Publications by authors named "Chengyang Liu"

49Publications

Norovirus-Specific CD8 T Cell Responses in Human Blood and Tissues.

Cell Mol Gastroenterol Hepatol 2021 Jan 11. Epub 2021 Jan 11.

Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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January 2021

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D.

Mol Metab 2020 Dec 30;42:101057. Epub 2020 Jul 30.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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December 2020

Lentinan Inhibits Tumor Progression by Immunomodulation in a Mouse Model of Bladder Cancer.

Integr Cancer Ther 2020 Jan-Dec;19:1534735420946823

Shengjing Hospital of China Medical University, Shenyang, China.

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August 2020

Direct Determination of Coagulation Factor IIa and Plasmin Activities for Monitoring of Thrombotic State.

J Appl Lab Med 2020 11;5(6):1265-1276

The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences, Beijing, PR China.

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November 2020

mA Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.

Immunity 2020 Jun 3;52(6):1007-1021.e8. Epub 2020 Jun 3.

Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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June 2020

Plasma Metabolomics and Lipidomics Reveal Perturbed Metabolites in Different Disease Stages of Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2020 9;15:553-565. Epub 2020 Mar 9.

Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China.

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March 2020

Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-B Pathways.

J Diabetes Res 2019 5;2019:8712492. Epub 2019 Sep 5.

Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China.

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February 2020

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Cell Metab 2019 03 31;29(3):769-783.e4. Epub 2019 Jan 31.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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March 2019

Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy.

Cell Death Dis 2018 09 20;9(10):950. Epub 2018 Sep 20.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

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September 2018

Safety and efficacy for robot-assisted versus open pancreaticoduodenectomy and distal pancreatectomy: A systematic review and meta-analysis.

Surg Oncol 2018 Sep 4;27(3):468-478. Epub 2018 Jun 4.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:

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September 2018

Islet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes.

BMC Endocr Disord 2018 Jul 27;18(1):49. Epub 2018 Jul 27.

Department of Urology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China.

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July 2018

Re-Arterialized Rat Partial Liver Transplantation with an in vivo Vessel-Oriented 70% Hepatectomy.

J Vis Exp 2018 04 8(134). Epub 2018 Apr 8.

Department of Transplantation, The First Affiliated Hospital of Wenzhou Medical University;

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April 2018

Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor.

Mol Metab 2017 10 4;6(10):1240-1253. Epub 2017 Aug 4.

Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.

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October 2017

Paracrine Secretion of Transforming Growth Factor β by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues.

Pancreas 2017 10;46(9):1202-1207

From the *Departments of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX; †Department of Cancer Biology, Mayo Clinic, Jacksonville, FL; and ‡Surgery Department, University of Pennsylvania School of Medicine, Philadelphia, PA.

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October 2017

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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July 2017

Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.

Am J Physiol Endocrinol Metab 2017 08 7;313(2):E148-E166. Epub 2017 Mar 7.

Abramson Family Cancer Research Institute, Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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August 2017

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Cell Metab 2016 10;24(4):616-626

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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October 2016

TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells.

Sci Rep 2016 08 3;6:30904. Epub 2016 Aug 3.

Departments of Cellular and Structural Biology, University of Texas Heath Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

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August 2016

Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets.

J Diabetes Res 2016 16;2016:1620821. Epub 2016 Jun 16.

The Sanford Project, Children Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA; Department of Surgery, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA.

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May 2017

Single-Cell Transcriptomics of the Human Endocrine Pancreas.

Diabetes 2016 10 30;65(10):3028-38. Epub 2016 Jun 30.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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October 2016

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Mol Metab 2015 Dec 8;4(12):926-39. Epub 2015 Oct 8.

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, United States; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, United States.

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December 2015

Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes.

Diabetes 2015 May 18;64(5):1713-8. Epub 2014 Dec 18.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Monell Chemical Senses Center, Philadelphia, PA.

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May 2015

Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.

Diabetes 2014 May 31;63(5):1804-16. Epub 2014 Jan 31.

Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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May 2014

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

Cell Metab 2014 Jan 26;19(1):135-45. Epub 2013 Dec 26.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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January 2014

On the use of [18F]DOPA as an imaging biomarker for transplanted islet mass.

Ann Nucl Med 2014 Jan 29;28(1):47-52. Epub 2013 Oct 29.

Department of Medicinal Chemistry, Preclinical PET Platform, Uppsala University, Uppsala, Sweden.

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January 2014

Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol.

Diabetes 2013 Aug 29;62(8):2890-7. Epub 2013 Apr 29.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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August 2013

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

J Clin Invest 2013 Mar 22;123(3):1275-84. Epub 2013 Feb 22.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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March 2013

MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells.

Diabetes 2013 Mar 6;62(3):887-95. Epub 2012 Dec 6.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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March 2013

Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets.

Mol Endocrinol 2012 Sep 13;26(9):1590-602. Epub 2012 Jul 13.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, 12-126 Translational Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5156, USA.

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September 2012

Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model.

Endocrinology 2012 Apr 21;153(4):1673-83. Epub 2012 Feb 21.

Division of Transplantation, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104-5160, USA.

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April 2012

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

Am J Physiol Endocrinol Metab 2012 Jan 27;302(1):E87-E102. Epub 2011 Sep 27.

Department of Biochemistry and Biophysics, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA 19104-6140, USA.

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January 2012

Calcineurin signaling regulates human islet {beta}-cell survival.

J Biol Chem 2010 Dec 13;285(51):40050-9. Epub 2010 Oct 13.

Division of Endocrinology, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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December 2010

Analysis of B cell subsets following pancreatic islet cell transplantation in a patient with type 1 diabetes by cytometric fingerprinting.

J Immunol Methods 2011 Jan 8;363(2):233-44. Epub 2010 Oct 8.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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January 2011

Genome-wide analysis of histone modifications in human pancreatic islets.

Genome Res 2010 Apr 24;20(4):428-33. Epub 2010 Feb 24.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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April 2010