Ching Tung Lum

Ching Tung Lum

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Ching Tung Lum

Ching Tung Lum

Publications by authors named "Ching Tung Lum"

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Shotgun Proteomics and Quantitative Pathway Analysis of the Mechanisms of Action of Dehydroeffusol, a Bioactive Phytochemical with Anticancer Activity from Juncus effusus.

J Proteome Res 2018 07 21;17(7):2470-2479. Epub 2018 Jun 21.

Department of Chemistry, Chemical Biology Center and State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , China.

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http://dx.doi.org/10.1021/acs.jproteome.8b00227DOI Listing
July 2018

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

J Inorg Biochem 2016 07 30;160:140-8. Epub 2015 Dec 30.

Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany; PVZ - Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2015.12.020DOI Listing
July 2016

Chemical biology of anticancer gold(III) and gold(I) complexes.

Chem Soc Rev 2015 Dec 14;44(24):8786-801. Epub 2015 Apr 14.

State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

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http://dx.doi.org/10.1039/c5cs00132cDOI Listing
December 2015

IFITM1 promotes the metastasis of human colorectal cancer via CAV-1.

Cancer Lett 2015 Nov 7;368(1):135-143. Epub 2015 Aug 7.

Shenzhen Key Lab of Translational Medicine of Tumor, School of Medicine, Shenzhen University, Shenzhen, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835150050
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http://dx.doi.org/10.1016/j.canlet.2015.07.034DOI Listing
November 2015

Luminescent cyclometalated platinum(II) complex forms emissive intercalating adducts with double-stranded DNA and RNA: differential emissions and anticancer activities.

Angew Chem Int Ed Engl 2014 Sep 15;53(38):10119-23. Epub 2014 Jul 15.

State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China).

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http://dx.doi.org/10.1002/anie.201405384DOI Listing
September 2014

A binuclear gold(I) complex with mixed bridging diphosphine and bis(N-heterocyclic carbene) ligands shows favorable thiol reactivity and inhibits tumor growth and angiogenesis in vivo.

Angew Chem Int Ed Engl 2014 Jun 11;53(23):5810-4. Epub 2014 Apr 11.

State Key Laboratory of Synthetic Chemistry, Institute of Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China).

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http://dx.doi.org/10.1002/anie.201400142DOI Listing
June 2014

A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells.

Chem Commun (Camb) 2013 May 7;49(39):4364-6. Epub 2012 Dec 7.

Department of Chemistry, State Key Laboratory of Synthetic Chemistry, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.

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http://dx.doi.org/10.1039/c2cc37366aDOI Listing
May 2013

Gold(III) complexes containing N-heterocyclic carbene ligands: thiol "switch-on" fluorescent probes and anti-cancer agents.

Angew Chem Int Ed Engl 2013 Mar 1;52(10):2930-3. Epub 2013 Feb 1.

Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

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http://dx.doi.org/10.1002/anie.201209787DOI Listing
March 2013

Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis.

Acta Oncol 2011 Jun 29;50(5):719-26. Epub 2010 Nov 29.

Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, China.

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http://dx.doi.org/10.3109/0284186X.2010.537693DOI Listing
June 2011

Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro.

Cancer Lett 2010 Aug 16;294(2):159-66. Epub 2010 Feb 16.

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

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http://dx.doi.org/10.1016/j.canlet.2010.01.033DOI Listing
August 2010

Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer.

Int J Cancer 2009 Aug;125(3):688-97

Department of Gastroenterology, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.24282DOI Listing
August 2009

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

Proc Natl Acad Sci U S A 2008 May 14;105(20):7275-80. Epub 2008 May 14.

Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse 10, D-13125 Berlin, Germany.

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http://dx.doi.org/10.1073/pnas.0710468105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438240PMC
May 2008

Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma.

Int J Cancer 2006 Mar;118(6):1527-38

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.21484DOI Listing
March 2006

Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages.

Int Immunol 2005 Nov 12;17(11):1391-7. Epub 2005 Sep 12.

Centre for the Study of Liver Disease and Department of Surgery, L9-41 Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1093/intimm/dxh316DOI Listing
November 2005

Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma.

Cancer Res 2005 Jan;65(1):219-25

Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China.

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January 2005

Protection of Xenopus laevis embryos against alcohol-induced delayed gut maturation and growth retardation by peroxiredoxin 5 and catalase.

J Mol Biol 2004 Jul;340(4):819-27

Institute of Molecular Biology and Open Lab of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.jmb.2004.05.047DOI Listing
July 2004

Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer.

Cancer Res 2003 Nov;63(22):7724-32

Department of Gastroenterology, Rui-jin Hospital, Shanghai Second Medical University, Shanghai, People's Republic of China.

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November 2003