Publications by authors named "Cheng-Rong Yu"

50Publications

STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs.

Sci Rep 2020 10 1;10(1):16188. Epub 2020 Oct 1.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Building 10, Room 10N248G, 10 Center Drive, Bethesda, MD, 20892-1857, USA.

View Article and Find Full Text PDF
October 2020

Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements.

J Leukoc Biol 2018 12 17;104(6):1147-1157. Epub 2018 Aug 17.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

View Article and Find Full Text PDF
December 2018

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis.

Front Immunol 2017 5;8:1258. Epub 2017 Oct 5.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, United States.

View Article and Find Full Text PDF
October 2017

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.

Nat Commun 2017 09 28;8(1):719. Epub 2017 Sep 28.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

View Article and Find Full Text PDF
September 2017

SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis).

Mediators Inflamm 2016 15;2016:2939370. Epub 2016 Sep 15.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article and Find Full Text PDF
June 2017

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.

PLoS One 2016 12;11(5):e0155420. Epub 2016 May 12.

Molecular Immunology Section, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

View Article and Find Full Text PDF
July 2017

Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases.

Cytokine Growth Factor Rev 2015 Oct 20;26(5):587-93. Epub 2015 Jul 20.

Laboratory of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

View Article and Find Full Text PDF
October 2015

Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.

J Autoimmun 2015 Aug 19;62:31-8. Epub 2015 Jun 19.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, USA. Electronic address:

View Article and Find Full Text PDF
August 2015

Interleukin 35-Producing B Cells (i35-Breg): A New Mediator of Regulatory B-Cell Functions in CNS Autoimmune Diseases.

Crit Rev Immunol 2015 ;35(1):49-57

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, Maryland 20892.

View Article and Find Full Text PDF
February 2016

Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection.

Inflammation 2015 Apr;38(2):555-65

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD, 20892-1857, USA.

View Article and Find Full Text PDF
April 2015

Interleukin-35 induces regulatory B cells that suppress autoimmune disease.

Nat Med 2014 Jun 17;20(6):633-41. Epub 2014 Apr 17.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, Maryland, USA.

View Article and Find Full Text PDF
June 2014

Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration.

Lab Invest 2014 Jun 7;94(6):674-82. Epub 2014 Apr 7.

1] Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA [2] Histopathology Core, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
June 2014

STAT3 regulates proliferation and survival of CD8+ T cells: enhances effector responses to HSV-1 infection, and inhibits IL-10+ regulatory CD8+ T cells in autoimmune uveitis.

Mediators Inflamm 2013 24;2013:359674. Epub 2013 Sep 24.

Molecular Immunology Section, National Eye Institute, National Institutes of Allergy and Viral Diseases, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD 20892-1857, USA.

View Article and Find Full Text PDF
June 2014

SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells.

J Immunol 2013 Nov 7;191(10):5036-43. Epub 2013 Oct 7.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.

View Article and Find Full Text PDF
November 2013

STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis.

Invest Ophthalmol Vis Sci 2013 Jun 10;54(6):4017-25. Epub 2013 Jun 10.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article and Find Full Text PDF
June 2013

Interleukin 27 induces the expression of complement factor H (CFH) in the retina.

PLoS One 2012 20;7(9):e45801. Epub 2012 Sep 20.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
February 2013