Chi-Bun Chan

Chi-Bun Chan

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Chi-Bun Chan

Chi-Bun Chan

Publications by authors named "Chi-Bun Chan"

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Developing Insulin and BDNF Mimetics for Diabetes Therapy.

Curr Top Med Chem 2019 ;19(24):2188-2204

Department of Pathology and Laboratory Medicine, Emory University of School of Medicine, Atlanta, GA, United States.

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http://dx.doi.org/10.2174/1568026619666191010160643DOI Listing
December 2019

Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice.

Biochem Biophys Res Commun 2019 Jun 2;514(2):407-414. Epub 2019 May 2.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica of Peking Union Medical College, Beijing, 100050, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.04.155DOI Listing
June 2019

Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation.

Cell Death Dis 2019 03 4;10(3):222. Epub 2019 Mar 4.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41419-019-1452-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399291PMC
March 2019

Interaction of CREB and PGC-1α Induces Fibronectin Type III Domain-Containing Protein 5 Expression in C2C12 Myotubes.

Cell Physiol Biochem 2018 25;50(4):1574-1584. Epub 2018 Oct 25.

School of Biological Sciences, the University of Hong Kong, 5N10 Kadoorie Biological Sciences Building, Hong Kong, China.

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https://www.karger.com/Article/FullText/494655
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http://dx.doi.org/10.1159/000494655DOI Listing
November 2018

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle.

Metabolism 2018 10 20;87:113-122. Epub 2018 Jun 20.

School of Biological Sciences, the University of Hong Kong, Hong Kong, SAR, China; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, SAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.06.007DOI Listing
October 2018

The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity.

Oxid Med Cell Longev 2016 19;2016:4693703. Epub 2016 Apr 19.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1155/2016/4693703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853961PMC
March 2017

Sex differences in brain-derived neurotrophic factor signaling and functions.

J Neurosci Res 2017 01;95(1-2):328-335

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, USA.

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http://dx.doi.org/10.1002/jnr.23863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271179PMC
January 2017

Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence.

Int J Biochem Cell Biol 2016 11 1;80:132-142. Epub 2016 Oct 1.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 20031, China. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.09.029DOI Listing
November 2016

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders.

Transl Neurodegener 2016 6;5. Epub 2016 Jan 6.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 USA.

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http://dx.doi.org/10.1186/s40035-015-0048-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702337PMC
January 2016

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Neuropsychopharmacology 2014 Feb 11;39(3):638-50. Epub 2013 Sep 11.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1038/npp.2013.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895241PMC
February 2014

PIKE is essential for oligodendroglia development and CNS myelination.

Proc Natl Acad Sci U S A 2014 Feb 21;111(5):1993-8. Epub 2014 Jan 21.

Department of Pathology and Laboratory Medicine, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322.

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http://dx.doi.org/10.1073/pnas.1318185111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918755PMC
February 2014

Blockade of glioma proliferation through allosteric inhibition of JAK2.

Sci Signal 2013 Jul 9;6(283):ra55. Epub 2013 Jul 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1126/scisignal.2003900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772155PMC
July 2013

Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.

Mol Cell Biol 2013 May 25;33(9):1797-808. Epub 2013 Feb 25.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1128/MCB.01410-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624174PMC
May 2013

SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.

J Neurosci 2012 Nov;32(48):17262-72

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3300-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518045PMC
November 2012

Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.

J Med Chem 2012 Oct 3;55(19):8524-37. Epub 2012 Oct 3.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1021/jm301099xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491656PMC
October 2012

Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.

J Biol Chem 2012 Feb 3;287(9):6113-27. Epub 2012 Jan 3.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M111.293605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307261PMC
February 2012

Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?

Rev Neurosci 2012 Jan 26;23(2):153-61. Epub 2012 Jan 26.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1515/revneuro-2011-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760202PMC
January 2012

What we have learnt about PIKE from the knockout mice.

Int J Biochem Mol Biol 2011 7;2(3):228-39. Epub 2011 Jun 7.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine Atlanta, GA USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193289PMC
November 2011

Identification of a molecular activator for insulin receptor with potent anti-diabetic effects.

J Biol Chem 2011 Oct 9;286(43):37379-88. Epub 2011 Sep 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M111.247387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199485PMC
October 2011

PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression.

EMBO J 2011 Aug 16;30(20):4274-86. Epub 2011 Aug 16.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1038/emboj.2011.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199380PMC
August 2011

The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity.

EMBO Rep 2011 Jul 1;12(8):847-54. Epub 2011 Jul 1.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/embor.2011.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147257PMC
July 2011

Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.

J Neurosci 2011 Jun;31(22):8083-92

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1129-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551346PMC
June 2011

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.

J Med Chem 2010 Dec 12;53(23):8274-86. Epub 2010 Nov 12.

Department of Pathology and Laboratory Medicine Emory University School of Medicine, Room 141 Whitehead Building, 615 Michael Street, Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/jm101206pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150605PMC
December 2010

Deoxygedunin, a natural product with potent neurotrophic activity in mice.

PLoS One 2010 Jul 13;5(7):e11528. Epub 2010 Jul 13.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011528PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903477PMC
July 2010

Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.

Diabetes 2010 Apr 12;59(4):883-93. Epub 2010 Jan 12.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-14
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http://dx.doi.org/10.2337/db09-1404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844836PMC
April 2010

Multiple functions of phosphoinositide-3 kinase enhancer (PIKE).

ScientificWorldJournal 2010 Apr 13;10:613-23. Epub 2010 Apr 13.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1100/tsw.2010.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763947PMC
April 2010

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.

EMBO J 2010 Mar 14;29(5):956-68. Epub 2010 Jan 14.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1038/emboj.2009.406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837170PMC
March 2010

Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.

Chem Biol 2009 Jun;16(6):644-56

Department of Pathology and Laboratory Medicine, Emory University, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.chembiol.2009.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844702PMC
June 2009

The constitutive activity of the ghrelin receptor attenuates apoptosis via a protein kinase C-dependent pathway.

Mol Cell Endocrinol 2009 Feb 24;299(2):232-9. Epub 2008 Dec 24.

Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

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http://linkinghub.elsevier.com/retrieve/pii/S030372070800583
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http://dx.doi.org/10.1016/j.mce.2008.12.006DOI Listing
February 2009

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.

Proc Natl Acad Sci U S A 2009 Jan 23;106(2):468-73. Epub 2008 Dec 23.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1073/pnas.0809824105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626726PMC
January 2009

Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green.

J Cell Biochem 2008 Dec;105(6):1399-409

Environmental Science Program, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1002/jcb.21960DOI Listing
December 2008

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.

Nat Cell Biol 2008 Jun 11;10(6):698-706. Epub 2008 May 11.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1038/ncb1732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839190PMC
June 2008

The presence of two distinct prolactin receptors in seabream with different tissue distribution patterns, signal transduction pathways and regulation of gene expression by steroid hormones.

J Endocrinol 2007 Aug;194(2):373-92

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China.

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http://dx.doi.org/10.1677/JOE-07-0076DOI Listing
August 2007

The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor.

Cell Signal 2007 May 28;19(5):1011-22. Epub 2006 Nov 28.

Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680600303
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http://dx.doi.org/10.1016/j.cellsig.2006.11.011DOI Listing
May 2007

PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death.

J Cell Mol Med 2007 Jan-Feb;11(1):39-53

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2007.00014.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401219PMC
May 2007

Cloning of the black seabream (Acanthopagrus schlegeli) antiquitin gene and functional characterization of its promoter region.

Mol Cell Biochem 2007 Mar 31;297(1-2):151-60. Epub 2006 Oct 31.

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/s11010-006-9340-2DOI Listing
March 2007

Cells of the anterior pituitary.

Int J Biochem Cell Biol 2006 3;38(9):1441-9. Epub 2006 Mar 3.

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1016/j.biocel.2006.02.012DOI Listing
September 2006

Seabream ghrelin: cDNA cloning, genomic organization and promoter studies.

J Endocrinol 2006 May;189(2):365-79

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1677/joe.1.06593DOI Listing
May 2006

The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream.

J Mol Endocrinol 2006 Feb;36(1):23-40

Department of Biochemistry, The Chinese University of Hong Kong, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1677/jme.1.01945DOI Listing
February 2006

Seabream antiquitin: molecular cloning, tissue distribution, subcellular localization and functional expression.

FEBS Lett 2005 Jul;579(17):3759-64

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1016/j.febslet.2005.05.070DOI Listing
July 2005

Signal transduction mechanism of the seabream growth hormone secretagogue receptor.

FEBS Lett 2004 Nov;577(1-2):147-53

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1016/j.febslet.2004.08.088DOI Listing
November 2004

Isolation and characterization of the 5'-flanking region of the growth hormone secretagogue receptor gene from black seabream Acanthopagrus schlegeli.

Mol Cell Endocrinol 2004 Aug;223(1-2):5-15

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China.

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http://dx.doi.org/10.1016/j.mce.2004.06.005DOI Listing
August 2004

Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli.

Mol Cell Endocrinol 2004 Feb;214(1-2):81-95

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

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http://dx.doi.org/10.1016/j.mce.2003.11.020DOI Listing
February 2004