Publications by authors named "Chih-Ting Cheng"

5 Publications

  • Page 1 of 1

Role of IGFBP-2 in oral cancer metastasis.

Biochim Biophys Acta Mol Basis Dis 2021 Apr 14;1867(7):166143. Epub 2021 Apr 14.

Department of Medical Science, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:

Cancer metastasis is one of most main causes of failure in cancer treatment. Nonetheless, more than half of oral cancer patients were diagnosed as advanced oral cancer with dramatically decreased 5-year survival rate to lower than 20%, while the stages become more advanced. In order to improve oral cancer treatment, the identification of cancer metastatic biomarkers and mechanisms is critical. In the current study, two pairs of oral squamous cell carcinoma lines, OC3/C9, and invasive OC3-I5/C9-I5were used as model systems to investigate invasive mechanism as well as to identify potential therapy-associated targets. Based on our previous proteomic analysis, insulin-like growth factor-binding protein 2 (IGFBP-2) was reported participating in oral cancer metastasis. Subsequent studies have applied interference RNA as well as recombinant protein techniques to confirm the roles of IGFBP-2 in oral cancer metastasis and examine their potency in regulating invasion as well as the mechanism IGFBP-2 involved. The results demonstrated that expression of epithelial-mesenchymal transition (EMT) markers including Twist, Snail1, SIP1, profilin, vimentin, uPA and MMP9 were increased in both OC3-I5 and C9-I5 compared to OC3 and C9 cells, while E-cadherin expression was down-regulated in the OC3-I5 and C9-I5 cells. Moreover, IGFBP-2 is shown to affect not only migration and invasion but also wound healing ability and cell proliferation. Our results also revealed that uPA is a downstream target of IGFBP-2 to intermediate oral cancer metastasis. To sum up, the current studies indicated that elevated IGFBP-2 is strongly correlated with oral cancer metastasis and progression, and that it could potentially serve as a prognostic biomarker as well as an innovative target for the treatment of oral cancer invasion.
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http://dx.doi.org/10.1016/j.bbadis.2021.166143DOI Listing
April 2021

Biomechanical effects of screw orientation and plate profile on tibial condylar valgus osteotomy - Finite-element analysis.

Comput Methods Biomech Biomed Engin 2020 Sep 1;23(12):906-913. Epub 2020 Jun 1.

Department of Orthopedics, Cathay General Hospital, Taipei, Taiwan.

Tibial condylar valgus osteotomy (TCVO) is a type of open wedge high tibial osteotomy for correcting intra-articular deformities of medial knee osteoarthritis. However, there are no implant design and related biomechanical investigations specifically for TCVO. This study aims to investigate the effects of the proximal screw direction and plate profile on the biomechanical behaviors of the TCVO construct. Based on computed tomography images, the tibia model with TCVO was simulated. Four variations (straight and contoured plate profile × convergent and divergent proximal screw direction) with two loading conditions (compressive loads and torsional load) were compared by finite-element method. Fracture risk and construct stability were chosen as the comparison indices. For both loading conditions, the fracture risk of screw, plate and bone was the lowest in straight plate with divergent screw direction (SD), while contoured plate with convergent screw direction (CC) was the highest. Similar results were found in construct stability, SD allowed the smallest micromotions of the L-shaped opening gap, but CC allowed the highest. Divergent screw direction can decrease fracture risk of all components and provide better construct stability, while contoured plate profile seems like to have converse effects. If stability is the major concern, straight plate with divergent screw is recommended for patients with heavy load demands. Contoured plate may be suitable for skinny patients that can reduce the soft tissue irritation.
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http://dx.doi.org/10.1080/10255842.2020.1772763DOI Listing
September 2020

Intramuscular hemangioma causing periosteal reaction and cortical hypertrophy misdiagnosed as osteoid osteoma.

Int J Surg Case Rep 2017 16;34:106-109. Epub 2017 Mar 16.

Department of Orthopedics, Hsinchu Mackay Memorial Hospital, Hsinchu City, Taiwan.

Introduction: Intramuscular hemangioma in the periosteal region is rare. Although comprising less than 1% of all hemangiomas, they represent the most common type of intramuscular tumors. When located adjacent to bone, a periosteal reaction can occur. The deep localization of the hemangioma poses the diagnosis difficult. Only 8% to 19% of cases were diagnosed before surgery according to the literature review.

Presentation Of Case: We present a case of forty-one-year-old female diagnosed with intramuscular hemangioma, mimicking osteoid osteoma, adjacent to the periosteal region of tibia diaphysis treated by surgical excision.

Discussion: When intramuscular hemangioma occurs nearby a bone structure, it can cause cortical, medullary and periosteal bone changes that are frequently misdiagnosed by plain radiography. Due to their infrequency, deep location, and atypical presentation, these lesions are seldom diagnosed at presentation. The hemangioma of the periosteal region can be locally destructive due to compression exerted on neighboring structures. It does not regress spontaneously, and surgical excision is frequently needed.

Conclusion: Intramuscular hemangioma of periosteal region occurs most commonly adjacent to long bones of the lower limb. They can cause hypertrophic periosteal reactions mimicking a periosteal or parosteal tumor. Although osteoid osteoma was considered in the differential diagnosis, MRI with enhancement should be performed to exclude intramuscular hemangioma. This may avoid unnecessary aggressive en-bloc tumor excisions resulting in bone weakness and prolonged rehabilitation. This case report has been written in line with the SCARE criteria (Agha et al., 2016 [1]).
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http://dx.doi.org/10.1016/j.ijscr.2017.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384294PMC
March 2017

Biomechanical effects of bone-implant fitness and screw breakage on the stability and stress performance of the nonstemmed hip system.

Clin Biomech (Bristol, Avon) 2014 Feb 4;29(2):161-9. Epub 2013 Dec 4.

Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan.

Background: Some nonstemmed hip systems have been developed to avoid stress shielding and aseptic loosening, which are major drawbacks of stemmed hip arthroplasty. Without the stem, the cup over the femoral head can be stabilized by anatomic fitness of the cup interior and mechanical fixation of the auxiliary screws.

Methods: Using finite-element method, neck-shaped systems with two bone-cup fitness situations and four types of screw breakages are systematically investigated to evaluate their biomechanical effects on construct performances. The construct stresses and interfacial micromotion were chosen for comparison between two bone-cup fitness situations and four types of screw breakages.

Findings: The screw breakage deteriorates the stresses of the mating screw and the neck cup and loosens the bone-cup interfaces. The breakages of central and locking screws decrease the bone stress by about 43.2% and 12.7%, respectively. This indicates that the central screw is a more effective load-bearer for the superimposed cup than the locking screw. As compared with the fitting cup, the stress of cup and the bone stresses of the unfitting cup obviously increase. This demonstrates that the load-transferring path at the cup bottom is important in directly relieving the prosthetic stresses.

Interpretation: Any screw design inducing stress concentration should be validated to avoid screw breakage. Comparatively, surgical unfitness has a more significant effect on the construct performance than does the screw breakage. Even for custom-made cups, cautious preparation of the neck resection is still necessary to ensure intimate bone-cup contact.
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http://dx.doi.org/10.1016/j.clinbiomech.2013.11.017DOI Listing
February 2014

Hemarthrosis associated with failure of a mobile meniscal-bearing total knee arthroplasty. A case report.

J Bone Joint Surg Am 2003 Dec;85(12):2445-8

Department of Orthopaedic Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Chung-San North Road, Taipei, Taiwan.

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http://dx.doi.org/10.2106/00004623-200312000-00027DOI Listing
December 2003