Publications

DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.
Arterioscler Thromb Vasc Biol 2018 Feb 28;38(2):425-437. Epub 2017 Dec 28.
From the School of Cardiovascular Medicine & Sciences, King's College London BHF Centre, United Kingdom (E.K., B.Y., C.M.F.P., M.M.W., R.M.L.S., Z.Z., X.W., Y.H., Q.X.); The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China (C. Zhai, L.Q., Y.Z., C. Zhang); State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China (Z.W., D.K., Q.Z.); Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany (I.d.B.B., C.N.); and Institute of Molecular Biology (IMB), Mainz, Germany (C.N.).

Metabolism in Pluripotent Stem Cells and Early Mammalian Development.
Cell Metab 2018 Feb;27(2):332-338
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

[Clinical features of patients with Becker muscular dystrophy and deletions of the rod domain of dystrophin gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Feb;35(1):14-17
Department of Internal Medicine, the Affiliated Hospital of Southern China University of Technology, Guangzhou, Guangdong 510640, China; Department of Neurology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Email:


Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.
Eur J Med Chem 2018 Feb 6;147:238-252. Epub 2018 Feb 6.
Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China. Electronic address:


Dynamics of dissolved organic matter (DOM) in a typical inland lake of the Three Gorges Reservoir area: Fluorescent properties and their implications for dissolved mercury species.
J Environ Manage 2018 Jan 2;206:418-429. Epub 2017 Nov 2.
Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Chongqing Key Laboratory of Agricultural Resources and Environment, College of Resources and Environment, Southwest University, Chongqing, 400716, China. Electronic address:

DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways.
J Mol Cell Cardiol 2018 Jan 5;114:243-252. Epub 2017 Dec 5.
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address:

Synthesis of spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles via divergent, thermally induced tandem cyclization/migration of alkyne-tethered diazo compounds.
Org Biomol Chem 2018 Jan;16(5):688-692
Key Laboratory of Organic Synthesis of Jiangsu Province; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.


Glutazumab, a novel long-lasting GLP-1/anti-GLP-1R antibody fusion protein, exerts anti-diabetic effects through targeting dual receptor binding sites.
Biochem Pharmacol 2018 Jan 26;150:46-53. Epub 2018 Jan 26.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address:


Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway.
Cell Death Dis 2018 Jan 26;9(2):123. Epub 2018 Jan 26.
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China.

Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm.
Stem Cell Res 2018 Jan 31;28:48-55. Epub 2018 Jan 31.
Department of Pediatrics, Division of Neonatology and Newborn Medicine, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Controllable synthesis of a novel magnetic core-shell nanoparticle for dual-modal imaging and pH-responsive drug delivery.
Nanotechnology 2017 Dec;28(49):495101
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University 430062, People's Republic of China. Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Xueyuan Road 11#, Wuchang, Wuhan City, Hubei Province 430062, People's Republic of China.

In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications.
Macromol Biosci 2017 Dec 17;17(12). Epub 2017 Oct 17.
Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47.
Environ Toxicol Pharmacol 2017 Dec 19;56:322-328. Epub 2017 Oct 19.
Department of Environmental Health and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, People's Republic of China. Electronic address:

Mediator complex components are frequent targets for genetic alterations in various types of human cancer.
J Genet Genomics 2017 Dec 23;44(12):587-591. Epub 2017 Nov 23.
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA. Electronic address:

CCAAT/enhancer-binding protein β overexpression alleviates myocardial remodelling by regulating angiotensin-converting enzyme-2 expression in diabetes.
J Cell Mol Med 2017 Dec 21. Epub 2017 Dec 21.
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.
Arterioscler Thromb Vasc Biol 2017 Nov 14;37(11):2182-2194. Epub 2017 Sep 14.
From the Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (L.Z., Q.C., F.Y., M.Y., B.D., J.Z., Q. Xu); Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (Q.C., W.A., F.Y., E.M.M., D.C., C.Z., G.W., L.A.L., Q. Xiao); Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, China (D.C., C.Z.); Key Laboratory of Cardiovascular Diseases, The Second Affiliated Hospital and Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences (G.W., Q. Xiao), Guangzhou Medical University, Guangdong, China; and Cardiovascular Division, King's College London British Heart Foundation Centre, United Kingdom (Q. Xu).

iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Cancer Cell 2017 Nov 12;32(5):561-573.e6. Epub 2017 Oct 12.
School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang Province 150001, China; Shenzhen Graduate School of Harbin Institute of Technology, Shenzhen 518055, China. Electronic address:

Iced photochemical reduction to synthesize atomically dispersed metals by suppressing nanocrystal growth.
Nat Commun 2017 Nov 14;8(1):1490. Epub 2017 Nov 14.
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, 100084, Beijing, China.

Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells.
Stem Cell Reports 2017 Nov;9(5):1604-1617
Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs.
Stem Cell Res Ther 2017 Nov 21;8(1):266. Epub 2017 Nov 21.
Organ Transplant Center of the First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology,Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, China.

Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells.
Cell Rep 2017 Nov;21(8):2058-2065
Cancer Biology and Genetics Program, The Center for Cell Engineering, The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

Cbx3 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration and Neointima Formation.
Cardiovasc Res 2017 Nov 30. Epub 2017 Nov 30.
Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

All-solid-state asymmetric supercapacitors based on Fe-doped mesoporous CoOand three-dimensional reduced graphene oxide electrodes with high energy and power densities.
Nanoscale 2017 Oct;9(40):15423-15433
Jiangsu Key Laboratory for Nanotechnology, Collaborative Innovation Center of Advanced Microstructures, Nanjing National Laboratory of Microstructures and Department of Physics, Nanjing University, Nanjing, 210093, P. R. China.

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells.
Stem Cell Reports 2017 Oct;9(4):1053-1061
Cancer Biology and Genetics Program, The Center for Cell Engineering, The Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis.
J Exp Clin Cancer Res 2017 Oct 11;36(1):141. Epub 2017 Oct 11.
Department of Orthopaedics, The Second Hospital of Shandong University, Shandong University, Jinan, China.

The modified pancreatic stent system for prevention of post-ERCP pancreatitis: a case-control study.
BMC Gastroenterol 2017 Oct 18;17(1):108. Epub 2017 Oct 18.
Department of Biliary Minimally Invasive Surgery, Affiliated Zhongshan Hospital of Dalian University, No, 6. Jiefang Road, Zhongshan District, Dalian, Liaoning Province, 116001, People's Republic of China.

Synthesis of highly efficient flame retardant polypropylene nanocomposites with surfactant intercalated layered double hydroxides.
Dalton Trans 2017 Oct 31. Epub 2017 Oct 31.
College of Environmental Science and Engineering, Beijing Forestry University, 35 Qinghua East Road, Haidian District, Beijing 100083, P. R. China. and Beijing Key Lab for Source Control Technology of Water Pollution, College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, P. R. China.


MiR-26a contributes to the PDGF-BB-induced phenotypic switch of vascular smooth muscle cells by suppressing Smad1.
Oncotarget 2017 Sep 18;8(44):75844-75853. Epub 2017 May 18.
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Shandong University Qilu Hospital, Jinan, Shandong, China.

Cirrhosis Is Associated with Increased Mortality in Patients with Diverticulitis: A Nationwide Cross-Sectional Study.
Dig Dis Sci 2017 11 6;62(11):3149-3155. Epub 2017 Oct 6.
Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Suite 200, Columbus, OH, 43210, USA.

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