Publications by authors named "Chenglong He"

8 Publications

  • Page 1 of 1

Clinical Effects of Stereotactic Body Radiation Therapy Targeting the Primary Tumor of Liver-Only Oligometastatic Pancreatic Cancer.

Front Oncol 2021 27;11:659987. Epub 2021 May 27.

Department of Medical Oncology, Jinling Hospital, Nanjing Clinical School of Nanjing Medical University, Nanjing, China.

Aim: To investigate the efficacy and safety of stereotactic body radiotherapy (SBRT) targeting the primary tumor for liver-only oligometastatic pancreatic cancer.

Methods: We compared the efficacy and safety of SBRT plus chemotherapy with chemotherapy alone in patients with liver-only oligometastatic pancreatic cancer. The populations were balanced by propensity score-weighted and propensity score-matched analyses based on baseline variables. The primary outcome was overall survival (OS). The secondary outcomes included progression free survival (PFS), local progression, metastatic progression and symptomatic local control.

Results: This is a retrospective study of 89 pancreatic cancer patients with liver-only oligometastasis. Overall, 34 (38.2%) and 55 (61.8%) patients received SBRT plus chemotherapy and chemotherapy alone, respectively. After propensity score matching, 1-year OS rate was 34.0% (95%CI, 17.8-65.1%) in the SBRT plus chemotherapy group and 16.5% (95%CI, 5.9-46.1%) in chemotherapy alone group (P=0.115). The 6-month PFS rate was 29.4% (95%CI, 15.4-56.1) in SBRT plus chemotherapy and 20.6% (95%CI, 8.8-48.6) in chemotherapy alone group (P=0.468), respectively. Further subgroup analysis indicated that the addition of SBRT improved OS in patients with primary tumor located in the head of pancreas (stratified HR, 0.28; 95% CI, 0.09 to 0.90) or good performance status (stratified HR, 0.24; 95% CI, 0.07 to 0.86). In terms of disease control, SBRT delayed local progression of pancreas (P=0.008), but not distant metastatic progression (P=0.56). Besides, SBRT offered significant abdominal/back pain relief (P=0.016) with acceptable toxicities.

Conclusions: The addition of SBRT to chemotherapy in patients with liver-only oligometastatic pancreatic cancer improves the OS of those with primary tumor located in the head of pancreas or good performance status. In addition, it is a safe and effective method for local progression control and local symptomatic palliation in patients with metastatic pancreatic cancer.
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http://dx.doi.org/10.3389/fonc.2021.659987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190391PMC
May 2021

CRISPR screen in cancer: status quo and future perspectives.

Am J Cancer Res 2021 15;11(4):1031-1050. Epub 2021 Apr 15.

Department of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University Nanjing 210002, China.

Clustered regularly interspaced short palindromic repeats (CRISPR) system offers a powerful platform for genome manipulation, including protein-coding genes, noncoding RNAs and regulatory elements. The development of CRISPR screen enables high-throughput interrogation of gene functions in diverse tumor biologies, such as tumor growth, metastasis, synthetic lethal interactions, therapeutic resistance and immunotherapy response, which are mostly performed or in transplant models. Recently, direct CRISPR screens have been developed to identify drivers of tumorigenesis in native microenvironment. Key parameters of CRISPR screen are constantly being optimized to achieve higher targeting efficiency and lower off-target effect. Here, we review the recent advances of CRISPR screen in cancer studies both and , with a particular focus on identifying cancer immunotherapy targets, and propose optimizing strategies and future perspectives for CRISPR screen.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085856PMC
April 2021

Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer.

Front Oncol 2021 10;11:650937. Epub 2021 Mar 10.

Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC. Patients diagnosed with first primary CRC between 2000 and 2011 were identified from the Surveillance, Epidemiology, and End Results cancer registries. The patients were divided into three cohorts: classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC). Standardized incidence ratios were calculated to assess the risk of SPMs among the patients. Overall risk of SPMs was significantly higher among patients with three histological subtypes of CRC than in the general population. The risk of esophagus cancer was significantly increased in SRCC. The risk of small intestine, colon and rectum, and corpus uteri cancers was high in three histological subtypes, with the highest risk observed in SRCC, followed by MA. Increased risks of second stomach, uterus, urinary bladder, kidney, and thyroid cancers were only observed in CA patients, while increased risk of second renal pelvis cancer was limited to MA patients. Furthermore, the high overall risk of SPMs in CA patients persisted regardless of clinicopathological factors. After surgery combined with chemotherapy treatment, CA patients were more prone to developing second small intestine, colon and rectum cancers than those treated with surgery only. A lower second prostate cancer risk was observed in rectal CA patients treated with surgery combined with radiotherapy than in patients treated with surgery only. The present study revealed that the risk of developing SPMs after CRC varied based on the histological subtypes of the first primary CRC. Although the mechanisms underlying the observed patterns of SPM risk remain unknown, the study provided insights into future cancer surveillance based on the histological subtypes of CRC.
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http://dx.doi.org/10.3389/fonc.2021.650937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988191PMC
March 2021

Efficient path planning for UAV formation via comprehensively improved particle swarm optimization.

ISA Trans 2020 Feb 8;97:415-430. Epub 2019 Aug 8.

School of Electrical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China.

Automatic generation of optimized flyable path is a key technology and challenge for autonomous unmanned aerial vehicle (UAV) formation system. Aiming to improve the rapidity and optimality of automatic path planner, this paper presents a three dimensional path planning algorithm for UAV formation based on comprehensively improved particle swarm optimization (PSO). In the proposed method, a chaos-based Logistic map is firstly adopted to improve the particle initial distribution. Then, the common used constant acceleration coefficients and maximum velocity are designed to adaptive linear-varying ones, which adjusts to the optimization process and meanwhile improves solution optimality. Besides, a mutation strategy that undesired particles are replaced by those desired ones is also proposed and the algorithm convergence speed is accelerated. Theoretically, the comprehensively improved PSO not only speeds up the convergence but also improves the solution optimality. Finally, Monte-Carlo simulation for UAV formation under terrain and threat constraints are carried out and the results illustrate the rapidity and optimality of the proposed method.
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http://dx.doi.org/10.1016/j.isatra.2019.08.018DOI Listing
February 2020

Preliminary Research on the Nonlinear Ultrasonic Detection of the Porosity of Porous Material Based on Dynamic Wavelet Fingerprint Technology.

Sensors (Basel) 2019 Jul 29;19(15). Epub 2019 Jul 29.

Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-Performance Mechanical Equipment, Changsha University of Science & Technology, Changsha 410004, China.

Porosity is an important characteristic of porous material, which affects mechanical and material properties. In order to solve the problem that the large distribution range of pore size of porous materials leads to the large detection errors of porosity, the non-linear ultrasonic testing technique is applied. A graphite composite was used as the experimental object in the study. As the accuracy of porosity is directly related with feature extraction, the dynamic wavelet fingerprint (DWFP) technology was utilized to extract the feature parameter of the ultrasonic signals. The effects of the wavelet function, scale factor, and white slice ratio on the extraction of the nonlinear feature are discussed. The SEM photos were conducted using gray value to identify the aperture. The relationship between pore diameter and detection accuracy was studied. Its results show that the DWFP technology could identify the second harmonic component well, and the extracted nonlinear feature could be used for the quantitative trait of porosity. The larger the proportion of the small diameter holes and the smaller the aperture distribution range was, the smaller the error was. This preliminary research aimed to improve the nondestructive testing accuracy of porosity and it is beneficial to the application of porous material in the manufacturing field.
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http://dx.doi.org/10.3390/s19153328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696354PMC
July 2019

Long non-coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression.

J Gastroenterol Hepatol 2017 Jun;32(6):1204-1211

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background And Aim: Long non-coding RNA zinc finger antisense 1 (ZFAS1) is frequently amplified in hepatocellular carcinoma and promotes metastasis by increasing zinc finger E-box binding homeobox 1 (ZEB1), which can potentiate the progression of epithelial-to-mesenchymal transition (EMT). However, the expression pattern and role of ZFAS1 in colonic cancer remains unknown. The present study aimed to investigate the role of ZFAS1 and its clinical significance in colonic cancer.

Methods: Paired clinical colonic cancer tissue samples and clinicopathologic characteristics of 73 patients were analyzed. Quantitative real-time polymerase chain reaction analysis was used to evaluate expression levels of ZFAS1 in colonic cancer tissues, cell lines, and plasma. ZEB1 and EMT-related markers expression levels also were explored. Cell biology assays were used to explore the biologic consequences of ZFAS1 in regulating cell proliferation and invasion, as well as the roles in regulating EMT.

Results: Zinc finger antisense 1 was up-regulated in colonic cancer tissues compared with adjacent mucosa (P < 0.01), and its expression level was significantly correlated with TNM stage, vascular invasion, and lymph node metastasis (P < 0.05). ZFAS1 and ZEB1 were also increased in patients' plasma. Moreover, ZFAS1 promoted proliferation, invasion, and impeded apoptosis. Knockdown of ZFAS1 decreased expression of ZEB1 and increased the epithelial markers E-cadherin, ZO-1 while decreasing mesenchymal markers vimentin and N-cadherin.

Conclusions: Long non-coding RNA ZFAS1 may function as an oncogene by modulating ZEB1 to induce EMT. Manipulation of ZFAS1 level may be a novel approach to suppress colonic cancer progression. In addition, ZFAS1 in plasma has the potential to be a diagnostic biomarker of colonic cancer.
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http://dx.doi.org/10.1111/jgh.13646DOI Listing
June 2017

Molecular Iodine-Mediated Difunctionalization of Alkenes with Nitriles and Thiols Leading to β-Acetamido Sulfides.

J Org Chem 2016 Mar 7;81(6):2252-60. Epub 2016 Mar 7.

The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong China.

A direct difunctionalization protocol of alkenes with nitriles and thiols toward β-acetamido sulfide derivatives has been proposed under metal-free synthesis conditions. The present protocol provides the facile and highly efficient synthesis of various β-acetamido sulfides in a scaled-up manner with good to excellent yields simply using inexpensive molecular iodine as a catalyst, DMSO as a mild oxidant, and readily available thiols as thiolating reagents.
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http://dx.doi.org/10.1021/acs.joc.5b02579DOI Listing
March 2016

Simple, green and high-yield production of single- or few-layer graphene by hydrothermal exfoliation of graphite.

Nanoscale 2014 May;6(9):4598-603

Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China.

Graphene is widely used as promising electronic material and devices, owing to its exceptional electronic and optoelectronic properties. Up to now, defect-free graphene has been limited to the method for controllable, reproducible and scalable mass production. A simple, green, and nontoxic approach for large-scale preparation of high quality graphene is produced by exfoliation of graphite sheets collaborated with intercalant (FeCl2) under hydrothermal conditions, the absence of defects or oxides in graphene with a yield up to 10 wt% can be a practical application and industrial process such as optical limiters, transparent conductors, and sensors. This new process could potentially be improved to give a yield of up to 35 wt% of the starting graphite mass with sediment recycling. We show with experiments and theories that exfoliation graphene is the result of a combined action by diminishing the van der Waals interactions between graphite layers and the shear force drove by the Brownian motion of H2O and FeCl2 molecules. Hydrothermal exfoliation has potential applications in the exfoliation of other layered materials (e.g. BN, MoS2) and carbon nantubes, and in the synthesis of intercalation compounds, nanoribbons, and nanoparticles, thus opening new ways of exfoliation engineering.
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http://dx.doi.org/10.1039/c3nr06219hDOI Listing
May 2014
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