Publications by authors named "Cheng-Rong Yu"

50Publications

STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs.

Authors:
Favour O Oladipupo Cheng-Rong Yu Ezekiel Olumuyide Yingyos Jittaysothorn Jin Kyeong Choi Charles E Egwuagu

Sci Rep 2020 10 1;10(1):16188. Epub 2020 Oct 1.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Building 10, Room 10N248G, 10 Center Drive, Bethesda, MD, 20892-1857, USA.

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October 2020

Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.

Authors:
Bernadette Marrero Chang He Hyun-Mee Oh Umegbewe T Ukwu Cheng-Rong Yu Ivy M Dambuza Lin Sun Charles E Egwuagu

Adv Exp Med Biol 2019 ;1185:353-358

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

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February 2020

Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements.

Authors:
Cheng-Rong Yu Jin Kyeong Choi Anita N Uche Charles E Egwuagu

J Leukoc Biol 2018 12 17;104(6):1147-1157. Epub 2018 Aug 17.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

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December 2018

STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

Authors:
Anthony J St Leger Anna M Hansen Hatice Karauzum Reiko Horai Cheng-Rong Yu Arian Laurence Katrin D Mayer-Barber Phyllis Silver Rafael Villasmil Charles Egwuagu Sandip K Datta Rachel R Caspi

J Exp Med 2018 04 28;215(4):1079-1090. Epub 2018 Feb 28.

Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD

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April 2018

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis.

Authors:
Jin Kyeong Choi Ivy M Dambuza Chang He Cheng-Rong Yu Anita N Uche Mary J Mattapallil Rachel R Caspi Charles E Egwuagu

Front Immunol 2017 5;8:1258. Epub 2017 Oct 5.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, United States.

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October 2017

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.

Authors:
Ivy M Dambuza Chang He Jin Kyeong Choi Cheng-Rong Yu Renxi Wang Mary J Mattapallil Paul T Wingfield Rachel R Caspi Charles E Egwuagu

Nat Commun 2017 09 28;8(1):719. Epub 2017 Sep 28.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

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September 2017

SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis).

Authors:
Chang He Cheng-Rong Yu Mary J Mattapallil Lin Sun Joseph Larkin Iii Charles E Egwuagu

Mediators Inflamm 2016 15;2016:2939370. Epub 2016 Sep 15.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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June 2017

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.

Authors:
Lin Sun Anthony J St Leger Cheng-Rong Yu Chang He Rashid M Mahdi Chi-Chao Chan Hongsheng Wang Herbert C Morse Charles E Egwuagu

PLoS One 2016 12;11(5):e0155420. Epub 2016 May 12.

Molecular Immunology Section, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

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July 2017

Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases.

Authors:
Charles E Egwuagu Cheng-Rong Yu Lin Sun Renxi Wang

Cytokine Growth Factor Rev 2015 Oct 20;26(5):587-93. Epub 2015 Jul 20.

Laboratory of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

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October 2015

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection.

Authors:
Sung-Hye Kim Jenna Burton Cheng-Rong Yu Lin Sun Chang He Hongsheng Wang Herbert C Morse Charles E Egwuagu

J Immunol 2015 Aug 10;195(4):1480-8. Epub 2015 Jul 10.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892; and

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August 2015

Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.

Authors:
Chang He Cheng-Rong Yu Lin Sun Rashid M Mahdi Joseph Larkin Charles E Egwuagu

J Autoimmun 2015 Aug 19;62:31-8. Epub 2015 Jun 19.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, USA. Electronic address:

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August 2015

Interleukin 35-Producing B Cells (i35-Breg): A New Mediator of Regulatory B-Cell Functions in CNS Autoimmune Diseases.

Authors:
Charles E Egwuagu Cheng-Rong Yu

Crit Rev Immunol 2015 ;35(1):49-57

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, Maryland 20892.

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February 2016

Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection.

Authors:
Cheng-Rong Yu Kozaburo Hayashi Yun Sang Lee Rashid M Mahdi De Fen Shen Chi-Chao Chan Charles E Egwuagu

Inflammation 2015 Apr;38(2):555-65

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD, 20892-1857, USA.

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April 2015

Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.

Authors:
Daniel Ardeljan Yujuan Wang Stanley Park Defen Shen Xi Kathy Chu Cheng-Rong Yu Mones Abu-Asab Jingsheng Tuo Charles G Eberhart Timothy W Olsen Robert F Mullins Gary White Sam Wadsworth Abraham Scaria Chi-Chao Chan

PLoS One 2014 29;9(4):e95900. Epub 2014 Apr 29.

Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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January 2015

Interleukin-35 induces regulatory B cells that suppress autoimmune disease.

Authors:
Ren-Xi Wang Cheng-Rong Yu Ivy M Dambuza Rashid M Mahdi Monika B Dolinska Yuri V Sergeev Paul T Wingfield Sung-Hye Kim Charles E Egwuagu

Nat Med 2014 Jun 17;20(6):633-41. Epub 2014 Apr 17.

Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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June 2014

Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration.

Authors:
Yujuan Wang Mones S Abu-Asab Cheng-Rong Yu Zhongshu Tang Defen Shen Jingsheng Tuo Xuri Li Chi-Chao Chan

Lab Invest 2014 Jun 7;94(6):674-82. Epub 2014 Apr 7.

1] Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA [2] Histopathology Core, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

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June 2014

STAT3 regulates proliferation and survival of CD8+ T cells: enhances effector responses to HSV-1 infection, and inhibits IL-10+ regulatory CD8+ T cells in autoimmune uveitis.

Authors:
Cheng-Rong Yu Ivy M Dambuza Yong-Jun Lee Gregory M Frank Charles E Egwuagu

Mediators Inflamm 2013 24;2013:359674. Epub 2013 Sep 24.

Molecular Immunology Section, National Eye Institute, National Institutes of Allergy and Viral Diseases, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD 20892-1857, USA.

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June 2014

SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells.

Authors:
Cheng-Rong Yu Sung-Hye Kim Rashid M Mahdi Charles E Egwuagu

J Immunol 2013 Nov 7;191(10):5036-43. Epub 2013 Oct 7.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.

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November 2013

STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis.

Authors:
Thelma Escobar Cheng-Rong Yu Stefan A Muljo Charles E Egwuagu

Invest Ophthalmol Vis Sci 2013 Jun 10;54(6):4017-25. Epub 2013 Jun 10.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Maryland 20892, USA.

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June 2013

Interleukin 27 induces the expression of complement factor H (CFH) in the retina.

Authors:
Ahjoku Amadi-Obi Cheng-Rong Yu Ivy Dambuza Sung-Hye Kim Bernadette Marrero Charles E Egwuagu

PLoS One 2012 20;7(9):e45801. Epub 2012 Sep 20.

Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

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February 2013