Publications by authors named "Chengyu Ji"

2 Publications

  • Page 1 of 1

Matrine ameliorates the inflammatory response and lipid metabolism in vascular smooth muscle cells through the NF-κB pathway.

Exp Ther Med 2021 Nov 16;22(5):1309. Epub 2021 Sep 16.

Department of Emergency Medicine, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China.

Atherosclerosis is a chronic inflammatory disease associated with inflammatory responses and the uncontrolled proliferation and excessive apoptosis of vascular smooth muscle cells. However, the effects of matrine on the inflammatory response, abnormal lipid metabolism and cell proliferation and apoptosis marker proteins in human aortic vascular smooth muscle cells (HAVSMCs) have not been elucidated. Therefore, the present study aimed to investigate the effect of matrine on an model of atherosclerosis using HAVSMCs. The HAVSMCs were divided into normal, model and matrine groups. The model group was treated with oxidized low-density lipoprotein (oxLDL), the matrine group was treated with oxLDL and matrine and the normal group was treated with physiological saline. Total cholesterol (TC), free cholesterol (FC) and cholesterol ester (CE) levels were measured in the cell supernatant. In addition, the relative mRNA levels of inflammatory factors were quantified using reverse transcription-quantitative PCR, and the cell proliferation and apoptosis rates were evaluated using Cell Counting Kit-8 and flow cytometry assays, respectively. The expression levels of proteins associated with proliferation and apoptosis were also determined using western blotting. The levels of TC, FC and CE and the mRNA levels of IL-1β, IL-6, and TNF-α in the matrine group were lower than those in the model group, but higher than those in the normal group. After 48 and 96 h of treatment, the cell proliferation and apoptotic rates were lower in the matrine group compared with the model group. The relative expression levels of Ki-67, proliferating cell nuclear antigen and Bax were decreased, while that of Bcl-2 was increased in the matrine group compared with the model group. In addition, the relative protein expression of nuclear factor κB (NF-κB) in the matrine group was lower than that in the model group, but higher than that in the normal group. In summary, matrine inhibited activation of the NF-κB pathway and reduced cell proliferation and apoptosis in the oxLDL-induced atherosclerosis model, and exhibited anti-inflammatory effects. These results suggest that matrine attenuated abnormal biological reactions in HAVSMCs through the NF-κB pathway.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
November 2021

Boosting the Efficiency of Photoelectrolysis by the Addition of Non-Noble Plasmonic Metals: Al & Cu.

Nanomaterials (Basel) 2018 Dec 20;9(1). Epub 2018 Dec 20.

Department of Materials and London Centre for Nanotechnology, Imperial College London, London SW7 2AZ, UK.

Solar water splitting by semiconductor based photoanodes and photocathodes is one of the most promising strategies to convert solar energy to chemical energy to meet the high demand for energy consumption in modern society. However, the state-of-the-art efficiency is too low to fulfill the demand. To overcome this challenge and thus enable the industrial realization of a solar water splitting device, different approaches have been taken to enhance the overall device efficiency, one of which is the incorporation of plasmonic nanostructures. Photoanodes and photocathodes coupled to the optimized plasmonic nanostructures, matching the absorption wavelength of the semiconductors, can exhibit a significantly increased efficiency. So far, gold and silver have been extensively explored to plasmonically enhance water splitting efficiency, with disadvantages of high cost and low enhancement. Instead, non-noble plasmonic metals such as aluminum and copper, are earth-abundant and low cost. In this article, we review their potentials in photoelectrolysis, towards scalable applications.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
December 2018