department of Molecular Neuroscience (K.S.), and Department of Clinical Neuroscience (R.O.), UCL Institute of Neurology; Basildon and Thurrock University Hospitals (K.A., A.M.), NHS Foundation Trust, Basildon; William Harvey Hospital (F.O.), Kent; Proteome Sciences plc (E.L.), South Wing Laboratory, Institute of Psychiatry, UK; Neurology (J.K.), University Hospital Basel, Switzerland; Department of Immunobiology (T.T.), King's College London; National Hospital for Neurology and Neurosurgery (N.S., R.H., R.O.), London; Musgrove Park Hospital (M.F.), Taunton; and Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, UK.

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http://dx.doi.org/10.1212/NXI.0000000000000244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897985PMC
August 2016

Plasma neurofilament heavy chain is not a useful biomarker in Charcot-Marie-Tooth disease.

Muscle Nerve 2016 06 27;53(6):972-5. Epub 2016 Apr 27.

Medical Research Council Centre for Neuromuscular Diseases, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, 811 Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1002/mus.25124DOI Listing
June 2016

Targeting protein homeostasis in sporadic inclusion body myositis.

Sci Transl Med 2016 Mar;8(331):331ra41

Medical Research Council (MRC) Centre for Neuromuscular Diseases, University College London (UCL) Institute of Neurology, Queen Square, London WC1N 3BG, UK. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043094PMC
http://dx.doi.org/10.1126/scitranslmed.aad4583DOI Listing
March 2016

CHCHD10 Pro34Ser is not a highly penetrant pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia.

Brain 2016 Feb 11;139(Pt 2):e9. Epub 2015 Sep 11.

1 Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK 4 Sobell Department of Motor Neuroscience and Movement Disorders, Queen Square, London, WC1N 3BG, UK

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http://dx.doi.org/10.1093/brain/awv223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963427PMC
February 2016

CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.

Ann Clin Transl Neurol 2015 Jul 25;2(7):748-55. Epub 2015 May 25.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531057PMC
July 2015

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.

Neurology 2015 Jun 1;84(22):2247-57. Epub 2015 May 1.

From the Centre for Neuroscience & Trauma (C.-H.L., G.G., J.K., A.M.), Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; Sobell Department of Motor Neuroscience and Movement Disorders (C.-H.L., L.G.), Departments of Neuroinflammation (A.P.), Neurodegenerative Disease (P.F.), Molecular Neuroscience (K.S.), and Clinical Neuroscience (R.O.), and MRC Centre for Neuromuscular Diseases (R.O., L.G.), UCL Institute of Neurology, London; MRC Integrative Epidemiology Unit (C.M.-W.), University of Bristol; Nuffield Department of Clinical Neurosciences (E.G., K.T., M.R.T.), University of Oxford; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, London, UK; UmanDiagnostics (N.N.), Umeå, Sweden; Medicine Clinical Trial Unit (M.F.), Musgrove Park Hospital, Taunton, UK; National Hospital for Neurology and Neurosurgery (R.O., R.H., A.M.), London, UK; Neurology (J.K.), University Hospital Basel, Switzerland; North-East London and Essex MND Care and Research Centre (A.M.), London; and Basildon and Thurrock University Hospitals NHS Foundation Trust (A.M.), Basildon, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456658PMC
June 2015

Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.

J Neurol Neurosurg Psychiatry 2015 May 9;86(5):565-73. Epub 2014 Jul 9.

Centre for Neuroscience & Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK Basildon and Thurrock University Hospitals NHS Foundation Trust, Essex, UK North-East London and Essex MND Care and Research Centre, London, UK.

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http://dx.doi.org/10.1136/jnnp-2014-307672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413806PMC
May 2015

The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol.

Pharmacol Ther 2014 Jan 23;141(1):40-54. Epub 2013 Aug 23.

Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N 3BG, UK; MRC Centre for Neuromuscular Disorders, UCL Institute of Neurology, London WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2013.08.003DOI Listing
January 2014

Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS.

PLoS One 2012 16;7(7):e40998. Epub 2012 Jul 16.

Sobell Department of Motor Neuroscience and Movement Disorders, MRC Centre for Neuromuscular Disorders, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040998PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397981PMC
January 2013

A method to solubilise protein aggregates for immunoassay quantification which overcomes the neurofilament "hook" effect.

J Neurosci Methods 2011 Feb 4;195(2):143-50. Epub 2010 Dec 4.

Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London WC1N3BG, UK.

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http://dx.doi.org/10.1016/j.jneumeth.2010.11.026DOI Listing
February 2011