Chih-Hung Chen

Chih-Hung Chen

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Chih-Hung Chen

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Effects of natural organic matters on bioavailability of petroleum hydrocarbons in soil-water environments.

Chemosphere 2019 Oct 30;233:843-851. Epub 2019 May 30.

Department of Environmental Engineering, National Cheng Kung University, No. 1, University Road, Tainan, 701, Taiwan; Sustainable Environment Research Center (SERC), National Cheng Kung University, No. 1, University Road, Tainan, 701, Taiwan; Research Center for Energy Technology and Strategy (RCETS), National Cheng Kung University, No. 1, University Road, Tainan, 701, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2019.05.202DOI Listing
October 2019

The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet.

Biomed Pharmacother 2019 Aug 17;116:108954. Epub 2019 May 17.

Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan, ROC; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan, ROC; Department of Nursing, Asia University, Taichung, 41354, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan, ROC; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2019.108954DOI Listing
August 2019

The training in SHARE communication course by physicians increases the signing of do-not-resuscitate orders for critical patients in the emergency room (cross-sectional study).

Int J Surg 2019 Aug 8;68:20-26. Epub 2019 Jun 8.

Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 833, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2019.06.005DOI Listing
August 2019

Oral vinorelbine plus cisplatin with concomitant radiotherapy as induction therapy for stage III non-small cell lung cancer: Results of a single-arm prospective cohort study.

Thorac Cancer 2019 Aug 5;10(8):1683-1691. Epub 2019 Jul 5.

Division of Thoracic Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan City, Taiwan.

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http://dx.doi.org/10.1111/1759-7714.13125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669803PMC
August 2019

MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats.

Cells 2019 Aug 19;8(8). Epub 2019 Aug 19.

Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

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http://dx.doi.org/10.3390/cells8080935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721717PMC
August 2019

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.

N Engl J Med 2019 05;380(19):1795-1803

From Florey Institute of Neuroscience and Mental Health (H.M., L. Churilov, N.Y., V.T., L. Carey, A.M., G.A.D.), the Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital (B.C.V.C., M.W.P., L. Churilov, S. Christensen, N.Y., G.S., A.B., B.Y., A.M., S.M.D., G.A.D.), and the Department of Radiology, Royal Melbourne Hospital (P.M.D., B.Y., P.J.M.), University of Melbourne, Parkville, the Department of Medicine, School of Clinical Science, Monash University, Clayton (H.M., T.G.P.), the Departments of Medicine and Neurology, Melbourne Medical School, University of Melbourne and Western Health, Sunshine Hospital, St. Albans (T.W.), the Department of Neurosciences, Eastern Health and Eastern Health Clinical School, Monash University, Box Hill (H.M.D., C.F.B.), the Department of Neurology, University Hospital Geelong, Deakin University, Geelong (B.C.), the Department of Neurology, Austin Hospital, Austin Health, Heidelberg (V.T.), and Occupational Therapy, School of Allied Health, College of Science, Health and Engineering, La Trobe University, Bundoora (L. Carey), VIC, the Department of Neurology, Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital (C.R.L., F.M.), University of Newcastle (J.S.), Newcastle, the Department of Neurology, Westmead Hospital (N.M.), the Department of Neurology, Royal North Shore Hospital and Kolling Institute, University of Sydney (M.K.), and the Department of Neurology, St. Vincent's Hospital Sydney (R.M.), Sydney, and the Department of Neurology, Gosford Hospital, Gosford (J.S.), NSW, the Department of Neurology, Royal Adelaide Hospital (T.J.K., J.J.), the Department of Neurology, Lyell McEwin Hospital (D.F.), and the Department of Neurology, Queen Elizabeth Hospital (J.J.), Adelaide, SA, the Department of Medicine, Sunshine Coast University Hospital, Nambour (R.G.), the Department of Neurology, Royal Brisbane and Women's Hospital and the University of Queensland, Brisbane (A.A.W.), and the Department of Neurology, Gold Coast University Hospital, Southport (A.S.), and Australia and Griffith University, Gold Coast (A.S.), QLD - all in Australia; the Graduate Institute of Clinical Medical Science (C.H.) and the School of Medicine (C.-H.T.), China Medical University, and the Department of Neurology, China Medical University Hospital (C.-H.T.), Taichung, the Department of Neurology, Tri-Service General Hospital, National Defense Medical Center (J.-T.L.), the Department of Neurology, Shuang Ho Hospital (C.-J.H.), the Department of Neurology, En Chu Kong Hospital (Y.S.), the Stroke Center and Department of Neurology, National Taiwan University Hospital (J.-S.J.), and the Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei Medical University College of Medicine (L.-M.L.), Taipei, the Stroke Center and Department of Neurology, Changhua Christian Hospital, Changhua (M.-C.S.), the Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan (C.-H.C.), and the Department of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung (C.-H.L.) - all in Taiwan; the Department of Neurology, Helsinki University Hospital, Helsinki (S. Curtze, A.M.); the Department of Neurology, Auckland City Hospital, University of Auckland, Auckland, New Zealand (P.A.B.); and the Stanford Stroke Center, Stanford University, Stanford, CA (S. Christensen).

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http://www.nejm.org/doi/10.1056/NEJMoa1813046
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http://dx.doi.org/10.1056/NEJMoa1813046DOI Listing
May 2019

Synergistic effect of combined melatonin and adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes on amelioration of dextran sulfate sodium (DSS)-induced acute colitis.

Am J Transl Res 2019 15;11(5):2706-2724. Epub 2019 May 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556660PMC
May 2019

Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study.

J Neurol Sci 2019 Apr 29;399:76-81. Epub 2019 Jan 29.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.01.047DOI Listing
April 2019

Clinical utility of mean platelet volume and immature platelet fraction in acute coronary syndrome.

Biomed J 2019 04 8;42(2):107-115. Epub 2019 May 8.

Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan; Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.bj.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541877PMC
April 2019

Diagnostic pitfalls and therapeutic outcomes of the macrofollicular variant of papillary thyroid carcinoma.

Biomed J 2019 02 20;42(1):59-65. Epub 2019 Mar 20.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.bj.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468112PMC
February 2019

Noncontact Wearable Wireless ECG Systems for Long-Term Monitoring.

IEEE Rev Biomed Eng 2018 29;11:306-321. Epub 2018 May 29.

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http://dx.doi.org/10.1109/RBME.2018.2840336DOI Listing
December 2018

Renal dysfunction increases the risk of recurrent stroke in patients with acute ischemic stroke.

Atherosclerosis 2018 10 27;277:15-20. Epub 2018 Jul 27.

Department of Neurology, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Science, College of Medicine, China Medical University, Taiwan.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.07.033DOI Listing
October 2018

Universality and Stability Phase Diagram of Two-Dimensional Brittle Fracture.

Phys Rev Lett 2018 Sep;121(13):134301

Chemical and Biological Physics Department, Weizmann Institute of Science, Rehovot 7610001, Israel.

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http://dx.doi.org/10.1103/PhysRevLett.121.134301DOI Listing
September 2018

A community-based study on the association between Helicobacter pylori Infection and obesity.

Sci Rep 2018 Jul 16;8(1):10746. Epub 2018 Jul 16.

Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University at Keelung, Keelung, Taiwan.

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http://dx.doi.org/10.1038/s41598-018-28792-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048143PMC
July 2018

Hyperglycemia predicts unfavorable outcomes in acute ischemic stroke patients treated with intravenous thrombolysis among a Chinese population: A prospective cohort study.

J Neurol Sci 2018 05 16;388:195-202. Epub 2018 Mar 16.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.03.022DOI Listing
May 2018

Adipose-derived mesenchymal stem cell-derived exosomes alleviate overwhelming systemic inflammatory reaction and organ damage and improve outcome in rat sepsis syndrome.

Am J Transl Res 2018 15;10(4):1053-1070. Epub 2018 Apr 15.

Division of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934566PMC
April 2018

Predictive Walking-Age Health Analyzer.

IEEE J Biomed Health Inform 2018 03 9;22(2):363-374. Epub 2017 Feb 9.

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http://dx.doi.org/10.1109/JBHI.2017.2666603DOI Listing
March 2018

Extracorporeal shock wave markedly alleviates radiation-induced chronic cystitis in rat.

Am J Transl Res 2018 15;10(3):1036-1052. Epub 2018 Mar 15.

Divisions of General Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883143PMC
March 2018

Delayed Endovascular Thrombectomy in a Patient Suffering from Stroke in Progression after Intravenous Thrombolytic Therapy.

Acta Neurol Taiwan 2018 Mar;27(1):18-21

Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan.

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March 2018

Assessment of doxorubicin-induced mouse testicular damage by the novel second-harmonic generation microscopy.

Am J Transl Res 2017 15;9(12):5275-5288. Epub 2017 Dec 15.

Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301, Taiwan, R.O.C.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752880PMC
December 2017

Extracorporeal shock wave therapy effectively protects brain against chronic cerebral hypo-perfusion-induced neuropathological changes.

Am J Transl Res 2017 15;9(11):5074-5093. Epub 2017 Nov 15.

Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714792PMC
November 2017

Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder.

Curr Alzheimer Res 2017 ;14(3):309-316

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

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http://dx.doi.org/10.2174/1567205013666161108104703DOI Listing
October 2017

Effective protection against acute respiratory distress syndrome/sepsis injury by combined adipose-derived mesenchymal stem cells and preactivated disaggregated platelets.

Oncotarget 2017 Oct 17;8(47):82415-82429. Epub 2017 Jul 17.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.19312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669900PMC
October 2017

Therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced fatty liver disease, fibrosis and inflammation in rabbit.

Am J Transl Res 2017 15;9(8):3827-3841. Epub 2017 Aug 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung UniversityKaohsiung 83301, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575196PMC
August 2017

DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning.

Oncotarget 2017 Aug 4;8(33):54821-54837. Epub 2017 Jul 4.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.18962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589624PMC
August 2017

Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients.

J Stroke Cerebrovasc Dis 2017 Jun 21;26(6):1349-1356. Epub 2017 Mar 21.

Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; Departmemt of Neurology, China Medical University Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.02.007DOI Listing
June 2017

Higher neutrophil counts and neutrophil-to-lymphocyte ratio predict prognostic outcomes in patients after non-atrial fibrillation-caused ischemic stroke.

Biomed J 2017 Jun 30;40(3):154-162. Epub 2017 May 30.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Nursing, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.bj.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136280PMC
June 2017

A Randomized Controlled Trial of Glycyrrhizin Plus Tenofovir vs. Tenofovir in Chronic Hepatitis B with Severe Acute Exacerbation.

Clin Transl Gastroenterol 2017 Jun 29;8(6):e104. Epub 2017 Jun 29.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1038/ctg.2017.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518952PMC
June 2017

Impact of impaired cardiac function on the progression of chronic kidney disease---role of pharmacomodulation of valsartan.

Am J Transl Res 2017 15;9(5):2548-2566. Epub 2017 May 15.

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446536PMC
May 2017

Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury.

Am J Transl Res 2017 15;9(4):1543-1560. Epub 2017 Apr 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411908PMC
April 2017

Safety and Effectiveness of Intravenous Thrombolysis for Acute Ischemic Stroke Outside the Coverage of National Health Insurance in Taiwan.

Acta Neurol Taiwan 2017 Mar;26(1):3-12

Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.

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March 2017

Early radiographic response to epidermal growth factor receptor-tyrosine kinase inhibitor in non-small cell lung cancer patients with epidermal growth factor receptor mutations: A prospective study.

Biomed J 2015 May-Jun;38(3):221-8

Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan; Department of Pathology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan; Department of Pathology, Tzu-Chi Medical Center, Taipei Branch, Tzu-Chi University, Taipei, Taiwan.

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http://biomedj.cgu.edu.tw/pdfs/2015/38/3/images/BiomedJ_2015
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http://dx.doi.org/10.4103/2319-4170.138320DOI Listing
December 2016

Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline-induced pulmonary artery hypertension in rat.

Am J Transl Res 2016 15;8(12):5151-5168. Epub 2016 Dec 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical UniversityTaichung 40402, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209472PMC
December 2016

Parkinsonism or Other Movement Disorders Presenting as Stroke Mimics.

Acta Neurol Taiwan 2016 Dec;25(4):124-128

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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December 2016

Preactivated and Disaggregated Shape-Changed Platelets Protected Against Acute Respiratory Distress Syndrome Complicated by Sepsis Through Inflammation Suppression.

Shock 2016 11;46(5):575-586

*Department of Anesthesiology, Chang Gung Memorial Hospital, Institute of Clinical Medical Science, Chang Gung University, Taiwan †Department of Anesthesiology, National Defense Medical Center, Taiwan ‡Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan §Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan ¶Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan ||Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan #Divisions of General Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan **Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan ††Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan ‡‡Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan §§Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan ¶¶Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan ||||Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan ##Department of Nursing, Asia University, Taichung, Taiwan.

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http://dx.doi.org/10.1097/SHK.0000000000000617DOI Listing
November 2016

The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome.

J Pineal Res 2016 Nov 26;61(4):438-456. Epub 2016 Sep 26.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/jpi.12357DOI Listing
November 2016

Validity of a stroke severity index for administrative claims data research: a retrospective cohort study.

BMC Health Serv Res 2016 Sep 22;16(1):509. Epub 2016 Sep 22.

Department of Information Management and Institute of Healthcare Information Management, National Chung Cheng University, 168 University Road, Min-Hsiung, Chiayi County, 62102, Taiwan.

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http://dx.doi.org/10.1186/s12913-016-1769-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034530PMC
September 2016

Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition.

J Pineal Res 2016 Aug 7;61(1):52-68. Epub 2016 Apr 7.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/jpi.12326DOI Listing
August 2016

Combination of adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes for protecting kidney from acute ischemia-reperfusion injury.

Int J Cardiol 2016 Aug 14;216:173-85. Epub 2016 Apr 14.

Department of Orthopedics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine 83301, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.04.061DOI Listing
August 2016

Combined Therapy With Adipose-Derived Mesenchymal Stem Cells and Ciprofloxacin Against Acute Urogenital Organ Damage in Rat Sepsis Syndrome Induced by Intrapelvic Injection of Cecal Bacteria.

Stem Cells Transl Med 2016 Jun 13;5(6):782-92. Epub 2016 Apr 13.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China Institute of Shock Wave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China Department of Nursing, Asia University, Taichung, Taiwan, Republic of China

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http://dx.doi.org/10.5966/sctm.2015-0116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878325PMC
June 2016

"Weekend effect" on stroke mortality revisited: Application of a claims-based stroke severity index in a population-based cohort study.

Medicine (Baltimore) 2016 Jun;95(25):e4046

aDepartment of Neurology, Tainan Sin Lau Hospital bDepartment of Neurology, Chi Mei Medical Center cDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University dDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan eDepartment of Public Health, China Medical University, Taichung fDepartment of Public Health, College of Medicine, Tainan gDivision of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City hDepartment of Nursing, Min-Hwei Junior College of Health Care Management, Tainan, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000004046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998342PMC
June 2016

Human lung cancer-derived microparticles enhanced angiogenesis and growth of hepatoma cells in rodent lung parenchyma.

Am J Transl Res 2016 15;8(3):1302-18. Epub 2016 Mar 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301, Taiwan; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical UniversityTaichung 40402, Taiwan; Department of Nursing, Asia UniversityTaichung 41354, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859621PMC
May 2016

Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study.

PLoS One 2015 28;10(5):e0128671. Epub 2015 May 28.

Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung, Taiwan; Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128671PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447445PMC
April 2016

Relationship between pre-treatment nutritional status, serum glutamine, arginine levels and clinicopathological features in Taiwan colorectal cancer patients.

Asia Pac J Clin Nutr 2015 ;24(4):598-604

Division of Hemato-oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung and Chang Gung University, College of Medicine, Taiwan. Email:

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http://www.apjcn.org/update%5Cpdf%5C0000%5C0%5C2014-0153%5C2
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http://dx.doi.org/10.6133/apjcn.2015.24.4.23DOI Listing
April 2016

Tenofovir versus entecavir in treatment of chronic hepatitis B virus with severe acute exacerbation.

Antimicrob Agents Chemother 2015 16;59(6):3168-73. Epub 2015 Mar 16.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

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http://aac.asm.org/lookup/doi/10.1128/AAC.00261-15
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http://dx.doi.org/10.1128/AAC.00261-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432180PMC
February 2016

Tissue plasminogen activator deficiency preserves neurological function and protects against murine acute ischemic stroke.

Int J Cardiol 2016 Feb 23;205:133-141. Epub 2015 Nov 23.

Department of Orthopedics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.11.168DOI Listing
February 2016

Extracorporeal shock wave therapy effectively prevented diabetic neuropathy.

Am J Transl Res 2015 15;7(12):2543-60. Epub 2015 Dec 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung, 83301, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung, 83301, Taiwan; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung, 83301, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical UniversityTaichung, 40402, Taiwan; Department of Nursing, Asia UniversityTaichung, 41354, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731656PMC
February 2016

Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.

Cell Rep 2016 Jan 7;14(3):479-492. Epub 2016 Jan 7.

Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731243PMC
January 2016

Levels of circulating microparticles in patients with chronic cardiorenal disease.

J Atheroscler Thromb 2015 22;22(3):247-56. Epub 2014 Oct 22.

Division of cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine.

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http://dx.doi.org/10.5551/jat.26658DOI Listing
December 2015

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential.

Cancer Lett 2015 Dec 14;369(1):76-85. Epub 2015 Aug 14.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.07.024DOI Listing
December 2015

Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.

J Pharmacol Exp Ther 2015 Dec 28;355(3):516-27. Epub 2015 Oct 28.

Division of Cardiology, Department of Internal Medicine (Y.-L.C., S.-Y.C., H.-T.C., Y.-L.C., T.-H.H., Y.-Y.Z., P.-H.S., S.C., H.-K.Y.); Division of General Medicine, Department of Internal Medicine (C.-H.C.); Department of Emergency Medicine (C.-F.L.); Division of Thoracic and Cardiovascular Surgery, Department of Surgery (H.-I.L., F.-Y.L., J.-J.S.); Institute for Translational Research in Biomedine (S.C., H.-K.Y.); and Center for Shockwave Medicine and Tissue Engineering (H.-K.Y.), Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Emergency Medicine, E-Da Hospital, I-Shou University School of Medicine for International Students, Kaohsiung, Taiwan (C.-K.S.); and Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan (H.-K.Y.)

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http://dx.doi.org/10.1124/jpet.115.225375DOI Listing
December 2015

Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.

Cell Stem Cell 2015 Dec 29;17(6):689-704. Epub 2015 Oct 29.

Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671830PMC
December 2015

Simple models of the hydrofracture process.

Phys Rev E Stat Nonlin Soft Matter Phys 2015 Dec 29;92(6):062408. Epub 2015 Dec 29.

Earth Sciences and Engineering Division, Upstream Petroleum Engineering Research Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1103/PhysRevE.92.062408DOI Listing
December 2015

Crack Front Segmentation and Facet Coarsening in Mixed-Mode Fracture.

Phys Rev Lett 2015 Dec 30;115(26):265503. Epub 2015 Dec 30.

Physics Department and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1103/PhysRevLett.115.265503DOI Listing
December 2015

Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine.

PLoS One 2014 24;9(6):e99729. Epub 2014 Jun 24.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cancer Research Center and Orthopedics Research Center, Taipei Medical University Hospital, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099729PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069003PMC
November 2015

Developing a stroke severity index based on administrative data was feasible using data mining techniques.

J Clin Epidemiol 2015 Nov 23;68(11):1292-300. Epub 2015 Jan 23.

Department of Information Management and Institute of Healthcare Information Management, National Chung Cheng University, No.168 University Road, Min-Hsiung, Chiayi County 62102, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jclinepi.2015.01.009DOI Listing
November 2015

Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat.

J Pineal Res 2015 Nov 25;59(4):434-47. Epub 2015 Oct 25.

Division of Urology, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/jpi.12273DOI Listing
November 2015

Protective effect of melatonin-supported adipose-derived mesenchymal stem cells against small bowel ischemia-reperfusion injury in rat.

J Pineal Res 2015 Sep 24;59(2):206-20. Epub 2015 Jun 24.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/jpi.12251DOI Listing
September 2015

Delayed Trigeminal Motor Denervation after Pontine Hemorrhage.

J Stroke Cerebrovasc Dis 2015 Sep 25;24(9):e261-3. Epub 2015 Jun 25.

Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.05.026DOI Listing
September 2015

Combined therapy with shock wave and autologous bone marrow-derived mesenchymal stem cells alleviates left ventricular dysfunction and remodeling through inhibiting inflammatory stimuli, oxidative stress & enhancing angiogenesis in a swine myocardial infarction model.

Int J Cardiol 2015 Aug 4;193:69-83. Epub 2015 Mar 4.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Institute of Shock Wave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.03.044DOI Listing
August 2015

Peripheral blood-derived endothelial progenitor cell therapy prevented deterioration of chronic kidney disease in rats.

Am J Transl Res 2015 15;7(5):804-24. Epub 2015 May 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 83301, Taiwan ; Center for Shock Wave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 83301, Taiwan ; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 83301, Taiwan ; Medical University Hospital, China Medical University Taichung, 40402, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494134PMC
July 2015

Does renal dysfunction modify the effect of intravenous thrombolysis for acute ischemic stroke within 4.5 hours of onset? A multicenter observational study.

J Stroke Cerebrovasc Dis 2015 Mar 7;24(3):673-9. Epub 2015 Jan 7.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.11.006DOI Listing
March 2015

Safety of intravenous thrombolysis for ischaemic stroke in Asian octogenarians and nonagenarians.

Age Ageing 2015 Jan 29;44(1):158-61. Epub 2014 Oct 29.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1093/ageing/afu172DOI Listing
January 2015

Identifying renal dysfunction in stroke patients using diagnostic codes in the Taiwan National Health Insurance Research Database.

Int J Stroke 2015 Jan;10(1):E5

Institute of Clinical Pharmacy and Pharmaceutical Science, National Cheng Kung University, Tainan, Taiwan; Department of Neurology, Tainan Sin Lau Hospital, Tainan, Taiwan.

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http://dx.doi.org/10.1111/ijs.12380DOI Listing
January 2015

Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors.

Acta Pharmacol Sin 2015 Jan 15;36(1):119-30. Epub 2014 Dec 15.

1] Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, China [2] Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, China.

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http://dx.doi.org/10.1038/aps.2014.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571325PMC
January 2015

Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: video-assisted therapeutic risk communication.

J Formos Med Assoc 2014 Dec 10;113(12):929-33. Epub 2014 Jan 10.

Stroke Center and Department of Neurology, Tainan Sin Lau Hospital, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2013.11.012DOI Listing
December 2014

Nosocomial extended-spectrum beta-lactamase-producing Klebsiella pneumoniae bacteremia in hemodialysis patients and the implications for antibiotic therapy.

Int J Infect Dis 2014 Nov 6;28:3-7. Epub 2014 Sep 6.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung City 833, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2014.07.012DOI Listing
November 2014

Chronic kidney disease and stroke.

Lancet Neurol 2014 Nov;13(11):1071

Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70199-1DOI Listing
November 2014

Melatonin treatment further improves adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in rat.

J Pineal Res 2014 Oct 27;57(3):248-61. Epub 2014 Aug 27.

Division of Urology, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/jpi.12164DOI Listing
October 2014

Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury.

Am J Transl Res 2014 11;6(5):439-58. Epub 2014 Oct 11.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Taiwan ; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Taiwan ; Institude of Shock Wave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212921PMC
October 2014

Diabetes mellitus is associated with gastroesophageal variceal bleeding in cirrhotic patients.

Kaohsiung J Med Sci 2014 Oct 22;30(10):515-20. Epub 2014 Jul 22.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.kjms.2014.06.002DOI Listing
October 2014

Is renal dysfunction associated with adverse stroke outcome after thrombolytic therapy?

Cerebrovasc Dis 2014 21;37(1):51-6. Epub 2013 Dec 21.

Department of Neurology, Tainan Sin Lau Hospital, Tainan, Taiwan, ROC.

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http://dx.doi.org/10.1159/000356348DOI Listing
September 2014

Different doses of recombinant tissue-type plasminogen activator for acute stroke in Chinese patients.

Stroke 2014 Aug 3;45(8):2359-65. Epub 2014 Jul 3.

From the Graduate Institute of Clinical Medicine and Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (A.-C.C., C.-K.L.); Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (A.-C.C., C.-K.L.); Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan (C.-H.C.); Department of Neurology, Chi-Mei Medical Center, Tainan, Taiwan (H.-J.L.); Department of Neurology, China Medical University Hospital, Taichung, Taiwan (C.-H.L.); Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan (J.-S.J.); Graduate Institute of Clinical Medicine and Department of Neurology, College of Medicine, Taipei Medical University, Taipei, Taiwan (C.-J.H., H.-H.H.); Department of Neurology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan (C.-P.C., W.-Y.S.); and Department of Neurology, Tungs' Taichung Metro Harbor Hospital and Department of Neurology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan (H.-Y.H.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005245DOI Listing
August 2014

Electrophoresis-enhanced detection of deoxyribonucleic acids on a membrane-based lateral flow strip using avian influenza H5 genetic sequence as the model.

Sensors (Basel) 2014 Mar 5;14(3):4399-415. Epub 2014 Mar 5.

Department of Chemical Engineering, Chung Yuan Christian University, Chung Li, Tao Yuan 32023, Taiwan.

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http://www.mdpi.com/1424-8220/14/3/4399
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http://dx.doi.org/10.3390/s140304399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003949PMC
March 2014