Publications by authors named "Chiara Francavilla"

29Publications

'Omics Approaches to Explore the Breast Cancer Landscape.

Front Cell Dev Biol 2019 22;7:395. Epub 2020 Jan 22.

Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.3389/fcell.2019.00395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987401PMC
January 2020

Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5).

Int J Mol Sci 2020 Jan 31;21(3). Epub 2020 Jan 31.

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.3390/ijms21030929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037328PMC
January 2020

Dynamic lineage priming is driven via direct enhancer regulation by ERK.

Nature 2019 11 6;575(7782):355-360. Epub 2019 Nov 6.

The Novo Nordisk Foundation Center for Stem Cell Biology, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41586-019-1732-zDOI Listing
November 2019

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.

Cell 2019 10;179(2):543-560.e26

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.09.008DOI Listing
October 2019

Number and brightness analysis reveals that NCAM and FGF2 elicit different assembly and dynamics of FGFR1 in live cells.

J Cell Sci 2019 01 3;132(1). Epub 2019 Jan 3.

Centro di Imaging Sperimentale (CIS), Ospedale San Raffaele, IRCCS, Milan 20132, Italy

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http://dx.doi.org/10.1242/jcs.220624DOI Listing
January 2019

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma.

Sci Signal 2018 11 20;11(557). Epub 2018 Nov 20.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.aap9752DOI Listing
November 2018

Regulation of FGF10 Signaling in Development and Disease.

Front Genet 2018 23;9:500. Epub 2018 Oct 23.

Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom.

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https://www.frontiersin.org/article/10.3389/fgene.2018.00500
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http://dx.doi.org/10.3389/fgene.2018.00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205963PMC
October 2018

Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling.

Cell Rep 2018 03;22(10):2784-2796

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Science, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.038DOI Listing
March 2018

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer.

Cell Rep 2017 03;18(13):3242-3256

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382236PMC
March 2017

Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking.

Nat Struct Mol Biol 2016 06 2;23(6):608-18. Epub 2016 May 2.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nsmb.3218DOI Listing
June 2016

Recent findings and technological advances in phosphoproteomics for cells and tissues.

Expert Rev Proteomics 2015 ;12(5):469-87

a Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1586/14789450.2015.1078730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819829PMC
June 2016

Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.

Mol Syst Biol 2015 Jun 2;11(6):810. Epub 2015 Jun 2.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501846PMC
http://dx.doi.org/10.15252/msb.20145880DOI Listing
June 2015

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.

Sci Signal 2015 Apr 28;8(374):ra40. Epub 2015 Apr 28.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.2005769DOI Listing
April 2015

Off-line high-pH reversed-phase fractionation for in-depth phosphoproteomics.

J Proteome Res 2014 Dec 4;13(12):6176-86. Epub 2014 Nov 4.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Science, University of Copenhagen , Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500893mDOI Listing
December 2014

SILAC-based temporal phosphoproteomics.

Methods Mol Biol 2014 ;1188:125-48

Department of Proteomics, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-1142-4_10DOI Listing
March 2015

Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.

Mol Cell 2014 Mar 27;53(6):1053-66. Epub 2014 Feb 27.

Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.02.001DOI Listing
March 2014

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Mol Cell 2013 Sep 5;51(6):707-22. Epub 2013 Sep 5.

Department of Proteomics, NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molcel.2013.08.002DOI Listing
September 2013

TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells.

J Proteome Res 2013 Sep 21;12(9):4136-51. Epub 2013 Aug 21.

Institute of Veterinary Disease Biology, Faculty of Health and Medical Sciences and Sino-Danish Breast Cancer Research Centre, University of Copenhagen, Dyrlægevej 88, 1., 1870 Frederiksberg C, Denmark.

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http://dx.doi.org/10.1021/pr400457uDOI Listing
September 2013

In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling.

Sci Signal 2013 Jun 4;6(278):rs11. Epub 2013 Jun 4.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.2003506DOI Listing
June 2013

Pinpointing phosphorylation sites: Quantitative filtering and a novel site-specific x-ion fragment.

J Proteome Res 2011 Jul 28;10(7):2937-48. Epub 2011 Apr 28.

Department for Proteomics, NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr200154tDOI Listing
July 2011

The functional role of cell adhesion molecules in tumor angiogenesis.

Semin Cancer Biol 2009 Oct 29;19(5):298-309. Epub 2009 May 29.

IFOM - The FIRC Institute of Molecular Oncology, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X090006
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http://dx.doi.org/10.1016/j.semcancer.2009.05.004DOI Listing
October 2009

Immunological applications of single-domain llama recombinant antibodies isolated from a naïve library.

Protein Eng Des Sel 2009 Apr 4;22(4):273-80. Epub 2009 Feb 4.

Consortium for Genomic Technologies, Biochemistry Unit, IFOM-IEO Campus, Via Adamello 16, 20139 Milano, Italy.

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http://dx.doi.org/10.1093/protein/gzp002DOI Listing
April 2009

Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor.

J Cell Sci 2007 Dec 27;120(Pt 24):4388-94. Epub 2007 Nov 27.

IFOM-FIRC Institute of Molecular Oncology, I-20139 Milano, Italy.

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http://dx.doi.org/10.1242/jcs.010744DOI Listing
December 2007