Chieh-Chen Huang

Chieh-Chen Huang

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Chieh-Chen Huang

Chieh-Chen Huang

Publications by authors named "Chieh-Chen Huang"

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75Publications

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Biomimetic strategy for constructing cellulosomal operons in .

Biotechnol Biofuels 2018 7;11:157. Epub 2018 Jun 7.

5Department of Life Sciences, National Chung Hsing University, Taichung, 40227 Taiwan.

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June 2018

Constructing a cellulosic yeast host with an efficient cellulase cocktail.

Biotechnol Bioeng 2018 03 19;115(3):751-761. Epub 2017 Dec 19.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.

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March 2018

Metabolic engineering a yeast to produce astaxanthin.

Bioresour Technol 2017 Dec 23;245(Pt A):899-905. Epub 2017 Jul 23.

Biodiversity Research Center, Academia Sinica, No. 128 Academia Road, Sec. 2, Nankang, Taipei 115, Taiwan; Department of Life Sciences, National Chung Hsing University, No. 250, Kuo Kuang Rd, Taichung 402, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, No. 91 Hsueh-Shih Road, Taichung 402, Taiwan; Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, United States. Electronic address:

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December 2017

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway.

Mol Med Rep 2017 Oct 10;16(4):5480-5488. Epub 2017 Aug 10.

Central Laboratory, Shin‑Kong Wu Ho‑Su Memorial Hospital, Taipei 11101, Taiwan R.O.C.

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October 2017

Improved n-butanol production via co-expression of membrane-targeted tilapia metallothionein and the clostridial metabolic pathway in Escherichia coli.

BMC Biotechnol 2017 04 11;17(1):36. Epub 2017 Apr 11.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

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April 2017

Genomic sequence analysis of a plant-associated Photobacterium halotolerans MELD1: from marine to terrestrial environment?

Stand Genomic Sci 2016 1;11(1):56. Epub 2016 Sep 1.

Department of Lifesciences, National Chung Hsing University, 145 Xingda Road, Taichung, Taiwan.

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September 2016

CircNet: a database of circular RNAs derived from transcriptome sequencing data.

Nucleic Acids Res 2016 Jan 7;44(D1):D209-15. Epub 2015 Oct 7.

Institute of Bioinformatics and Systems Biology, National Chiao Tung University, HsinChu, Taiwan Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan Center for Bioinformatics Research, National Chiao Tung University, Hsinchu 300, Taiwan Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

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January 2016

Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells.

Nucleic Acids Res 2016 Jan 23;44(D1):D944-51. Epub 2015 Nov 23.

Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan PhD Program in Medical Biotechnology National Chung Hsing University, Taichung 402, Taiwan

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January 2016

Draft Genome Sequence of Burkholderia cenocepacia Strain 869T2, a Plant-Beneficial Endophytic Bacterium.

Genome Announc 2015 Nov 12;3(6). Epub 2015 Nov 12.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan

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November 2015

Bio-butanol production from glycerol with Clostridium pasteurianum CH4: the effects of butyrate addition and in situ butanol removal via membrane distillation.

Biotechnol Biofuels 2015 13;8:168. Epub 2015 Oct 13.

Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan ; Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan ; Research Center for Energy Technology and Strategy, National Cheng Kung University, Tainan, Taiwan.

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October 2015

Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR.

Nucleic Acids Res 2015 Sep 6;43(15):7612-23. Epub 2015 Jul 6.

Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan Institute of Biochemistry, College of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan Agricultural Biotechnology Centre, National Chung Hsing University, Taichung 402, Taiwan

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September 2015

Infection Control Programs and Antibiotic Control Programs to Limit Transmission of Multi-Drug Resistant Acinetobacter baumannii Infections: Evolution of Old Problems and New Challenges for Institutes.

Int J Environ Res Public Health 2015 Jul 30;12(8):8871-82. Epub 2015 Jul 30.

Department of Life Science, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 402, Taiwan.

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July 2015

Anti-photoaging effects of soy isoflavone extract (aglycone and acetylglucoside form) from soybean cake.

Int J Mol Sci 2010 24;11(12):4782-95. Epub 2010 Nov 24.

School of Medicine, Fu Jen Catholic University, Taipei, Taiwan; E-Mail:

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June 2015

Improving protein production of indigenous microalga Chlorella vulgaris FSP-E by photobioreactor design and cultivation strategies.

Biotechnol J 2015 Jun 5;10(6):905-14. Epub 2015 May 5.

Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.

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June 2015

Genome Sequence of Photobacterium halotolerans MELD1, with Mercury Reductase (merA), Isolated from Phragmites australis.

Genome Announc 2015 Jun 4;3(3). Epub 2015 Jun 4.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan

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June 2015

Effects of nitrogen source availability and bioreactor operating strategies on lutein production with Scenedesmus obliquus FSP-3.

Bioresour Technol 2015 May 19;184:131-138. Epub 2014 Oct 19.

Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan; Research Center for Energy Technology and Strategy Center, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:

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May 2015

Integrating an algal β-carotene hydroxylase gene into a designed carotenoid-biosynthesis pathway increases carotenoid production in yeast.

Bioresour Technol 2015 May 3;184:2-8. Epub 2014 Dec 3.

Department of Life Sciences, National Chung Hsing University, No. 250, Kuo Kuang Rd, Taichung 402, Taiwan. Electronic address:

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May 2015

Role of voltage-gated K(+) channels in regulating Ca(2+) entry in rat cortical astrocytes.

J Physiol Sci 2015 Mar 24;65(2):171-7. Epub 2015 Jan 24.

Department of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.

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March 2015

Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine.

Pharmacol Rep 2014 Aug 24;66(4):576-84. Epub 2014 Apr 24.

Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan. Electronic address:

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August 2014

Tracing the emergence of multidrug-resistant Acinetobacter baumannii in a Taiwanese hospital by evaluating the presence of integron gene intI1.

J Negat Results Biomed 2014 Aug 14;13:15. Epub 2014 Aug 14.

College of Life Science, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 402, Taiwan.

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August 2014

Fixed-bed biosorption of cadmium using immobilized Scenedesmus obliquus CNW-N cells on loofa (Luffa cylindrica) sponge.

Bioresour Technol 2014 May 11;160:175-81. Epub 2014 Feb 11.

Center for Biosciences and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan; Research Center for Energy Technology and Strategy, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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May 2014

Engineering strategies for enhancing the production of eicosapentaenoic acid (EPA) from an isolated microalga Nannochloropsis oceanica CY2.

Bioresour Technol 2013 Nov 13;147:160-7. Epub 2013 Aug 13.

University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:

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November 2013

Fermentation approach for enhancing 1-butanol production using engineered butanologenic Escherichia coli.

Bioresour Technol 2013 Oct 6;145:204-9. Epub 2013 Feb 6.

Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.

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October 2013

Construction of a plant-microbe phytoremediation system: combination of vetiver grass with a functional endophytic bacterium, Achromobacter xylosoxidans F3B, for aromatic pollutants removal.

Bioresour Technol 2013 Oct 7;145:43-7. Epub 2013 Mar 7.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC.

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October 2013

Knockdown of PsbO leads to induction of HydA and production of photobiological H2 in the green alga Chlorella sp. DT.

Bioresour Technol 2013 Sep 4;143:154-62. Epub 2013 Jun 4.

Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan.

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September 2013

Risk factor analysis for extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections in central Taiwan.

BMC Infect Dis 2013 Sep 8;13:417. Epub 2013 Sep 8.

College of Life Science, National Chung Hsing University, No, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.

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September 2013

Improvement of n-butanol tolerance in Escherichia coli by membrane-targeted tilapia metallothionein.

Biotechnol Biofuels 2013 Sep 11;6(1):130. Epub 2013 Sep 11.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

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September 2013

Molecular epidemiological study of clinical Acinetobacter baumannii isolates: phenotype switching of antibiotic resistance.

Ann Clin Microbiol Antimicrob 2013 Aug 21;12:21. Epub 2013 Aug 21.

Department of Life Science, College of Life Science, National Chung Hsing University, No, 250 Kuo-Kuang Road, Taichung 402, Taiwan, R,O,C.

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August 2013

Two case reports of gastroendoscopy-associated Acinetobacter baumannii bacteremia.

World J Gastroenterol 2013 May;19(18):2835-40

Section of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.

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May 2013

Assembling a cellulase cocktail and a cellodextrin transporter into a yeast host for CBP ethanol production.

Biotechnol Biofuels 2013 Feb 4;6(1):19. Epub 2013 Feb 4.

Biodiversity Research Center, Academia Sinica, 115, Taipei, Taiwan.

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February 2013

Enhancement of photoheterotrophic biohydrogen production at elevated temperatures by the expression of a thermophilic clostridial hydrogenase.

Appl Microbiol Biotechnol 2012 Aug 30;95(4):969-77. Epub 2012 Mar 30.

Department of Life Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan, Republic of China.

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August 2012

Characterization of Gordonia sp. strain CC-NAPH129-6 capable of naphthalene degradation.

Microbiol Res 2012 Jul 11;167(7):395-404. Epub 2012 Jan 11.

Department of Soil and Environmental Sciences, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan, ROC.

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July 2012

PGASO: A synthetic biology tool for engineering a cellulolytic yeast.

Biotechnol Biofuels 2012 Jul 27;5(1):53. Epub 2012 Jul 27.

Biodiversity Research Center, Academia Sinica, Taipei, 115, Taiwan.

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July 2012

Microbial community analysis in the termite gut and fungus comb of Odontotermes formosanus: the implication of Bacillus as mutualists.

FEMS Microbiol Ecol 2012 Feb 22;79(2):504-17. Epub 2011 Nov 22.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

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February 2012

The flexibility of UV-inducible mutation in Deinococcus ficus as evidenced by the existence of the imuB-dnaE2 gene cassette and generation of superior feather degrading bacteria.

Microbiol Res 2011 Dec 2;167(1):40-7. Epub 2011 Apr 2.

Department of Soil and Environmental Sciences, College of Agriculture and Natural Resources, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan.

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December 2011

Novel nanohybrids of silver particles on clay platelets for inhibiting silver-resistant bacteria.

PLoS One 2011 17;6(6):e21125. Epub 2011 Jun 17.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

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October 2011

Genetic improvement of butanol tolerance in Escherichia coli by cell surface expression of fish metallothionein.

Bioeng Bugs 2011 Jan-Feb;2(1):55-7

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC.

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September 2011

Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage.

J Agric Food Chem 2011 Aug 6;59(15):8391-400. Epub 2011 Jul 6.

Department of Dermatology, Mackay Memorial Hospital, Hsinchu, Taiwan.

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August 2011

Splicing of a bacterial group II intron from bacillus megaterium is independent of intron-encoded protein.

Microbes Environ 2009 ;24(1):28-32

Faculty of Engineering, Tohoku Gakuin University, 1-13-1, Chuo, Tagajo 985-8537, Japan..

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July 2011

Control of ionic selectivity by a pore helix residue in the Kv1.2 channel.

J Physiol Sci 2010 Nov 15;60(6):441-6. Epub 2010 Sep 15.

Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan.

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November 2010

Zeaxanthin inhibits PDGF-BB-induced migration in human dermal fibroblasts.

Exp Dermatol 2010 Aug;19(8):e173-81

Department of Dermatology, Mackay Memorial Hospital, Hsinchu, Taiwan.

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August 2010

Organomercurials removal by heterogeneous merB genes harboring bacterial strains.

J Biosci Bioeng 2010 Jul 4;110(1):94-8. Epub 2010 Feb 4.

Faculty of Engineering, Tohoku Gakuin University, 1-13-1 Chuo, Tagajo, Miyagi 985-8537, Japan.

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July 2010

Mercury resistance and accumulation in Escherichia coli with cell surface expression of fish metallothionein.

Appl Microbiol Biotechnol 2010 Jun 20;87(2):561-9. Epub 2010 Feb 20.

Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan.

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June 2010

Protective effects of myricetin against ultraviolet-B-induced damage in human keratinocytes.

Toxicol In Vitro 2010 Feb 22;24(1):21-8. Epub 2009 Sep 22.

School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan.

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February 2010

Efficacy and safety of topical tacrolimus for the treatment of face and neck vitiligo.

J Dermatol 2010 Feb;37(2):125-9

Department of Dermatology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

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February 2010

In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake.

J Ethnopharmacol 2009 Oct 11;126(1):108-13. Epub 2009 Aug 11.

Department of Dermatology, Changhua Christian Hospital, Changhua Hsien, Taiwan, ROC.

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October 2009

Molecular detection and phylogenetic analysis of the catechol 1,2-dioxygenase gene from Gordonia spp.

Syst Appl Microbiol 2009 Aug 9;32(5):291-300. Epub 2009 May 9.

Center for Environmental Restoration and Disaster Reduction (CERDR), National Chung Hsing University, Taichung, Taiwan, ROC.

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August 2009

Expressing a bacterial mercuric ion binding protein in plant for phytoremediation of heavy metals.

J Hazard Mater 2009 Jan 26;161(2-3):920-5. Epub 2008 Apr 26.

Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan.

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January 2009

Biosorption of nickel, chromium and zinc by MerP-expressing recombinant Escherichia coli.

J Hazard Mater 2008 Oct 19;158(1):100-6. Epub 2008 Jan 19.

Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan.

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October 2008

Interactions between two MerR regulators and three operator/promoter regions in the mercury resistance module of Bacillus megaterium.

Biosci Biotechnol Biochem 2008 Sep 7;72(9):2403-10. Epub 2008 Sep 7.

Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, Republic of China.

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September 2008

Facilities for transcription and mobilization of an exon-less bacterial group II intron nested in transposon TnMERI1.

Gene 2008 Jan 12;408(1-2):164-71. Epub 2007 Nov 12.

Graduate School of Life Sciences, Tohoku University, Sendai, Japan.

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January 2008

Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB.

Life Sci 2007 Nov 2;81(21-22):1509-17. Epub 2007 Oct 2.

School of Medicine, Fu-Jen Catholic University, No. 510, Chung-Cheng Road, Hsinchuang, Taipei Hsien, Taiwan.

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November 2007

Overexpression of a single membrane component from the Bacillus mer operon enhanced mercury resistance in an Escherichia coli host.

Biosci Biotechnol Biochem 2007 Jun;71(6):1494-9

Department of Life Sciences, National Chung Hsing University, Taiwan, Republic of China.

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June 2007

Flow-FISH analysis and isolation of clostridial strains in an anaerobic semi-solid bio-hydrogen producing system by hydrogenase gene target.

Appl Microbiol Biotechnol 2007 Apr 3;74(5):1126-34. Epub 2007 Feb 3.

Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan.

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April 2007

Inhibition of mite-induced immunoglobulin E synthesis, airway inflammation, and hyperreactivity by herbal medicine STA-1.

Immunopharmacol Immunotoxicol 2006 ;28(4):683-95

Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, Republic of China.

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March 2007

Predictive biomarkers for drug-resistant Acinetobacter baumannii isolates with bla(TEM-1), AmpC-type bla and integrase 1 genotypes.

J Microbiol Immunol Infect 2006 Oct;39(5):372-9

Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.

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October 2006

Expression of mercuric reductase from Bacillus megaterium MB1 in eukaryotic microalga Chlorella sp. DT: an approach for mercury phytoremediation.

Appl Microbiol Biotechnol 2006 Aug 18;72(1):197-205. Epub 2006 Mar 18.

Department of Life Sciences, National Chung-Hsing University, Tai-Chung 40227, Taiwan.

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August 2006

(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation.

Life Sci 2006 Jul 29;79(8):801-7. Epub 2006 Mar 29.

School of Medicine, Fu-Jen Catholic University, No. 510, Jhongjheng Rd., Sinjhuang City, Taipei County 24205, Taiwan ROC.

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July 2006

Molecular detection of the clostridia in an anaerobic biohydrogen fermentation system by hydrogenase mRNA-targeted reverse transcription-PCR.

Appl Microbiol Biotechnol 2006 May 11;70(5):598-604. Epub 2005 Oct 11.

Department of Life Sciences, National Chung Hsing University, Taichung, 40227, Taiwan.

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May 2006

Clinical evaluation of the Chinese herbal medicine formula STA-1 in the treatment of allergic asthma.

Phytother Res 2006 May;20(5):342-7

Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.

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May 2006

Cutaneous phaeohyphomycosis caused by an Itraconazole and Amphoterecin B resistant strain of Veronaeae botryosa.

Int J Dermatol 2006 Apr;45(4):429-32

Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

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April 2006

Protective effects of (-)-epicatechin-3-gallate on UVA-induced damage in HaCaT keratinocytes.

Arch Dermatol Res 2005 Apr 22;296(10):473-81. Epub 2005 Feb 22.

Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei County, Taiwan.

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April 2005

Diversity of mercury resistance determinants among Bacillus strains isolated from sediment of Minamata Bay.

FEMS Microbiol Lett 2003 Jun;223(1):73-82

Laboratory of Environmental Biotechnology, Faculty of Engineering, Tohoku Gakuin University, Tagajo, 985-8537, Japan.

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June 2003

Tacrolimus ointment for the treatment of atopic dermatitis: report of first clinical experience in Taiwan.

Kaohsiung J Med Sci 2003 Jun;19(6):296-304

Department of Dermatology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.

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June 2003

Characterization of two regulatory genes of the mercury resistance determinants from TnMERI1 by luciferase-based examination.

Gene 2002 Nov;301(1-2):13-20

Laboratory of Environmental Biotechnology, Faculty of Engineering, Tohoku Gakuin University, 1-13-1 Chuo, Tagajo-shi, 985-8537, Miyagi, Japan.

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November 2002