Publications by authors named "Chenyang Zhang"

132 Publications

Development of a label free electrochemical sensor based on a sensitive monoclonal antibody for the detection of tiamulin.

Food Chem 2021 Jul 12;366:130573. Epub 2021 Jul 12.

School of Life Sciences, Zhengzhou University, Zhengzhou, China. Electronic address:

Based on a murine monoclonal antibody (mAb) against tiamulin (TML), an electrochemical immunosensor was proposed using silver-graphene oxide (Ag-GO) nanocomposites and gold nanocomposites (AuNPs) to detect tiamulin (TML). Due to the synergetic properties of Ag-GO nanocomposites and AuNPs, the conductivity of the immunosensor was significantly enhanced. On account of the specific mAb and conductive nanocomposites, the proposed electrochemical immunosensor exhibited a low LOD of 0.003 ng mL for the detection of TML in a wide linear range of 0.01 to 1000 ng mL. In addition, the immunosensor did not involve additional redox species. Furthermore, the efficient and simple electrochemical immunosensor was employed to detect TML in real samples with high accuracy, suggesting a potential detection platform for other veterinary antibiotics in animal derived foods.
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http://dx.doi.org/10.1016/j.foodchem.2021.130573DOI Listing
July 2021

X-ray-facilitated redox cycling of nanozyme possessing peroxidase-mimicking activity for reactive oxygen species-enhanced cancer therapy.

Biomaterials 2021 Jul 10;276:121023. Epub 2021 Jul 10.

College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100190, China; The GBA National Institute for Nanotechnology Innovation, Guangzhou, Guangdong, 510700, China.

Nanomaterials with shifting or mixed redox states is one of the most common studied nanozyme with peroxidase-like activity for chemodynamic therapy (CDT), which can decompose hydrogen peroxide (HO) of tumor microenvironment into highly toxic reactive oxygen species (ROS) by a nano-catalytic way. However, most of them exhibit an insufficient catalytic efficiency due to their dependence on catalytic condition. Herein, a potential methodology is proposed to enhance their enzymatic activity by accelerating the redox cycling of these nanomaterials with shifting or mixed redox states in the presence of X-ray. In this study, the nanocomposite consisting of SnS nanoplates and FeO quantum dots with shifting or mixed redox states (Fe/Fe) is used to explore the strategy. Under external X-ray irradiation, SnS cofactor as electron donor can be triggered to transfer electrons to FeO, which promotes the regeneration of Fe sites on the surface of the FeO. Consequently, the regenerated Fe sites react with the overexpressed HO to persistently generate ROS for enhanced tumor therapy. The designed nanocomposite displays the synergistic effects of radiotherapy and CDT. The strategy provides a new avenue for the development of artificial nanozymes with shifting or mixed redox states in precise cancer treatments based on X-ray-enhanced enzymatic efficacy.
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http://dx.doi.org/10.1016/j.biomaterials.2021.121023DOI Listing
July 2021

A novel electrochemical immunosensor for the sensitive detection of tiamulin based on staphylococcal protein A and silver nanoparticle-graphene oxide nanocomposites.

Bioelectrochemistry 2021 Jun 15;141:107877. Epub 2021 Jun 15.

School of Life Sciences, Zhengzhou University, Zhengzhou, China; Henan Zhongze Biological Engineering Co. LTD, Zhengzhou, China. Electronic address:

Tiamulin (TML) is a pleuromutilin antibiotic and mainly used to treat pulmonary and gastrointestinal infections. However, excessive use of TML can bring health threats to consumers. In this work, a label-free electrochemical immunosensor was proposed for sensitive detection of TML in pork and pork liver. Silver nanoparticles (AgNPs) were synthesized in situ on graphene oxide (GO), in which GO acted as a carrier for loading more AgNPs and AgNPs exhibited both strong conductivity and good redox property. In addition, staphylococcal protein A (SPA) was applied to oriented immobilization of fragment crystallizable (Fc) region of the TML monoclonal antibody. Under the optimal condition, the developed electrochemical immunosensor exhibited a good linear response with a concentration of TML ranging from 0.05 ng mL to 100 ng mL and the limit of detection (LOD) was 0.04 ng mL. Furthermore, the designed immunosensor was applied to detect TML in real samples with a good accuracy. Therefore, the label-free electrochemical immunosensor could be used as a potential method to detect TML and other antibiotic residues in animal derived foods.
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http://dx.doi.org/10.1016/j.bioelechem.2021.107877DOI Listing
June 2021

Successive Storage of Cations and Anions by Ligands of π-d-Conjugated Coordination Polymers Enabling Robust Sodium-Ion Batteries.

Angew Chem Int Ed Engl 2021 Jun 16. Epub 2021 Jun 16.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, China.

The oxidation of π-d-conjugated coordination polymers (CCPs) accompanied with anion insertion has the merits of increasing the capacity and elevating the discharge voltages. However, previous reports on this mechanism either required more investigations or showed low capacity and poor cyclablity. Herein, triphenylene-catecholate-based two-dimensional CCPs are constructed by employing inactive transition-metal ions (Zn ) as nodes, forming Zn-HHTP. Substantial characterizations and theoretical calculations indicate the successive storage of cations and anions by redox reactions of only ligands, leading to a high reversible capacity of ≈150 mAh g at 100 mA g and a remarkable capacity retention of 90 % after 1000 cycles. On the contrary, as a control experiment, the analogous CCPs (Cu-HHTP) with Cu nodes, where both ligands and metal ions undergo redox reactions, accompanied by the storage of only Na cations, show a much poorer cyclability. These results highlight the importance of redox reactions of only ligands for long-term cycle life and the insight into the storage mechanisms deepens our understanding on CCPs for the further design of CCPs with high performance.
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http://dx.doi.org/10.1002/anie.202106055DOI Listing
June 2021

Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy.

Biomed Pharmacother 2021 Jun 12;141:111780. Epub 2021 Jun 12.

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address:

Diabetic cardiomyopathy (DCM), one severe complication in the diabetes, leads to high mortality in the diabetic patients. However, the understanding of molecular mechanisms underlying DCM is far from completion. Herein, we investigated the disease-related differences in the proteomes of DCM based on db/db mice and verified the protective roles of peroxiredoxin-4 (Prdx4) in H9c2 cardiomyocytes treated by palmitic acid (PA). Fasting blood glucose (FBG) and cardiac function was detected in the 6-month-old control and diabetic mice. The hearts were then collected and analyzed by a coupled label-free and mass spectrometry approach. In vivo investigation indicated that body weight and FBG of db/db mice markedly increased, and diabetic heart exhibited obvious cardiac hypertrophy and lipid droplet accumulation, and cardiac dysfunction as is indicated by the increases of left ventricle posterior wall thickness in systole (LVPWd) and diastole (LVPWs), and reduction of fractional shortening (FS). We used proteomic analysis and then detected a grand total of 2636 proteins. 175 differentially expressed proteins (DEPs) were markedly detected in the diabetic heart. Thereinto, Prdx4 was markedly down-regulated in the diabetic heart. In vitro experiments revealed that 250 μM PA significantly inhibited viability of H9c2 cell. PA induced much accumulation of lipid droplet in cardiomyocytes and resulted in an increase of mRNA expressions of lipogenic genes (FASN and SCD1) and cardiac hypertrophic genes. Additionally, protein level of Prdx4 evidently reduced in the PA-treated H9c2 cell. It was further found that shRNA-mediated Prdx4 knockdown exacerbated PA-induced oxidative stress and cardiomyocyte apoptosis, whereas overexpressing Prdx4 in the H9c2 cells noteworthily limited PA-induced ROS generation and cardiomyocytes apoptosis. These data collectively reveal the essential role of abnormal Prdx4 in pathological alteration of DCM, and provide potentially therapeutic target for the prevention of DCM.
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http://dx.doi.org/10.1016/j.biopha.2021.111780DOI Listing
June 2021

Supramolecular 2D monolayered nanosheets constructed by using synergy of non-covalent interactions.

Chem Commun (Camb) 2021 Jun;57(51):6272-6275

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.

Here, a straightforward and rational approach to construct supramolecular assemblies with ordered nanostructures in a two-dimensional arrangement is reported. Taking advantage of the synergistic effect of multiple non-covalent interactions (hydrogen bonding and π-π interactions), the designed molecular monomer has a specific orientation in the self-assembly process, thus realizing two-dimensional control. Supramolecular two-dimensional nanosheets with single-layer thickness and controllable dimensions have been obtained, which can be clearly confirmed using TEM, SEM, AFM and XRD and by comparing with the self-assembled structures of the control system. The strategy of collaborative self-assembly proposed here using multiple non-covalent interactions is expected to be extended to the construction of various kinds of unique supramolecular 2D materials.
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http://dx.doi.org/10.1039/d1cc01640gDOI Listing
June 2021

A New Type of Hierarchical Honeycomb in-Plane Impact Study.

Materials (Basel) 2021 Apr 12;14(8). Epub 2021 Apr 12.

College of Aerospace and Civil Engineering, Harbin Engineering University, Harbin 150001, China.

Honeycomb materials have low density, high specific strength and stiffness, impact resistance, and good sound insulation effect, and therefore are widely used in aerospace, automobile, and ship field applications. In this paper, we study the in-plane impact response of a second-order hierarchical honeycomb (SHH) material. Its main structure is a hexagonal honeycomb, and the substructure is composed of an augmented double arrow honeycomb (ADAH) negative Poisson's ratio unit. Through a finite element simulation, the failure stress of an hierarchical honeycomb in two directions of quasi-static crushing and dynamic crushing was analyzed; the failure stress of the hierarchical honeycomb under different densities, different speeds, and different substructures was discussed; and the theoretical failure stress was verified. The numerical analysis results show that a second-order hierarchical honeycomb (SHH) has better collapse stress than a first-order regular hexagonal honeycomb (FHH) and an augmented double arrow honeycomb (ADAH).
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http://dx.doi.org/10.3390/ma14081917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068846PMC
April 2021

TiO-sensitized double-shell ZnCdS hollow nanospheres for photoelectrochemical immunoassay of carcinoembryonic antigen coupled with hybridization chain reaction-dependent Cu quenching.

Biosens Bioelectron 2021 Aug 17;185:113251. Epub 2021 Apr 17.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, Anhui, PR China. Electronic address:

A novel photoelectrochemical immunosensor was constructed to monitor carcinoembryonic antigen (CEA) based on hybridization chain reaction (HCR)-mediated in situ generation of copper nanoparticles (Cu NPs) and subsequent Cu-dependent quenching reaction, in which titanium dioxide nanoparticles-sensitized double-shell zinc cadmium sulfide hollow nanospheres (TiO/DS-ZnCdS)-modified ITO electrode and anti-CEA antibody-modified 96-well plate served as biological recognition and signal detection platforms, respectively. The synergistic effect of TiO NPs and DS-ZnCdS hollow nanospheres contributed to the improvement of photoelectric conversion efficiency, and HCR-mediated signal cascade benefited the enhancement of detection sensitivity. In the presence of CEA, biotin-labelled anti-CEA antibodies were immobilized onto anti-CEA antibody-modified 96-well plate, and triggered HCR process to form long double stranded DNA, which could adsorb a large number of Cu ions and then in situ form Cu NPs on double stranded DNA template by a facile reduction reaction. After acid treatment, the dissolved Cu ions could significantly reduce the photocurrent response due to the generation of CuS. Under optimal conditions, the immunosensor exhibited a desirable liner range of 1 pg mL - 50 ng mL and a low detection limit of 0.1 pg mL, as well as excellent selectivity and stability. Meanwhile, the recoveries of human serum sample analysis ranged from 96.8% to 103.6%, and the relative standard deviation was less than 7.40%, showing a good feasibility in early clinical diagnosis.
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http://dx.doi.org/10.1016/j.bios.2021.113251DOI Listing
August 2021

Effect of Saponins and Major Anti-Obesity Components on Weight Loss.

Front Pharmacol 2020 25;11:601751. Epub 2021 Mar 25.

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

The prevalence of individuals who are overweight or obese is rising rapidly globally. Currently, majority of drugs used to treat obesity are ineffective or are accompanied by obvious side effects; hence, the options are very limited. Therefore, it is necessary to find more effective and safer anti-obesity drugs. It has been proven and that the active ingredient notoginsenosides isolated from traditional Chinese medicine (Burk.) F. H. Chen exhibits anti-obesity effects. Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. Although notoginsenosides are potential drugs for the treatment of obesity, their effects and mechanisms have not been analyzed in depth. In this review, the anti-obesity potential and mechanism of action of notoginsenosides were analyzed; thus laying emphasis on the timely prevention and treatment of obesity.
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http://dx.doi.org/10.3389/fphar.2020.601751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027240PMC
March 2021

Involvement of cytotoxic Eomes-expressing CD4 T cells in secondary progressive multiple sclerosis.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502 Japan;

Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes of peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to a chronic disease course with progressive neurological dysfunctions (secondary progressive MS, SPMS), with the progression rate varying between patients and over time. SPMS pathogenesis is now linked to immune-cell-mediated processes, although the mechanisms driving SPMS transition and progression remain elusive, and SPMS lacks biomarkers and effective treatments. We report the crucial involvement of cytotoxic CD4 T cells expressing Eomes (Eomes Th cells) in SPMS pathogenesis-a Th cell subset previously identified in a mouse model of late/chronic autoimmune CNS inflammation. Few Eomes Th cells circulate in RRMS patient peripheral blood ( = 44), primary progressive MS (PPMS) patients ( = 25), or healthy controls ( = 42), but Eomes Th cells were significantly increased in SPMS ( = 105, < 0.0001). Strikingly, lymphocytes isolated from SPMS autopsy brain samples revealed CD4 T cells infiltrating CNS that coexpressed Eomes and the cytotoxic molecule granzyme B. In particular, the Eomes Th cell levels were increased in SPMS patients in progressive disease phases versus SPMS patients without current disability increases ( < 0.0001). Moreover, Eomes level acted as a biomarker to predict SPMS patients at risk of disease worsening with over 80% accuracy (ROC-AUC = 0.8276). Overall, our results indicate that granzyme B-expressing Eomes T helper cells are involved in the pathogenesis of SPMS, with significant implications for SPMS biomarkers and therapeutic targets.
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http://dx.doi.org/10.1073/pnas.2021818118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980371PMC
March 2021

[Current status and future perspectives of metabolic network models of industrial microorganisms].

Sheng Wu Gong Cheng Xue Bao 2021 Mar;37(3):860-873

Science Center for Future Foods, Jiangnan University, Wuxi 214122, Jiangsu, China.

Genome-scale metabolic network model (GSMM) is an extremely important guiding tool in the targeted modification of industrial microbial strains, which helps researchers to quickly obtain industrial microbes with specific traits and has attracted increasing attention. Here we reviewe the development history of GSMM and summarized the construction method of GSMM. Furthermore, the development and application of GSMM in industrial microorganisms are elaborated by using four typical industrial microorganisms (Bacillus subtilis, Escherichia coli, Corynebacterium glutamicum, and Saccharomyces cerevisiae) as examples. In addition, prospects in the development trend of GSMM are proposed.
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http://dx.doi.org/10.13345/j.cjb.200640DOI Listing
March 2021

A Novel Perovskite Electron-Ion Conductive Coating to Simultaneously Enhance Cycling Stability and Rate Capability of Li Ni Co Mn O Cathode Material for Lithium-Ion Batteries.

Small 2021 May 26;17(19):e2008132. Epub 2021 Mar 26.

State Key Laboratory of Silicon Materials and School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Poor cycling stability and rate capability are two key issues needing to be solved for Li- and Mn-rich oxide cathode material for lithium-ion batteries (LIBs). Herein, a novel perovskite electron-ion mixed conductor Nd Sr CoO (NSCO) is used as the coating layer on Li Ni Co Mn O (LNCMO) to simultaneously enhance its cycling stability and rate capability. By coating 3 wt% NSCO, LNCMO-3NSCO exhibits an optimal cycling performance with a capacity retention of 99% at 0.1C (1C = 200 mA g ) after 60 cycles, 91% at 1C after 300 cycles, and 54% at 20C after 1000 cycles, much better than 78%, 63%, and 3% of LNCMO, respectively. Even at a high charge and discharge rate of 50C, LNCMO-3NSCO exhibits a discharge capacity of 53 mAh g and a mid-point discharge voltage of 2.88 V, much higher than those of LNCMO (24 mA h g and 2.40 V, respectively). Benefiting from the high electronic conductivity (1.46 S cm ) and ionic conductivity (1.48 × 10  S cm ), NSCO coating not only suppresses transition metals dissolution and structure transformation, but also significantly enhances electronic conductivity and Li diffusion coefficient of LNCMO by an order of magnitude.
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http://dx.doi.org/10.1002/smll.202008132DOI Listing
May 2021

Meningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report.

BMC Neurol 2021 Mar 9;21(1):109. Epub 2021 Mar 9.

Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, 75004, China.

Background: Neuromyelitis optica spectrum disorders (NMOSD), a group of autoimmune neurological diseases, involve the optic nerve, spinal cord, and brain. Meningitis is rarely reported as the primary clinical manifestation of both anti-aquaporin-4 (AQP4)/ anti-myelin oligodendrocyte glycoprotein (MOG) antibody-negative NMOSD (NMOSD).

Case Presentation: A 30-year-old man initially presented with fever, headache, and neck stiffness. Lumbar puncture revealed mixed cell reaction and decreased glucose levels. As a result, tuberculous meningitis was suspected. After 1 month, the patient developed longitudinally extensive transverse myelitis and area postrema syndrome. This was followed by the presentation of meningitis-like symptoms once again in the third attack, but his condition eventually improved after corticosteroid treatment without relapse for 2 years. However, he was readmitted to our hospital owing to symptoms of diplopia, hiccup, and numbness in the right hand. Brain magnetic resonance imaging (MRI) revealed that the area postrema still contained lesions. Spinal MRI revealed several segmental enhancements at the C4-C5, T1, and T5 levels. Anti-AQP4 and anti-MOG antibodies were persistently absent in the serum and cerebrospinal fluid (CSF). The patient was finally diagnosed with NMOSD.

Conclusions: Meningitis could be a recurrent manifestation of NMOSD and requires more careful evaluation.
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http://dx.doi.org/10.1186/s12883-021-02133-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941943PMC
March 2021

Reduction in number to treat versus number needed to treat.

BMC Med Res Methodol 2021 03 9;21(1):48. Epub 2021 Mar 9.

Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.

Background: We propose a new measure of treatment effect based on the expected reduction in the number of patients to treat (RNT) which is defined as the difference of the reciprocals of clinical measures of interest between two arms. Compared with the conventional number needed to treat (NNT), RNT shows superiority with both binary and time-to-event endpoints in randomized controlled trials (RCTs).

Methods: Five real RCTs, two with binary endpoints and three with survival endpoints, are used to illustrate the concept of RNT and compare the performances between RNT and NNT. For survival endpoints, we propose two versions of RNT: one is based on the survival rate and the other is based on the restricted mean survival time (RMST). Hypothetical scenarios are also constructed to explore the advantages and disadvantages of RNT and NNT.

Results: Because there is no baseline for computation of NNT, it fails to differentiate treatment effect in the absolute scale. In contrast, RNT conveys more information than NNT due to its reversed order of differencing and inverting. For survival endpoints, two versions of RNT calculated as the difference of the reciprocals of survival rates and RMSTs are complementary to each other. The RMST-based RNT can capture the entire follow-up profile and thus is clinically more intuitive and meaningful, as it inherits the time-to-event characteristics for survival endpoints instead of using truncated binary endpoints at a specific time point.

Conclusions: The RNT can serve as an alternative measure for quantifying treatment effect in RCTs, which complements NNT to help patients and clinicians better understand the magnitude of treatment benefit.
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http://dx.doi.org/10.1186/s12874-021-01246-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945324PMC
March 2021

Accuracy of rapid diagnostic test to diagnose malaria in children under 5 years of age, a meta-analysis.

Diagn Microbiol Infect Dis 2021 Jun 19;100(2):115351. Epub 2021 Feb 19.

Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin Province, China. Electronic address:

Objective: To assess the accuracy of the rapid diagnostic test for malaria diagnosis in children under 5 years of age.

Methods: As of August 31, 2020, PubMed, Web of Science and Cochrane Library databases had been systematically searched. Relevant data were extracted and meta-analysis was carried out. A random effects model was used for subgroup analysis.

Results: According to the inclusion criteria, a total of 26 studies were included in this meta-analysis. The pooled sensitivity and specificity were 0.92 (95% confidence interval 0.83-0.96) and 0.92 (0.86-0.95), the parasite-specific lactate dehydrogenase-based test were 0.96 (0.85-0.98) and 0.93 (0.86-0.95), the histidine-rich protein 2-based test were 0.94 (0.84-0.98) and 0.86 (0.77-0.91).

Conclusions: This meta-analysis showed that rapid diagnostic test had good accuracy in diagnosing malaria in children under 5 years of age. And the diagnostic performance of parasite-specific lactate dehydrogenase test was better than that of the histidine-rich protein 2 test.
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http://dx.doi.org/10.1016/j.diagmicrobio.2021.115351DOI Listing
June 2021

Anion Transmembrane Nanochannels from Pore-Forming Helices Constructed by the Dynamic Covalent Reaction of Dihydrazide and Dialdehyde Units.

Chempluschem 2021 Mar 8;86(3):492-495. Epub 2021 Feb 8.

Department State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Qianjin Street, Changchun, P. R. China.

Anion transmembrane nanochannels constructed from dynamic covalent helices (DCHs) are reported. The dynamic covalent structures can be synthesized by one-pot dynamic covalent reactions and helically self-fold into nanotubes through intramolecular hydrogen bonding and π-π interactions. Such helical structures can vertically self-assemble into long nanofibers under π-π stacking and their hollow nanocavities finally form ion permeation pathways across the lipid membranes. Single-channel electrophysiology signals provide solid evidence of DCHs following the channel rather than the carrier mechanism. Owing to the pore-forming capacity of DCHs, nanochannels are able to accelerate the movement of anions across lipid membranes with high transport activity (EC =0.08 mol %). Moreover, DCH channels show dehydration energy dependent anion selectivity. This report highlights the importance of such DCHs as general channel scaffolds with economical synthesis and special nanocavities.
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http://dx.doi.org/10.1002/cplu.202000813DOI Listing
March 2021

Interface Interaction of Benzohydroxamic Acid with Lead Ions on Oxide Mineral Surfaces: A Coordination Mechanism Study.

Langmuir 2021 Mar 12;37(11):3490-3499. Epub 2021 Mar 12.

Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources, School of Minerals Processing and Bioengineering, Central South University, Changsha, Hunan 410083, China.

Surface coordination chemistry is important in areas such as adsorption, separation, and catalysts. In this work, surface coordination interactions of benzohydroxamic acid (BHA) with the lead ion [Pb(II)] adsorbed on the cassiterite surface have been investigated by first-principles calculations due to its great significance in froth flotation. Cluster calculations show that BHA possesses the weakest chelation with Pb(II) due to the electron withdrawal ability of the benzyl ring in comparison with other hydroxamic acids. Pb(II) thermodynamically prefers to react with the cassiterite surface rather than BHA. On the other hand, the partial density of states and the atomic overlap populations have consistently verified that the adsorption of BHA results in a better symmetry in electron densities than the hydrated Pb(II). The electron density maps and the electronic localization functions have further visualized the rearrangement of the 6s lone pair around the lead atom. It can be concluded that the surface coordination mechanisms of Pb(II) on oxide minerals can be attributed to the coordination ability of BHA and the unique electronic structure of Pb(II), which accounts for the reported better flotation performance of the pre-assemble strategy than the pre-activating approach. This work sheds some new light on the unique coordination activation mechanism of metal ions on oxide mineral surfaces. It should be instructive to design and screen new environment-friendly flotation reagents and flotation flowsheets.
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http://dx.doi.org/10.1021/acs.langmuir.1c00322DOI Listing
March 2021

Interpretation of the differential UV-visible absorbance spectra of metal-NOM complexes based on the quantum chemical simulations for the model compound esculetin.

Chemosphere 2021 Aug 22;276:130043. Epub 2021 Feb 22.

Department of Environmental Engineering, College of Environmental Science and Engineering, Peking University, China. Electronic address:

In this study, the model compound esculetin that has functional groups typical for natural organic matter (NOM) was used to ascertain the nature of the characteristic bands in the differential UV-visible absorbance spectra (DAS) associated with the formation of metal-NOM complexes. The binding of ten different metal ions (Cu(II), Ni(II), Co(II), Fe(III), Cr(III), Al(III), Zn(II), Ca(II), Mg(II) and Pb(II)) with esculetin generate four bands in the DAS. These bands are similar to those present in the DAS of metal-NOM complexes. The UV-visible absorbance spectra of the metal-esculetin systems were calculated using time-dependent density functional theory (TD-DFT). The TD-DFT results demonstrate that the prominent features of the DAS of esculetin are primarily associated with the electron transitions between the molecular orbitals near the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) in the metal-esculetin complex. Charge decomposition analysis (CDA) results demonstrated that these electron transitions originate from the esculetin fragment to the Zn(II) fragment in the complex. Covalent indexes [(χ)r] of the metal ions were found to be correlated with the metal-specific features of the DAS of metal-esculetin systems. The strength of the linear correlations between the quantitative parameters of the electron density of the bond critical points (BCP) is indicative of the strength of the metal-esculetin interactions.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130043DOI Listing
August 2021

Foldamer-Based Potassium Channels with High Ion Selectivity and Transport Activity.

J Am Chem Soc 2021 03 1;143(9):3284-3288. Epub 2021 Mar 1.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China.

Small molecules that independently perform natural channel-like functions show greatly potential in the treatment of human diseases. Taking advantage of aromatic helical scaffolds, we develop a kind of foldamer-based ion channels with lumen size varying from 3.8 to 2.3 Å through a sequence substitution strategy. Our results clearly elucidate the importance of channel size in ion transport selectivity in molecular detail, eventually leading to the discoveries of the best artificial K channel by far and a rare sodium-preferential channel as well. High K selectivity and transport activity together make foldamers promising in therapeutic applications.
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http://dx.doi.org/10.1021/jacs.0c12128DOI Listing
March 2021

Regulating the Solvation Sheath of Li Ions by Using Hydrogen Bonds for Highly Stable Lithium-Metal Anodes.

Angew Chem Int Ed Engl 2021 May 6;60(19):10871-10879. Epub 2021 Apr 6.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, China.

The performance of Li anodes is extremely affected by the solvation of Li ions, leading to preferential reduction of the solvation sheath and subsequent formation of fragile solid-electrolyte interphase (SEI), Li dendrites, and low coulombic efficiency (CE). Herein, we propose a novel strategy to regulate the solvation sheath, through the introduction of intermolecular hydrogen bonds with both the anions of Li salt and the solvent by small amount additives. The addition of such hydrogen bonds reduced the LUMO energy level of anions in electrolyte, promoted the formation of a robust SEI, reduced the amount of free solvent molecules, and enhanced stability of electrolytes. Based on this strategy, flat and dense lithium deposition was obtained. Even under lean electrolytes, at a current density of 1 mA cm with a fixed capacity of 3 mAh cm , the Li-Cu cells showed an impressive CE value of 99.2 %. The Li-LiFePO full cells showed long-term cycling stability for more than 1000 cycles at 1 C, with a total capacity loss of only 15 mAh g .
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http://dx.doi.org/10.1002/anie.202101976DOI Listing
May 2021

Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment.

Adv Sci (Weinh) 2021 Feb 20;8(3):2002797. Epub 2020 Dec 20.

College of Materials Science and Optoelectronic Technology University of Chinese Academy of Sciences Beijing 100049 China.

Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving the topics in ROS-regulating therapy such as antioxidant therapy triggered by ROS scavengers and ROS-induced toxic therapy mediated by ROS-elevation agents. Benefiting from the remarkable advances of nanotechnology, a large number of nanomaterials with the ROS-regulating ability are developed to seek new and effective ROS-related nanotherapeutic modalities or nanomedicines. Although considerable achievements have been made in ROS-based nanomedicines for disease treatments, some fundamental but key questions such as the rational design principle for ROS-related nanomaterials are held in low regard. Here, the design principle can serve as the initial framework for scientists and technicians to design and optimize the ROS-regulating nanomedicines, thereby minimizing the gap of nanomedicines for biomedical application during the design stage. Herein, an overview of the current progress of ROS-associated nanomedicines in disease treatments is summarized. And then, by particularly addressing these known strategies in ROS-associated therapy, several fundamental and key principles for the design of ROS-associated nanomedicines are presented. Finally, future perspectives are also discussed in depth for the development of ROS-associated nanomedicines.
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http://dx.doi.org/10.1002/advs.202002797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856897PMC
February 2021

Effects of Hydration on the Adsorption of Benzohydroxamic Acid on the Lead-Ion-Activated Cassiterite Surface: A DFT Study.

Langmuir 2021 Feb 2;37(6):2205-2212. Epub 2021 Feb 2.

Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources, School of Minerals Processing and Bioengineering, Central South University, Changsha, Hunan 410083, China.

The strategy of enhancing the surface activity by preadsorption of metal ions (surface activation) is an effective way to promote the adsorption of surfactant on surfaces, which is very important in surface process engineering. However, the adsorption mechanism of surfactant (collector) on the surface preadsorbed by metal ions in the explicit solution phase is still poorly understood. Herein, the effects of hydration on the adsorption of benzohydroxamic acid (BHA) onto the oxide mineral surface before and after lead-ion activation are investigated by first-principles calculations, owing to its importance in the field of flotation. The results show that the direct adsorption of BHA on the hydrated surface is not thermodynamically allowed in the absence of metal ions. However, the adsorption of BHA onto the lead-ion-activated surface possesses a very low barrier and a very negative reaction energy difference, indicating that the adsorption of BHA on hydrated Pb at cassiterite surface is very favorable in both thermodynamics and kinetics. In addition, the adsorption of BHA results in the dehydration of hydrated Pb. More interestingly, the surface hydroxyl groups could participate in and may promote the coordination adsorption through proton transfer. This work sheds some new lights on understanding the roles of interfacial water and the mechanisms of metal-ion surface activation.
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http://dx.doi.org/10.1021/acs.langmuir.0c03575DOI Listing
February 2021

Effect of Gegenqinlian decoction on intestinal mucosal flora in mice with diarrhea induced by high temperature and humidity treatment.

3 Biotech 2021 Feb 19;11(2):83. Epub 2021 Jan 19.

Hunan University of Chinese Medicine, Xueshi Road 300, Yuelu District, Changsha, 410208 Hunan Province China.

The objective of this study is to investigate the regulation effects of the active ingredients in Gegenqinlian Decoction (GD) on the intestinal mucosal flora of mice with diarrhea induced by high temperature and humidity based on systems pharmacology approach. Fifteen mice were randomly assigned to three equal groups of five mice, namely control (ctcm) group, model (ctmm) group and treatment (cttm) group. Mice in the cttm group were given 20 mL/kg of GD and sterile water was used as a placebo control twice a day for four consecutive days. We used the third-generation molecular high-throughput sequencing technology to measure the intestinal mucosal flora changes in mice. Combined with network pharmacology to predict the medicinal substances and action targets of GD against diarrhea. Results showed that Operational Taxonomic Unit (OTU) number and Alpha diversity in the intestinal mucosal flora of cttm group recovered and higher than that of the ctcm group. There were differences in the community structure between the ctmm and cttm groups in the Principal Coordinates Analysis (PCoA). The relative abundance results indicated dominant bacteria species (such as , , ) in the intestinal mucosa of the three groups. Moreover, we screened out 146 active ingredients in GD corresponding to 252 component targets, and 328 disease targets in diarrhea to obtain 31 drug-disease common targets. Protein-protein interaction (PPI) networks mainly involved the core proteins such as Tumor necrosis factor (TNF) and Interleukin-6 (IL-6). Enrichment analyses showed that GD played a role in the treatment of diarrhea by regulating the hypoxia inducible factor-1 (HIF-1), vascular endothelial growth factor (VEGF) and adipocytokine signaling pathways and so on. In brief, the active ingredients of GD could intervene from oxidative stress and inflammatory response through multiple targets and multiple channels to adjust the balance of intestinal mucosa flora, thereby playing a role in the treatment of diarrhea.

Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-020-02628-0.
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http://dx.doi.org/10.1007/s13205-020-02628-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815854PMC
February 2021

Characteristics of intestinal microbiota and enzyme activities in mice fed with lily bulb.

3 Biotech 2021 Jan 2;11(1):17. Epub 2021 Jan 2.

Hunan University of Chinese Medicine, Xueshi Road 300, Yuelu District, Changsha, 410208 Hunan Province China.

The aim was to investigate the effect of lily bulbs on the microecological characteristics of intestinal microbiota and enzyme activities in normal mice. Thirty SPF Kunming mice were randomly divided into the control group, (LL) group and i var. unicolor (LDU) group. Mice of the latter two groups were given 0.15 g·mL lily bulb solution, respectively, by gavage twice a day, while the control group was given the same volume of sterilized water. After 49 days, intestinal contents and mucosa of all mice were collected and the characteristics of intestinal microbiota and enzyme activities were analyzed. Results showed that the number of spp. and spp. in the LL group was significantly higher than that in the control group ( = 2.68 × 10,  = 0.000;  = 5.96 × 10;  = 0.000) and the LDU group ( = 6.12 × 10,  = 0.000;  = 2.71 × 10,  = 0.000), while the number of total bacteria was significantly lower ( = 0.040). Microbial activity in intestinal contents and mucosa of the LDU group ( = 0.43,  = 0.001;  = 0.69,  = 0.000) decreased, and microbial activity in intestinal mucosa of the LL group decreased significantly ( = 0.89,  = 0.000) but increased significantly in intestinal contents of the LL group ( = 0.81,  = 0.000). The activities of amylase ( = 455.73,  = 0.000;  = 206.56,  = 0.000) and protease ( = 52.32,  = 0.000) increased but the activities of lactase ( = 443.51,  = 0.000;  = 15.71,  = 0.000) and sucrase ( = 5.82,  = 0.000;  = 366.82,  = 0.000) decreased significantly in contents from the LL group and LDU group. Except for the sucrase activity, enzyme activities in mucosa of the LL group were completely opposite to those in contents ( = 44.15,  = 0.000;  = 1.25,  = 0.007;  = 14.64,  = 0.011). In conclusion, dietary lily bulbs increased intestinal contents amylase activities and mucosa lactase activity significantly. Lily bulbs, especially , can promote the growth of spp. and spp., and inhibit the growth of total bacteria in the intestines of normal mice. bulbs have the potential to be a functional food.
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http://dx.doi.org/10.1007/s13205-020-02597-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778670PMC
January 2021

Interpretation of the formation of unstable halogen-containing disinfection by-products based on the differential absorbance spectroscopy approach.

Chemosphere 2021 Apr 7;268:129241. Epub 2020 Dec 7.

Department of Civil and Environmental Engineering Box 352700 University of Washington, Seattle, WA, 98195-2700, United States. Electronic address:

Concentrations of several toxic disinfection by-products (DBP), notably haloacetonitriles (e.g., trichloroacetonitrile, TCAN) and haloketones (e.g., di- and trichloropropanone, DCPN and TCPN, respectively) are affected by chlorination conditions and the inherent instability of these DBPs. In this study, effects of temperature, chlorine dose and reaction time on the formation of TCAN, DCPN and TCPN were interpreted using the approach of differential absorbance spectroscopy. Experimental data obtained for a wide range of water quality conditions demonstrate that in some cases the concentrations of some of the unstable DBPs increased rather than decreased at low temperatures and realistically long contact times. Despite the presence of pronounced changes of the kinetics of generation and degradation of these DBPs at varying temperatures and chlorine doses, their concentrations were strongly correlated with the concurrent changes of spectroscopic properties of DOM quantified via differential absorbance measurements at 272 nm (ΔA). The maximum values of TCAN, DCPN and TCPN concentrations observed for the chlorination of eight different surface waters occur at the relative decreases of absorbance at 272 nm (defined as RΔA) values of ca. 0.32 (±0.03), 0.24 (±0.05), and 0.42 (±0.03), respectively. The activation energies of degradation reactions of unstable DBPs were examined and the results indicate that TCAN and TCPN are caused by their hydrolysis with OH while the degradation of DCPN is mainly caused by halogenation reaction with HOCl. These results in this study may be important for controlling the formation of unstable DBPs and further optimization of drinking water treatment.
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http://dx.doi.org/10.1016/j.chemosphere.2020.129241DOI Listing
April 2021

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes.

Front Pharmacol 2020 27;11:587457. Epub 2020 Nov 27.

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Orphan nuclear receptors are important members of the nuclear receptor family and may regulate cell proliferation, metabolism, differentiation, and apoptosis. NR4As, a subfamily of orphan nuclear receptors, have been reported to play key roles in carbohydrate and lipid metabolism and energy homeostasis. Popularity of obesity has resulted in a series of metabolic diseases such as diabetes and its complications. While imbalance of energy intake and expenditure is the main cause of obesity, the concrete mechanism of obesity has not been fully understood. It has been reported that NR4As have significant regulatory effects on energy homeostasis and diabetes and are expected to become new targets for discovering drugs for metabolic syndrome. A number of studies have demonstrated that abnormalities in metabolism induced by altered levels of NR4As may contribute to numerous diseases, such as chronic inflammation, tumorigenesis, diabetes and its complications, atherosclerosis, and other cardiovascular diseases. However, systematic reviews focusing on the roles of NR4As in mediating energy homeostasis and diabetes remain limited. Therefore, this article reviews the structure and regulation of NR4As and their critical function in energy homeostasis and diabetes, as well as small molecules that may regulate NR4As. Our work is aimed at providing valuable support for the research and development of drugs targeting NR4As for the treatment of obesity and related metabolic diseases.
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http://dx.doi.org/10.3389/fphar.2020.587457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728612PMC
November 2020

FOXM1 modulates docetaxel resistance in prostate cancer by regulating KIF20A.

Cancer Cell Int 2020 Nov 10;20(1):545. Epub 2020 Nov 10.

Department of Urology, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital), No. 366, Taihu Road, Taizhou, China.

Background: Docetaxel resistance affects prognosis in advanced prostate cancer (PCa). The precise mechanisms remain unclear. Transcription factor Forkhead box M1 (FOXM1), which participates in cell proliferation and cell cycle progression, has been reported to affect the sensitivity of chemotherapy. This study explores the role of FOXM1 in PCa docetaxel resistance and its association with kinesin family member 20 A (KIF20A), which is known to promote therapeutic resistance in some cancers.

Methods: We monitored cell growth using MTT and colony formation assays, and cell apoptosis and cell cycle progression using flow cytometry. Wound-healing and transwell assays were used to detect cell invasion and migration. mRNA and protein expression were analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting. We monitored FOXM1 binding to the KIF20A promoter using a ChIP assay. Tumorigenicity in nude mice was used to assess in vivo tumorigenicity.

Results: FOXM1 knockdown induced cell apoptosis and G2/M cell cycle arrest, suppressing cell migration and invasion in docetaxel-resistant PCa cell lines (DU145-DR and VCaP-DR). Exogenous FOXM1 overexpression was found in their parental cells. Specific FOXM1 inhibitor thiostrepton significantly weakened docetaxel resistance in vitro and in vivo. We also found that FOXM1 and KIF20A exhibited consistent and highly correlated overexpression in PCa cells and tissues. FOXM1 also regulated KIF20A expression at the transcriptional level by acting directly on a Forkhead response element (FHRE) in its promoter. KIF20A overexpression could partially reverse the effect on cell proliferation, cell cycle proteins (cyclinA2, cyclinD1 and cyclinE1) and apoptosis protein (bcl-2 and PARP) of FOXM1 depletion.

Conclusions: Our findings indicate that highly expressed FOXM1 may help promote docetaxel resistance by inducing KIF20A expression, providing insight into novel chemotherapeutic strategies for combatting PCa docetaxel resistance.
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http://dx.doi.org/10.1186/s12935-020-01631-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653758PMC
November 2020

Effects of pre-oxidation on residual dissolved aluminum in coagulated water: A pilot-scale study.

Water Res 2021 Feb 25;190:116682. Epub 2020 Nov 25.

Department of Environmental Engineering, Peking University, The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing100871,China. Electronic address:

Residual dissolved aluminum (Al) in drinking water is becoming a serious concern due to its high potential risks to human health. However, the mechanism by which residual dissolved Al forms is yet to be elucidated in detail. In this study, the effects of pre-oxidation by ozonation and chlorination on the properties of dissolved organic matter (DOM) and residual Al concentrations remaining in solution after coagulation were explored in a pilot-scale test. Changes in the DOM properties caused by the water treatment process were characterized by ultraviolet-visible absorbance spectroscopy. Theprotonation-active sites, carboxylic- and phenolic-type groupsof DOM were quantified by spectral parameter DlnA400 (differential log-transformed spectra at wavelength 400 nm) in combination with the revised non-ideal competitive adsorption model. The results show that ozonation and chlorination significantly affect the properties of DOM and the amount of residual dissolved Al in coagulated drinking water. This effect was associated with the changes in the carboxylic- and phenolic-type groups in DOM. Results of the study show that residual dissolved Al in coagulated water can be controlled by affecting theAl binding sites in DOM by pre-oxidation before coagulation. The nature of pre-oxidation agent and its dosage should be selected depending on the quality of the raw water to be treated. Ozonation was concluded to be preferable pre-oxidation agent for the water in examined this study.
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http://dx.doi.org/10.1016/j.watres.2020.116682DOI Listing
February 2021

Corrigendum: Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury Regulating PI3K/AKT Inhibited HIF-1a/VEGF Signaling Pathway.

Front Pharmacol 2020 23;11:1312. Epub 2020 Oct 23.

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

[This corrects the article DOI: 10.3389/fphar.2020.00695.].
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http://dx.doi.org/10.3389/fphar.2020.01312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645230PMC
October 2020

Accurate In Vivo Nanothermometry through NIR-II Lanthanide Luminescence Lifetime.

Small 2020 12 5;16(48):e2004118. Epub 2020 Nov 5.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, P. R. China.

Luminescence nanothermometry is promising for noninvasive probing of temperature in biological microenvironment at nanometric spatial resolution. Yet, wavelength- and temperature-dependent absorption and scattering of tissues distort measured spectral profile, rendering conventional luminescence nanothermometers (ratiometric, intensity, band shape, or spectral shift) problematic for in vivo temperature determination. Here, a class of lanthanide-based nanothermometers, which are able to provide precise and reliable temperature readouts at varied tissue depths through NIR-II luminescence lifetime, are described. To achieve this, an inert core/active shell/inert shell structure of tiny nanoparticles (size, 13.5 nm) is devised, in which thermosensitive lanthanide pairs (ytterbium and neodymium) are spatially confined in the thin middle shell (sodium yttrium fluoride, 1 nm), ensuring being homogenously close to the surrounding environment while protected by the outmost calcium fluoride shell (CaF , ≈2.5 nm) that shields out bioactive milieu interferences. This ternary structure enables the nanothermometers to consistently resolve temperature changes at depths of up to 4 mm in biological tissues, having a high relative temperature sensitivity of 1.4-1.1% °C in the physiological temperature range of 10-64 °C. These lifetime-based thermosensitive nanoprobes allow for in vivo diagnosis of murine inflammation, mapping out the precise temperature distribution profile of nanoprobes-interrogated area.
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http://dx.doi.org/10.1002/smll.202004118DOI Listing
December 2020
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