Publications by authors named "Chi-Chung Hui"

100Publications

IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis.

J Bone Miner Res 2020 Jul 14. Epub 2020 Jul 14.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, HKSAR, China.

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http://dx.doi.org/10.1002/jbmr.4132DOI Listing
July 2020

IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†.

Biol Reprod 2020 Aug;103(3):620-629

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1093/biolre/ioaa100DOI Listing
August 2020

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.

Dev Cell 2020 Mar;52(5):647-658.e6

Program in Developmental & Stem Cell Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.02.003DOI Listing
March 2020

The impact of sex hormones on genital wound healing in mice: a comparative study.

J Pediatr Urol 2019 Dec 18;15(6):635-641. Epub 2019 Sep 18.

Division of Urology, University of Wisconsin, Madison, WI, USA; Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jpurol.2019.09.001DOI Listing
December 2019

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses.

Gastroenterology 2019 12 20;157(6):1556-1571.e5. Epub 2019 Aug 20.

Department of Surgery, Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.08.019DOI Listing
December 2019

GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis.

Cell Rep 2019 06;27(10):3006-3018.e4

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.016DOI Listing
June 2019

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.

Dev Cell 2019 01 13;48(2):167-183.e5. Epub 2018 Dec 13.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Joint Institute of Genetics and Genomic Medicine, Zhejiang University and University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183093
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http://dx.doi.org/10.1016/j.devcel.2018.11.015DOI Listing
January 2019

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.

Neuron 2018 11 18;100(4):799-815.e7. Epub 2018 Oct 18.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.09.046DOI Listing
November 2018

Genetic interaction between Gli3 and Ezh2 during limb pattern formation.

Mech Dev 2018 06 2;151:30-36. Epub 2018 May 2.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Orthopaedics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mod.2018.05.002DOI Listing
June 2018

The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.

Wiley Interdiscip Rev Dev Biol 2017 07 20;6(4). Epub 2017 Mar 20.

Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/wdev.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679199PMC
July 2017

A genetic female mouse model with congenital genitourinary anomalies and adult stages of urinary incontinence.

Neurourol Urodyn 2017 Nov 28;36(8):1981-1987. Epub 2017 Feb 28.

University Hospitals Cleveland Medical Center, Urology Institute, Cleveland, Ohio.

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http://dx.doi.org/10.1002/nau.23230DOI Listing
November 2017

Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling.

Mol Cell Biol 2017 02 19;37(3). Epub 2017 Jan 19.

Department of Developmental Genetics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China

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http://dx.doi.org/10.1128/MCB.00421-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247608PMC
February 2017

Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation.

PLoS One 2016 4;11(11):e0165958. Epub 2016 Nov 4.

Program in Developmental & Stem Cell Biology, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165958PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096680PMC
June 2017

Tibial hemimelia associated with GLI3 truncation.

J Hum Genet 2016 May 21;61(5):443-6. Epub 2016 Jan 21.

Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/jhg.2015.161DOI Listing
May 2016

Irx3 is required for postnatal maturation of the mouse ventricular conduction system.

Sci Rep 2016 Jan 20;6:19197. Epub 2016 Jan 20.

The Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON M5S 3E2, Canada.

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http://dx.doi.org/10.1038/srep19197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726432PMC
January 2016

FTO Obesity Variant and Adipocyte Browning in Humans.

N Engl J Med 2016 01;374(2):192-3

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http://dx.doi.org/10.1056/NEJMc1513316DOI Listing
January 2016

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

N Engl J Med 2015 Sep 19;373(10):895-907. Epub 2015 Aug 19.

From Beth Israel Deaconess Medical Center and Hebrew SeniorLife, Gerontology Division, Harvard Medical School, Boston (M.C., Y.-H.H.); Massachusetts Institute of Technology (MIT) Computer Science and Artificial Intelligence Laboratory (M.C., G.Q., W.M., N.A.A., M.K.), and Broad Institute of MIT and Harvard, Cambridge (M.C., G.Q., W.M., M.K.); Clinical Cooperation Group "Nutrigenomics and Type 2 Diabetes," Helmholtz Center Munich (M.C., H.H.), and Else Kröner-Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, ZIEL-Institute for Food and Health, Technische Universität München (M.C., V.G., I.S.S., H.H.), Munich, Germany; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, and Hormone Laboratory, Haukeland University Hospital, Bergen, Norway (S.N.D., C.H., G.M.); Program in Developmental and Stem Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto (K.-H.K., V.P., J.L., C.-C.H.), and Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital (J.L.B., D.J.D.), Toronto; and the Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden (P.-A.S.).

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http://dx.doi.org/10.1056/NEJMoa1502214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959911PMC
September 2015

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.

Gastroenterology 2015 Dec 7;149(7):1837-1848.e5. Epub 2015 Aug 7.

Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085150109
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http://dx.doi.org/10.1053/j.gastro.2015.07.060DOI Listing
December 2015

Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

PLoS One 2015 21;10(7):e0133274. Epub 2015 Jul 21.

The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133274PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510596PMC
May 2016

BCC or not: Sufu keeps it in check.

Oncoscience 2015 20;2(2):77-8. Epub 2015 Feb 20.

Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381698PMC
http://dx.doi.org/10.18632/oncoscience.134DOI Listing
April 2015

Sufu and Kif7 in limb patterning and development.

Dev Dyn 2015 Mar 24;244(3):468-78. Epub 2015 Jan 24.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/dvdy.24249DOI Listing
March 2015

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.

Sci Signal 2014 Dec 9;7(355):ra117. Epub 2014 Dec 9.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada. Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1126/scisignal.2005608DOI Listing
December 2014

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.

Dev Biol 2015 Jan 13;397(2):191-202. Epub 2014 Nov 13.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.10.023DOI Listing
January 2015

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.

Dev Biol 2014 Aug 2;392(2):324-33. Epub 2014 Jun 2.

Cardiovascular Research Institute, University of California, San Francisco, CA 94158, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106470PMC
August 2014

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.

Dev Cell 2014 Apr 10;29(2):241-9. Epub 2014 Apr 10.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.03.002DOI Listing
April 2014

Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.

Dev Cell 2014 Apr 10;29(2):233-40. Epub 2014 Apr 10.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON MS5 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.03.001DOI Listing
April 2014

Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation.

J Invest Dermatol 2014 Jul 3;134(7):1981-1990. Epub 2014 Feb 3.

Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.63DOI Listing
July 2014

Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner.

PLoS One 2013 7;8(6):e65448. Epub 2013 Jun 7.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065448PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676467PMC
January 2014

Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.

Dev Cell 2013 Jun 6;25(6):636-44. Epub 2013 Jun 6.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1016/j.devcel.2013.05.006DOI Listing
June 2013

Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.

PLoS One 2012 16;7(11):e50193. Epub 2012 Nov 16.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500354PMC
April 2013

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.

Development 2012 Nov 3;139(22):4152-61. Epub 2012 Oct 3.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dev.biologists.org/cgi/doi/10.1242/dev.081190
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http://dx.doi.org/10.1242/dev.081190DOI Listing
November 2012

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.

Development 2012 Nov 19;139(21):4007-19. Epub 2012 Sep 19.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1242/dev.081703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472592PMC
November 2012

Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.

J Biol Chem 2012 Oct 28;287(43):36222-8. Epub 2012 Aug 28.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1074/jbc.M112.382275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476289PMC
October 2012

Iroquois homeodomain transcription factors in heart development and function.

Circ Res 2012 May;110(11):1513-24

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.265041DOI Listing
May 2012

Gli proteins in development and disease.

Annu Rev Cell Dev Biol 2011 21;27:513-37. Epub 2011 Jul 21.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1146/annurev-cellbio-092910-154048DOI Listing
February 2012

Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.

Development 2011 Sep 27;138(17):3791-801. Epub 2011 Jul 27.

Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dev.biologists.org/cgi/doi/10.1242/dev.069492
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http://dx.doi.org/10.1242/dev.069492DOI Listing
September 2011

Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor.

J Neurosci 2011 Feb;31(5):1825-36

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.2166-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623745PMC
February 2011

A cascade of irx1a and irx2a controls shh expression during retinogenesis.

Dev Dyn 2010 Dec;239(12):3204-14

Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.

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http://dx.doi.org/10.1002/dvdy.22462DOI Listing
December 2010

Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.

Dev Biol 2011 Jan 20;349(2):417-26. Epub 2010 Oct 20.

Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.ydbio.2010.10.010DOI Listing
January 2011

Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms.

Blood 2010 Jul 25;116(4):653-60. Epub 2010 Mar 25.

Developmental and Stem Cell Biology Program, Hospital for Sick Children Research Institute, 555 University Ave.,Toronto, Ontario, Canada.

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http://dx.doi.org/10.1182/blood-2009-12-256644DOI Listing
July 2010

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.

Am J Physiol Lung Cell Mol Physiol 2010 Jan 6;298(1):L45-56. Epub 2009 Nov 6.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St., East Tower, Rm. 14-309, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1152/ajplung.90550.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806195PMC
January 2010

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.

PLoS One 2009 Oct 7;4(10):e7313. Epub 2009 Oct 7.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007313PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754339PMC
October 2009

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

Sci Signal 2009 Jun 23;2(76):ra29. Epub 2009 Jun 23.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2000405
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http://dx.doi.org/10.1126/scisignal.2000405DOI Listing
June 2009

Hedgehog signaling in development and cancer.

Dev Cell 2008 Dec;15(6):801-12

Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.devcel.2008.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443374PMC
December 2008

Sonic Hedgehog mediator Gli2 regulates bladder mesenchymal patterning.

J Urol 2008 Oct 16;180(4):1543-50. Epub 2008 Aug 16.

Division of Paediatric Surgery, Department of Paediatrics, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.juro.2008.06.003DOI Listing
October 2008

Zebrafish homologue irx1a is required for the differentiation of serotonergic neurons.

Dev Dyn 2007 Sep;236(9):2661-7

Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong.

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http://dx.doi.org/10.1002/dvdy.21272DOI Listing
September 2007

Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.

Dev Biol 2007 Aug 26;308(2):547-60. Epub 2007 Jun 26.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Towers, 101 College Street, Toronto, Ontario, Canada M5G1L7.

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http://dx.doi.org/10.1016/j.ydbio.2007.06.016DOI Listing
August 2007

Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.

Biochim Biophys Acta 2006 Nov-Dec;1759(11-12):562-72. Epub 2006 Oct 21.

Biochemistry and Molecular Genetics Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, 310 East, 67th St, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.bbaexp.2006.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277547PMC
March 2007

Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain.

Dev Biol 2007 Feb 9;302(1):345-55. Epub 2006 Aug 9.

Program in Developmental Biology, The Hospital for Sick Children, Room 13-314, Toronto Medical Discovery Tower, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ydbio.2006.08.005DOI Listing
February 2007

Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality.

Mol Cell Biol 2006 Sep;26(17):6656-63

Research Institute, Program in Genetics and Genomic Biology, Room 15-313 TMDT, 101 College Street, East Tower, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1128/MCB.00091-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592835PMC
September 2006

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.

Mol Cell Biol 2006 Sep;26(17):6609-22

Program in Developmental Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, MaRS Building, East Tower, Room 13-314, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1128/MCB.00295-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592833PMC
September 2006

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

Genes Dev 2006 Jun;20(12):1651-66

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gad.1411406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482484PMC
June 2006

The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina.

Mech Dev 2006 Mar 2;123(3):252-63. Epub 2006 Feb 2.

Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.

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http://dx.doi.org/10.1016/j.mod.2005.12.001DOI Listing
March 2006

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.

Development 2006 Feb 5;133(3):569-78. Epub 2006 Jan 5.

Program in Developmental Biology, Hospital for Sick Children, University of Toronto, Canada.

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http://dx.doi.org/10.1242/dev.02220DOI Listing
February 2006

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.

Nat Genet 2006 Feb 25;38(2):175-83. Epub 2005 Dec 25.

Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1038/ng1707DOI Listing
February 2006

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.

Differentiation 2005 Oct;73(8):397-405

Hospital for Sick Children, Program in Developmental Biology, 101 College Street, TMDT, Rm. 13-314, Toronto, ON, Canada M5G 1L7.

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http://linkinghub.elsevier.com/retrieve/pii/S030146810960350
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http://dx.doi.org/10.1111/j.1432-0436.2005.00042.xDOI Listing
October 2005

The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.

Dev Biol 2005 Nov 22;287(1):48-60. Epub 2005 Sep 22.

Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.ydbio.2005.08.029DOI Listing
November 2005

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development.

Mech Dev 2005 Nov 1;122(11):1218-33. Epub 2005 Aug 1.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.

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http://dx.doi.org/10.1016/j.mod.2005.06.012DOI Listing
November 2005

Shh controls epithelial proliferation via independent pathways that converge on N-Myc.

Dev Cell 2005 Aug;9(2):293-303

Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.devcel.2005.05.009DOI Listing
August 2005

Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.

Development 2005 Jan 16;132(2):345-57. Epub 2004 Dec 16.

Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01537
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http://dx.doi.org/10.1242/dev.01537DOI Listing
January 2005

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.

Oncogene 2004 Jun;23(26):4577-83

The Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1038/sj.onc.1207605DOI Listing
June 2004

Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction.

Development 2003 Dec 5;130(25):6233-43. Epub 2003 Nov 5.

Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA.

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http://dx.doi.org/10.1242/dev.00851DOI Listing
December 2003

Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.

Mech Dev 2003 Oct;120(10):1097-111

Division of Morphogenesis, Department of Embryogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2-2-1, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1016/j.mod.2003.09.001DOI Listing
October 2003

Cbl-3-deficient mice exhibit normal epithelial development.

Mol Cell Biol 2003 Nov;23(21):7708-18

Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC207562PMC
http://dx.doi.org/10.1128/mcb.23.21.7708-7718.2003DOI Listing
November 2003

Gli2 is required for normal Shh signaling and oligodendrocyte development in the spinal cord.

Mol Cell Neurosci 2003 Jul;23(3):440-50

Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1016/s1044-7431(03)00067-8DOI Listing
July 2003

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.

Dev Biol 2003 Jul;259(1):150-61

Molecular Neuropathology Group, Brain Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/s0012-1606(03)00159-3DOI Listing
July 2003

Notch1 functions as a tumor suppressor in mouse skin.

Nat Genet 2003 Mar 18;33(3):416-21. Epub 2003 Feb 18.

Ludwig Institute for Cancer Research, Lausanne Branch, University Lausanne, 1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1038/ng1099DOI Listing
March 2003

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.

Genes Dev 2003 Jan;17(2):282-94

Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1101/gad.1038103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC195973PMC
January 2003

Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.

Cancer Res 2002 Sep;62(18):5308-16

Comprehensive Cancer Center, Department of Dermatology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

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http://cancerres.aacrjournals.org/content/62/18/5308.full.pd
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September 2002