Publications by authors named "Chengyang Liu"

49Publications

Norovirus-Specific CD8 T Cell Responses in Human Blood and Tissues.

Authors:
Ajinkya Pattekar Lena S Mayer Chi Wai Lau Chengyang Liu Olesya Palko Meenakshi Bewtra H P A P Consortium Lisa C Lindesmith Paul D Brewer-Jensen Ralph S Baric Michael R Betts Ali Naji E John Wherry Vesselin T Tomov

Cell Mol Gastroenterol Hepatol 2021 Jan 11. Epub 2021 Jan 11.

Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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January 2021

Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes.

Authors:
Ming Yu Divyansh Agarwal Laxminarayana Korutla Catherine L May Wei Wang Negin Noorchashm Griffith Bernhard J Hering Klaus H Kaestner Omaida C Velazquez James F Markmann Prashanth Vallabhajosyula Chengyang Liu Ali Naji

Nat Metab 2020 10 7;2(10):1013-1020. Epub 2020 Sep 7.

Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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October 2020

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D.

Authors:
Dana Avrahami Yue J Wang Jonathan Schug Eseye Feleke Long Gao Chengyang Liu Ali Naji Benjamin Glaser Klaus H Kaestner

Mol Metab 2020 Dec 30;42:101057. Epub 2020 Jul 30.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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December 2020

Lentinan Inhibits Tumor Progression by Immunomodulation in a Mouse Model of Bladder Cancer.

Authors:
Ming Sun Renge Bu Bin Zhang Yaming Cao Chengyang Liu Wenyan Zhao

Integr Cancer Ther 2020 Jan-Dec;19:1534735420946823

Shengjing Hospital of China Medical University, Shenyang, China.

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August 2020

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

Authors:
Liuliu Yang Yuling Han Benjamin E Nilsson-Payant Vikas Gupta Pengfei Wang Xiaohua Duan Xuming Tang Jiajun Zhu Zeping Zhao Fabrice Jaffré Tuo Zhang Tae Wan Kim Oliver Harschnitz David Redmond Sean Houghton Chengyang Liu Ali Naji Gabriele Ciceri Sudha Guttikonda Yaron Bram Duc-Huy T Nguyen Michele Cioffi Vasuretha Chandar Daisy A Hoagland Yaoxing Huang Jenny Xiang Hui Wang David Lyden Alain Borczuk Huanhuan Joyce Chen Lorenz Studer Fong Cheng Pan David D Ho Benjamin R tenOever Todd Evans Robert E Schwartz Shuibing Chen

Cell Stem Cell 2020 07 19;27(1):125-136.e7. Epub 2020 Jun 19.

Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

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July 2020

Direct Determination of Coagulation Factor IIa and Plasmin Activities for Monitoring of Thrombotic State.

Authors:
Junhua Zhang Lihui Zou Chengyang Liu Chuanbao Li Meng Wang He Yang Yan Wang Zheng Tan Hexin Li Fei Su Tong Zou Kang Li Xiaogang Wang Ying Li Bingqing Han Zhu Zhang Zhenguo Zhai Xiangyi Liu Xiaomao Xu Fei Xiao

J Appl Lab Med 2020 11;5(6):1265-1276

The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences, Beijing, PR China.

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November 2020

mA Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.

Authors:
Yimeng Gao Radovan Vasic Yuanbin Song Rhea Teng Chengyang Liu Rana Gbyli Giulia Biancon Raman Nelakanti Kirsten Lobben Eriko Kudo Wei Liu Anastasia Ardasheva Xiaoying Fu Xiaman Wang Poorval Joshi Veronica Lee Burak Dura Gabriella Viero Akiko Iwasaki Rong Fan Andrew Xiao Richard A Flavell Hua-Bing Li Toma Tebaldi Stephanie Halene

Immunity 2020 Jun 3;52(6):1007-1021.e8. Epub 2020 Jun 3.

Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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June 2020

Plasma Metabolomics and Lipidomics Reveal Perturbed Metabolites in Different Disease Stages of Chronic Obstructive Pulmonary Disease.

Authors:
Juntuo Zhou Qiuyu Li Chengyang Liu Ruifang Pang Yuxin Yin

Int J Chron Obstruct Pulmon Dis 2020 9;15:553-565. Epub 2020 Mar 9.

Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China.

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March 2020

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling.

Authors:
Neha Shrestha Tongyu Liu Yewei Ji Rachel B Reinert Mauricio Torres Xin Li Maria Zhang Chih-Hang Anthony Tang Chih-Chi Andrew Hu Chengyang Liu Ali Naji Ming Liu Jiandie D Lin Sander Kersten Peter Arvan Ling Qi

J Clin Invest 2020 Jul;130(7):3499-3510

Department of Molecular and Integrative Physiology, University of Michigan Medical School.

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July 2020

Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-B Pathways.

Authors:
Xiandong Zhu Feixia Guo Hengjie Tang Chongchu Huang Gangyin Xie Tingting Huang Yonglin Li Chengyang Liu Hongwei Wang Bicheng Chen

J Diabetes Res 2019 5;2019:8712492. Epub 2019 Sep 5.

Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China.

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February 2020

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity.

Authors:
Yewei Ji Shengyi Sun Neha Shrestha Laurel B Darragh Jun Shirakawa Yuan Xing Yi He Bethany A Carboneau Hana Kim Duo An Minglin Ma Jose Oberholzer Scott A Soleimanpour Maureen Gannon Chengyang Liu Ali Naji Rohit N Kulkarni Yong Wang Sander Kersten Ling Qi

Nat Immunol 2019 06 20;20(6):677-686. Epub 2019 May 20.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.

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June 2019

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Authors:
Yue J Wang Daniel Traum Jonathan Schug Long Gao Chengyang Liu Mark A Atkinson Alvin C Powers Michael D Feldman Ali Naji Kyong-Mi Chang Klaus H Kaestner

Cell Metab 2019 03 31;29(3):769-783.e4. Epub 2019 Jan 31.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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March 2019

Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy.

Authors:
Yunqiang He Mei Zhang Ying Wu Hemin Jiang Hongxing Fu Yong Cai Ziqiang Xu Chengyang Liu Bicheng Chen Tao Yang

Cell Death Dis 2018 09 20;9(10):950. Epub 2018 Sep 20.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

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September 2018

Safety and efficacy for robot-assisted versus open pancreaticoduodenectomy and distal pancreatectomy: A systematic review and meta-analysis.

Authors:
Wenyan Zhao Chengyang Liu Shuqiang Li Donghua Geng Yong Feng Ming Sun

Surg Oncol 2018 Sep 4;27(3):468-478. Epub 2018 Jun 4.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:

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September 2018

Islet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes.

Authors:
Zhigang Wu Hongwei Wang Fubiao Ni Xuan Jiang Ziqiang Xu Chengyang Liu Yong Cai Hongxing Fu Jiao Luo Wenwei Chen Bicheng Chen Zhixian Yu

BMC Endocr Disord 2018 Jul 27;18(1):49. Epub 2018 Jul 27.

Department of Urology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China.

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July 2018

Discovery of a drug candidate for GLIS3-associated diabetes.

Authors:
Sadaf Amin Brandoch Cook Ting Zhou Zaniar Ghazizadeh Raphael Lis Tuo Zhang Mona Khalaj Miguel Crespo Manuradhi Perera Jenny Zhaoying Xiang Zengrong Zhu Mark Tomishima Chengyang Liu Ali Naji Todd Evans Danwei Huangfu Shuibing Chen

Nat Commun 2018 07 11;9(1):2681. Epub 2018 Jul 11.

Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY, 10065, USA.

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July 2018

Re-Arterialized Rat Partial Liver Transplantation with an in vivo Vessel-Oriented 70% Hepatectomy.

Authors:
Xuehai Chen Rong Yu Ziqiang Xu Yan Zhang Chengyang Liu Bicheng Chen Hao Jin

J Vis Exp 2018 04 8(134). Epub 2018 Apr 8.

Department of Transplantation, The First Affiliated Hospital of Wenzhou Medical University;

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April 2018

Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor.

Authors:
Nicolai M Doliba Qin Liu Changhong Li Pan Chen Chengyang Liu Ali Naji Franz M Matschinsky

Mol Metab 2017 10 4;6(10):1240-1253. Epub 2017 Aug 4.

Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.

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October 2017

Paracrine Secretion of Transforming Growth Factor β by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues.

Authors:
Naoki Akanuma Jun Liu Geou-Yarh Liou Xue Yin Kaitlyn R Bejar Chengyang Liu Lu-Zhe Sun Peter Storz Pei Wang

Pancreas 2017 10;46(9):1202-1207

From the *Departments of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX; †Department of Cancer Biology, Mayo Clinic, Jacksonville, FL; and ‡Surgery Department, University of Pennsylvania School of Medicine, Philadelphia, PA.

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October 2017

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells.

Authors:
Zaniar Ghazizadeh Der-I Kao Sadaf Amin Brandoch Cook Sahana Rao Ting Zhou Tuo Zhang Zhaoying Xiang Reyn Kenyon Omer Kaymakcalan Chengyang Liu Todd Evans Shuibing Chen

Nat Commun 2017 08 21;8(1):298. Epub 2017 Aug 21.

Department of Surgery, Weill Cornell Medical College, New York, 10065, USA.

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August 2017

Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.

Authors:
Camillo Ricordi Julia S Goldstein A N Balamurugan Gregory L Szot Tatsuya Kin Chengyang Liu Christine W Czarniecki Barbara Barbaro Nancy D Bridges Jose Cano William R Clarke Thomas L Eggerman Lawrence G Hunsicker Dixon B Kaufman Aisha Khan David-Erick Lafontant Elina Linetsky Xunrong Luo James F Markmann Ali Naji Olle Korsgren Jose Oberholzer Nicole A Turgeon Daniel Brandhorst Andrew S Friberg Ji Lei Ling-Jia Wang Joshua J Wilhelm Jamie Willits Xiaomin Zhang Bernhard J Hering Andrew M Posselt Peter G Stock A M James Shapiro

Diabetes 2017 09 29;66(9):2531. Epub 2017 Jun 29.

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September 2017

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Authors:
Changhong Li Amanda M Ackermann Kara E Boodhansingh Tricia R Bhatti Chengyang Liu Jonathan Schug Nicolai Doliba Bing Han Karen E Cosgrove Indraneel Banerjee Franz M Matschinsky Itzhak Nissim Klaus H Kaestner Ali Naji N Scott Adzick Mark J Dunne Charles A Stanley Diva D De León

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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July 2017

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue.

Authors:
Prashanth Vallabhajosyula Laxminarayana Korutla Andreas Habertheuer Ming Yu Susan Rostami Chao-Xing Yuan Sanjana Reddy Chengyang Liu Varun Korutla Brigitte Koeberlein Jennifer Trofe-Clark Michael R Rickels Ali Naji

J Clin Invest 2017 Apr 20;127(4):1375-1391. Epub 2017 Mar 20.

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April 2017

Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.

Authors:
Abdul Bari Muhammad Bowen Xing Chengyang Liu Ali Naji Xiaosong Ma Rebecca A Simmons Xianxin Hua

Am J Physiol Endocrinol Metab 2017 08 7;313(2):E148-E166. Epub 2017 Mar 7.

Abramson Family Cancer Research Institute, Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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August 2017

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.

Authors:
Benjamin N Ediger Hee-Woong Lim Christine Juliana David N Groff LaQueena T Williams Giselle Dominguez Jin-Hua Liu Brandon L Taylor Erik R Walp Vasumathi Kameswaran Juxiang Yang Chengyang Liu Chad S Hunter Klaus H Kaestner Ali Naji Changhong Li Maike Sander Roland Stein Lori Sussel Kyoung-Jae Won Catherine Lee May Doris A Stoffers

J Clin Invest 2017 01 12;127(1):215-229. Epub 2016 Dec 12.

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January 2017

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Authors:
Yue J Wang Maria L Golson Jonathan Schug Daniel Traum Chengyang Liu Kumar Vivek Craig Dorrell Ali Naji Alvin C Powers Kyong-Mi Chang Markus Grompe Klaus H Kaestner

Cell Metab 2016 10;24(4):616-626

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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October 2016

TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells.

Authors:
Jun Liu Naoki Akanuma Chengyang Liu Ali Naji Glenn A Halff William K Washburn Luzhe Sun Pei Wang

Sci Rep 2016 08 3;6:30904. Epub 2016 Aug 3.

Departments of Cellular and Structural Biology, University of Texas Heath Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

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August 2016

National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.

Authors:
Camillo Ricordi Julia S Goldstein A N Balamurugan Gregory L Szot Tatsuya Kin Chengyang Liu Christine W Czarniecki Barbara Barbaro Nancy D Bridges Jose Cano William R Clarke Thomas L Eggerman Lawrence G Hunsicker Dixon B Kaufman Aisha Khan David-Erick Lafontant Elina Linetsky Xunrong Luo James F Markmann Ali Naji Olle Korsgren Jose Oberholzer Nicole A Turgeon Daniel Brandhorst Xiaojuan Chen Andrew S Friberg Ji Lei Ling-Jia Wang Joshua J Wilhelm Jamie Willits Xiaomin Zhang Bernhard J Hering Andrew M Posselt Peter G Stock A M James Shapiro Xiaojuan Chen

Diabetes 2016 11 27;65(11):3418-3428. Epub 2016 Jul 27.

Clinical Islet Transplant Program and Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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November 2016

Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets.

Authors:
Ansarullah Colette Free Jenica Christopherson Quanhai Chen Jie Gao Chengyang Liu Ali Naji Alex Rabinovitch Zhiguang Guo

J Diabetes Res 2016 16;2016:1620821. Epub 2016 Jun 16.

The Sanford Project, Children Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA; Department of Surgery, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA.

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May 2017

Single-Cell Transcriptomics of the Human Endocrine Pancreas.

Authors:
Yue J Wang Jonathan Schug Kyoung-Jae Won Chengyang Liu Ali Naji Dana Avrahami Maria L Golson Klaus H Kaestner

Diabetes 2016 10 30;65(10):3028-38. Epub 2016 Jun 30.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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October 2016

A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.

Authors:
Ling-Jia Wang Tatsuya Kin Doug O'Gorman A M James Shapiro Bashoo Naziruddin Morihito Takita Marlon F Levy Andrew M Posselt Gregory L Szot Omid Savari Barbara Barbaro James McGarrigle Chun Chieh Yeh Jose Oberholzer Ji Lei Tao Chen Moh Lian James F Markmann Alejandro Alvarez Elina Linetsky Camillo Ricordi A N Balamurugan Gopalakrishnan Loganathan Joshua J Wilhelm Bernhard J Hering Rita Bottino Massimo Trucco Chengyang Liu Zaw Min Yanjing Li Ali Naji Luis A Fernandez Martynas Ziemelis Juan S Danobeitia J Michael Millis Piotr Witkowski

Cell Transplant 2016 26;25(8):1515-1523. Epub 2016 Feb 26.

Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL.

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October 2017

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Authors:
Nicolai M Doliba Qing Liu Changhong Li Jie Chen Pan Chen Chengyang Liu David W Frederick Joseph A Baur Michael J Bennett Ali Naji Franz M Matschinsky

Mol Metab 2015 Dec 8;4(12):926-39. Epub 2015 Oct 8.

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, United States; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, United States.

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December 2015

Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes.

Authors:
Michael R Rickels Carissa Fuller Cornelia Dalton-Bakes Eileen Markmann Maral Palanjian Kevin Cullison Janice Tiao Shiv Kapoor Chengyang Liu Ali Naji Karen L Teff

Diabetes 2015 May 18;64(5):1713-8. Epub 2014 Dec 18.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Monell Chemical Senses Center, Philadelphia, PA.

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May 2015

Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.

Authors:
David E Metzger Chengyang Liu Amin Sam Ziaie Ali Naji Kenneth S Zaret

Diabetes 2014 May 31;63(5):1804-16. Epub 2014 Jan 31.

Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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May 2014

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

Authors:
Vasumathi Kameswaran Nuria C Bramswig Lindsay B McKenna Melinda Penn Jonathan Schug Nicholas J Hand Ying Chen Inchan Choi Anastassios Vourekas Kyoung-Jae Won Chengyang Liu Kumar Vivek Ali Naji Joshua R Friedman Klaus H Kaestner

Cell Metab 2014 Jan 26;19(1):135-45. Epub 2013 Dec 26.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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January 2014

On the use of [18F]DOPA as an imaging biomarker for transplanted islet mass.

Authors:
Olof Eriksson Akiva Mintz Chengyang Liu Ming Yu Ali Naji Abass Alavi

Ann Nucl Med 2014 Jan 29;28(1):47-52. Epub 2013 Oct 29.

Department of Medicinal Chemistry, Preclinical PET Platform, Uppsala University, Uppsala, Sweden.

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January 2014

Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol.

Authors:
Michael R Rickels Chengyang Liu Richard D Shlansky-Goldberg Scott A Soleimanpour Kumar Vivek Malek Kamoun Zaw Min Eileen Markmann Maral Palangian Cornelia Dalton-Bakes Carissa Fuller Allen J Chiou Clyde F Barker Eline T Luning Prak Ali Naji

Diabetes 2013 Aug 29;62(8):2890-7. Epub 2013 Apr 29.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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August 2013

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

Authors:
Nuria C Bramswig Logan J Everett Jonathan Schug Craig Dorrell Chengyang Liu Yanping Luo Philip R Streeter Ali Naji Markus Grompe Klaus H Kaestner

J Clin Invest 2013 Mar 22;123(3):1275-84. Epub 2013 Feb 22.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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March 2013

Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.

Authors:
Changhong Li Chengyang Liu Itzhak Nissim Jie Chen Pan Chen Nicolai Doliba Tingting Zhang Ilana Nissim Yevgeny Daikhin David Stokes Marc Yudkoff Michael J Bennett Charles A Stanley Franz M Matschinsky Ali Naji

J Biol Chem 2013 Feb 24;288(6):3938-51. Epub 2012 Dec 24.

Division of Endocrinology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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February 2013

MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells.

Authors:
You Wang Jiangying Liu Chengyang Liu Ali Naji Doris A Stoffers

Diabetes 2013 Mar 6;62(3):887-95. Epub 2012 Dec 6.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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March 2013

Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets.

Authors:
Sebastian Rieck Jia Zhang Zhaoyu Li Chengyang Liu Ali Naji Karen K Takane Nathalie M Fiaschi-Taesch Andrew F Stewart Jake A Kushner Klaus H Kaestner

Mol Endocrinol 2012 Sep 13;26(9):1590-602. Epub 2012 Jul 13.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, 12-126 Translational Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5156, USA.

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September 2012

Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model.

Authors:
Chengyang Liu Brigitte Koeberlein Michael D Feldman Rebecca Mueller Zhonglin Wang Yanjing Li Kristin Lane Clifford C Hoyt John E Tomaszewski Ali Naji Michael R Rickels

Endocrinology 2012 Apr 21;153(4):1673-83. Epub 2012 Feb 21.

Division of Transplantation, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104-5160, USA.

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April 2012

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

Authors:
Nicolai M Doliba Wei Qin Habiba Najafi Chengyang Liu Carol W Buettger Johanna Sotiris Heather W Collins Changhong Li Charles A Stanley David F Wilson Joseph Grimsby Ramakanth Sarabu Ali Naji Franz M Matschinsky

Am J Physiol Endocrinol Metab 2012 Jan 27;302(1):E87-E102. Epub 2011 Sep 27.

Department of Biochemistry and Biophysics, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA 19104-6140, USA.

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January 2012

Calcineurin signaling regulates human islet {beta}-cell survival.

Authors:
Scott A Soleimanpour Michael F Crutchlow Alana M Ferrari Jeffrey C Raum David N Groff Matthew M Rankin Chengyang Liu Diva D De León Ali Naji Jake A Kushner Doris A Stoffers

J Biol Chem 2010 Dec 13;285(51):40050-9. Epub 2010 Oct 13.

Division of Endocrinology, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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December 2010

Analysis of B cell subsets following pancreatic islet cell transplantation in a patient with type 1 diabetes by cytometric fingerprinting.

Authors:
Debora R Sekiguchi Jennifer A Sutter Michael R Rickels Ali Naji Chengyang Liu Kathleen J Propert Wade T Rogers Eline T Luning Prak

J Immunol Methods 2011 Jan 8;363(2):233-44. Epub 2010 Oct 8.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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January 2011

Genome-wide analysis of histone modifications in human pancreatic islets.

Authors:
Reena Bhandare Jonathan Schug John Le Lay Alan Fox Olga Smirnova Chengyang Liu Ali Naji Klaus H Kaestner

Genome Res 2010 Apr 24;20(4):428-33. Epub 2010 Feb 24.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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April 2010

B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

Authors:
Chengyang Liu Hooman Noorchashm Jennifer A Sutter Mina Naji Eline Luning Prak Jean Boyer Taryn Green Michael R Rickels John E Tomaszewski Brigitte Koeberlein Zhonglin Wang Michelle E Paessler Ergun Velidedeoglu Susan Y Rostami Ming Yu Clyde F Barker Ali Naji

Nat Med 2007 Nov 28;13(11):1295-8. Epub 2007 Oct 28.

Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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November 2007

Transplantation for type I diabetes: comparison of vascularized whole-organ pancreas with isolated pancreatic islets.

Authors:
Adam Frank Shaoping Deng Xiaolun Huang Ergun Velidedeoglu Yong-Suk Bae Chengyang Liu Peter Abt Robert Stephenson Muhammad Mohiuddin Thav Thambipillai Eileen Markmann Maral Palanjian Marty Sellers Ali Naji Clyde F Barker James F Markmann

Ann Surg 2004 Oct;240(4):631-40; discussion 640-3

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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October 2004

The use of non-heart-beating donors for isolated pancreatic islet transplantation.

Authors:
James F Markmann Shaoping Deng Niraj M Desai Xiaolun Huang Ergun Velidedeoglu Adam Frank Chengyang Liu Kenneth L Brayman Moh Moh Lian Bryan Wolf Ewan Bell Marko Vitamaniuk Nicolai Doliba Franz Matschinsky Eileen Markmann Clyde F Barker Ali Naji

Transplantation 2003 May;75(9):1423-9

Department of Surgery, University of Pennsylvania Health System, Philadelphia 19104, USA.

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May 2003