Chihiro Tohda

Chihiro Tohda

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Chihiro Tohda

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Combined Treatment with Two Water Extracts of Leaf and Rhizome of Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults.

Nutrients 2020 Jan 23;12(2). Epub 2020 Jan 23.

Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.3390/nu12020303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070741PMC
January 2020

Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury.

Neural Regen Res 2019 Nov;14(11):1961-1967

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.4103/1673-5374.259625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676875PMC
November 2019

(Schenk) Wight Extract Enhances Hindlimb Performance and Attenuates Myosin Heavy Chain IId/IIx Expression in Cast-Immobilized Mice.

Evid Based Complement Alternat Med 2019 22;2019:9283171. Epub 2019 Oct 22.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1155/2019/9283171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925718PMC
October 2019

Porcine placental extract facilitates memory and learning in aged mice.

Food Sci Nutr 2019 Sep 15;7(9):2995-3005. Epub 2019 Aug 15.

Research Institute Japan Bio Products Co., Ltd. Kurume Japan.

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http://dx.doi.org/10.1002/fsn3.1156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766592PMC
September 2019

Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury.

J Neurotrauma 2019 Jun 10;36(12):1935-1948. Epub 2019 Jan 10.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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https://www.liebertpub.com/doi/10.1089/neu.2018.6000
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http://dx.doi.org/10.1089/neu.2018.6000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599386PMC
June 2019

Memory Enhancement by Oral Administration of Extract of Leaves and Active Compounds Transferred in the Brain.

Nutrients 2019 May 22;11(5). Epub 2019 May 22.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.3390/nu11051142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567285PMC
May 2019

Kihito, a Traditional Japanese Kampo Medicine, Improves Cognitive Function in Alzheimer's Disease Patients.

Evid Based Complement Alternat Med 2019 14;2019:4086749. Epub 2019 May 14.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1155/2019/4086749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537006PMC
May 2019

Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression.

Phytother Res 2019 Apr 15;33(4):1114-1121. Epub 2019 Feb 15.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1002/ptr.6305DOI Listing
April 2019

Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth and .

Front Pharmacol 2018 30;9:1228. Epub 2018 Oct 30.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2018.01228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232869PMC
October 2018

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70).

Sci Rep 2018 08 3;8(1):11707. Epub 2018 Aug 3.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1038/s41598-018-30102-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076317PMC
August 2018

Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice.

Front Pharmacol 2018 7;9:446. Epub 2018 May 7.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2018.00446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949560PMC
May 2018

Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis.

Exp Neurol 2018 04 15;302:57-67. Epub 2017 Dec 15.

Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2017.12.003DOI Listing
April 2018

Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease.

Front Pharmacol 2018 30;9:48. Epub 2018 Jan 30.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2018.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797615PMC
January 2018

Extracellular Cytosolic Aspartate Aminotransferase Promotes Axonal Growth and Object Recognition Memory.

Neurochem Res 2017 Dec 29;42(12):3465-3473. Epub 2017 Aug 29.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://link.springer.com/10.1007/s11064-017-2394-6
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http://dx.doi.org/10.1007/s11064-017-2394-6DOI Listing
December 2017

Extracellular cathepsin L stimulates axonal growth in neurons.

BMC Res Notes 2017 Nov 23;10(1):613. Epub 2017 Nov 23.

Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1186/s13104-017-2940-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701428PMC
November 2017

Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer's Disease.

Front Pharmacol 2017 14;8:805. Epub 2017 Nov 14.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2017.00805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694549PMC
November 2017

A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.

Front Pharmacol 2017 19;8:340. Epub 2017 Jun 19.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of ToyamaToyama, Japan.

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http://dx.doi.org/10.3389/fphar.2017.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474478PMC
June 2017

New Age Therapy for Alzheimer's Disease by Neuronal Network Reconstruction.

Authors:
Chihiro Tohda

Biol Pharm Bull 2016 ;39(10):1569-1575

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama.

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http://dx.doi.org/10.1248/bpb.b16-00438DOI Listing
January 2017

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.

J Biol Chem 2017 01 9;292(4):1240-1250. Epub 2016 Dec 9.

From the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan,

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http://dx.doi.org/10.1074/jbc.M116.748871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270470PMC
January 2017

Effects of Oleanane-Type Triterpene Saponins from the Leaves of Eleutherococcus senticosus in an Axonal Outgrowth Assay.

J Nat Prod 2016 07 11;79(7):1834-41. Epub 2016 Jul 11.

Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition , Ibaraki 567-0085, Japan.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00329DOI Listing
July 2016

Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cord-injured mice.

Sci Rep 2016 06 21;6:28293. Epub 2016 Jun 21.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/srep28293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915015PMC
June 2016

The Extract of Roots of Sophora flavescens Enhances the Recovery of Motor Function by Axonal Growth in Mice with a Spinal Cord Injury.

Front Pharmacol 2015 14;6:326. Epub 2016 Jan 14.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama Toyama, Japan.

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http://dx.doi.org/10.3389/fphar.2015.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712302PMC
February 2016

Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer's Disease Activities.

Org Lett 2015 Dec 20;17(23):5910-3. Epub 2015 Nov 20.

Graduate School of Medicine and Pharmaceutical Sciences, and ‡Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1021/acs.orglett.5b03138DOI Listing
December 2015

Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ(25-35)-Induced Axonal Atrophy.

J Nat Prod 2015 Sep 24;78(9):2297-300. Epub 2015 Aug 24.

Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.5b00290
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http://dx.doi.org/10.1021/acs.jnatprod.5b00290DOI Listing
September 2015

Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth.

Sci Rep 2015 Jul 14;5:12055. Epub 2015 Jul 14.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/srep12055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501001PMC
July 2015

Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage.

Neurobiol Aging 2015 May 13;36(5):1808-19. Epub 2015 Feb 13.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580150010
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http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.005DOI Listing
May 2015

[Kamikihito improves memory dysfunction in Alzheimer's disease].

Nihon Yakurigaku Zasshi 2015 May;145(5):224-8

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http://dx.doi.org/10.1254/fpj.145.224DOI Listing
May 2015

Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working towards the development of a global study.

Phytother Res 2015 Mar 23;29(3):351-6. Epub 2014 Oct 23.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan; Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1002/ptr.5250DOI Listing
March 2015

Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.

Biol Pharm Bull 2014 ;37(6):892-7

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama.

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http://dx.doi.org/10.1248/bpb.b14-00022DOI Listing
January 2015

New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice.

BMC Res Notes 2014 Jun 3;7:332. Epub 2014 Jun 3.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1186/1756-0500-7-332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057812PMC
June 2014

New Treatment for Alzheimer's Disease, Kamikihito, Reverses Amyloid-β-Induced Progression of Tau Phosphorylation and Axonal Atrophy.

Evid Based Complement Alternat Med 2014 23;2014:706487. Epub 2014 Feb 23.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1155/2014/706487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953424PMC
April 2014

[New perspective in pharmacology brought by studying traditional medicine].

Nihon Yakurigaku Zasshi 2014 Feb;143(2):73-7

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http://dx.doi.org/10.1254/fpj.143.73DOI Listing
February 2014

Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent.

Bioorg Med Chem Lett 2014 Jan 9;24(2):604-8. Epub 2013 Dec 9.

Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.12.008DOI Listing
January 2014

Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D₃-MARRS.

Sci Rep 2013 Dec 2;3:3395. Epub 2013 Dec 2.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/srep03395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844946PMC
December 2013

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.

Exp Neurol 2013 Oct 21;248:157-69. Epub 2013 Jun 21.

Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan; Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.expneurol.2013.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773816PMC
October 2013

Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent.

Bioorg Med Chem 2013 Aug 5;21(15):4459-71. Epub 2013 Jun 5.

Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.bmc.2013.05.059DOI Listing
August 2013

Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice.

Sci Rep 2012 26;2:535. Epub 2012 Jul 26.

Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/srep00535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405293PMC
March 2013

Epimedium koreanum Extract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury.

Evid Based Complement Alternat Med 2012 23;2012:731208. Epub 2012 Aug 23.

Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://www.hindawi.com/journals/ecam/2012/731208/
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http://dx.doi.org/10.1155/2012/731208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432561PMC
September 2012

Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25-35)-Induced Neuritic Atrophy.

Evid Based Complement Alternat Med 2011 21;2011:131042. Epub 2011 Aug 21.

Division of Natural Products Chemistry, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1093/ecam/nep149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162985PMC
August 2012

Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer's disease agent.

Bioorg Med Chem Lett 2012 Jan 18;22(1):449-52. Epub 2011 Nov 18.

Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2011.10.127DOI Listing
January 2012

Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD.

Int J Neurosci 2011 Dec 11;121(12):641-8. Epub 2011 Aug 11.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Japan.

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http://dx.doi.org/10.3109/00207454.2011.602809DOI Listing
December 2011

Current and future therapeutic strategies for functional repair of spinal cord injury.

Pharmacol Ther 2011 Oct 27;132(1):57-71. Epub 2011 May 27.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 930-0194 Toyama, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01637258110011
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http://dx.doi.org/10.1016/j.pharmthera.2011.05.006DOI Listing
October 2011

Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.

J Nat Med 2011 Jul 8;65(3-4):417-23. Epub 2011 Feb 8.

Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan.

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http://link.springer.com/10.1007/s11418-011-0509-y
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http://dx.doi.org/10.1007/s11418-011-0509-yDOI Listing
July 2011

Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD.

Int J Neurosci 2011 Apr;121(4):181-90

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3109/00207454.2010.541571DOI Listing
April 2011

Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy.

Phytother Res 2010 Nov;24(11):1658-63

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1002/ptr.3183DOI Listing
November 2010

Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin".

Org Lett 2009 Sep;11(17):3970-3

Graduate School of Medicine and Pharmaceutical Sciences and Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1021/ol901553wDOI Listing
September 2009

Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET.

Br J Pharmacol 2009 Aug 8;157(8):1427-40. Epub 2009 Jul 8.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://doi.wiley.com/10.1111/j.1476-5381.2009.00313.x
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http://dx.doi.org/10.1111/j.1476-5381.2009.00313.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765306PMC
August 2009

Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85alpha subunit of phosphoinositide-3 kinase.

Brain Dev 2009 Jan 5;31(1):69-74. Epub 2008 Jun 5.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S038776040800109
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http://dx.doi.org/10.1016/j.braindev.2008.04.006DOI Listing
January 2009

[Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms].

Authors:
Chihiro Tohda

Yakugaku Zasshi 2008 Aug;128(8):1159-67

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Insitute of Natural Medicine, University of Toyama, Toyama City, Japan.

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http://dx.doi.org/10.1248/yakushi.128.1159DOI Listing
August 2008

Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses.

BMC Complement Altern Med 2008 Aug 16;8:49. Epub 2008 Aug 16.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://bmccomplementalternmed.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/1472-6882-8-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532680PMC
August 2008

Learning deficits and agenesis of synapses and myelinated axons in phosphoinositide-3 kinase-deficient mice.

Neurosignals 2006-2007;15(6):293-306. Epub 2007 Sep 27.

Divisions of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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https://www.karger.com/Article/FullText/108936
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http://dx.doi.org/10.1159/000108936DOI Listing
July 2008

Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss.

J Pharmacol Sci 2008 Jul 8;107(3):329-39. Epub 2008 Jul 8.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1254/jphs.08046fpDOI Listing
July 2008

Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury.

Neurosci Res 2007 Jun 2;58(2):176-82. Epub 2007 Mar 2.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S016801020700088
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http://dx.doi.org/10.1016/j.neures.2007.02.014DOI Listing
June 2007

Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats.

Biol Pharm Bull 2007 Apr;30(4):687-91

Institute of Natural Medicine, University of Toyama, Japan.

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http://dx.doi.org/10.1248/bpb.30.687DOI Listing
April 2007

Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Abeta(25-35)-treated cortical neurons.

Biol Pharm Bull 2006 Sep;29(9):1892-6

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyoma, Japan.

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http://dx.doi.org/10.1248/bpb.29.1892DOI Listing
September 2006

Protective effect of grape seed polyphenols against high glucose-induced oxidative stress.

Biosci Biotechnol Biochem 2006 Sep 7;70(9):2104-11. Epub 2006 Sep 7.

Institute of Natural Medicine, University of Toyama.

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http://dx.doi.org/10.1271/bbb.60053DOI Listing
September 2006

Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade.

Neuropsychopharmacology 2006 Jun;31(6):1158-64

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.

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http://dx.doi.org/10.1038/sj.npp.1300943DOI Listing
June 2006

Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration.

Eur J Neurosci 2006 Mar;23(6):1417-26

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2006.04664.xDOI Listing
March 2006

Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.

J Nutr Sci Vitaminol (Tokyo) 2005 Dec;51(6):413-8

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.3177/jnsv.51.413DOI Listing
December 2005

Search for natural products related to regeneration of the neuronal network.

Neurosignals 2005 ;14(1-2):34-45

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.

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https://www.karger.com/Article/FullText/85384
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http://dx.doi.org/10.1159/000085384DOI Listing
August 2005

Neuritic regeneration and synaptic reconstruction induced by withanolide A.

Br J Pharmacol 2005 Apr;144(7):961-71

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1038/sj.bjp.0706122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576076PMC
April 2005

Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins.

Neuropsychopharmacology 2004 May;29(5):860-8

1Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

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http://dx.doi.org/10.1038/sj.npp.1300388DOI Listing
May 2004

Repair of amyloid beta(25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to.

Brain Res 2003 Nov;990(1-2):141-7

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/s0006-8993(03)03449-8DOI Listing
November 2003

Effects of curcuma drugs on vasomotion in isolated rat aorta.

Biol Pharm Bull 2003 Aug;26(8):1135-43

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University.

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http://dx.doi.org/10.1248/bpb.26.1135DOI Listing
August 2003

Comprehensive identifying method for localized mRNAs in single neuronal axons.

Authors:
Chihiro Tohda

J Biochem Biophys Methods 2003 Jul;57(1):57-63

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani,Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/s0165-022x(03)00079-4DOI Listing
July 2003

Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells.

Jpn J Pharmacol 2002 Nov;90(3):254-62

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

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http://dx.doi.org/10.1254/jjp.90.254DOI Listing
November 2002

Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha.

Neuroreport 2002 Oct;13(14):1715-20

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

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http://dx.doi.org/10.1097/00001756-200210070-00005DOI Listing
October 2002

Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.

J Nat Prod 2002 Sep;65(9):1288-92

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan.

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http://dx.doi.org/10.1021/np0201117DOI Listing
September 2002

Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.

Chem Pharm Bull (Tokyo) 2002 Jun;50(6):760-5

Department of Metabolic Engineering, Toyama Medical and Pharmaceutical University, Sugitani, Japan.

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http://dx.doi.org/10.1248/cpb.50.760DOI Listing
June 2002

Dammarane-type triterpene saponins from Panax japonicus.

J Nat Prod 2002 Mar;65(3):346-51

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1021/np010354jDOI Listing
March 2002