Publications by authors named "Chengping Luo"

2 Publications

  • Page 1 of 1

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats.

Evid Based Complement Alternat Med 2021 26;2021:5570356. Epub 2021 Mar 26.

Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

This study aimed to investigate the therapeutic effects of candesartan combined with music therapy on diabetic retinopathy with depression and to assess the molecular mechanisms. Associated animal model of diabetes mellitus and depression was established in rats. Pathological changes in the hippocampus were detected by haematoxylin eosin (H&E) staining. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) was used to detect retinal cell apoptosis. Angiotensin II (Ang II) in peripheral blood and neurotransmitters, including serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in the hippocampus, was measured by enzyme linked immunosorbent assay (ELISA). Fluorescence quantitative PCR and western blotting were used to detect the expression of brain-derived neurotrophic factor (BDNF) and c-fos in the hippocampus. Our data showed that chromatin aggregation and cytoplasmic vacuolation were observable in the hippocampal cells of the rats in the model group, while candesartan and music therapy could reduce morphological changes in the hippocampus of diabetic rats with depression. Compared with the control group, the apoptosis of retinal cells was significantly higher, the contents of 5-HT, DA, and NE in the hippocampus were significantly lower, Ang II level in peripheral blood was significantly higher, and the expression of BDNF and c-fos in the hippocampus decreased significantly in the model group. By contrast, candesartan or candesartan + music therapy ameliorated the changes in retina cell apoptosis, reduction of neurotransmitters, increase in AII, and the expression of c-fos and BDNF. Especially, music therapy further improved the effects of candesartan on retina cell apoptosis and neurotransmitter release in diabetic retinopathy rats with depression. In conclusion, candesartan and music therapy have an additive effect in DM with both visual impairment and depression, which might serve a potential alternative treatment for this complex disease.
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http://dx.doi.org/10.1155/2021/5570356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018856PMC
March 2021

Heterogeneous nucleation of β-type precipitates on nanoscale Zr-rich particles in a Mg-6Zn-0.5Cu-0.6Zr alloy.

Nanoscale Res Lett 2012 Jun 8;7:300. Epub 2012 Jun 8.

Australian Centre for Microscopy and Microanalysis, The University of Sydney, New South Wales, 2006, Australia.

Zirconium (Zr) is an important alloying element to Mg-Zn-based alloy system. In this paper, we report the formation of the β-type precipitates on the nanoscale Zr-rich particles in a Mg-6Zn-0.5Cu-0.6Zr alloy during ageing at 180°C. Scanning transmission electron microscopy examinations revealed that the nanoscale Zr-rich [0001]α rods/laths are dominant in the Zr-rich core regions of the as-quenched sample after a solution treatment at 430°C. More significantly, these Zr-rich particles served as favourable sites for heterogeneous nucleation of the Zn-rich β-type phase during subsequent isothermal ageing at 180°C. This research provides a potential route to engineer precipitate microstructure for better strengthening effect in the Zr-containing Mg alloys.
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http://dx.doi.org/10.1186/1556-276X-7-300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431999PMC
June 2012