Cheng-Wen Wu

Cheng-Wen Wu

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Cheng-Wen Wu

Publications by authors named "Cheng-Wen Wu"

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In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer.

J Cell Mol Med 2019 Dec 22;23(12):8184-8195. Epub 2019 Oct 22.

Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jcmm.14689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850923PMC
December 2019

Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy.

Exp Eye Res 2019 08 23;185:107678. Epub 2019 May 23.

Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183080
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http://dx.doi.org/10.1016/j.exer.2019.05.018DOI Listing
August 2019

Pigment epithelium-derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway.

J Cell Mol Med 2019 Jul 8;23(7):4759-4769. Epub 2019 May 8.

Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jcmm.14364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584522PMC
July 2019

OCT4B mediates hypoxia-induced cancer dissemination.

Oncogene 2019 02 12;38(7):1093-1105. Epub 2018 Sep 12.

Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.

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http://dx.doi.org/10.1038/s41388-018-0487-6DOI Listing
February 2019

Palliative Chemotherapy Near the End of Life in Oncology Patients.

Am J Hosp Palliat Care 2018 Sep 12;35(9):1215-1220. Epub 2018 Mar 12.

1 Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.

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http://dx.doi.org/10.1177/1049909118763338DOI Listing
September 2018

Upregulation of E3 Ubiquitin Ligase CBLC Enhances EGFR Dysregulation and Signaling in Lung Adenocarcinoma.

Cancer Res 2018 09 26;78(17):4984-4996. Epub 2018 Jun 26.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-3858DOI Listing
September 2018

The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma.

Gynecol Oncol 2018 02 6;148(2):383-392. Epub 2017 Dec 6.

Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei 112, Taiwan; Institute of Biomedical Science, Academia Sinica, Taipei 115, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.11.033DOI Listing
February 2018

EGFR-mediated interleukin enhancer-binding factor 3 contributes to formation and survival of cancer stem-like tumorspheres as a therapeutic target against EGFR-positive non-small cell lung cancer.

Lung Cancer 2018 02 29;116:80-89. Epub 2017 Dec 29.

Division of Hematology and Oncology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Laboratory of Good Clinical Research Center, Department of Medical Research, MacKay Memorial Hospital, Tamsui District, New Taipei City, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.12.017DOI Listing
February 2018

Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas.

Sci Rep 2018 01 10;8(1):271. Epub 2018 Jan 10.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41598-017-18527-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762715PMC
January 2018

Use of Palliative Chemo- and Radiotherapy at the End of Life in Patients With Cancer: A Retrospective Cohort Study.

Am J Hosp Palliat Care 2017 Nov 8;34(9):801-805. Epub 2016 Jun 8.

1 Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.

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http://dx.doi.org/10.1177/1049909116653733DOI Listing
November 2017

YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas.

Oncotarget 2017 Oct 27;8(52):89539-89551. Epub 2017 Jul 27.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.19647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685690PMC
October 2017

Upregulation of Wnt signaling under hypoxia promotes lung cancer progression.

Oncol Rep 2017 Sep 12;38(3):1706-1714. Epub 2017 Jul 12.

Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 11221, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/or.2017.5807DOI Listing
September 2017

Brain metastases in patients with non-small cell lung cancer: the role of mutated- with an exon 19 deletion or L858R point mutation in cancer cell dissemination.

Oncotarget 2017 Aug 16;8(32):53405-53418. Epub 2017 Jun 16.

Program in Molecular Medicine, School of Life Sciences, National Yang-Ming University and Academia Sinica, Taipei 112, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.18509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581119PMC
August 2017

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma.

Oncotarget 2017 Aug 18;8(34):56612-56625. Epub 2017 May 18.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.17979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593587PMC
August 2017

Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity.

Cancer Res 2016 12 7;76(23):7036-7048. Epub 2016 Oct 7.

Institute of Biotechnology, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan.

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http://cancerres.aacrjournals.org/content/early/2016/10/07/0
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http://dx.doi.org/10.1158/0008-5472.CAN-15-3178DOI Listing
December 2016

Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings.

Oncotarget 2016 Sep;7(37):60395-60406

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.10939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312391PMC
September 2016

Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer.

Glycobiology 2016 Feb 6;26(2):155-65. Epub 2015 Oct 6.

Institute of Biochemistry and Molecular Biology Institute of Microbiology and Immunology and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan

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http://dx.doi.org/10.1093/glycob/cwv088DOI Listing
February 2016

MicroRNA-7 Compromises p53 Protein-dependent Apoptosis by Controlling the Expression of the Chromatin Remodeling Factor SMARCD1.

J Biol Chem 2016 Jan 5;291(4):1877-89. Epub 2015 Nov 5.

the Institute of Clinical Medicine, Institute of Biochemistry and Molecular Biology, and Institute of Microbiology and Immunology, National Yang Ming University, Taipei 11221, and the Institute of Biomedical Science, Academia Sinica, Taipei 11221, Taiwan

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.667568
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http://dx.doi.org/10.1074/jbc.M115.667568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722465PMC
January 2016

Cultural and ethical considerations for cardiopulmonary resuscitation in chinese patients with cancer at the end of life.

Am J Hosp Palliat Care 2015 Mar 23;32(2):210-5. Epub 2014 Jan 23.

Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

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http://dx.doi.org/10.1177/1049909113520215DOI Listing
March 2015

YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research.

Nucleic Acids Res 2015 Jan 14;43(Database issue):D862-7. Epub 2014 Nov 14.

Institute of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan VGH-YM Genomic Research Center, National Yang-Ming University, Taipei 11221, Taiwan Institute of Clinical Medicine, Medical College, National Yang-Ming University, Taipei 11221, Taiwan Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 11221, Taiwan Department of Education and Research, Taipei City Hospital, Taipei 10341, Taiwan

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http://dx.doi.org/10.1093/nar/gku1156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383957PMC
January 2015

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Oncotarget 2014 Oct;5(19):9514-29

Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan. Stem Cell Research Center, Taipei Medical University, Taipei 110, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253450PMC
http://dx.doi.org/10.18632/oncotarget.2413DOI Listing
October 2014

Communication as an approach to resolve conflict about the implementation of palliative care.

Am J Hosp Palliat Care 2014 May 2;31(3):338-40. Epub 2013 Apr 2.

1Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1177/1049909113484168DOI Listing
May 2014

Histological subtype and smoking status, but not gender, are associated with mutations in non-small-cell lung cancer.

Mol Clin Oncol 2014 Mar 23;2(2):252-258. Epub 2013 Dec 23.

Molecular Medicine Program, School of Life Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C. ; Institute of Biomedical Science, Academia Sinica, Taipei Medical University, Taipei, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/mco.2013.232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917768PMC
March 2014

Polyethyleneimine and DNA nanoparticles-based gene therapy for acute lung injury.

Nanomedicine 2013 Nov 28;9(8):1293-303. Epub 2013 May 28.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taiwan; Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan.

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http://dx.doi.org/10.1016/j.nano.2013.05.004DOI Listing
November 2013

Targeting cancer stem cells: emerging role of Nanog transcription factor.

Onco Targets Ther 2013 Sep 4;6:1207-20. Epub 2013 Sep 4.

Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.2147/OTT.S38114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772775PMC
September 2013

The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancer.

Carcinogenesis 2013 Aug 4;34(8):1708-16. Epub 2013 Apr 4.

Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1093/carcin/bgt109DOI Listing
August 2013

Improvement of ventilator-induced lung injury by IPS cell-derived conditioned medium via inhibition of PI3K/Akt pathway and IP-10-dependent paracrine regulation.

Biomaterials 2013 Jan 11;34(1):78-91. Epub 2012 Oct 11.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.biomaterials.2012.09.042DOI Listing
January 2013

Oncostatin m modulates the mesenchymal-epithelial transition of lung adenocarcinoma cells by a mesenchymal stem cell-mediated paracrine effect.

Cancer Res 2012 Nov 8;72(22):6051-64. Epub 2012 Nov 8.

Institute of Biochemistry and Molecular Biology, National Yang Ming University, Academia Sinica, Taipei, Taiwan.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-1568DOI Listing
November 2012

Suppression of the invasion and migration of cancer cells by SERPINB family genes and their derived peptides.

Oncol Rep 2012 Jan 6;27(1):238-45. Epub 2011 Oct 6.

National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan, ROC.

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http://dx.doi.org/10.3892/or.2011.1497DOI Listing
January 2012

Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation.

Biochem Biophys Res Commun 2011 Jun 8;409(3):442-7. Epub 2011 May 8.

National Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, Taiwan.

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http://dx.doi.org/10.1016/j.bbrc.2011.05.022DOI Listing
June 2011

Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer.

Mol Cancer Ther 2011 Apr 31;10(4):637-47. Epub 2011 Jan 31.

Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0827DOI Listing
April 2011

Lifelong reporter gene imaging in the lungs of mice following polyethyleneimine-mediated sleeping-beauty transposon delivery.

Biomaterials 2011 Mar 17;32(7):1978-85. Epub 2010 Dec 17.

Institute of Biomedical Materials and Engineering, and Center of Excellence for Cancer Research, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.biomaterials.2010.11.026DOI Listing
March 2011

EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF.

Cancer Res 2010 Nov 26;70(21):8822-31. Epub 2010 Oct 26.

Institute of Biomedical Sciences and NRPGM Core Facilities for Proteomics and Glycomcis and Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0638DOI Listing
November 2010

c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair.

Mol Cell Neurosci 2009 Sep 13;42(1):23-32. Epub 2009 May 13.

National Institute of Cancer Research, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.mcn.2009.05.001DOI Listing
September 2009

MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.

J Biol Chem 2009 Jul 14;284(29):19613-22. Epub 2009 May 14.

Graduate Institute of Life Science, National Defense Medical Center, Taipei 11490, Taiwan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.005017
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http://dx.doi.org/10.1074/jbc.M109.005017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740587PMC
July 2009

[Three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma].

Zhonghua Zhong Liu Za Zhi 2006 Mar;28(3):222-6

Department of Integrative Chinese and Western Medicine, Fudan University Cancer Hospital, Shanghai 200032, China.

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March 2006

Expression of axl in lung adenocarcinoma and correlation with tumor progression.

Neoplasia 2005 Dec;7(12):1058-64

School of Dentistry, National Defense Medical Center, Taipei, Taiwan, ROC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501169PMC
http://dx.doi.org/10.1593/neo.05640DOI Listing
December 2005

DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma.

Cancer 2005 Sep;104(5):1013-21

School of Dentistry, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1002/cncr.21278DOI Listing
September 2005

[Effects of strengthening and regulating spleen-qi recipe on nude mice with metastatic human hepatocellular carcinoma].

Zhonghua Gan Zang Bing Za Zhi 2005 Jun;13(6):460-1

Cancer Hospital, Fudan University, Shanghai 200032, China.

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June 2005

Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.

Carcinogenesis 2005 Jan 24;26(1):1-10. Epub 2004 Jun 24.

Laboratory of Molecular and Cellular Toxicology, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1093/carcin/bgh220DOI Listing
January 2005

Prognosis of non-small cell lung cancer patients by detecting circulating cancer cells in the peripheral blood with multiple marker genes.

Clin Cancer Res 2005 Jan;11(1):173-9

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.

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January 2005

Cost-effective trapezoidal modified Boyden chamber with comparable accuracy to a commercial apparatus.

Biotechniques 2004 Nov;37(5):724-6

National Health Research Institutes, Academia Sinica, Taipei 115, Taiwan.

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http://dx.doi.org/10.2144/04375BM01DOI Listing
November 2004

Human cytomegalovirus UL76 encodes a novel virion-associated protein that is able to inhibit viral replication.

J Virol 2004 Sep;78(18):9750-62

100 Shih-Chuan 1st Road, Department of Microbiology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

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http://dx.doi.org/10.1128/JVI.78.18.9750-9762.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515012PMC
September 2004

HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.

EMBO J 2004 Jun 13;23(11):2269-80. Epub 2004 May 13.

Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.

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http://dx.doi.org/10.1038/sj.emboj.7600239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419916PMC
June 2004

Inhibition of established subcutaneous and metastatic murine tumors by intramuscular electroporation of the interleukin-12 gene.

J Biomed Sci 2003 Jan-Feb;10(1):73-86

National Health Research Institutes, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1007/bf02256000DOI Listing
November 2003

Inhibition of invasion and angiogenesis by zinc-chelating agent disulfiram.

Mol Pharmacol 2003 Nov;64(5):1076-84

National Health Research Institute, Taipei 115, Taiwan.

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http://dx.doi.org/10.1124/mol.64.5.1076DOI Listing
November 2003

Antitumor and antimetastatic activity of IL-23.

J Immunol 2003 Jul;171(2):600-7

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.4049/jimmunol.171.2.600DOI Listing
July 2003

Tumor-associated antigen L6 and the invasion of human lung cancer cells.

Clin Cancer Res 2003 Jul;9(7):2807-16

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 115, Republic of China.

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July 2003

Differential effects of two growth inhibitory K vitamin analogs on cell cycle regulating proteins in human hepatoma cells.

Life Sci 2003 May;72(24):2769-84

Division of Cancer Research, Institute of Biomedical Sciences, Academia Sinica, 115, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1016/s0024-3205(03)00188-7DOI Listing
May 2003

Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome.

J Oral Pathol Med 2003 May;32(5):297-304

Graduate Institute of Life Science, School of Dentistry, National Defense Medical Center, Taipei 114, Taiwan.

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http://dx.doi.org/10.1034/j.1600-0714.2003.00144.xDOI Listing
May 2003

Anti-tumor immunoglobulin M increases lung metastasis in an experimental model of malignant melanoma.

Clin Exp Metastasis 2003 ;20(2):103-9

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.

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http://dx.doi.org/10.1023/a:1022616223359DOI Listing
May 2003

Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway.

J Biol Chem 2003 Feb 5;278(8):5750-9. Epub 2002 Dec 5.

Laboratory of Molecular and Cellular Toxicology, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 110, Taiwan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M204863200
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http://dx.doi.org/10.1074/jbc.M204863200DOI Listing
February 2003

Aberrant expression of cell-cycle regulator cyclin D1 in breast cancer is related to chromosomal genomic instability.

Genes Chromosomes Cancer 2002 Jul;34(3):276-84

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1002/gcc.10072DOI Listing
July 2002