Publications by authors named "Chenxi Zhu"

23 Publications

  • Page 1 of 1

Enhanced Thermoelectric Performance in Ge Sb Te/FeGe Composites Enabled by Hierarchical Defects.

Small 2021 May 25:e2100915. Epub 2021 May 25.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.

Manipulations of carrier and phonon scatterings through hierarchical structures have been proved to be effective in improving thermoelectric performance. Previous efforts in GeTe-based materials mainly focus on simultaneously optimizing the carrier concentration and band structure. In this work, a synergistic strategy to tailor thermal and electrical transport properties of GeTe by combination with the scattering effects from both Ge vacancies and other defects is reported. The addition of Fe in GeTe-based compounds introduces the secondary phase of FeGe , synchronously increasing the concentration of Ge vacancies and arousing more Ge planar defects. These hierarchical defects contribute to a large scattering factor, leading to a significant enhancement of Seebeck coefficient and further a splendid power factor. Meanwhile, benefiting from the reinforced phonon scatterings by multiscale hierarchical structures, an extremely low lattice thermal conductivity is successfully achieved. With simultaneously optimized electrical and thermal transport properties, a maximum figure of merit, zT, value of 2.1 at 750 K and an average zT value of 1.5 in 400-800 K are realized in Ge Sb Te/1.5%FeGe . This work demonstrates that manipulation of hierarchical defects is an effective strategy to optimize the thermoelectric properties.
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http://dx.doi.org/10.1002/smll.202100915DOI Listing
May 2021

Total Synthesis of Chalaniline B: An Antibiotic Aminoxanthone from Vorinostat-Treated Fungus sp. 6661.

J Org Chem 2021 Jun 17;86(11):7773-7780. Epub 2021 May 17.

Department of Chemistry, Oregon State University, Corvallis, Oregon 97331-4003, United States.

Chalaniline B [1-anilino-2,8-dihydroxy-3-(hydroxymethyl)xanthone], an antibiotic previously isolated from vorinostat-treated sp., was prepared in 7 steps from 2-hydroxyxanthone by a route incorporating regioselective oxidative transformations (bromination at C1/C3, ketone directed Pd(II)-catalyzed hydroxylation at C8), installation of the C1-anilino moiety by a regioselective Buchwald-Hartwig amination reaction from 1,3-dibromo-2,8-dimethoxyxanthone, and late-stage hydroxymethylation at C3 using a Stille cross-coupling. Biological evaluation of deshydroxymethylchalaniline B (1-anilino-2,8-dihydroxyxanthone) revealed MIC values of 8 μg mL (25 μM) against both methicillin resistant and .
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http://dx.doi.org/10.1021/acs.joc.1c00528DOI Listing
June 2021

Metallic Ions Encapsulated in Electrospun Nanofiber for Antibacterial and Angiogenesis Function to Promote Wound Repair.

Front Cell Dev Biol 2021 25;9:660571. Epub 2021 Mar 25.

Department of Breast Surgery, Hainan General Hospital, Hainan Medical University, Haikou, China.

Electrospun nanofiber is an attractive biomaterial for skin tissue engineering because it mimics the natural fibrous extracellular matrix structure and creates a physical structure suitable for skin tissue regeneration. However, endowing the nanofibrous membranes with antibacterial and angiogenesis functions needs to be explored. In the current study, we aimed to fabricate gelatin/polycaprolactone (GT/PCL) (GT/PCL-Ag-Mg) nanofibers loaded with silver (Ag) and magnesium (Mg) ions for antibacterial activity and pro-angiogenesis function for wound repair. The fabricated GT/PCL membranes had a nanofibrous structure with random arrangement and achieved sustained release of Ag and Mg ions. results indicated that the GT/PCL-Ag-Mg membranes presented satisfactory cytocompatibility with cell survival and proliferation. In addition, the membranes with Ag demonstrated good antibacterial capacity to both gram-positive and gram-negative bacteria, and the Mg released from the membranes promoted the tube formation of vascular endothelial cells. Furthermore, results demonstrated that the GT/PCL-Ag-Mg membrane presented an accelerated wound healing process compared with GT/PCL membranes incorporated with either Ag or Mg ions and pure GT/PCL alone. Superior epidermis formation, vascularization, and collagen deposition were also observed in GT/PCL-Ag-Mg membrane compared with the other membranes. In conclusion, a multifunctional GT/PCL-Ag-Mg membrane was fabricated with anti-infection and pro-angiogenesis functions, serving as a potential metallic ion-based therapeutic platform for applications in wound repair.
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http://dx.doi.org/10.3389/fcell.2021.660571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027477PMC
March 2021

Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19.

Vaccines (Basel) 2021 Mar 22;9(3). Epub 2021 Mar 22.

Tongji University School of Medicine, Shanghai 200092, China.

The structures of immunogens that elicit the most potent neutralization antibodies to prevent COVID-19 infection are still under investigation. In this study, we tested the efficacy of a recombinant trimeric Spike protein containing polyI:C (PIKA) adjuvant in mice immunized by a 0-7-14 day schedule. The results showed that a Spike protein-specific antibody was induced at Day 21 with titer of above 50,000 on average, as measured by direct binding. The neutralizing titer was above 1000 on average, as determined by a pseudo-virus using monoclonal antibodies (40592-MM57 and 40591-MM43) with IC50 at 1 μg/mL as standards. The protein/peptide array-identified receptor-binding domain (RBD) was considered as immunodominant. No linear epitopes were found in the RBD, although several linear epitopes were found in the C-terminal domain right after the RBD and heptad repeat regions. Our study supports the efficacy of a recombinant trimeric Spike protein vaccine candidate for COVID-19 that is safe and ready for storage and distribution in developing countries.
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http://dx.doi.org/10.3390/vaccines9030296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004863PMC
March 2021

Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid.

Angew Chem Int Ed Engl 2021 Jun 14;60(25):14163-14170. Epub 2021 May 14.

Department of Chemistry, Oregon State University, Corvallis, Oregon, 97331, USA.

A new bicyclic diterpenoid, benditerpenoic acid, was isolated from soil-dwelling Streptomyces sp. (CL12-4). We sequenced the bacterial genome, identified the responsible biosynthetic gene cluster, verified the function of the terpene synthase, and heterologously produced the core diterpene. Comparative bioinformatics indicated this Streptomyces strain is phylogenetically unique and possesses nine terpene synthases. The absolute configurations of the new trans-fused bicyclo[8.4.0]tetradecanes were achieved by extensive spectroscopic analyses, including Mosher's analysis, J-based coupling analysis, and computations based on sparse NMR-derived experimental restraints. Interestingly, benditerpenoic acid exists in two distinct ring-flipped bicyclic conformations with a rotational barrier of ≈16 kcal mol in solution. The diterpenes exhibit moderate antibacterial activity against Gram-positive bacteria including methicillin and multi-drug resistant Staphylococcus aureus. This is a rare example of an eunicellane-type diterpenoid from bacteria and the first identification of a diterpene synthase and biosynthetic gene cluster responsible for the construction of the eunicellane scaffold.
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http://dx.doi.org/10.1002/anie.202102453DOI Listing
June 2021

Ultralow Lattice Thermal Conductivity and Superhigh Thermoelectric Figure-of-Merit in (Mg, Bi) Co-Doped GeTe.

Adv Mater 2021 Apr 24;33(17):e2008773. Epub 2021 Mar 24.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.

High-efficiency thermoelectric (TE) technology is determined by the performance of TE materials. Doping is a routine approach in TEs to achieve optimized electrical properties and lowered thermal conductivity. However, how to choose appropriate dopants with desirable solution content to realize high TE figure-of-merit (zT) is very tough work. In this study, via the use of large mass and strain field fluctuations as indicators for low lattice thermal conductivity, the combination of (Mg, Bi) in GeTe is screened as very effective dopants for potentially high zTs. In experiments, a series of (Mg, Bi) co-doped GeTe compounds are prepared and the electrical and thermal transport properties are systematically investigated. Ultralow lattice thermal conductivity, about 0.3 W m K at 600 K, is obtained in Ge Mg Bi Te due to the introduced large mass and strain field fluctuations by (Mg, Bi) co-doping. In addition, (Mg, Bi) co-doping can introduce extra electrons for optimal carrier concentration and diminish the energy offset at the top of the valence band for high density-of-states effective mass. Via these synthetic effects, a superhigh zT of ≈2.5 at 700 K is achieved for Ge Mg Bi Te. This study sheds light on the rational design of effective dopants in other TE materials.
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http://dx.doi.org/10.1002/adma.202008773DOI Listing
April 2021

Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria.

Chem Biodivers 2021 Apr 24;18(4):e2100046. Epub 2021 Mar 24.

Department of Chemistry, Oregon State University, Corvallis, Oregon, 97331, USA.

From arid, high desert soil samples collected near Bend, Oregon, 19 unique bacteria were isolated. Each strain was identified by 16S rRNA gene sequencing, and their organic extracts were tested for antibacterial and antiproliferative activities. Noteworthy, six extracts (30 %) exhibited strong inhibition resulting in less than 50 % cell proliferation in more than one cancer cell model, tested at 10 μg/mL. Principal component analysis (PCA) of LC/MS data revealed drastic differences in the metabolic profiles found in the organic extracts of these soil bacteria. In total, fourteen potent antibacterial and/or cytotoxic metabolites were isolated via bioactivity-guided fractionation, including two new natural products: a pyrazinone containing tetrapeptide and 7-methoxy-2,3-dimethyl-4H-chromen-4-one, as well as twelve known compounds: furanonaphthoquinone I, bafilomycin C1 and D, FD-594, oligomycin A, chloramphenicol, MY12-62A, rac-sclerone, isosclerone, tunicamycin VII, tunicamycin VIII, and (6S,16S)-anthrabenzoxocinone 1.264-C.
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http://dx.doi.org/10.1002/cbdv.202100046DOI Listing
April 2021

Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma.

Aging (Albany NY) 2020 11 16;13(2):1842-1858. Epub 2020 Nov 16.

Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

We investigated the prognostic significance of Death-Associated Protein Kinase 1 (DAPK1) and its role in sunitinib resistance in clear cell renal cell carcinoma (ccRCC). DAPK1 mRNA levels were significantly lower in tumor tissues than normal kidney tissues in TCGA-KIRC dataset (n=428). Both overall survival and disease-free survival were significantly shorter in ccRCC patients with low DAPK1 expression than those with high DAPK1 expression. Receiver operating characteristic curve analysis showed that low DAPK1 expression correlated with poor prognosis in ccRCC patients. Multivariate analysis confirmed that DAPK1 expression was an independent prognostic indicator in ccRCC. Gene set enrichment analysis showed that low DAPK1 expression correlates with upregulation of pathways related to metastasis, drug resistance, hypoxia and invasiveness in ccRCC patients. Sunitinib-resistant ccRCC cells show significantly lower DAPK1 mRNA and protein levels than sunitinib-sensitive ccRCC cells. DAPK1 overexpression enhances apoptosis in sunitinib-resistant ccRCC cells via the ATF6-dependent ER stress pathway. Xenograft tumors derived from DAPK1-overxpressing ccRCC cells were significantly smaller than the controls in nude mice. Our finding demonstrates that low DAPK1 expression is an independent prognostic indicator that correlates with ccRCC progression and sunitinib resistance.
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http://dx.doi.org/10.18632/aging.103638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880360PMC
November 2020

Antisoiling Performance of Lotus Leaf and Other Leaves after Prolonged Outdoor Exposure.

ACS Appl Mater Interfaces 2020 Nov 11;12(47):53394-53402. Epub 2020 Nov 11.

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, China, 310014.

Recently, the antisoiling performances of superhydrophobic (SH) surfaces have received much attention due to their potential applications in self-cleaning photovoltaic glass and other surfaces without the need to be rinsed with water. In this work, we systematically compared the antisoiling performances of lotus leaf and other plant leaves by first drying them in the shade and then placing them outdoors in a slight breeze for 1-2 months. The results show that after being dried in the shade, the lotus leaf and the canna leaf retain their SH properties, comparable with their fresh states. The firmiana leaf is still hydrophilic. However, when the leaves are exposed to rain, no rain drops adhere to the surface of the lotus leaf but many droplets adhere to the canna leaf. Furthermore, after being incubated outdoors in the absence of rain for 1 month, the lotus leaf retained its SH properties, the canna leaf was no longer SH, and the firmiana leaf became more hydrophilic. SEM imaging with EDS and elemental mapping all confirmed that after outdoor exposure for 1-2 months, only a small amount of dust was found on the lotus leaf but a significant amount of dust was present on the canna leaf, with even more on the firmiana leaf. These results confirm that the lotus leaf has excellent antisoiling performance. The low interactions between the lotus leaf surface and the dust particles are most likely responsible for this unique property. On the contrary, the canna leaf, and especially the firmiana leaf, do not possess this property because neither their surface microstructures nor their surface free energies are favorable to reduce interactions between the leaf surface and dust particles. This study will be helpful in designing and preparing a surface with antisoiling performance.
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http://dx.doi.org/10.1021/acsami.0c13477DOI Listing
November 2020

The order-disorder transition in CuSe and medium-range ordering in the high-temperature phase.

Acta Crystallogr B Struct Sci Cryst Eng Mater 2020 Apr 14;76(Pt 2):201-207. Epub 2020 Mar 14.

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences (CAS), 1295 Dingxi Road, Shanghai, 200050, People's Republic of China.

The high thermoelectric performance of cuprous selenide (CuSe) arises from its specific structures consisting of two independent sublattices, i.e. the rigid face-centered cubic (f.c.c.) Se sublattice and the flexible Cu sublattice showing a variety of ordered configurations at numerous interstitial sites. Upon increasing the temperature, the Cu sublattice undergoes an order-to-disorder transition but the details of the structural evolution have not been fully elucidated. Here, in situ transmission electron microscopy (TEM) is used to investigate the thermally induced structural changes of CuSe in both real and reciprocal spaces. Order-disorder transition was found to proceed in nanoblocks accompanied by the structural fluctuations between low-temperature and high-temperature phases. Electron diffraction revealed the emergence of medium-range ordering of Cu atoms in the high-temperature f.c.c. phase. By referring to the Coulomb interaction evaluations, the superstructures for the medium-range ordering were constructed. Such medium-range atomic ordering was sustained over a wide temperature range (from the phase transition temperature to over 800 K in the TEM) but gradually changed to short-range ordering as indicated by the appearance of diffuse scattering rings.
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http://dx.doi.org/10.1107/S2052520620002164DOI Listing
April 2020

Integrated electronics in 130 nm CMOS process for quantum key distribution sender device.

Rev Sci Instrum 2020 Mar;91(3):034701

State Key Laboratory of Particle Detection and Electronics, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.

Quantum Key Distribution (QKD) is the most mature method for implementing commercial quantum communications in practice. As part of the miniaturization of practical QKD devices, an integrated electronic system in the 130 nm complementary metal oxide semiconductor process is presented for the QKD sender device. The electronics provide driving signals for the optics at the sender terminal of the quantum channel in QKD and consist mainly of three key modules, namely, a laser diode driver with a high slew rate, a high-speed physical random number generator, and a pre-driver for the electro-optic modulator. The electronic system is designed to operate at frequencies as high as 625-MHz to accommodate the frequency of the QKD system. The high degree of integration is advantageous for miniaturizing QKD sender devices.
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http://dx.doi.org/10.1063/1.5123238DOI Listing
March 2020

The Influence of Different Forest Characteristics on Non-point Source Pollution: A Case Study at Chaohu Basin, China.

Int J Environ Res Public Health 2020 03 10;17(5). Epub 2020 Mar 10.

Jiangsu Institute of Land Surveying and Planning, Nanjing 210017, China.

Forestland is a key land use/land cover (LULC) type that affects nonpoint source (NPS) pollution, and has great impacts on the spatiotemporal features of watershed NPS pollution. In this study, the forestland characteristics of the Chaohu Basin, China, were quantitatively represented using forestland types (FLTs), watershed forest coverage (WFC) and forest distance from the river (DFR). To clarify the impact of forests on NPS pollution, the relationship between forestland characteristics and watershed nutrient outputs (TN and TP) was explored on a monthly scale using SWAT (Soil and Water Assessment Tool) and the period simulation was 2008-2016. The results showed that: (1) the TN and TP showed similar output characteristics and the rainy season was the peak period of nitrogen and phosphorus output. (2) Among the forestland characteristics of forestland types, watershed forest coverage and forest distance from the river, watershed forest coverage and forest distance from the river had greater effects than forestland types on the control of watershed nutrient outputs (TN and TP). (3) In different forestland types, the watershed nutrient outputs intensity remained at the lowest level when the FLTs was mixed forest, with a TN output of 1244.73kg/km and TP output of 341.39 kg/km. (4) The watershed nutrient outputs and watershed forest coverage were negatively correlated, with the highest watershed forest coverage (over 75%) reducing the TN outputs by 56.69% and the TP outputs by 53.46% compared to the lowest watershed forest coverage (below 25%), it showed that in areas with high forest land coverage, the non-point source pollution load in the watershed is smaller than in other areas. (5) forest distance from the river had an uncertain effect on the TN and TP output of the basin, the forestland itself is a source of pollution, but it also has the function of intercepting pollution movement; the forest distance from the river in the range of 500-1000 m had the lowest NPS pollution. Considering the different forest characteristics and topographical factors, an optimal allocation mode of differentiated forest land was proposed, these suggestions will provide a scheme for surface source pollution prevention and control in the basin. This research gap is the basis of real forestland optimization. We may optimize the forestland layout for NPS pollution prevention and control by clarifying the internal mechanism.
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http://dx.doi.org/10.3390/ijerph17051790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084210PMC
March 2020

Effect of a patient education and rehabilitation program on anxiety, depression and quality of life in muscle invasive bladder cancer patients treated with adjuvant chemotherapy.

Medicine (Baltimore) 2019 Nov;98(44):e17437

Department of Thoracic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.

This study aimed to investigate the effect of a patient education and rehabilitation program (PERP) on anxiety, depression, and quality of life in muscle invasive bladder cancer (MIBC) patients underwent adjuvant chemotherapy.One hundred and thirty MIBC patients about to receive adjuvant chemotherapy with 4-cycle gemcitabine and cisplatin (GC) regimen (16 weeks) were consecutively enrolled and randomly allocated into PERP group and control group as 1:1 ratio. Hospital Anxiety and Depression Scale (HADS) anxiety and depression scores and Quality of Life Questionnaire (QLQ-C30) scores were assessed before treatment (W0) and after treatment (W16).After 16-week treatment, PERP group exhibited decreased HADS anxiety score (P = .036), ΔHADS anxiety score (W16-W0) (P < .001) and percentage of anxiety patients (P = .019) compared to control group. And PERP group presented with numerically reduced HADS depression score but without statistical significance (P = .076) compared to control group, while lower ΔHADS depression score (W16-W0) (P = .014) and percentage of depression patients (P = .015) compared to control group. As to quality of life, QLQ-C30 global health status score (P = .032), Δglobal health status score (W16-W0) (P = .003) and Δfunctional score (W16-W0) (P = .005) were higher in PERP group compared to control group. However, no difference of QLQ-C30 functional score (P = .103), QLQ-C30 symptom score (P = .808) or Δsymptom score (W16-W0) (P = .680) was observed between two groups.PERP relieves anxiety, depression and improves quality of life in MIBC patients underwent adjuvant chemotherapy.
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http://dx.doi.org/10.1097/MD.0000000000017437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946406PMC
November 2019

A laser source driver with adjustable amplitude and pulse-width in 130-nm CMOS technology for quantum key distribution experiments.

Rev Sci Instrum 2019 Jun;90(6):064704

State Key Laboratory of Particle Detection and Electronics, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.

We present a laser source driver using a 130-nm complementary metal oxide semiconductor technology, named quantum laser source driver 2018 (QLSD2018). QLSD2018 drives the optical source with a current pulse signal, and the output of QLSD2018 has an adjustable pulse-width from 300 ps to 3.8 ns and an adjustable amplitude up to 70 mA. The data rate is up to 625 Mb/s, and the extinction ratio of the optical source (the 1550-nm distributed feedback laser or the 850-nm vertical-cavity surface-emitting laser) driven by QLSD2018 can reach 26 dB. The test results indicate that QLSD2018 can be used in quantum key distribution experiments. Using QLSD2018 on the transmitter side can significantly simplify the peripheral circuit of the optical source.
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http://dx.doi.org/10.1063/1.5100318DOI Listing
June 2019

Cryogenic Exfoliation of Non-layered Magnesium into Two-Dimensional Crystals.

Angew Chem Int Ed Engl 2019 Jun 21;58(26):8814-8818. Epub 2019 May 21.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

Physical exfoliation of layered precursors is one of the most prevailing techniques to prepare two-dimensional (2D) crystals, which, however, is considered to be intrinsically inapplicable to non-layered bulks. Now, plane cleavage differentiation is identified in metallic magnesium at cryogenic temperature (CT), and a cryogenic exfoliation strategy of non-layered magnesium into 2D crystals is developed. The cleavage anisotropy of the Mg lattice in response to the external mechanical stress originates from the CT-induced specific inactivation of basal slip, which results in the basal cleavage perpendicular to c axis. The exfoliated novel 2D Mg crystals exhibit remarkable localized surface plasmon resonances, holding great promise for the applications in harvesting and converting solar energy. Beyond creating a new member for the burgeoning 2D family, this study may provide a useful tool for the physical exfoliations of various non-layered materials.
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http://dx.doi.org/10.1002/anie.201903485DOI Listing
June 2019

Preparation of Colorful, Infrared-Reflective, and Superhydrophobic Polymer Films with Obvious Resistance to Dust Deposition.

ACS Appl Mater Interfaces 2018 Nov 13;10(46):40219-40227. Epub 2018 Nov 13.

College of Materials Science & Engineering , Zhejiang University of Technology , Hangzhou 310014 , China.

In recent years, polymer films containing deep color and near-infrared (NIR)-reflective pigments have received much attention for their potential applications in energy-saving fields. However, in practical environments, dust present in the air is easily adsorbed and adheres to the surface of these films, thus gradually reducing their NIR reflectance. In this work, black or deep-red infrared-reflective pigments were firstly mixed with melted low-density polyethylene (LDPE) and then the resulting composite was thermally pressed on to a metal template possessing micro- and nanostructure surface roughness. After being cooled to a suitable temperature, the LDPE composite film was peeled from the template. Ultraviolet-visible-near-infrared spectroscopy and an indoor infrared lamp irradiation test both confirmed that the prepared films exhibit high NIR reflectance and high heat reflectance. Moreover, due to the stretching-controlled micromolding process, the films all exhibited a superhydrophobic (SH) property. After incubation in outdoor conditions for 1 month, the NIR reflectance of the SH films remained almost consistent; however, the films that did not possess SH property showed a marked decrease in their ability to reflect NIR radiation. By a combination of scanning electron microscopy imaging, we conclude that our films are able to resist dust deposition and thus avoid deterioration of their infrared-reflective properties. We believe that these colorful, infrared-reflective, SH, and cost-effective films have potential application for reducing energy consumption where minimal solar irradiation is required.
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http://dx.doi.org/10.1021/acsami.8b12567DOI Listing
November 2018

Dark, Infrared Reflective, and Superhydrophobic Coatings by Waterborne Resins.

Langmuir 2018 05 2;34(19):5600-5605. Epub 2018 May 2.

College of Materials Science & Engineering , Zhejiang University of Technology , Hangzhou 310014 , China.

Recently, infrared reflective pigments possessing deep colors have attracted much attention. However, in polluted air, the coatings consisting of such pigments are easily contaminated which abates infrared reflectivity. In this work, black and infrared reflective pigments, fluorine silicon sol and a small number of SiO nanoparticles were introduced into waterborne epoxy resin emulsion and then coated on an aluminum plate. After drying, black coatings with infrared reflective and superhydrophobic (SH) properties were obtained. The average near-infrared (NIR) reflectivity of the coating over wavelength range of 780-2600 nm can reach 68%, which is much larger than that of carbon black coatings and even approaches that of white nano SiO coatings. Under the irradiation of a 275-W infrared lamp (with height 40 cm), the surface temperature of the coating is 63 °C, which is much lower than that of the carbon black coating (90 °C) and only 7 °C higher than that of the white nano SiO coating. Furthermore, the NIR reflective coating exhibited a typical SH property due to its low surface energy and high surface roughness, which may allow for self-cleaning performance in a practical environment, maintaining the coating's NIR reflective property.
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http://dx.doi.org/10.1021/acs.langmuir.8b00929DOI Listing
May 2018

Actinidia chlorotic ringspot-associated virus: a novel emaravirus infecting kiwifruit plants.

Mol Plant Pathol 2017 05 18;18(4):569-581. Epub 2016 Jul 18.

National Key Laboratory of Agromicrobiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.

By integrating next-generation sequencing (NGS), bioinformatics, electron microscopy and conventional molecular biology tools, a new virus infecting kiwifruit vines has been identified and characterized. Being associated with double-membrane-bound bodies in infected tissues and having a genome composed of RNA segments, each one containing a single open reading frame in negative polarity, this virus shows the typical features of members of the genus Emaravirus. Five genomic RNA segments were identified. Additional molecular signatures in the viral RNAs and in the proteins they encode, together with data from phylogenetic analyses, support the proposal of creating a new species in the genus Emaravirus to classify the novel virus, which is tentatively named Actinidia chlorotic ringspot-associated virus (AcCRaV). Bioassays showed that AcCRaV is mechanically transmissible to Nicotiana benthamiana plants which, in turn, may develop chlorotic spots and ringspots. Field surveys disclosed the presence of AcCRaV in four different species of kiwifruit vines in five different provinces of central and western China, and support the association of the novel virus with symptoms of leaf chlorotic ringspots in Actinidia. Data on the molecular features of small RNAs of 21-24 nucleotides, derived from AcCRaV RNAs targeted by host RNA silencing mechanisms, are also reported, and possible molecular pathways involved in their biogenesis are discussed.
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http://dx.doi.org/10.1111/mpp.12421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638214PMC
May 2017

Clinical outcome of direct pulp capping with MTA or calcium hydroxide: a systematic review and meta-analysis.

Int J Clin Exp Med 2015 15;8(10):17055-60. Epub 2015 Oct 15.

Research Center, Zhejiang Provincial Health Information Center Hangzhou, Zhejiang, China.

Direct pulp capping is one of the most common dental practices in endodontic therapy. This systematic review and meta-analysis aim to determine whether the effect of mineral trioxide aggregate (MTA) and calcium hydroxide for direct pulp capping is different, as measured by the clinical and radiographic analysis. The study list was obtained by searching PubMed, Springer Link, Scopus and Cochrane Database. Only those papers that met the inclusion criteria were analyzed. The results indicated that four studies met the inclusion criteria. Statistically significant difference was found between the success rates of MTA and calcium hydroxide treated teeth that needed direct pulp capping (P=0.002). Clinical assessments of the MTA versus calcium hydroxide for direct pulp capping suggested that MTA was superior to calcium hydroxide in direct pulp capping resulting in a lower failure rate (risk difference 0.1 [95% CI 0.04 to 0.16]). In conclusion, MTA has a higher clinical success rate for direct pulp capping comparing to calcium hydroxide, and might be a suitable replacement for calcium hydroxide.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694196PMC
January 2016

[Potential utility of a renal function adjusted D-dimer cut-off value for improving the exclusion of pulmonary embolism].

Zhonghua Yi Xue Za Zhi 2015 Aug;95(30):2433-6

Department of Respiratory Medicine, Capital Medical University; Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China; Email:

Objective: To evaluate the potential utility of a renal function adjusted D-dimer cut-off value for improving the exclusion of pulmonary embolism.

Methods: Retrospective analyses were performed for 1 784 inpatients and outpatients with low and moderate probability of pulmonary embolism at Anzhen Hospital from January 2011 to June 2013. The Well's score was used. The diagnoses of pulmonary embolism were confirmed by computed tomography pulmonary angiogram and ventilation-perfusion scan. Based upon estimated glomerular filtration rate (GFR), they were divided into three subgroups of normal renal function, mild renal impairment and moderate renal impairment. Negative D-dimer was defined as a level of age-standardized D-dimer value<500 µg/L. The proportions of patients with negative D-dimer and the utility of D-dimer for ruling out pulmonary embolism were compared between three subgroups. A new D-dimer cut-off point in patients with renal impairment was developed by receiver operating characteristics (ROC) curves and the effect of diagnostic efficiency of ruling out pulmonary embolism with renal function adjusted D-dimer cut-off was assessed.

Results: The medians of D-dimer of three subgroups with normal renal function, mild renal impairment and moderate renal impairment were 291.5, 995.5 and 1 901.5 µg/L (P<0.001) respectively. The sensitivity of negative D-dimer for ruling out pulmonary embolism was 99%-100% and the specificity 70%, 42% and 23% in three subgroups. The number of patients needed to test (NNT) for one negative test of D-dimer in three subgroups of different renal function was 3.32, 3.58 and 3.95 respectively. The new D-dimer cut-off value increased to 1.2 and 1.75 times of old one in patients with mild and moderate renal impairments and the proportion of patients with a negative D-dimer level rose from 48.7% to 53.0% as compared with old D-dimer cut-off value. The sensitivity and specificity of negative D-dimer for ruling out pulmonary embolism was 98% and 62% with the new cut-off value versus 99% and 57% with the old cut-off value and the NNT of D-dimer for ruling out pulmonary embolism declined from 3.52 to 3.34.

Conclusion: The renal function adjusted D-dimer cut-off point can improve the diagnostic efficiency of D-dimer test for ruling out pulmonary embolism.
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August 2015

Using Dynamic Multi-Task Non-Negative Matrix Factorization to Detect the Evolution of User Preferences in Collaborative Filtering.

PLoS One 2015 13;10(8):e0135090. Epub 2015 Aug 13.

Health Information Center of Zhejiang Province, Hangzhou, Zhejiang, P.R. China.

Predicting what items will be selected by a target user in the future is an important function for recommendation systems. Matrix factorization techniques have been shown to achieve good performance on temporal rating-type data, but little is known about temporal item selection data. In this paper, we developed a unified model that combines Multi-task Non-negative Matrix Factorization and Linear Dynamical Systems to capture the evolution of user preferences. Specifically, user and item features are projected into latent factor space by factoring co-occurrence matrices into a common basis item-factor matrix and multiple factor-user matrices. Moreover, we represented both within and between relationships of multiple factor-user matrices using a state transition matrix to capture the changes in user preferences over time. The experiments show that our proposed algorithm outperforms the other algorithms on two real datasets, which were extracted from Netflix movies and Last.fm music. Furthermore, our model provides a novel dynamic topic model for tracking the evolution of the behavior of a user over time.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135090PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535854PMC
May 2016

Association between vitamin D receptor gene polymorphisms and idiopathic hypocitraturia in the Chinese population.

Urol Int 2010 26;85(1):100-5. Epub 2010 Mar 26.

Departments of Urology, Tongji Hospital, China. dc2007zcx @ yahoo.cn [corrected]

Introduction: Idiopathic hypocitraturia is a known risk factor for urolithiasis. Several studies have shown an association between vitamin D receptor (VDR) gene polymorphisms and urolithiasis. The aim of this study was to investigate the relationship between VDR gene polymorphisms and idiopathic hypocitraturia in a Chinese population.

Subjects And Methods: We chose 50 Chinese subjects with normal urinary citrate levels (N) and 31 Chinese subjects with idiopathic hypocitraturia (L). The VDR polymorphisms BsmI, FokI, TaqI, and ApaI were detected using the PCR-RFLP technique, and the relationship between these polymorphisms and the presence of idiopathic hypocitraturia was analyzed.

Results: We found that the prevalence of 'bb', 'ff', and 'TT' VDR genotypes were significantly higher in the 'L' group than in the 'N' group (p < 0.05). We also found much lower 24-hour urinary citrate concentrations in patients with 'bb', 'ff', and 'TT' genotypes than in patients with other genotypes (p < 0.05).

Conclusions: These results showed that there might be a genetic association between BsmI, FokI, and TaqI VDR polymorphisms and idiopathic hypocitraturia in the Chinese population.
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http://dx.doi.org/10.1159/000304733DOI Listing
December 2010