Chin B Eap

Chin B Eap

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Chin B Eap

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Clinically Significant Drug-Drug Interactions with Agents for Attention-Deficit/Hyperactivity Disorder.

CNS Drugs 2019 Dec;33(12):1201-1222

Alexianer Hospital Aachen, Alexianergraben 33, 52062, Aachen, Germany.

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http://dx.doi.org/10.1007/s40263-019-00683-7DOI Listing
December 2019

Amisulpride: Real-World Evidence of Dose Adaptation and Effect on Prolactin Concentrations and Body Weight Gain by Pharmacokinetic/Pharmacodynamic Analyses.

Clin Pharmacokinet 2019 Sep 25. Epub 2019 Sep 25.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Hospital of Cery, Prilly, Switzerland.

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http://dx.doi.org/10.1007/s40262-019-00821-wDOI Listing
September 2019

Early changes of blood lipid levels during psychotropic drug treatment as predictors of long-term lipid changes and of new onset dyslipidemia.

J Clin Lipidol 2018 Jan - Feb;12(1):219-229. Epub 2017 Oct 16.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.10.002DOI Listing
July 2019

Influence of body weight and UGT2B7 polymorphism on varenicline exposure in a cohort of smokers from the general population.

Eur J Clin Pharmacol 2019 Jul 13;75(7):939-949. Epub 2019 Mar 13.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, University of Lausanne, Prilly, Switzerland.

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http://link.springer.com/10.1007/s00228-019-02662-9
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http://dx.doi.org/10.1007/s00228-019-02662-9DOI Listing
July 2019

Genetic and clinic predictors of new onset diabetes mellitus after transplantation.

Pharmacogenomics J 2019 02 27;19(1):53-64. Epub 2017 Dec 27.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.

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http://dx.doi.org/10.1038/s41397-017-0001-5DOI Listing
February 2019

The effect of a single dose of escitalopram on sensorimotor networks.

Brain Behav 2018 06 20;8(6):e00975. Epub 2018 Apr 20.

Support Center for Advanced Imaging (SCAN), Department of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, Bern, Switzerland.

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http://dx.doi.org/10.1002/brb3.975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991571PMC
June 2018

Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain.

J Child Adolesc Psychopharmacol 2018 05 3;28(4):258-265. Epub 2018 Jan 3.

2 Interdisciplinary Division for Adolescent Health (DISA), Lausanne University Hospital , Lausanne, Switzerland .

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http://dx.doi.org/10.1089/cap.2017.0038DOI Listing
May 2018

Associations of Urinary Caffeine and Caffeine Metabolites With Arterial Stiffness in a Large Population-Based Study.

Mayo Clin Proc 2018 05 15;93(5):586-596. Epub 2018 Mar 15.

Unit of Population Epidemiology, Department of Community Medicine and Primary Care and Emergency Medicine, University Hospital of Geneva, Switzerland; Division of Chronic Diseases, Institute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mayocp.2017.12.010DOI Listing
May 2018

Psychotropic Drug Prescription in Adolescents: A Retrospective Study in a Swiss Psychiatric University Hospital.

J Child Adolesc Psychopharmacol 2018 04 13;28(3):192-204. Epub 2017 Nov 13.

1 Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital , Hospital of Cery, Prilly-Lausanne, Switzerland .

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http://dx.doi.org/10.1089/cap.2017.0054DOI Listing
April 2018

Influence of polygenic risk scores on lipid levels and dyslipidemia in a psychiatric population receiving weight gain-inducing psychotropic drugs.

Pharmacogenet Genomics 2017 Dec;27(12):464-472

aUnit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neuroscience bDepartment of Psychiatry, Centre of Psychiatric Epidemiology and Psychopathology cDepartment of Psychiatry, Service of Old Age Psychiatry dDepartment of Psychiatry, Service of General Psychiatry, Lausanne University Hospital, Prilly eSchool of Pharmaceutical Sciences, University of Geneva-Lausanne, Geneva, Switzerland.

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http://dx.doi.org/10.1097/FPC.0000000000000313DOI Listing
December 2017

Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.

Transl Psychiatry 2017 12 8;7(12):1269. Epub 2017 Dec 8.

Center for Psychiatric Neuroscience, Department of Psychiatry, University Medical Center, University of Lausanne, Prilly, Switzerland.

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http://dx.doi.org/10.1038/s41398-017-0023-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802703PMC
December 2017

Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy.

Exp Clin Psychopharmacol 2017 10;25(5):353-362

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital.

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http://dx.doi.org/10.1037/pha0000141DOI Listing
October 2017

Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs.

Gene 2017 Sep 8;628:8-15. Epub 2017 Jul 8.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.07.005DOI Listing
September 2017

Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jul 27;1057:101-109. Epub 2017 Apr 27.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15700232173005
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http://dx.doi.org/10.1016/j.jchromb.2017.04.039DOI Listing
July 2017

Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients.

Clin Pharmacokinet 2016 12;55(12):1521-1533

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s40262-016-0415-2DOI Listing
December 2016

Prediction of early weight gain during psychotropic treatment using a combinatorial model with clinical and genetic markers.

Pharmacogenet Genomics 2016 Dec;26(12):547-557

aUnit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neuroscience bDepartment of Psychiatry, Center for Psychiatric Epidemiology and Psychopathology cDepartment of Psychiatry, Service of Old Age Psychiatry dDepartment of Psychiatry, Service of General Psychiatry, Lausanne University Hospital, Hospital of Cery, Prilly eDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://dx.doi.org/10.1097/FPC.0000000000000249DOI Listing
December 2016

Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry.

J Pharm Biomed Anal 2016 Nov 20;131:233-245. Epub 2016 Aug 20.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2016.08.014DOI Listing
November 2016

Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population.

Nutr Metab (Lond) 2016 17;13:81. Epub 2016 Nov 17.

Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la corniche 10, Lausanne, 1010 Switzerland ; Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine and Primary Care and Emergency Medicine, University Hospital of Geneva (HUG), Rue Gabrielle Perret-Gentil 4, Geneva, 1205 Switzerland ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, USA ; Lausanne University Outpatient Clinic, Rue du Bugnon 44, Lausanne, 1011 Switzerland ; Unit of Population Epidemiology, University Hospital of Geneva (HUG), Rue Gabrielle Perret-Gentil 4, Geneva, 1205 Switzerland.

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http://dx.doi.org/10.1186/s12986-016-0144-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112879PMC
November 2016

Personalized prescribing: a new medical model for clinical implementation of psychotropic drugs.

Authors:
Chin B Eap

Dialogues Clin Neurosci 2016 09;18(3):313-322

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland; School of Pharmacy, Department of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067148PMC
September 2016

Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression.

J Affect Disord 2016 07 10;198:43-9. Epub 2016 Mar 10.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Electronic address:

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http://www.tweelingenregister.org/nederlands/verslaggeving/N
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http://dx.doi.org/10.1016/j.jad.2016.03.031DOI Listing
July 2016

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.

PLoS One 2015 13;10(10):e0139155. Epub 2015 Oct 13.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139155PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604197PMC
June 2016

Association of genetic risk scores with body mass index in Swiss psychiatric cohorts.

Pharmacogenet Genomics 2016 May;26(5):208-17

aUnit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neuroscience bDepartment of Psychiatry, Centre of Psychiatric Epidemiology and Psychopathology cService of Old Age Psychiatry, Department of Psychiatry dService of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Prilly eDepartment of Mental Health and Psychiatry, University Hospital of Geneva fSchool of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva gInstitute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital hSwiss Institute of Bioinformatics, Lausanne, Switzerland.

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http://dx.doi.org/10.1097/FPC.0000000000000210DOI Listing
May 2016

Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort.

Clin Pharmacokinet 2015 Dec;54(12):1259-72

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Hospital of Cery, Lausanne University Hospital, 1008, Prilly, Switzerland.

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http://dx.doi.org/10.1007/s40262-015-0289-8DOI Listing
December 2015

Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment.

J Clin Psychiatry 2015 Nov;76(11):e1417-23

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, Prilly, Switzerland.

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http://dx.doi.org/10.4088/JCP.14m09358DOI Listing
November 2015

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments.

J Clin Psychopharmacol 2015 Oct;35(5):544-52

From the *Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neuroscience, †Department of Psychiatry, Centre of Psychiatric Epidemiology and Psychopathology, ‡Department of Psychiatry, Centre for Psychiatric Neuroscience, Lausanne University Hospital, Prilly, Switzerland; §Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne; ∥Department of Mental Health and Psychiatry, University Hospital of Geneva, Geneva; ¶Service of Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Prilly; #Department of Medicine, Lausanne University Hospital; **Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital; ††Swiss Institute of Bioinformatics, Lausanne; ‡‡Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Prilly; and §§School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://dx.doi.org/10.1097/JCP.0000000000000388DOI Listing
October 2015

Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments.

Pharmacogenet Genomics 2015 May;25(5):246-58

aUnit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neuroscience bDepartment of Psychiatry, Centre of Psychiatric Epidemiology and Psychopathology cDepartment of Psychiatry, Service of Old Age Psychiatry dDepartment of Psychiatry, Service of General Psychiatry, Lausanne University Hospital, Prilly eLaboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne fDepartment of Medicine gInstitute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital hDepartment of Medical Genetics, University of Lausanne iSwiss Institute of Bioinformatics, Lausanne jDepartment of Mental Health and Psychiatry, University Hospital of Geneva kSchool of Pharmaceutical Sciences, University of Geneve, University of Lausanne, Geneva, Switzerland lFaculty of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

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http://dx.doi.org/10.1097/FPC.0000000000000131DOI Listing
May 2015

Severe manic episode associated with tramadol in a patient with recurrent depressive disorder.

J Clin Psychopharmacol 2015 Apr;35(2):203-4

Unit of Pharmacogenetics and Clinical Psychopharmacology Department of Psychiatry Center for Psychiatric Neurosciences Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland Department of Psychiatry Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland Unit of Pharmacogenetics and Clinical Psychopharmacology Department of Psychiatry Center for Psychiatric Neurosciences Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland School of Pharmaceutical Sciences University of Geneva University of Lausanne Geneva, Switzerland

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http://dx.doi.org/10.1097/JCP.0000000000000275DOI Listing
April 2015

Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions.

Hypertension 2015 Mar 8;65(3):691-6. Epub 2014 Dec 8.

From the Unit of Population Epidemiology, Department of Community Medicine and Primary Care and Emergency Medicine (I.G.), Service of Nephrology, Department of Specialties (B.P., P.-Y.M.), Department of Cardiology (G.E.), and Unit of Hypertension, Department of Community Medicine and Primary Care and Emergency Medicine (I.G., A.P.-B.), University Hospital of Geneva, Switzerland; Institute of Social and Preventive Medicine (IUMSP) (I.G., B.P., G.E., P.V., F.P., M.B.), and Department of Medicine, Service of Nephrology (M.P., M.B.), University Hospital of Lausanne, Switzerland; Department of Nephrology and Hypertension, Clinic for Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital and University of Bern, Switzerland (D.A., M.M., B.V.); Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Hospital of Cery, Prilly, Switzerland (N.A., C.B.E.); Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven, Department of Cardiovascular Sciences, University Leuven, Belgium (J.S., Y.G.); Department of Epidemiology, Maastricht University, Maastricht, Netherlands (J.S.); and Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland (C.B.E.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04512DOI Listing
March 2015

Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence.

Expert Opin Drug Saf 2015 Mar 2;14(3):413-27. Epub 2015 Jan 2.

School of Pharmaceutical Sciences, University of Geneva and University of Lausanne , Geneva , Switzerland.

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http://dx.doi.org/10.1517/14740338.2015.997708DOI Listing
March 2015

[Pharmacokinetic alterations in pregnancy and use of therapeutic drug monitoring].

Therapie 2014 May-Jun;69(3):223-34. Epub 2014 Jul 14.

Centre suisse de Teratovigilance et Division de Pharmacologie cliniqueCentre hospitalier universitaire Vaudois et Université de Lausanne, Lausanne, Suisse - Pharmacie des Hôpitaux de l'Est Lémanique, Vevey, Suisse.

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http://dx.doi.org/10.2515/therapie/2014026DOI Listing
September 2014

Blood pressure in relation to coffee and caffeine consumption.

Curr Hypertens Rep 2014 Sep;16(9):468

Unit of Population Epidemiology, Department of Community Medicine and Primary Care and Emergency Medicine, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland,

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http://dx.doi.org/10.1007/s11906-014-0468-2DOI Listing
September 2014

Serotonin toxicity after addition of mirtazapine to escitalopram.

J Clin Psychopharmacol 2014 Aug;34(4):540-1

Unit of Pharmacogenetics and Clinical Psychopharmacology Center for Psychiatric Neurosciences Department of Psychiatry Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland Private Practice Lausanne, Switzerland Unit of Pharmacogenetics and Clinical Psychopharmacology Center for Psychiatric Neurosciences Department of Psychiatry Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland and School of Pharmaceutical Sciences University of Geneva University of Lausanne Geneva, Switzerland

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http://dx.doi.org/10.1097/JCP.0000000000000170DOI Listing
August 2014

Efficacy and tolerability of quetiapine in cluster B personality disorder: an open-label study.

Int J Psychiatry Clin Pract 2007 ;11(2):123-8

Département Universitaire de Psychiatrie Adulte et Service Universitaire de Psychiatrie de l'Âge Avancé, Site de Cery, Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1080/13651500600885556DOI Listing
June 2014

Serotonin toxicity after addition of mirtazapine to escitalopram.

J Clin Psychopharmacol 2014 Aug;34(4):540-1

Unit of Pharmacogenetics and Clinical Psychopharmacology Center for Psychiatric Neurosciences Department of Psychiatry Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland Private Practice Lausanne, Switzerland Unit of Pharmacogenetics and Clinical Psychopharmacology Center for Psychiatric Neurosciences Department of Psychiatry Lausanne University Hospital Hospital of Cery Prilly, Lausanne, Switzerland and School of Pharmaceutical Sciences University of Geneva University of Lausanne Geneva, Switzerland

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http://dx.doi.org/10.1097/JCP.0000000000000170DOI Listing
August 2014

Quantification of typical antipsychotics in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring.

J Pharm Biomed Anal 2014 Jan 7;88:36-44. Epub 2013 Aug 7.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, 1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jpba.2013.07.041DOI Listing
January 2014

Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects.

J Clin Psychopharmacol 2013 Jun;33(3):289-98

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Centre and University of Lausanne, Prilly, Switzerland.

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http://dx.doi.org/10.1097/JCP.0b013e31828f62cdDOI Listing
June 2013

Fast quantification of ten psychotropic drugs and metabolites in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring.

J Chromatogr A 2013 May 9;1292:160-72. Epub 2013 Jan 9.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, 1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.chroma.2012.12.071DOI Listing
May 2013

Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers.

Pharmacogenet Genomics 2013 May;23(5):286-92

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neurosciences, Lausanne University Hospital, Prilly, Lausanne, Switzerland.

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http://dx.doi.org/10.1097/FPC.0b013e3283602e75DOI Listing
May 2013

Buprenorphine and norbuprenorphine quantification in human plasma by simple protein precipitation and ultra-high performance liquid chromatography tandem mass spectrometry.

J Pharm Biomed Anal 2013 Apr 28;77:1-8. Epub 2012 Dec 28.

Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, 1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jpba.2012.12.023DOI Listing
April 2013

Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease.

Clin Pharmacokinet 2013 Apr;52(4):225-41

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Hospital of Cery, 1008 Prilly - Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s40262-013-0038-9DOI Listing
April 2013

Relationship of CYP2D6, CYP3A, POR, and ABCB1 genotypes with galantamine plasma concentrations.

Ther Drug Monit 2013 Apr;35(2):270-5

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Lausanne, Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1097/FTD.0b013e318282ff02DOI Listing
April 2013

Population pharmacokinetic study of memantine: effects of clinical and genetic factors.

Clin Pharmacokinet 2013 Mar;52(3):211-23

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Hospital of Cery, University Hospital Lausanne, 1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s40262-013-0032-2DOI Listing
March 2013

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.

Pharmacogenet Genomics 2013 Feb;23(2):84-93

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neurosciences,University Hospital Center, University of Lausanne, Lausanne.

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http://pdfs.journals.lww.com/jpharmacogenetics/2013/02000/Co
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FPC.0b013e32835cb2e2DOI Listing
February 2013

Addition of aripiprazole to the clozapine may be useful in reducing anxiety in treatment-resistant schizophrenia.

Case Rep Psychiatry 2011 14;2011:846489. Epub 2011 Sep 14.

Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Section Eugene Minkowski, Site de Cery, 1008 Prilly, Switzerland.

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http://dx.doi.org/10.1155/2011/846489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420713PMC
August 2012

Simultaneous determination of antidementia drugs in human plasma: procedure transfer from HPLC-MS to UPLC-MS/MS.

J Pharm Biomed Anal 2012 May 18;64-65:16-25. Epub 2012 Feb 18.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, Prilly, Switzerland.

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http://dx.doi.org/10.1016/j.jpba.2012.02.008DOI Listing
May 2012

Psychotropic drug-induced weight gain and other metabolic complications in a Swiss psychiatric population.

J Psychiatr Res 2012 Apr 7;46(4):540-8. Epub 2012 Feb 7.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Centre and University of Lausanne, Prilly, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jpsychires.2012.01.014DOI Listing
April 2012

Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking.

Pharmacogenet Genomics 2012 Feb;22(2):143-51

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Centre for Psychiatric Neurosciences, CHUV, Hospital of Cery, University of Lausanne, Prilly, Switzerland.

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http://dx.doi.org/10.1097/FPC.0b013e32834e9e1aDOI Listing
February 2012

Simultaneous quantification of selective serotonin reuptake inhibitors and metabolites in human plasma by liquid chromatography-electrospray mass spectrometry for therapeutic drug monitoring.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Feb 8;885-886:117-30. Epub 2012 Jan 8.

Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Hospital of Cery, 1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jchromb.2011.12.028DOI Listing
February 2012

Quantification of nicotine, cotinine, trans-3'-hydroxycotinine and varenicline in human plasma by a sensitive and specific UPLC-tandem mass-spectrometry procedure for a clinical study on smoking cessation.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Nov 1;879(30):3574-82. Epub 2011 Oct 1.

Centre for Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland.

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http://dx.doi.org/10.1016/j.jchromb.2011.09.046DOI Listing
November 2011

Usefulness of methadone plasma concentration measurement in patients receiving nevirapine or efavirenz.

Am J Drug Alcohol Abuse 2011 Jul 23;37(4):264-8. Epub 2011 Jun 23.

Department of Ambulatory Care and Community Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland.

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http://www.tandfonline.com/doi/full/10.3109/00952990.2011.59
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http://dx.doi.org/10.3109/00952990.2011.591465DOI Listing
July 2011

Quantification of 4 antidepressants and a metabolite by LC-MS for therapeutic drug monitoring.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Jun 4;879(19):1544-50. Epub 2011 Apr 4.

Centre for Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland.

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http://dx.doi.org/10.1016/j.jchromb.2011.03.049DOI Listing
June 2011

Simultaneous determination of antidementia drugs in human plasma for therapeutic drug monitoring.

Ther Drug Monit 2011 Apr;33(2):227-38

Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland .

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http://dx.doi.org/10.1097/FTD.0b013e31821126cfDOI Listing
April 2011

The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution.

Expert Opin Drug Metab Toxicol 2010 Aug;6(8):953-65

University of Lausanne, Centre for Psychiatric Neurosciences, Department of Psychiatry, CHUV, Hospital of Cery, Prilly, Switzerland.

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http://dx.doi.org/10.1517/17425251003789394DOI Listing
August 2010

Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval.

Arch Intern Med 2010 Mar;170(6):529-36

Center for Psychiatric Neurosciences, Department of Psychiatry, Hospital of Cery, Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1001/archinternmed.2010.26DOI Listing
March 2010

Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.

J Pharm Biomed Anal 2009 Dec 15;50(5):1000-8. Epub 2009 Aug 15.

Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jpba.2009.07.007DOI Listing
December 2009

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.

Pharmacogenet Genomics 2009 Nov;19(11):877-83

Unit of Biochemistry and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry-CHUV, University of Lausanne, Hospital of Cery, Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1097/FPC.0b013e32833225e7DOI Listing
November 2009

Validation and long-term evaluation of a modified on-line chiral analytical method for therapeutic drug monitoring of (R,S)-methadone in clinical samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Aug 17;877(23):2301-7. Epub 2009 Mar 17.

Unit of Biochemistry and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry-CHUV, University of Lausanne, Hospital of Cery, Prilly, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jchromb.2009.03.013DOI Listing
August 2009

ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.

J Clin Psychopharmacol 2009 Aug;29(4):319-26

Psychiatrische Dienste Aargau AG, mediQ, Klinik Königsfelden, Brugg.

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http://dx.doi.org/10.1097/JCP.0b013e3181acc372DOI Listing
August 2009

CYP3A5 and ABCB1 genes and hypertension.

Pharmacogenomics 2009 Mar;10(3):477-87

Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) et Université de Lausanne, Rue du Bugnon 17, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.2217/14622416.10.3.477DOI Listing
March 2009

Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study.

Pharmacol Res 2008 Nov-Dec;58(5-6):344-7. Epub 2008 Sep 30.

Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, 36043 Fulda, Germany.

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http://dx.doi.org/10.1016/j.phrs.2008.09.010DOI Listing
February 2009

CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.

Ther Drug Monit 2008 Dec;30(6):689-99

Unité de Biochimie et de Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Hôpital de Cery, Prilly-Lausanne, Switzerland.

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https://insights.ovid.com/crossref?an=00007691-200812000-000
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http://dx.doi.org/10.1097/FTD.0b013e31818a2a60DOI Listing
December 2008

Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment.

Prog Neuropsychopharmacol Biol Psychiatry 2008 Oct 17;32(7):1722-7. Epub 2008 Jul 17.

Unité de Biochimie et de Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Hôpital de Cery, CH-1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.pnpbp.2008.07.009DOI Listing
October 2008

CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response.

Ther Drug Monit 2008 Aug;30(4):474-82

Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Chêne-Bourg, Switzerland.

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http://dx.doi.org/10.1097/FTD.0b013e31817d6f5dDOI Listing
August 2008

Brain dopamine response in human opioid addiction.

Br J Psychiatry 2008 Jul;193(1):65-72

Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, UK.

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http://dx.doi.org/10.1192/bjp.bp.107.041228DOI Listing
July 2008

[Principles of therapeutic drug monitoring].

Rev Med Suisse 2008 Jul;4(165):1644-8

Division de pharmacologie et toxicologie cliniques, CHUV et Université de Lausanne.

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July 2008

[Therapeutic drug monitoring: clinical practice].

Rev Med Suisse 2008 Jul;4(165):1649-50, 1652-60

Division de pharmacologie et toxicologie cliniques, CHUV et Université de Lausanne.

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July 2008

Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients.

Pharmacogenet Genomics 2008 Apr;18(4):307-15

Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland.

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https://insights.ovid.com/crossref?an=01213011-200804000-000
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http://dx.doi.org/10.1097/FPC.0b013e3282f7046fDOI Listing
April 2008

In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites.

Pharmacology 2007 9;80(4):304-11. Epub 2007 Aug 9.

Unité de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Hôpital de Cery, Prilly-Lausanne, Suisse.

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http://dx.doi.org/10.1159/000107104DOI Listing
October 2007

Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients.

J Clin Psychopharmacol 2007 Jun;27(3):273-8

Centre Psychosocial, Unité de Traitement des Addictions, Fribourg, Switzerland.

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http://dx.doi.org/10.1097/JCP.0b013e3180592ad2DOI Listing
June 2007

Could pharmacogenetic data explain part of the interindividual sensitivity to methadone-induced respiratory depression?

Crit Care 2007 ;11(1):119

Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, University Psychiatry Department, Cery Hospital, CH-1008 Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1186/cc5699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151888PMC
May 2007

CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt.

Hypertension 2007 May 19;49(5):1007-14. Epub 2007 Mar 19.

Unité de Biochimie et Psychopharmacologie Clinique, Centre des Neurosciences Psychiatriques, Département de Psychiatrie-Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.106.084236DOI Listing
May 2007

Time course of response to paroxetine: influence of plasma level.

Prog Neuropsychopharmacol Biol Psychiatry 2007 May 15;31(4):892-900. Epub 2007 Feb 15.

Service of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, 2 chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Switzerland.

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http://dx.doi.org/10.1016/j.pnpbp.2007.02.003DOI Listing
May 2007

ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.

Clin Pharmacol Ther 2006 Dec;80(6):668-81

Unité de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie-Centre Hospitalier Universitaire Vaudois, Hôpital de Cery, Prilly-Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.clpt.2006.09.012DOI Listing
December 2006