Publications by authors named "Chia-Chen Li"

14 Publications

  • Page 1 of 1

Adjuvant versus Neoadjuvant Immunotherapy for Hepatocellular Carcinoma: Clinical and Immunologic Perspectives.

Semin Liver Dis 2021 Aug 15;41(3):263-276. Epub 2021 Jun 15.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.

Advancement in systemic therapy, particularly immune checkpoint inhibitor (ICI)-based combination regimens, has transformed the treatment landscape for patients with advanced hepatocellular carcinoma (HCC). The advancement in systemic therapy also provides new opportunities of reducing recurrence after curative therapy through adjuvant therapy or improving resectability through neoadjuvant therapy. Improved recurrence-free survival by adjuvant or neoadjuvant ICI-based therapy has been reported in other cancer types. In this article, developments of systemic therapy in adjuvant and neoadjuvant settings for HCC were reviewed. The design of adjuvant and neoadjuvant therapy using ICI-based regimens and potential challenges of trial conduct and result analysis was discussed. Results from these trials may extend the therapeutic benefit of ICI-based systemic therapy beyond the advanced-stage disease and lead to a new era of multidisciplinary management for HCC.
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http://dx.doi.org/10.1055/s-0041-1730949DOI Listing
August 2021

Well-Dispersed Garnet Crystallites for Applications in Solid-State Li-S Batteries.

ACS Appl Mater Interfaces 2021 Mar 3;13(10):11995-12005. Epub 2021 Mar 3.

Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.

A uniform ceramic tape of well-dispersed garnet-type LiLaZrTaO particles (LLZTO) with a high solid content of 70 wt % is prepared as an electrolyte in solid-state Li-S batteries. The use of appropriate dispersants is crucial for achieving fine dispersion and uniform distribution of LLZTO particles in the ceramic tape. This leads to improved surface flatness and mechanical strength of the ceramic tape. Moreover, the ionic conductivity increases remarkably at the same time from 10 to 10 to 10 to 10 S cm, and the Li transport number doubles from 0.35 to 0.70. The Li-S battery constructed with the dispersed LLZTO electrolyte shows an adequate capacity of above 600 mA h g after 100 cycles at a discharge current of 84 mA g, and it is capable of charging/discharging at a high current of 1672 mA g. In comparison, the battery with a nondispersed LLZTO electrolyte functions only at the lower current of 84 mA g and fails to work after 25 cycles.
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http://dx.doi.org/10.1021/acsami.0c22915DOI Listing
March 2021

Encapsulating Well-Dispersed Carbon Nanoparticles for Applications in the Autonomous Restoration of Electronic Circuits.

ACS Appl Mater Interfaces 2020 Aug 14;12(34):38690-38699. Epub 2020 Aug 14.

Advanced Material and Process Development Department, General Interface Solution Holding Ltd., No. 16, Kedong 3rd Rd., Zhunan Science Park, Miaoli County 35053, Taiwan.

Two types of conductive microcapsules with a median size of less than 5 μm are proposed, and their high potential as a key functional material for self-restorable conductive pastes for applications in printed electronic circuits is verified. A well-dispersed suspension of carbon nanoparticles in toluene is prepared as the core material of the microcapsules. The restoration capabilities of the microcapsules for the physical structure and electrical conductivity of silver-based electronic circuit lines are compared. In the assessment of the microcapsule restoration efficiency, the two conductive microcapsules exhibit distinct capabilities for the restoration of damages caused by different mechanical fracturing. That is, the smaller microcapsule is more effective than the larger one to restore circuit lines from a tensile test, whereas the opposite result is obtained from a scratching test, demonstrating the significance of microcapsule size for the restoration of dissimilar fractures that may occur in various applications.
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http://dx.doi.org/10.1021/acsami.0c11235DOI Listing
August 2020

New Brush Copolymers as an Effective Dispersant for Stabilizing Concentrated Suspensions of Silver Nanoparticles.

Langmuir 2020 Apr 26;36(13):3377-3385. Epub 2020 Mar 26.

Institute of Materials Science and Engineering, and Department of Materials & Mineral Resources Engineering, National Taipei University of Technology, Taipei 10608, Taiwan.

Silver nanopowders (nano-Ag) have extremely high surface energy and are generally difficult to have an effective dispersant for their dispersion stabilization. This study proposes two brush copolymers that show a strong preference for adsorption on the nano-Ag surface their backbone, while their side chains extend into the dispersion solvent for particle stabilization. After adding only 5 wt % (based on the mass of nano-Ag) of the proposed dispersants, the nano-Ag particles can be stably suspended without settling for at least 2 months. Besides, 5 wt % of these dispersants can well stabilize at least 40 wt % nano-Ag dispersed in di(ethylene glycol) ethyl ether, which is a common solvent for conductive inks and pastes. For applications, a thin film cast using the dispersed nano-Ag shows greatly improved surface flatness as compared to that made without the dispersant, and a low electrical resistivity of 2 × 10 Ω cm is obtained after the film is annealed at 170 °C for 20 min.
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http://dx.doi.org/10.1021/acs.langmuir.0c00361DOI Listing
April 2020

Dispersion of Poly(urea-formaldehyde)-Based Microcapsules for Self-Healing and Anticorrosion Applications.

Langmuir 2019 Jun 24;35(24):7871-7878. Epub 2019 May 24.

Institute of Materials Science and Engineering, and Department of Materials & Mineral Resources Engineering , National Taipei University of Technology , Box 2761, No. 1, Sec. 3, Zhongxiao E. Rd. , Taipei 10608 , Taiwan.

An effective dispersant, oleyl phosphate (OP), for the dispersion of poly(urea-formaldehyde)-based microcapsules in a typical epoxy coating material is proposed. Based on electron microscopy observations and rheological and mechanical characterizations, it is observed that the addition of merely 0.5 wt % of OP is sufficient to obtain good dispersion of the microcapsules in the epoxy. In the self-healing and anticorrosion experiments, a microcapsule content of at least 15 wt % is required to efficiently restore the epoxy matrix and provide corrosion protection to underlying low-carbon steel when the particles are not dispersed; however, the amount of microcapsules required to obtain good self-healing and anticorrosion efficiencies can be greatly reduced to only 5 wt % when the microcapsules are dispersed by OP.
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http://dx.doi.org/10.1021/acs.langmuir.9b00526DOI Listing
June 2019

Preparation of highly dispersed and concentrated aqueous suspensions of nanodiamonds using novel diblock dispersants.

J Colloid Interface Sci 2018 Jun 7;520:119-126. Epub 2018 Mar 7.

Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 30011, Taiwan.

Hypothesis: Finding an efficient dispersant for obtaining a good dispersion of 5-nm detonation nanodiamond (DND) is always a challenge. Two newly designed diblock copolymers, both poly(ammonium methacrylate)-block-poly(2-phenoxyethyl acrylate) (PMA-b-PBEA) but with different molar ratios of PMA to PBEA, were proposed to be efficient dispersants in stabilizing the concentrated aqueous suspensions of DND.

Experiments: The dispersion efficiency of dispersants for DND in aqueous suspensions was studied by the measurements of particle size, sedimentation property, and rheological behavior. The interactions between the added dispersants and DND were identified by the zeta potential and adsorption analyses. Calculations based on Derjaguin-Landau-Verwey-Overbeek (DLVO) theory were conducted for clarifying the dominant parameters relating to the dispersion efficiency of dispersants.

Findings: Compared with the commercially popular dispersant ammonium polyacrylate, these two diblock dispersants exhibited superior efficiency in the stabilization of DND suspensions. Using the diblock copolymers as dispersants, good dispersion stability in a DND suspension with an extremely high solid content of 30 wt% was achieved. According to experimental analyses and based on DLVO calculations, a low number of accompanied counter-ions, high adsorption capability, and thick PMA-b-PBEA adsorption layer are the main reasons for the extremely high dispersion efficiency of the two new dispersants.
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http://dx.doi.org/10.1016/j.jcis.2018.03.017DOI Listing
June 2018

Newly designed diblock dispersant for powder stabilization in water-based suspensions.

J Colloid Interface Sci 2017 Nov 17;506:180-187. Epub 2017 Jul 17.

Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 30011, Taiwan.

A newly designed dispersant for water-based suspensions, ammonium poly(methacrylate)-block-poly(2-phenoxyethyl acrylate) (PMA-b-PBEA), is proposed in this study. According to the results of rheological analysis, the dispersion efficiency of this new dispersant is superior to that of the commercially available ammonium polyacrylate (PAA-NH). The diblock structure of PMA-b-PBEA, which simultaneously contains a low-polar anchoring head group and a water-dissociable stabilizing moiety, is the main cause for its extremely high efficiency for powder dispersion. The unique structure not only results in effective adsorption approximately double that of PAA-NH, but also produces a low number of counter-ions that compress the electrical double layer and ruin powder stabilization. Based on Derjaquin-Landau-Verwey-Overbeek calculations, the large adsorbance of PMA-b-PBEA gives the powder, titania (TiO) in this study, a high steric stabilization energy. In addition, PMA-b-PBEA provides TiO with a remarkably high electrostatic energy because it generates fewer counter-ions. This energy provides excellent dispersity of powder in the suspensions with a high solid content of 60wt% without showing any rheological hysteresis.
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http://dx.doi.org/10.1016/j.jcis.2017.07.045DOI Listing
November 2017

New Approach for the Synthesis of Nanozirconia Fortified Microcapsules.

Langmuir 2017 06 26;33(23):5843-5851. Epub 2017 May 26.

Institute of Materials Science and Engineering, and Department of Materials & Mineral Resources Engineering, National Taipei University of Technology , Taipei 10608, Taiwan.

Robust poly(urea-formaldehyde) (PUF) microcapsules with composite shells comprising zirconia (ZrO) nanopowder incorporated in PUF were fabricated via a novel and facile one-pot synthesis. ZrO nanopowder was chosen because it owns one of the highest mechanical strengths among ceramics. The nanopowder was predispersed in the core material to combine encapsulation and fortification into a single process. In the core, the well-dispersed nanopowder migrated to the interface, where PUF polymerization took place. The mechanical strength of the microcapsule with nano-ZrO incorporated in the shell (42% by weight) is three times greater than that of the microcapsule without ZrO. In a preliminary application wherein the microcapsules were embedded in a model of poly(vinyl alcohol) (PVA) membrane, the PVA specimen exhibited a higher ultimate tensile strength when fortified microcapsules were embedded than when unfortified microcapsules were used.
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http://dx.doi.org/10.1021/acs.langmuir.7b01066DOI Listing
June 2017

Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.

Chem Biol Interact 2013 May 6;203(3):580-7. Epub 2013 Apr 6.

Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.

Tomatidine is an aglycone of glycoalkaloid tomatine in tomato. Tomatidine is found to possess anti-inflammatory properties and may serve as a chemosensitizer in multidrug-resistant tumor cells. However, the effect of tomatidine on cancer cell metastasis remains unclear. This study examines the effect of tomatidine on the migration and invasion of human lung adenocarcinoma A549 cell in vitro. The data demonstrates that tomatidine does not effectively inhibit the viability of A549 cells. When treated with non-toxic doses of tomatidine, cell invasion is markedly suppressed by Boyden chamber invasion assay, while cell migration is not affected. Tomatidine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), as well as tissue inhibitor of metalloproteinase-1 (TIMP-1). The immunoblotting assays indicate that tomatidine is very effective in suppressing the phosphorylation of Akt and extracellular signal regulating kinase (ERK). In addition, tomatidine significantly decreases the nuclear level of nuclear factor kappa B (NF-κB), which suggests that tomatidine inhibits NF-κB activity. Furthermore, the treatment of inhibitors specific for PI3K/Akt (LY294002), ERK (U0126), or NF-κB (pyrrolidine dithiocarbamate) to A549 cells reduced cell invasion and MMP-2/9 expression. The results suggest that tomatidine inhibits the invasion of A549 cells by reducing the expression of MMPs. It also inhibits ERK and Akt signaling pathways and NF-κB activity. These findings demonstrate a new therapeutic potential for tomatidine in anti-metastatic therapy.
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http://dx.doi.org/10.1016/j.cbi.2013.03.016DOI Listing
May 2013

Multiple recognition systems adopting four different glycotopes at the same domain for the Agaricus bisporus agglutinin-glycan interactions.

FEBS Lett 2010 Aug 17;584(16):3561-6. Epub 2010 Jul 17.

Glyco-immunochemistry Research Laboratory, Institute of Molecular and Cellular Biology, College of Medicine, Chang-Gung University, Kwei-san, Tao-yuan 333, Taiwan.

For the GalNAcalpha1--> specific Agaricus bisporus agglutinin (ABA) from an edible mushroom, the mechanism of polyvalent Galbeta1-->3/4GlcNAcbeta1--> complex in ABA-carbohydrate recognition has not been well defined since Gal and GlcNAc are weak ligands. By enzyme-linked lectinosorbent and inhibition assays, we show that the polyvalent Galbeta1-->3/4GlcNAcbeta1--> in natural glycans also play vital roles in binding and we propose that four different intensities of glycotopes (Galbeta1-3GalNAcalpha1-, GalNAcalpha1-Ser/Thr and Galbeta1-3/4GlcNAcbeta1-) construct three recognition systems at the same domain. This peculiar concept provides the most comprehensive mechanism for the attachment of ABA to target glycans and malignant cells at the molecular level.
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http://dx.doi.org/10.1016/j.febslet.2010.07.021DOI Listing
August 2010

Duality of the carbohydrate-recognition system of Pseudomonas aeruginosa-II lectin (PA-IIL).

FEBS Lett 2010 Jun 14;584(11):2371-5. Epub 2010 Apr 14.

Institute of Molecular and Cellular Biology, College of Medicine, Chang-Gung University, Kwei-san, Tao-yuan, Taiwan.

The study of Pseudomonas aeruginosa-II lectin (PA-IIL) complexes with Man derivatives as a recognition factor has been neglected since its monomer is a very weak ligand. Here, the roles of Man oligomers and complexes in PA-IIL carbohydrate-recognition were studied by both enzyme-linked lectinosorbent and inhibition assays. From the results obtained, it is proposed that high density weak -OH conformation as seen in yeast mannan is also an important PA-IIL recognition factor. This finding provides a peculiar concept of the duality of PA-IIL recognition system for LFucalpha1--> and related complexes and for high density Manalpha1--> complexes present in polymannosylated target macromolecules.
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http://dx.doi.org/10.1016/j.febslet.2010.04.026DOI Listing
June 2010

Impact of diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma: a retrospective cohort study.

Ann Surg Oncol 2010 Aug 12;17(8):2175-83. Epub 2010 Mar 12.

Oral and Maxillofacial Surgery, Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Diabetes mellitus (DM) is a prevalent chronic metabolic disease reported to affect the treatment outcomes of malignancies. This study explores the impact of diabetes on the prognosis of oral squamous cell carcinoma (OSCC).

Materials And Methods: Clinicopathological characteristics and survival in terms of overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival (CSS) of patients with OSCC who underwent surgical intervention at the Taipei Veterans General Hospital between 2002 and 2005 were stratified by diabetic status and compared.

Results: Patients with DM tend to have a lower OS, RFS, and CSS compared with nondiabetics (adjusted hazard ratio [HR] = 2.22, 2.42, and 2.16, respectively) even in less aggressive tumor stages (stage I and II). In advanced tumors, diabetic patients who were not prescribed adjuvant therapy had a significantly higher recurrence rate than nondiabetic patients (HR = 2.66). However, there was no significant difference in treatment outcome in patients with locally advanced tumors amenable to receive adjuvant therapy, even with the delayed initiation of adjuvant therapy in the DM group (49.1 +/- 22.3 days vs. 40.0 +/- 16.6 days, P = .04). DM was also associated with a higher frequency of perineural invasion (adjusted odds ratio [OR] = 2.53).

Conclusion: DM status could be a prognostic factor for OSCC, particularly for its effect in the survival and perineural invasion. Although diabetes-associated comorbidities may impair decision making toward less aggressive therapeutic modality, adjuvant treatment may be essential for DM patients to improve their survival.
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http://dx.doi.org/10.1245/s10434-010-0996-1DOI Listing
August 2010

An efficient approach to derive hydroxyl groups on the surface of barium titanate nanoparticles to improve its chemical modification ability.

J Colloid Interface Sci 2009 Jan 31;329(2):300-5. Epub 2008 Oct 31.

Institute of Materials Science and Engineering, and Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, Taiwan.

Highly hydroxylated barium titanate (BaTiO(3)) nanoparticles have been prepared via an easy and gentle approach which oxidizes BaTiO(3) nanoparticles using an aqueous solution of hydrogen peroxide (H(2)O(2)). The hydroxylated BaTiO(3) surface reacts with sodium oleate (SOA) to form oleophilic layers that greatly enhance the dispersion of BaTiO(3) nanoparticles in organic solvents such as tetrahydrofuran, toluene, and n-octane. The results of Fourier transform infrared spectroscopy confirmed that the major functional groups on the surface of H(2)O(2)-treated BaTiO(3) nanoparticles are hydroxyl groups which are chemically active, favoring chemical bonding with SOA. The results of transmission electron microscopy of SOA-modified BaTiO(3) nanoparticles suggested that the oleate molecules were bonded to the surfaces of nanoparticles and formed a homogeneous layer having a thickness of about 2 nm. Furthermore, the improved dispersion capability of the modified BaTiO(3) nanoparticles in organic solvents was verified through analytic results of its settling and rheological behaviors.
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http://dx.doi.org/10.1016/j.jcis.2008.10.011DOI Listing
January 2009

Application of the acetylacetone chelation solid-phase extraction method to measurements of trace amounts of beryllium in human hair by GFAAS.

Anal Sci 2002 May;18(5):607-9

Department of Environmental Science, Tunghai University, Taiwan, Republic of China.

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http://dx.doi.org/10.2116/analsci.18.607DOI Listing
May 2002
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