Chia-Yen Chen

Chia-Yen Chen

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Chia-Yen Chen

Chia-Yen Chen

Publications by authors named "Chia-Yen Chen"

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Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems.

Am J Psychiatry 2019 Oct 16;176(10):846-855. Epub 2019 Aug 16.

Psychiatric and Neurodevelopmental Genetics Unit (Zheutlin, Chen, Ge, Smoller) and Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston (Chen); Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Mass. (Zheutlin, Chen, Stahl, Smoller); Division of Genetic Medicine, Department of Medicine (Dennis, Straub, Ruderfer, Davis), Vanderbilt Genetics Institute (Dennis, Straub, Ruderfer, Davis), and Department of Biomedical Informatics (Ruderfer), Vanderbilt University Medical Center, Nashville; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam (Karlsson Linnér); Autism and Developmental Medicine Institute, Geisinger, Lewisburg, Pa. (Karlsson Linnér, Chabris); Charles Bronfman Institute for Personalized Medicine (Moscati), Pamela Sklar Division of Psychiatric Genomics (Huckins, Charney, Stahl), and Department of Genetics and Genomic Sciences (Huckins, Charney, Stahl, ), Icahn School of Medicine at Mount Sinai, New York; Department of Biomedical and Translational Informatics, Geisinger, Rockville, Md. (Restrepo, Kirchner); Research Information Science and Computing, Partners HealthCare, Somerville, Mass. (Castro).

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http://dx.doi.org/10.1176/appi.ajp.2019.18091085DOI Listing
October 2019

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Authors:
Caroline M Nievergelt Adam X Maihofer Torsten Klengel Elizabeth G Atkinson Chia-Yen Chen Karmel W Choi Jonathan R I Coleman Shareefa Dalvie Laramie E Duncan Joel Gelernter Daniel F Levey Mark W Logue Renato Polimanti Allison C Provost Andrew Ratanatharathorn Murray B Stein Katy Torres Allison E Aiello Lynn M Almli Ananda B Amstadter Søren B Andersen Ole A Andreassen Paul A Arbisi Allison E Ashley-Koch S Bryn Austin Esmina Avdibegovic Dragan Babić Marie Bækvad-Hansen Dewleen G Baker Jean C Beckham Laura J Bierut Jonathan I Bisson Marco P Boks Elizabeth A Bolger Anders D Børglum Bekh Bradley Megan Brashear Gerome Breen Richard A Bryant Angela C Bustamante Jonas Bybjerg-Grauholm Joseph R Calabrese José M Caldas-de-Almeida Anders M Dale Mark J Daly Nikolaos P Daskalakis Jürgen Deckert Douglas L Delahanty Michelle F Dennis Seth G Disner Katharina Domschke Alma Dzubur-Kulenovic Christopher R Erbes Alexandra Evans Lindsay A Farrer Norah C Feeny Janine D Flory David Forbes Carol E Franz Sandro Galea Melanie E Garrett Bizu Gelaye Elbert Geuze Charles Gillespie Aferdita Goci Uka Scott D Gordon Guia Guffanti Rasha Hammamieh Supriya Harnal Michael A Hauser Andrew C Heath Sian M J Hemmings David Michael Hougaard Miro Jakovljevic Marti Jett Eric Otto Johnson Ian Jones Tanja Jovanovic Xue-Jun Qin Angela G Junglen Karen-Inge Karstoft Milissa L Kaufman Ronald C Kessler Alaptagin Khan Nathan A Kimbrel Anthony P King Nastassja Koen Henry R Kranzler William S Kremen Bruce R Lawford Lauren A M Lebois Catrin E Lewis Sarah D Linnstaedt Adriana Lori Bozo Lugonja Jurjen J Luykx Michael J Lyons Jessica Maples-Keller Charles Marmar Alicia R Martin Nicholas G Martin Douglas Maurer Matig R Mavissakalian Alexander McFarlane Regina E McGlinchey Katie A McLaughlin Samuel A McLean Sarah McLeay Divya Mehta William P Milberg Mark W Miller Rajendra A Morey Charles Phillip Morris Ole Mors Preben B Mortensen Benjamin M Neale Elliot C Nelson Merete Nordentoft Sonya B Norman Meaghan O'Donnell Holly K Orcutt Matthew S Panizzon Edward S Peters Alan L Peterson Matthew Peverill Robert H Pietrzak Melissa A Polusny John P Rice Stephan Ripke Victoria B Risbrough Andrea L Roberts Alex O Rothbaum Barbara O Rothbaum Peter Roy-Byrne Ken Ruggiero Ariane Rung Bart P F Rutten Nancy L Saccone Sixto E Sanchez Dick Schijven Soraya Seedat Antonia V Seligowski Julia S Seng Christina M Sheerin Derrick Silove Alicia K Smith Jordan W Smoller Scott R Sponheim Dan J Stein Jennifer S Stevens Jennifer A Sumner Martin H Teicher Wesley K Thompson Edward Trapido Monica Uddin Robert J Ursano Leigh Luella van den Heuvel Miranda Van Hooff Eric Vermetten Christiaan H Vinkers Joanne Voisey Yunpeng Wang Zhewu Wang Thomas Werge Michelle A Williams Douglas E Williamson Sherry Winternitz Christiane Wolf Erika J Wolf Jonathan D Wolff Rachel Yehuda Ross McD Young Keith A Young Hongyu Zhao Lori A Zoellner Israel Liberzon Kerry J Ressler Magali Haas Karestan C Koenen

Nat Commun 2019 Oct 8;10(1):4558. Epub 2019 Oct 8.

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12576-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783435PMC
October 2019

Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia.

Biol Psychiatry 2019 Jul 7;86(1):56-64. Epub 2019 Feb 7.

Institute of Epidemiology and Preventive Medicine, College of Public Health, Taipei, Taiwan; Department of Public Health, College of Public Health, Taipei, Taiwan; Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193006
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http://dx.doi.org/10.1016/j.biopsych.2019.01.023DOI Listing
July 2019

Polygenic prediction via Bayesian regression and continuous shrinkage priors.

Nat Commun 2019 04 16;10(1):1776. Epub 2019 Apr 16.

Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41467-019-09718-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467998PMC
April 2019

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Nat Genet 2019 02 14;51(2):245-257. Epub 2019 Jan 14.

Department of Economics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41588-018-0309-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713272PMC
February 2019

GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.

Am J Hum Genet 2019 01 21;104(1):157-163. Epub 2018 Dec 21.

National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Old Road, Oxford OX3 7LE, UK; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, Big Data Institute Building, Roosevelt Drive, University of Oxford, Oxford OX3 7LF, UK; Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.ajhg.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323625PMC
January 2019

Genome-wide analysis of insomnia disorder.

Mol Psychiatry 2018 11 8;23(11):2238-2250. Epub 2018 Mar 8.

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41380-018-0033-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129221PMC
November 2018

The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology.

Cereb Cortex 2018 Oct 1. Epub 2018 Oct 1.

Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1093/cercor/bhy216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644848PMC
October 2018

Publisher Correction: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.

Nat Genet 2018 08;50(8):1196

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-018-0164-2DOI Listing
August 2018

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.

Nat Genet 2018 05 23;50(5):693-698. Epub 2018 Apr 23.

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-018-0099-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083837PMC
May 2018

Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos.

J Psychiatr Res 2018 04 16;99:167-176. Epub 2017 Dec 16.

Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S00223956173057
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http://dx.doi.org/10.1016/j.jpsychires.2017.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192675PMC
April 2018

Phenome-wide heritability analysis of the UK Biobank.

PLoS Genet 2017 04 7;13(4):e1006711. Epub 2017 Apr 7.

Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400281PMC
April 2017

Antagonism of BST-2/Tetherin Is a Conserved Function of the Env Glycoprotein of Primary HIV-2 Isolates.

J Virol 2016 Dec 28;90(24):11062-11074. Epub 2016 Nov 28.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01451-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126365PMC
December 2016

Antagonism of BST-2/Tetherin Is a Conserved Function of the Env Glycoprotein of Primary HIV-2 Isolates.

J Virol 2016 Dec 28;90(24):11062-11074. Epub 2016 Nov 28.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01451-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126365PMC
December 2016

Malignant Ureteral Obstruction: Functional Duration of Metallic versus Polymeric Ureteral Stents.

PLoS One 2015 12;10(8):e0135566. Epub 2015 Aug 12.

Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135566PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534199PMC
May 2016

Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction.

Genet Epidemiol 2015 Sep 21;39(6):427-38. Epub 2015 May 21.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.21906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734143PMC
September 2015

Sun1 deficiency leads to cerebellar ataxia in mice.

Dis Model Mech 2015 Aug 5;8(8):957-67. Epub 2015 May 5.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan

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http://dx.doi.org/10.1242/dmm.019240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527285PMC
August 2015

Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary report.

Am J Med Genet B Neuropsychiatr Genet 2015 Apr 4;168B(3):151-61. Epub 2015 Mar 4.

Department of Psychiatry Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Boston, Massachusetts; Psychiatric and Neurodevelopmental Genetics Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajmg.b.32298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458348PMC
April 2015

Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study.

Ann Rheum Dis 2014 Nov 23;73(11):1914-22. Epub 2014 Jul 23.

Division of Rheumatology, Immunology & Allergy, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2014-205459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207219PMC
November 2014

Improved ancestry inference using weights from external reference panels.

Bioinformatics 2013 Jun 28;29(11):1399-406. Epub 2013 Mar 28.

Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661048PMC
June 2013

Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies.

Virus Res 2013 Feb 16;171(2):357-65. Epub 2012 Jul 16.

Molecular Virology Section 1, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.virusres.2012.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493675PMC
February 2013

Reversal of laminopathies: the curious case of SUN1.

Nucleus 2012 Sep-Oct;3(5):418-21. Epub 2012 Aug 16.

Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.4161/nucl.21714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474661PMC
February 2013

The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replication.

J Virol 2013 Feb 21;87(3):1699-707. Epub 2012 Nov 21.

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.02147-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554132PMC
February 2013

An incremental target-adapted strategy for active geometric calibration of projector-camera systems.

Sensors (Basel) 2013 Feb 22;13(2):2664-81. Epub 2013 Feb 22.

Department of Computer Science and Information Engineering, National University of Kaohsiung, Kaohsiung 811, Taiwan.

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http://dx.doi.org/10.3390/s130202664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649383PMC
February 2013

NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression.

MBio 2013 Jan 29;4(1):e00596-12. Epub 2013 Jan 29.

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/mBio.00596-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560530PMC
January 2013

Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis.

Retrovirology 2012 Dec 21;9:114. Epub 2012 Dec 21.

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, USA.

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http://dx.doi.org/10.1186/1742-4690-9-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532233PMC
December 2012

On-site sensor recalibration of a spinning multi-beam LiDAR system using automatically-detected planar targets.

Sensors (Basel) 2012 Oct 12;12(10):13736-52. Epub 2012 Oct 12.

Department of Computer Science and Information Engineering, National University of Kaohsiung, 700 Kaohsiung University Rd Nan Tzu Dist, Kaohsiung, Taiwan.

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http://dx.doi.org/10.3390/s121013736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545590PMC
October 2012

Evaluation of polygenic risk scores for predicting breast and prostate cancer risk.

Genet Epidemiol 2011 Sep 26;35(6):506-514. Epub 2011 May 26.

Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.20600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089860PMC
September 2011

Urinary nerve growth factor in women with overactive bladder syndrome.

BJU Int 2011 Mar 26;107(5):799-803. Epub 2010 Aug 26.

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

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http://doi.wiley.com/10.1111/j.1464-410X.2010.09585.x
Publisher Site
http://dx.doi.org/10.1111/j.1464-410X.2010.09585.xDOI Listing
March 2011

Urinary nerve growth factor levels in overactive bladder syndrome and lower urinary tract disorders.

J Formos Med Assoc 2010 Dec;109(12):862-78

Department of Urology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan.

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http://dx.doi.org/10.1016/S0929-6646(10)60133-7DOI Listing
December 2010

A method to study the role of DDX3 RNA helicase in HIV-1.

Methods Mol Biol 2010 ;587:281-9

Molecular Virology Section, Laboratory of Molecular, Microbiology, the NIAID, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-60327-355-8_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535447PMC
May 2010

Botulinum toxin A injection to the bladder neck and urethra for medically refractory lower urinary tract symptoms in men without prostatic obstruction.

J Formos Med Assoc 2009 Dec;108(12):950-6

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

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http://dx.doi.org/10.1016/S0929-6646(10)60008-3DOI Listing
December 2009

Upper urinary tract urothelial carcinoma in eastern Taiwan: high proportion among all urothelial carcinomas and correlation with chronic kidney disease.

J Formos Med Assoc 2007 Dec;106(12):992-8

Department of Urology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

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http://dx.doi.org/10.1016/S0929-6646(08)60074-1DOI Listing
December 2007

Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan.

Toxicol Appl Pharmacol 2005 Aug;206(2):198-206

Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen-Ai Road Section1, Taipei 10018, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.taap.2004.10.023DOI Listing
August 2005

Synergistic effect of bismuth subgallate and borneol, the major components of Sulbogin, on the healing of skin wound.

Biomaterials 2003 Aug;24(18):3005-12

Department of Anatomy (LMM), School of Medicine, Institute of Public Health (CYC), Taiwan, ROC.

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http://dx.doi.org/10.1016/s0142-9612(03)00126-1DOI Listing
August 2003