Chiara Zucal

Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.

Nature 2020 Dec;588(7839):E33

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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December 2020

Fasting-mimicking diet and hormone therapy induce breast cancer regression.

Nature 2020 07 15;583(7817):620-624. Epub 2020 Jul 15.

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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July 2020

Ultrasensitive detection of cancer biomarkers by nickel-based isolation of polydisperse extracellular vesicles from blood.

Authors:

Michela Notarangelo Chiara Zucal Angelika Modelska Isabella Pesce Giorgina Scarduelli Cristina Potrich Lorenzo Lunelli Cecilia Pederzolli Paola Pavan Giancarlo la Marca Luigi Pasini Paola Ulivi Himisha Beltran Francesca Demichelis Alessandro Provenzani Alessandro Quattrone Vito G D'Agostino

EBioMedicine 2019 May 29;43:114-126. Epub 2019 Apr 29.

Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, Trento 38123, Italy. Electronic address:

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May 2019

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies.

Authors:

Serena Della Volpe Rita Nasti Michele Queirolo M Yagiz Unver Varsha K Jumde Alexander Dömling Francesca Vasile Donatella Potenza Francesca Alessandra Ambrosio Giosué Costa Stefano Alcaro Chiara Zucal Alessandro Provenzani Marcello Di Giacomo Daniela Rossi Anna K H Hirsch Simona Collina

ACS Med Chem Lett 2019 Apr 21;10(4):615-620. Epub 2019 Jan 21.

Department of Drug Sciences, Medicinal Chemistry and Technology Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.

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April 2019

Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery.

Authors:

Vito Giuseppe D'Agostino Denise Sighel Chiara Zucal Isabelle Bonomo Mariachiara Micaelli Graziano Lolli Alessandro Provenzani Alessandro Quattrone Valentina Adami

SLAS Discov 2019 03 7;24(3):314-331. Epub 2019 Jan 7.

2 University of Trento, HTS Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.

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March 2019

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach.

Authors:

Francesca Vasile Serena Della Volpe Francesca Alessandra Ambrosio Giosuè Costa M Yagiz Unver Chiara Zucal Daniela Rossi Emanuela Martino Alessandro Provenzani Anna K H Hirsch Stefano Alcaro Donatella Potenza Simona Collina

Sci Rep 2018 09 13;8(1):13780. Epub 2018 Sep 13.

Department of Drug Sciences, Medicinal Chemistry and Technology Section, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.

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September 2018

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA.

Authors:

Natthakan Thongon Chiara Zucal Vito Giuseppe D'Agostino Toma Tebaldi Silvia Ravera Federica Zamporlini Francesco Piacente Ruxanda Moschoi Nadia Raffaelli Alessandro Quattrone Alessio Nencioni Jean-Francois Peyron Alessandro Provenzani

Cancer Metab 2018 8;6. Epub 2018 Mar 8.

1Center For Integrative Biology (CIBIO), University of Trento, via Sommarive 9, Trento, Italy.

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March 2018

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.

Authors:

Leonardo Manzoni Chiara Zucal Danilo Di Maio Vito G D'Agostino Natthakan Thongon Isabelle Bonomo Preet Lal Marco Miceli Vanessa Baj Marta Brambilla Linda Cerofolini Saioa Elezgarai Emiliano Biasini Claudio Luchinat Ettore Novellino Marco Fragai Luciana Marinelli Alessandro Provenzani Pierfausto Seneci

J Med Chem 2018 02 31;61(4):1483-1498. Epub 2018 Jan 31.

Chemistry Department, University of Milan , Via Golgi 19, 20133 Milan, Italy.

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February 2018

Regulation of HuR structure and function by dihydrotanshinone-I.

Nucleic Acids Res 2017 Sep;45(16):9514-9527

Centre for Integrative Biology, CIBIO, University of Trento, Trento 38122, Italy.

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September 2017

The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer.

Authors:

Elisa Latorre Stephana Carelli Ivan Raimondi Vito D'Agostino Ilaria Castiglioni Chiara Zucal Giacomina Moro Andrea Luciani Giorgio Ghilardi Eleonora Monti Alberto Inga Anna Maria Di Giulio Alfredo Gorio Alessandro Provenzani

Cancer Res 2016 05 20;76(9):2626-36. Epub 2016 Apr 20.

Laboratory of Genomic Screening, Center for Integrative Biology, University of Trento, Trento, Italy.

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May 2016

The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level.

Authors:

Natthakan Thongon Ilaria Castiglioni Chiara Zucal Elisa Latorre Vito D'Agostino Inga Bauer Michael Pancher Alberto Ballestrero Georg Feldmann Alessio Nencioni Alessandro Provenzani

Oncotarget 2016 May;7(18):26551-66

Laboratory of Genomic Screening, Centre for Integrative Biology, University of Trento, Trento, Italy.

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May 2016

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function.

Authors:

Vito Giuseppe D'Agostino Preet Lal Barbara Mantelli Christopher Tiedje Chiara Zucal Natthakan Thongon Matthias Gaestel Elisa Latorre Luciana Marinelli Pierfausto Seneci Marialaura Amadio Alessandro Provenzani

Sci Rep 2015 Nov 10;5:16478. Epub 2015 Nov 10.

Centre For Integrative Biology (CIBIO), University of Trento, Trento, 38123, Italy.

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November 2015

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.

Authors:

Chiara Zucal Vito G D'Agostino Antonio Casini Barbara Mantelli Natthakan Thongon Debora Soncini Irene Caffa Michele Cea Alberto Ballestrero Alessandro Quattrone Stefano Indraccolo Alessio Nencioni Alessandro Provenzani

BMC Cancer 2015 Nov 5;15:855. Epub 2015 Nov 5.

Laboratory of Genomic Screening, CIBIO, University of Trento, Trento, Italy.

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November 2015

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.

Clin Cancer Res 2015 Sep 11;21(17):3934-45. Epub 2015 May 11.

Department of Hematology and Oncology, IRCCS AOU S. Martino-IST, Genoa, Italy. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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September 2015

Targeting the multifaceted HuR protein, benefits and caveats.

Authors:

Chiara Zucal Vito D'Agostino Rosa Loffredo Barbara Mantelli NatthakanThongon Preet Lal Elisa Latorre Alessandro Provenzani

Curr Drug Targets 2015 ;16(5):499-515

Laboratory of Genomic Screening, Centre for Integrative Biology (CIBIO), University of Trento, Via delle regole 101, 38123, Mattarello, Trento, Italy.

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January 2016