Chien-Hsiun Chen

Chien-Hsiun Chen

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Chien-Hsiun Chen

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Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Nat Commun 2018 11 28;9(1):5052. Epub 2018 Nov 28.

Medical Genomics Center, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.

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http://dx.doi.org/10.1038/s41467-018-07345-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261994PMC
November 2018

Recognizing spatial and temporal clustering patterns of dengue outbreaks in Taiwan.

BMC Infect Dis 2018 06 4;18(1):256. Epub 2018 Jun 4.

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 1 University Road Tainan, 701, Tainan, Taiwan.

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http://dx.doi.org/10.1186/s12879-018-3159-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987425PMC
June 2018

Assessing current temporal and space-time anomalies of disease incidence.

PLoS One 2017 13;12(11):e0188065. Epub 2017 Nov 13.

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683561PMC
December 2017

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Authors:
Eleanor Wheeler Aaron Leong Ching-Ti Liu Marie-France Hivert Rona J Strawbridge Clara Podmore Man Li Jie Yao Xueling Sim Jaeyoung Hong Audrey Y Chu Weihua Zhang Xu Wang Peng Chen Nisa M Maruthur Bianca C Porneala Stephen J Sharp Yucheng Jia Edmond K Kabagambe Li-Ching Chang Wei-Min Chen Cathy E Elks Daniel S Evans Qiao Fan Franco Giulianini Min Jin Go Jouke-Jan Hottenga Yao Hu Anne U Jackson Stavroula Kanoni Young Jin Kim Marcus E Kleber Claes Ladenvall Cecile Lecoeur Sing-Hui Lim Yingchang Lu Anubha Mahajan Carola Marzi Mike A Nalls Pau Navarro Ilja M Nolte Lynda M Rose Denis V Rybin Serena Sanna Yuan Shi Daniel O Stram Fumihiko Takeuchi Shu Pei Tan Peter J van der Most Jana V Van Vliet-Ostaptchouk Andrew Wong Loic Yengo Wanting Zhao Anuj Goel Maria Teresa Martinez Larrad Dörte Radke Perttu Salo Toshiko Tanaka Erik P A van Iperen Goncalo Abecasis Saima Afaq Behrooz Z Alizadeh Alain G Bertoni Amelie Bonnefond Yvonne Böttcher Erwin P Bottinger Harry Campbell Olga D Carlson Chien-Hsiun Chen Yoon Shin Cho W Timothy Garvey Christian Gieger Mark O Goodarzi Harald Grallert Anders Hamsten Catharina A Hartman Christian Herder Chao Agnes Hsiung Jie Huang Michiya Igase Masato Isono Tomohiro Katsuya Chiea-Chuen Khor Wieland Kiess Katsuhiko Kohara Peter Kovacs Juyoung Lee Wen-Jane Lee Benjamin Lehne Huaixing Li Jianjun Liu Stephane Lobbens Jian'an Luan Valeriya Lyssenko Thomas Meitinger Tetsuro Miki Iva Miljkovic Sanghoon Moon Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Ramaiah Nagaraja Matthias Nauck James S Pankow Ozren Polasek Inga Prokopenko Paula S Ramos Laura Rasmussen-Torvik Wolfgang Rathmann Stephen S Rich Neil R Robertson Michael Roden Ronan Roussel Igor Rudan Robert A Scott William R Scott Bengt Sennblad David S Siscovick Konstantin Strauch Liang Sun Morris Swertz Salman M Tajuddin Kent D Taylor Yik-Ying Teo Yih Chung Tham Anke Tönjes Nicholas J Wareham Gonneke Willemsen Tom Wilsgaard Aroon D Hingorani Josephine Egan Luigi Ferrucci G Kees Hovingh Antti Jula Mika Kivimaki Meena Kumari Inger Njølstad Colin N A Palmer Manuel Serrano Ríos Michael Stumvoll Hugh Watkins Tin Aung Matthias Blüher Michael Boehnke Dorret I Boomsma Stefan R Bornstein John C Chambers Daniel I Chasman Yii-Der Ida Chen Yduan-Tsong Chen Ching-Yu Cheng Francesco Cucca Eco J C de Geus Panos Deloukas Michele K Evans Myriam Fornage Yechiel Friedlander Philippe Froguel Leif Groop Myron D Gross Tamara B Harris Caroline Hayward Chew-Kiat Heng Erik Ingelsson Norihiro Kato Bong-Jo Kim Woon-Puay Koh Jaspal S Kooner Antje Körner Diana Kuh Johanna Kuusisto Markku Laakso Xu Lin Yongmei Liu Ruth J F Loos Patrik K E Magnusson Winfried März Mark I McCarthy Albertine J Oldehinkel Ken K Ong Nancy L Pedersen Mark A Pereira Annette Peters Paul M Ridker Charumathi Sabanayagam Michele Sale Danish Saleheen Juha Saltevo Peter Eh Schwarz Wayne H H Sheu Harold Snieder Timothy D Spector Yasuharu Tabara Jaakko Tuomilehto Rob M van Dam James G Wilson James F Wilson Bruce H R Wolffenbuttel Tien Yin Wong Jer-Yuarn Wu Jian-Min Yuan Alan B Zonderman Nicole Soranzo Xiuqing Guo David J Roberts Jose C Florez Robert Sladek Josée Dupuis Andrew P Morris E-Shyong Tai Elizabeth Selvin Jerome I Rotter Claudia Langenberg Inês Barroso James B Meigs

PLoS Med 2017 Sep 12;14(9):e1002383. Epub 2017 Sep 12.

Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595282PMC
September 2017

Genetic loci associated with an earlier age at onset in multiplex schizophrenia.

Sci Rep 2017 07 25;7(1):6486. Epub 2017 Jul 25.

National Taiwan University, College of Public Health, Institute of Epidemiology and Preventive Medicine, Taipei, 100, Taiwan.

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http://dx.doi.org/10.1038/s41598-017-06795-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527118PMC
July 2017

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Authors:
Cassandra N Spracklen Peng Chen Young Jin Kim Xu Wang Hui Cai Shengxu Li Jirong Long Ying Wu Ya Xing Wang Fumihiko Takeuchi Jer-Yuarn Wu Keum-Ji Jung Cheng Hu Koichi Akiyama Yonghong Zhang Sanghoon Moon Todd A Johnson Huaixing Li Rajkumar Dorajoo Meian He Maren E Cannon Tamara S Roman Elias Salfati Keng-Hung Lin Xiuqing Guo Wayne H H Sheu Devin Absher Linda S Adair Themistocles L Assimes Tin Aung Qiuyin Cai Li-Ching Chang Chien-Hsiun Chen Li-Hsin Chien Lee-Ming Chuang Shu-Chun Chuang Shufa Du Qiao Fan Cathy S J Fann Alan B Feranil Yechiel Friedlander Penny Gordon-Larsen Dongfeng Gu Lixuan Gui Zhirong Guo Chew-Kiat Heng James Hixson Xuhong Hou Chao Agnes Hsiung Yao Hu Mi Yeong Hwang Chii-Min Hwu Masato Isono Jyh-Ming Jimmy Juang Chiea-Chuen Khor Yun Kyoung Kim Woon-Puay Koh Michiaki Kubo I-Te Lee Sun-Ju Lee Wen-Jane Lee Kae-Woei Liang Blanche Lim Sing-Hui Lim Jianjun Liu Toru Nabika Wen-Harn Pan Hao Peng Thomas Quertermous Charumathi Sabanayagam Kevin Sandow Jinxiu Shi Liang Sun Pok Chien Tan Shu-Pei Tan Kent D Taylor Yik-Ying Teo Sue-Anne Toh Tatsuhiko Tsunoda Rob M van Dam Aili Wang Feijie Wang Jie Wang Wen Bin Wei Yong-Bing Xiang Jie Yao Jian-Min Yuan Rong Zhang Wanting Zhao Yii-Der Ida Chen Stephen S Rich Jerome I Rotter Tzung-Dau Wang Tangchun Wu Xu Lin Bok-Ghee Han Toshihiro Tanaka Yoon Shin Cho Tomohiro Katsuya Weiping Jia Sun-Ha Jee Yuan-Tsong Chen Norihiro Kato Jost B Jonas Ching-Yu Cheng Xiao-Ou Shu Jiang He Wei Zheng Tien-Yin Wong Wei Huang Bong-Jo Kim E-Shyong Tai Karen L Mohlke Xueling Sim

Hum Mol Genet 2017 05;26(9):1770-1784

Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1093/hmg/ddx062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075203PMC
May 2017

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.

Circ Cardiovasc Genet 2017 Apr;10(2):e001527

From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Korea (Y.K.K., J.L., S.H., B.-G.H., S.M., B.-J.K.); Genome Institute of Singapore, Agency for Science, Technology and Research (R.D., J.L., Y.-Y.T.); Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences (H.L., Y.H., Y.W., L.S., X.L.); National Yang-Ming University Hospital, Taipei, Taiwan (I-T.L.); National Yang-Ming University Hospital, Taipei, Taiwan; Singapore Eye Research Institute, Singapore National Eye Center (Y.C., Y.K., Y.Z., N.K., T.Y.W.); Duke-NUS Graduate Medical School, National University of Singapore, (Y.C., N.K., T.Y.W., E-S.T.); Department of Ophthalmology (Y.C., T.Y.W.), Department of Statistics and Applied Probability (Y.-Y.T.), Life Sciences Institute (Y.-Y.T.), NUS Graduate School for Integrative Science and Engineering (Y.-Y.T.), Department of Medicine, National University Health System, Singapore (E-S.T.); MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.H., H.H., L.G., Y.H., T.W.); Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, Taiwan (I-T.L., W.H-h.S); School of Medicine, National Yang-Ming University, Taipei, Taiwan (W.H-h.S., K.-W.L.); Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., K.D.T., J.I.R., Y.-d.I.C.); Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, Ann Arbor (S.K.G.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.L., Y.-Y.T., X.S., E-S.T.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R.); Department of Medical Genetics (F.-J.T.) and School of Chinese Medicine (C.-H.C., J.-Y.W.), China Medical University Hospital, Taichung, Taiwan; Department of Medicine, Columbia University Medical Center, New York, NY (W.P.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Department of Internal Medicine, Ditmanson Medical Foundation, Chiayi Christian Hospital, Taiwan (C.H.L.); Department of Business Administration, National Chung Cheng University, Chia-yi, Taiwan (C.H.L.); Department of Nursing, DaYeh University, Changhua, Taiwan (C.H.L.); Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (W.-J.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (C.-H.C., J.-Y.W.); Department of Ophthalmology and Visual Science, Khoo Teck Puat Hospital, Singapore, Singapore (N.K.); Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (L.J.R.); and Department of Epidemiology and Biostatistics, University of Georgia at Athens, Athens (C.L.); Department of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan (K.-W.L.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704911PMC
April 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

Identification of Susceptible Loci and Enriched Pathways for Bipolar II Disorder Using Genome-Wide Association Studies.

Int J Neuropsychopharmacol 2016 12 3;19(12). Epub 2016 Dec 3.

Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan (Dr Kao, Mr Lee, and Dr Kuo); Department of Agronomy, College of Agriculture & Natural Resources, National Chung Hsing University, Taichung, Taiwan (Dr Kao); National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (Mrs Chen, Dr Yang, Dr Chen, and Dr Wu); Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan (Dr Chen); Department of Nursing, Cardinal Tien Junior College of Healthcare & Management, Yilan, Taiwan (Dr Chuang); Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan (Drs Huang, Chiu, and Lin); Department of Psychiatry, Taipei City Psychiatric Center, Taipei, Taiwan (Dr Huang); Department of Psychiatry, Wan Fang Medical Center, Taipei, Taiwan (Dr Chiu); Department of Psychiatry, Taipei City Hospital and Psychiatric Center, Taipei, Taiwan (Dr Lin); Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan (Dr Liu); Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan (Dr Liu); Department of Psychiatry, National Cheng Kung University and Hospital, Tainan, Taiwan (Dr Lu); Research Center for Genes, Environment and Human Health, National Taiwan University, Taipei, Taiwan (Dr Kuo).

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http://dx.doi.org/10.1093/ijnp/pyw064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203756PMC
December 2016

Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study.

Hum Genet 2016 Nov 8;135(11):1287-1294. Epub 2016 Aug 8.

National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, 128 Sec. 2, Academia Rd. Nankang, Taipei, 11529, Taiwan.

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http://dx.doi.org/10.1007/s00439-016-1716-0DOI Listing
November 2016

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.

Anal Chem 2016 11 21;88(21):10661-10666. Epub 2016 Oct 21.

Institute of Biomedical Sciences, Academia Sinica , Taipei 11529, Taiwan.

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http://dx.doi.org/10.1021/acs.analchem.6b03109DOI Listing
November 2016

Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.

PLoS One 2015 23;10(9):e0138695. Epub 2015 Sep 23.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580585PMC
June 2016

Novel susceptibility gene for nonfamilial hypokalemic periodic paralysis.

Neurology 2016 Mar 2;86(13):1190-8. Epub 2016 Mar 2.

From the Institute of Biomedical Sciences (I.-W.S., C.-H.C., Y.-C.C., J.-H.Y., Y.-T.C., J.-Y.W.), Academia Sinica; Graduate Institute of Life Science (I.-W.S.), Division of Nephrology, Department of Medicine, Tri-Service General Hospital (C.-C.S., C.-J.C., S.-S.Y., S.-H.L.), and Graduate Institute of Medical Science (C.-C.S., S.-S.Y., S.-H.L.), National Defense Medical Center, Taipei, Taiwan; Department of Pediatrics (Y.-T.C.), Duke University Medical Center, Durham, NC; and Graduate Institute of Chinese Medical Science (J.-Y.W.), China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1212/WNL.0000000000002524DOI Listing
March 2016

An integrated analysis tool for analyzing hybridization intensities and genotypes using new-generation population-optimized human arrays.

BMC Genomics 2016 Mar 31;17:266. Epub 2016 Mar 31.

Bioinformatics Program, Taiwan International Graduate Program, Institute of Information Science, Academia Sinica, Taipei, 115, Taiwan.

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http://dx.doi.org/10.1186/s12864-016-2478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815280PMC
March 2016

Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder.

PLoS One 2015 19;10(3):e0121245. Epub 2015 Mar 19.

Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Research Center for Genes, Environment and Human Health, National Taiwan University, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366256PMC
February 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets.

J Clin Med 2015 Sep 15;4(9):1798-814. Epub 2015 Sep 15.

Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

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http://dx.doi.org/10.3390/jcm4091798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600160PMC
September 2015

CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease.

Circ Res 2015 Feb 20;116(5):876-83. Epub 2015 Jan 20.

From the Institute of Biomedical Sciences (T.-M.K., S.-P.C., Y.-M.L., H.-W.C., C.-H.C., J.-Y.W., Y.-T.C.) and Institute of Cellular and Organismic Biology (Y.-C.L.), Academia Sinica, Taipei, Taiwan; Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan (H.-C.K.); Chang Gung University College of Medicine, Taoyuan, Taiwan (H.-C.K.); Department of Pediatric Cardiology, Children's Hospital of China Medical University, Taichung, Taiwan (J.-S.C.); School of Medicine (J.-S.C.), School of Chinese Medicine (F.-J.T.), and Department of Medical Genetics (F.-J.T., C.-H.C., J.-Y.W.), China Medical University Hospital, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan (F.-J.T.); and Department of Pediatrics, Duke University Medical Center, Durham, NC (Y.-T.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305834DOI Listing
February 2015

Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms.

Cell Biosci 2014 19;4(1):67. Epub 2014 Nov 19.

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan ; School of Chinese Medicine, China Medical University, Taichung, Taiwan ; Asia University, Taichung, Taiwan.

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http://dx.doi.org/10.1186/2045-3701-4-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258047PMC
December 2014

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

Hum Mol Genet 2014 Oct 26;23(20):5492-504. Epub 2014 May 26.

Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.

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http://hmg.oxfordjournals.org/content/early/2014/06/20/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu248
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http://dx.doi.org/10.1093/hmg/ddu248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168820PMC
October 2014

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.

Diabetes 2014 Jul 19;63(7):2551-62. Epub 2014 Mar 19.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDuke-National University of Singapore Graduate Medical School, Singapore

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http://dx.doi.org/10.2337/db13-1815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284402PMC
July 2014

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Authors:
Anubha Mahajan Min Jin Go Weihua Zhang Jennifer E Below Kyle J Gaulton Teresa Ferreira Momoko Horikoshi Andrew D Johnson Maggie C Y Ng Inga Prokopenko Danish Saleheen Xu Wang Eleftheria Zeggini Goncalo R Abecasis Linda S Adair Peter Almgren Mustafa Atalay Tin Aung Damiano Baldassarre Beverley Balkau Yuqian Bao Anthony H Barnett Ines Barroso Abdul Basit Latonya F Been John Beilby Graeme I Bell Rafn Benediktsson Richard N Bergman Bernhard O Boehm Eric Boerwinkle Lori L Bonnycastle Noël Burtt Qiuyin Cai Harry Campbell Jason Carey Stephane Cauchi Mark Caulfield Juliana C N Chan Li-Ching Chang Tien-Jyun Chang Yi-Cheng Chang Guillaume Charpentier Chien-Hsiun Chen Han Chen Yuan-Tsong Chen Kee-Seng Chia Manickam Chidambaram Peter S Chines Nam H Cho Young Min Cho Lee-Ming Chuang Francis S Collins Marylin C Cornelis David J Couper Andrew T Crenshaw Rob M van Dam John Danesh Debashish Das Ulf de Faire George Dedoussis Panos Deloukas Antigone S Dimas Christian Dina Alex S Doney Peter J Donnelly Mozhgan Dorkhan Cornelia van Duijn Josée Dupuis Sarah Edkins Paul Elliott Valur Emilsson Raimund Erbel Johan G Eriksson Jorge Escobedo Tonu Esko Elodie Eury Jose C Florez Pierre Fontanillas Nita G Forouhi Tom Forsen Caroline Fox Ross M Fraser Timothy M Frayling Philippe Froguel Philippe Frossard Yutang Gao Karl Gertow Christian Gieger Bruna Gigante Harald Grallert George B Grant Leif C Grrop Chrisropher J Groves Elin Grundberg Candace Guiducci Anders Hamsten Bok-Ghee Han Kazuo Hara Neelam Hassanali Andrew T Hattersley Caroline Hayward Asa K Hedman Christian Herder Albert Hofman Oddgeir L Holmen Kees Hovingh Astradur B Hreidarsson Cheng Hu Frank B Hu Jennie Hui Steve E Humphries Sarah E Hunt David J Hunter Kristian Hveem Zafar I Hydrie Hiroshi Ikegami Thomas Illig Erik Ingelsson Muhammed Islam Bo Isomaa Anne U Jackson Tazeen Jafar Alan James Weiping Jia Karl-Heinz Jöckel Anna Jonsson Jeremy B M Jowett Takashi Kadowaki Hyun Min Kang Stavroula Kanoni Wen Hong L Kao Sekar Kathiresan Norihiro Kato Prasad Katulanda Kirkka M Keinanen-Kiukaanniemi Ann M Kelly Hassan Khan Kay-Tee Khaw Chiea-Chuen Khor Hyung-Lae Kim Sangsoo Kim Young Jin Kim Leena Kinnunen Norman Klopp Augustine Kong Eeva Korpi-Hyövälti Sudhir Kowlessur Peter Kraft Jasmina Kravic Malene M Kristensen S Krithika Ashish Kumar Jesus Kumate Johanna Kuusisto Soo Heon Kwak Markku Laakso Vasiliki Lagou Timo A Lakka Claudia Langenberg Cordelia Langford Robert Lawrence Karin Leander Jen-Mai Lee Nanette R Lee Man Li Xinzhong Li Yun Li Junbin Liang Samuel Liju Wei-Yen Lim Lars Lind Cecilia M Lindgren Eero Lindholm Ching-Ti Liu Jian Jun Liu Stéphane Lobbens Jirong Long Ruth J F Loos Wei Lu Jian'an Luan Valeriya Lyssenko Ronald C W Ma Shiro Maeda Reedik Mägi Satu Männisto David R Matthews James B Meigs Olle Melander Andres Metspalu Julia Meyer Ghazala Mirza Evelin Mihailov Susanne Moebus Viswanathan Mohan Karen L Mohlke Andrew D Morris Thomas W Mühleisen Martina Müller-Nurasyid Bill Musk Jiro Nakamura Eitaro Nakashima Pau Navarro Peng-Keat Ng Alexandra C Nica Peter M Nilsson Inger Njølstad Markus M Nöthen Keizo Ohnaka Twee Hee Ong Katharine R Owen Colin N A Palmer James S Pankow Kyong Soo Park Melissa Parkin Sonali Pechlivanis Nancy L Pedersen Leena Peltonen John R B Perry Annette Peters Janini M Pinidiyapathirage Carl G Platou Simon Potter Jackie F Price Lu Qi Venkatesan Radha Loukianos Rallidis Asif Rasheed Wolfgang Rathman Rainer Rauramaa Soumya Raychaudhuri N William Rayner Simon D Rees Emil Rehnberg Samuli Ripatti Neil Robertson Michael Roden Elizabeth J Rossin Igor Rudan Denis Rybin Timo E Saaristo Veikko Salomaa Juha Saltevo Maria Samuel Dharambir K Sanghera Jouko Saramies James Scott Laura J Scott Robert A Scott Ayellet V Segrè Joban Sehmi Bengt Sennblad Nabi Shah Sonia Shah A Samad Shera Xiao Ou Shu Alan R Shuldiner Gunnar Sigurđsson Eric Sijbrands Angela Silveira Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Wing Yee So Alena Stančáková Kari Stefansson Gerald Steinbach Valgerdur Steinthorsdottir Kathleen Stirrups Rona J Strawbridge Heather M Stringham Qi Sun Chen Suo Ann-Christine Syvänen Ryoichi Takayanagi Fumihiko Takeuchi Wan Ting Tay Tanya M Teslovich Barbara Thorand Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Joseph Trakalo Elena Tremoli Mieke D Trip Fuu Jen Tsai Tiinamaija Tuomi Jaakko Tuomilehto Andre G Uitterlinden Adan Valladares-Salgado Sailaja Vedantam Fabrizio Veglia Benjamin F Voight Congrong Wang Nicholas J Wareham Roman Wennauer Ananda R Wickremasinghe Tom Wilsgaard James F Wilson Steven Wiltshire Wendy Winckler Tien Yin Wong Andrew R Wood Jer-Yuarn Wu Ying Wu Ken Yamamoto Toshimasa Yamauchi Mingyu Yang Loic Yengo Mitsuhiro Yokota Robin Young Delilah Zabaneh Fan Zhang Rong Zhang Wei Zheng Paul Z Zimmet David Altshuler Donald W Bowden Yoon Shin Cho Nancy J Cox Miguel Cruz Craig L Hanis Jaspal Kooner Jong-Young Lee Mark Seielstad Yik Ying Teo Michael Boehnke Esteban J Parra Jonh C Chambers E Shyong Tai Mark I McCarthy Andrew P Morris

Nat Genet 2014 Mar 9;46(3):234-44. Epub 2014 Feb 9.

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http://dx.doi.org/10.1038/ng.2897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969612PMC
March 2014

Novel susceptibility genes associated with diabetic cataract in a Taiwanese population.

Ophthalmic Genet 2013 Mar-Jun;34(1-2):35-42. Epub 2012 Nov 9.

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.3109/13816810.2012.736590DOI Listing
August 2013

Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome.

Circ J 2012 20;76(9):2226-33. Epub 2012 Jun 20.

Department of Emergency Medicine, Chang-Gung Memorial Hospital, Linkuo, Taiwan.

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http://dx.doi.org/10.1253/circj.cj-12-0238DOI Listing
February 2013

Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort.

Parkinsonism Relat Disord 2013 Feb 20;19(2):251-5. Epub 2012 Nov 20.

Human Molecular Genetics Laboratory, Department of Medical Research, Chang Gung Memorial Hospital and Chang Gung University, Kweishan, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.parkreldis.2012.10.019DOI Listing
February 2013

Procalcitonin as a biomarker for bacterial infections in patients with liver cirrhosis in the emergency department.

Acad Emerg Med 2011 Feb 28;18(2):121-6. Epub 2011 Jan 28.

Department of Emergency Medicine, Chang-Gung Memorial Hospital, Keelung Branch, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1111/j.1553-2712.2010.00991.xDOI Listing
February 2011

A comparative study to screen dementia and APOE genotypes in an ageing East African population.

Neurobiol Aging 2010 May 13;31(5):732-40. Epub 2008 Aug 13.

Laboratory of Neurogeriatrics, Department of Neurology and Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857314PMC
May 2010

Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.

Pharmacogenomics 2010 Mar;11(3):349-56

Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 11529, Taiwan.

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http://dx.doi.org/10.2217/pgs.09.162DOI Listing
March 2010

Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect.

Fertil Steril 2010 Jan 5;93(1):141-9. Epub 2008 Nov 5.

Departments of Obstetrics and Gynecology, National Cheng Kung University College of Medicine, Tainan City, Taiwan, Republic of China.

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http://dx.doi.org/10.1016/j.fertnstert.2008.09.030DOI Listing
January 2010

Genetic determinants of warfarin dosing in the Han-Chinese population.

Pharmacogenomics 2009 Dec;10(12):1905-13

Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, NanKang, Taipei, Taiwan.

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http://dx.doi.org/10.2217/pgs.09.106DOI Listing
December 2009

Mapping human genetic diversity in Asia.

Science 2009 Dec;326(5959):1541-5

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http://dx.doi.org/10.1126/science.1177074DOI Listing
December 2009

VKORC1 haplotypes in five East-Asian populations and Indians.

Pharmacogenomics 2009 Oct;10(10):1609-16

Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, NanKang, Taipei, Taiwan.

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http://dx.doi.org/10.2217/pgs.09.80DOI Listing
October 2009

Acculturation, psychiatric comorbidity and posttraumatic stress disorder in a Taiwanese aboriginal population.

Soc Psychiatry Psychiatr Epidemiol 2009 Jan 11;44(1):55-62. Epub 2008 Jul 11.

Department of Psychiatry, Lo-Tung Poh-Ai Hospital, Yilan, Taiwan.

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http://dx.doi.org/10.1007/s00127-008-0405-2DOI Listing
January 2009

Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke.

J Am Coll Cardiol 2008 Jun;51(22):2173-80

Section of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jacc.2008.01.060DOI Listing
June 2008

Glutamate decarboxylase genes and alcoholism in Han Taiwanese men.

Alcohol Clin Exp Res 2006 Nov;30(11):1817-23

Division of Mental Health and Drug Abuse Research, National Health Research Institutes, Taipei, Taiwan.

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http://dx.doi.org/10.1111/j.1530-0277.2006.00218.xDOI Listing
November 2006

Data mining of the GAW14 simulated data using rough set theory and tree-based methods.

BMC Genet 2005 Dec 30;6 Suppl 1:S133. Epub 2005 Dec 30.

Institute of Biomedical Sciences, Academia Sinica, Huafan University, Taipei, Taiwan.

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http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156
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http://dx.doi.org/10.1186/1471-2156-6-S1-S133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866803PMC
December 2005

Construction of endophenotypes for complex diseases in the presence of heterogeneity.

BMC Genet 2005 Dec 30;6 Suppl 1:S139. Epub 2005 Dec 30.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866797PMC
December 2005

Association between transforming growth factor-beta1 gene C-509T and T869C polymorphisms and rheumatic heart disease.

Am Heart J 2004 Jul;148(1):181-6

Division of Cardiology, Department of Medicine, China Medical University Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.ahj.2004.03.032DOI Listing
July 2004

A genome-wide scan using tree-based association analysis for candidate loci related to fasting plasma glucose levels.

BMC Genet 2003 Dec 31;4 Suppl 1:S65. Epub 2003 Dec 31.

The Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1186/1471-2156-4-S1-S65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866503PMC
December 2003

Segregation analysis of blood pressure and body mass index in a rural US community.

Hum Biol 2002 Feb;74(1):11-23

Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA.

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February 2002