Dr. Cheng-Jun Hu, PhD - University of Colorado - Associate Professor

Dr. Cheng-Jun Hu

PhD

University of Colorado

Associate Professor

Aurora, CO | United States

Main Specialties: Pulmonary Disease

Additional Specialties: Pulmonary hypertension

Dr. Cheng-Jun Hu, PhD - University of Colorado - Associate Professor

Dr. Cheng-Jun Hu

PhD

Introduction

Primary Affiliation: University of Colorado - Aurora, CO , United States

Specialties:

Additional Specialties:

Research Interests:

Education

Oct 2002
University of Pennsylvania
Postdoctoral Fellow
Oct 1999
Rush University
PHD
Jun 1993
Zhejiang University
MS

Publications

33Publications

295Reads

603Profile Views

1595PubMed Central Citations

Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension.

J Physiol 2019 Feb 7;597(4):1103-1119. Epub 2018 Aug 7.

Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1113/JP275857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375873PMC
February 2019
8 Reads
5.040 Impact Factor

How Many FOXs Are There on The Road to Pulmonary Hypertension?

Am J Respir Crit Care Med 2018 Sep;198(6):704-707

5 Department of Lung Development and Remodeling Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research Bad Nauheim, Germany.

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https://www.atsjournals.org/doi/10.1164/rccm.201804-0702ED
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http://dx.doi.org/10.1164/rccm.201804-0702EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222465PMC
September 2018
1 Read
13.000 Impact Factor

Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.

Oncogenesis 2017 Jan 16;6(1):e287. Epub 2017 Jan 16.

Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1038/oncsis.2016.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294252PMC
January 2017
20 Reads

Hypoxia regulates RNA splicing of HIF targets.

Authors:
Cheng-Jun Hu

Oncoscience 2014 21;1(8):500-1. Epub 2014 Aug 21.

Department of Craniofacial Biology, University of Colorado School of Dental Medicine, Aurora, CO 80045, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278329PMC
http://dx.doi.org/10.18632/oncoscience.75DOI Listing
January 2015
1 Citation

Hypoxia regulates alternative splicing of HIF and non-HIF target genes.

Mol Cancer Res 2014 Sep 21;12(9):1233-43. Epub 2014 May 21.

Molecular Biology Graduate Program and Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163527PMC
September 2014
15 Reads
12 Citations
4.380 Impact Factor

Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.

Cell Rep 2014 Aug 14;8(4):1077-92. Epub 2014 Aug 14.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346175PMC
August 2014
18 Reads
26 Citations
7.210 Impact Factor

STAT3 or USF2 contributes to HIF target gene specificity.

PLoS One 2013 21;8(8):e72358. Epub 2013 Aug 21.

Molecular Biology Graduate Program, School of Dental Medicine University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072358PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749168PMC
June 2014
16 Reads
14 Citations
3.234 Impact Factor

HIFs enhance the transcriptional activation and splicing of adrenomedullin.

Mol Cancer Res 2014 May 12;12(5):728-41. Epub 2014 Feb 12.

Authors' Affiliations: Molecular Biology Graduate Program, 2Department of Craniofacial Biology School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020993PMC
May 2014
15 Reads
9 Citations
4.380 Impact Factor

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.

Oncogene 2014 Mar 22;33(13):1670-9. Epub 2013 Apr 22.

1] Molecular Biology Graduate Program, Graduate School, University of Colorado Anschuts Medical Campus, Aurora, CO, USA [2] Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1038/onc.2013.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868635PMC
March 2014
2 Reads
55 Citations
8.460 Impact Factor

Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.

Int J Biochem Cell Biol 2013 Nov 16;45(11):2359-68. Epub 2013 Aug 16.

Laboratory of Biochemistry, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa 41110, Greece.

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http://dx.doi.org/10.1016/j.biocel.2013.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855297PMC
November 2013
2 Reads
8 Citations
4.050 Impact Factor

BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.

Mol Cell Biol 2013 Oct 29;33(19):3849-63. Epub 2013 Jul 29.

Molecular Biology Graduate Program.

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http://dx.doi.org/10.1128/MCB.00731-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811865PMC
October 2013
21 Reads
12 Citations
4.780 Impact Factor

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.

Biochem Pharmacol 2013 Sep 19;86(6):836-43. Epub 2013 Jul 19.

Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210011, China.

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http://dx.doi.org/10.1016/j.bcp.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863645PMC
September 2013
7 Reads
32 Citations
5.010 Impact Factor

Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response.

Cell Signal 2013 Sep 21;25(9):1895-903. Epub 2013 May 21.

Molecular Biology Graduate Program, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.cellsig.2013.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700616PMC
September 2013
20 Reads
23 Citations
4.320 Impact Factor

Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.

Mol Cell Biol 2012 Nov 10;32(22):4595-610. Epub 2012 Sep 10.

Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1128/MCB.00724-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486188PMC
November 2012
7 Reads
28 Citations
4.780 Impact Factor

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.

Mol Biol Cell 2007 Nov 5;18(11):4528-42. Epub 2007 Sep 5.

Abramson Family Cancer Research Institute,University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.e06-05-0419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043574PMC
November 2007
7 Reads
108 Citations
4.470 Impact Factor

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

Cancer Cell 2007 Apr;11(4):335-47

Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145406PMC
April 2007
14 Reads
272 Citations
23.523 Impact Factor

Acute postnatal ablation of Hif-2alpha results in anemia.

Proc Natl Acad Sci U S A 2007 Feb 6;104(7):2301-6. Epub 2007 Feb 6.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0608382104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892942PMC
February 2007
20 Reads
165 Citations
9.810 Impact Factor

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.

Exp Cell Res 2007 Jan 19;313(1):1-9. Epub 2006 Sep 19.

Theodor-Boveri-Institute, Physiological Chemistry I, Biocenter of the University of Wurzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2006.09.009DOI Listing
January 2007
18 Reads
65 Citations
3.250 Impact Factor

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.

Mol Cell Biol 2006 May;26(9):3514-26

Howard Hughes Medical Institute and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.26.9.3514-3526.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447431PMC
May 2006
11 Reads
85 Citations
4.780 Impact Factor

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Genes Dev 2006 Mar;20(5):557-70

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1399906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410808PMC
March 2006
11 Reads
241 Citations
10.800 Impact Factor

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.

Mol Cell Biol 2003 Dec;23(24):9361-74

Abramson Family Cancer Research Institute. Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309606PMC
http://dx.doi.org/10.1128/mcb.23.24.9361-9374.2003DOI Listing
December 2003
4 Reads
370 Citations
4.780 Impact Factor

Hypoxia, HIFs, and cardiovascular development.

Cold Spring Harb Symp Quant Biol 2002 ;67:127-32

Howard Hughes Medical Institute, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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September 2003
9 Citations

PU.1/Spi-B regulation of c-rel is essential for mature B cell survival.

Immunity 2001 Oct;15(4):545-55

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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October 2001
9 Citations
21.561 Impact Factor

Functional significance of alternate phosphorylation in Sendai virus P protein.

Authors:
C j Hu K C Gupta

Virology 2000 Mar;268(2):517-32

Department of Immunology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, 60612, USA.

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http://dx.doi.org/10.1006/viro.1999.0176DOI Listing
March 2000
10 Citations
3.321 Impact Factor

Role of primary constitutive phosphorylation of Sendai virus P and V proteins in viral replication and pathogenesis.

Virology 1999 Oct;263(1):195-208

Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1006/viro.1999.9953DOI Listing
October 1999
10 Citations
3.321 Impact Factor

Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression.

Cancer Gene Ther 1996 Jan-Feb;3(1):31-8

Department of Biology, Indiana University, Bloomington 91320, USA.

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September 1996
2 Reads
6 Citations
2.420 Impact Factor

Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy.

Proc Natl Acad Sci U S A 1996 Apr;93(9):4513-8

Department of Biology, Indiana University, Bloomington 47405, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39570PMC
http://dx.doi.org/10.1073/pnas.93.9.4513DOI Listing
April 1996
7 Citations
9.810 Impact Factor

Comparison of the in vitro host range of recombinant met-interferon-con1, interferon-alpha 2b, and interferon-beta [corrected].

J Interferon Cytokine Res 1995 Mar;15(3):231-4

Department of Biology, Indiana University, Bloomington 47405, USA.

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http://dx.doi.org/10.1089/jir.1995.15.231DOI Listing
March 1995
3 Citations
2.000 Impact Factor

Top co-authors

Liyi Wang
Liyi Wang

University of Colorado Anschutz Medical Campus

6
Matthew R Pawlus
Matthew R Pawlus

University of Colorado Anschutz Medical Campus

4
Brian Keith
Brian Keith

University of Pennsylvania

3
Kurt R Stenmark
Kurt R Stenmark

University of Colorado Health Sciences Center

3
L Wang
L Wang

National Pingtung University of Science and Technology

2
Kelly L Covello
Kelly L Covello

University of Pennsylvania School of Medicine

2
Lewis A Chodosh
Lewis A Chodosh

University of Pennsylvania School of Medicine

2
Aneesa Sataur
Aneesa Sataur

University of Pennsylvania School of Medicine

2
John D Gordan
John D Gordan

University of California

2