Publications by authors named "Cheng Liu"

1,375 Publications

  • Page 1 of 1

Progress of NiO-based anodes for high-performance Li-ion batteries.

Chem Rec 2022 Jun 24:e202200111. Epub 2022 Jun 24.

Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.

Rechargeable lithium-ion batteries (LIBs) are of great significance to the development of renewable energy. The traditional graphite anode is gradually unable to meet increasing demands for high energy density and power density due to its low theoretical capacity. NiO has gained considerable attention because of its high theoretical capacity, low toxicity, and stable chemical properties. This review summarizes the research progress of NiO-based nanomaterials in LIBs and centers on the electrochemical reaction mechanism, synthesis methods, and strategies for improving the electrochemical properties of NiO anodes. The results demonstrate that the electrochemical characteristics highly depend on the synthesis method, morphology, surface area, conductive substrate, etc. Compared with pure NiO, NiO-based composites including NiO/carbon-based materials and NiO/metal oxide often present higher capacity and cycle stability. Furthermore, challenges and future perspectives of NiO-based anodes are also discussed.
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http://dx.doi.org/10.1002/tcr.202200111DOI Listing
June 2022

Isotypic analysis of anti-p53 serum autoantibodies and p53 protein tissue phenotypes in colorectal cancer.

Hum Pathol 2022 Jun 21. Epub 2022 Jun 21.

Immune Profiling and Cancer Group, Faculty of Medicine, Mater Research Institute - the University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4011, Australia. Electronic address:

The presence of IgA- and IgM-specific autoantibody (AAb) isotypes and their relationship to p53 tissue expression patterns are not well understood. This study aims to investigate the clinical utility of the anti-p53 AAb isotypes and tissue positivity in colorectal cancer (CRC). We analysed anti-p53 IgG, IgM, and IgA AAbs in sera of 99 CRC patients and 99 non-cancer control subjects. Corresponding tissue expression of the p53 protein was evaluated by immunohistochemistry (IHC). Anti-p53 AAbs of the IgG isotype were present in the sera of 21 out of 99 patients (21%), while IgM AAbs were observed in 9 (9%) and IgA in 2 (2%) CRC patients. Anti-p53 AAbs of all three isotypes were generally associated with IHC staining indicative of mutated TP53. Seropositive anti-p53 IgM cases in the absence of anti-p53 IgG were linked to wild-type p53. Anti-p53 IgA in the absence of IgG AAbs was detected in two non-cancer controls indicating a potential p53 epitope mimicry. Although seropositivity was not associated with patient survival (P = 0.650), mutant-pattern p53 tissue expression was associated with reduced 5-year overall survival (P = 0.032), however, it was not an independent prognostic marker (Multivariate Cox regression, P = 0.193). In conclusion, immunoglobulin isotyping revealed that anti-p53 IgM and IgA AAbs were predominantly concurrent with anti-p53 serum IgG and the mutant-pattern p53 tissue phenotype. IgM and IgA seropositive cases in absence of anti-p53 IgG were linked to wild-type p53 tissue phenotype indicating early anti-p53 immune responses preceding isotype class-switch (IgM) or p53 antigen mimicry (IgA).
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http://dx.doi.org/10.1016/j.humpath.2022.06.017DOI Listing
June 2022

Vanadium carbide MXene: as a reductant for the synthesis of gold nanoparticles and its biosensing application.

Amino Acids 2022 Jun 22. Epub 2022 Jun 22.

College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541004, China.

Vanadium carbide MXene (VC) acts as a new type of two-dimensional (2D) graphene-like transition metal material that has attracted research interest. VC has been widely used in various fields due to its excellent physical and chemical properties. Herein, the self-assembled [email protected] nanoparticles ([email protected]) are prepared by water bath process at 80 °C. With the addition of glutathione (GSH), the absorbance (Abs.) at 550 nm of [email protected] was decreased. Therefore, an optical sensor is developed to detect GSH based on the properties of [email protected] Under the optimal conditions, the detection range is 1-32 µM and the detection limit is 0.099 µM. Furthermore, the proposed GSH sensor exhibits high sensitivity, high selectivity, strong stability, and excellent recovery. The work will expand the application of VC in biosensing.
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http://dx.doi.org/10.1007/s00726-022-03173-1DOI Listing
June 2022

Vertical distribution and temporal evolution of formaldehyde and glyoxal derived from MAX-DOAS observations: The indicative role of VOC sources.

J Environ Sci (China) 2022 Dec 1;122:92-104. Epub 2022 Feb 1.

Guangdong Key Laboratory of Environmental Protection and Resources Utilization, State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Formaldehyde (HCHO) and glyoxal (CHOCHO) are important oxidization intermediates of most volatile organic compounds (VOCs), but their vertical evolution in urban areas is not well understood. Vertical profiles of HCHO, CHOCHO, and nitrogen dioxide (NO) were retrieved from ground-based Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) observations in Hefei, China. HCHO and CHOCHO vertical profiles prefer to occur at higher altitudes compared to NO, which might be caused by the photochemistry-oxidation of longer-lived VOCs at higher altitudes. Monthly means of HCHO concentrations were higher in summer, while enhanced amounts of NO were mainly observed in winter. CHOCHO exhibited a hump-like seasonal variation, with higher monthly-averaged values not only occurred in warm months (July-August) but also in cold months (November-December). Peak values mainly occurred during noon for HCHO but emerged in the morning for CHOCHO and NO, suggesting that HCHO is stronger link to photochemistry than CHOCHO. We further use the glyoxal to formaldehyde ratio (GFR) to investigate the VOC sources at different altitudes. The lowest GFR value is almost found in the altitude from 0.2 to 0.4 km, and then rises rapidly as the altitude increases. The GFR results indicate that the largest contributor of the precursor VOC is biogenic VOCs at lower altitudes, while at higher altitudes is anthropogenic VOCs. Our findings provide a lot more insight into VOC sources at vertical direction, but more verification is recommended to be done in the future.
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http://dx.doi.org/10.1016/j.jes.2021.09.025DOI Listing
December 2022

Percutaneous vertebroplasty through an antero-lateral approach for treatment of C2 bone cyst: A case report.

Asian J Surg 2022 Jun 14. Epub 2022 Jun 14.

People's Hospital of Macheng City, No.138 Jintong Road, Macheng Economic Development Area, Huanggang, 438300, Hubei, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2022.06.036DOI Listing
June 2022

Construction of the miRNA-mRNA Regulatory Networks and Explore Their Role in the Development of Lung Squamous Cell Carcinoma.

Front Mol Biosci 2022 31;9:888020. Epub 2022 May 31.

Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

MicroRNA (miRNA) binds to target mRNA and inhibit post-transcriptional gene expression. It plays an essential role in regulating gene expression, cell cycle, and biological development. This study aims to identify potential miRNA-mRNA regulatory networks that contribute to the pathogenesis of lung squamous cell carcinoma (LUSC). MiRNA microarray and RNA-Seq datasets were obtained from the gene expression omnibus (GEO) databases, the cancer genome atlas (TCGA), miRcancer, and dbDEMC. The GEO2R tool, "limma" and "DEseq" R packages were used to perform differential expression analysis. Gene enrichment analysis was conducted using the DAVID, DIANA, and Hiplot tools. The miRNA-mRNA regulatory networks were screened from the experimentally validated miRNA-target interactions databases (miRTarBase and TarBase). External validation was carried out in 30 pairs of LUSC tissues by Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Receiver operating characteristic curve (ROC) and decision curve analysis (DCA) were conducted to evaluate the diagnostic value. Clinical, survival and phenotypic analysis of miRNA-mRNA regulatory networks were further explored. We screened 5 miRNA and 10 mRNA expression datasets from GEO and identified 7 DE-miRNAs and 270 DE-mRNAs. After databases screening and correlation analysis, four pairs of miRNA-mRNA regulatory networks were screened out. The miRNA-mRNA network of miR-205-5p (up) and PTPRM (down) was validated in 30 pairs of LUSC tissues. MiR-205-5p and PTPRM have good diagnostic efficacy and are expressed differently in different clinical features and are related to tumor immunity. The research identified a potential miRNA-mRNA regulatory network, providing a new way to explore the genesis and development of LUSC.
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http://dx.doi.org/10.3389/fmolb.2022.888020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197544PMC
May 2022

Native Endophytes of -Mediated Biotransformation Reduces Toxicity of Celastrol.

Front Microbiol 2022 25;13:810565. Epub 2022 May 25.

College of Pharmacy, Ningxia Medical University, Yinchuan, China.

Celastrol (), obtained from the roots of Hook F., is most likely to become an antitumor drug, but with severe cytotoxicity. Due to the lack of modifiable sites in the structure of celastrol, the structural diversity of the modified products obtained by synthesis in the previous studies is insufficient, which hinders the pace of its patent medicine. This study describes a method of microbial transformation to increase the modification site of celastrol and reduce its toxicity. The screening of endophytes from native plants was introduced in this context, which led to two novel stereoselective oxidation products such as -16-hydroxyl celastrol () and A-ring aromatized -16-hydroxyl celastrol (), along with a rare 7,9-octadecadienoic acid ester of celastrol (). Their structures were determined by extensive spectroscopic data analysis, especially 1D and 2D NMR. Compared with , compounds and exhibited similar antitumor activity in U251, A549, KG-1, and B16 cell lines. Compound had slightly decreased antitumor activity when compared with compound . Furthermore, compound - showed lower cytotoxicity against BV-2 (about 21-fold lower, : 92.82 μM, : 34.25 μM, and : 74.75 μM vs. celastrol: 4.35 μM), and also identical trends against H9c2 and PC12 cell lines.
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http://dx.doi.org/10.3389/fmicb.2022.810565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177160PMC
May 2022

A Scoring System for Optimal Selection of Endoscopic Treatment for 1-2cm Lower Pole Renal Calculi.

Urol J 2022 Jun 11:7195. Epub 2022 Jun 11.

Department of Urology, Sun Yat-sen Memorial Hospital, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen University, 107W Yanjiang Road, Yuexiu District, Guangzhou, Guangdong, China.

Purpose: To explore the establishment of a scoring system that can provide a reference for clinical decision making regarding the endoscopic treatment of 1-2 cm lower pole stones (LPS).

Materials And Methods: The data of patients with renal calculi who were treated with percutaneous nephrolithotomy (PCNL) or retrograde intrarenal surgery (RIRS) in three hospitals from January 2013 to December 2017 were analyzed retrospectively. Multivariable logistic analysis was performed to determine the statistically significant indicators and regression coefficients, which were used to construct the scoring system. The stone-free rate (SFR) and postoperative complication rates of PCNL and RIRS within the two fractional segments of the scoring system were compared to select the optimal procedures.

Results: A total of 137 patients in the PCNL group and 152 patients in the RIRS group were included in this study. Five factors were found to be most predictive of endoscopic treatment choice: stone number, stone diameter, infundibulopelvic angle (IPA), infundibular length (IL), and infundibular width (IW), yielding a total score ranging from 0-5. In the 0-2 segments, the RIRS group had better outcomes than the PCNL group in terms of the postoperative complication rates (6.8% versus 18.0%, P = .026). In segments 3-5, the SFR of the PCNL group was significantly higher than that of the RIRS group (88.5% versus 70.6%, P = .017).

Conclusion: Our scoring system was based on the patient's preoperative imaging examination to measure the stone number, stone diameter, IPA, IL and IW. RIRS was recommended at 0-2 segments, and PCNL was recommended at 3-5 segments. This new scoring system is expected to provide guidance for urologists to make endoscopic treatment decisions for 1-2 cm LPS.
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http://dx.doi.org/10.22037/uj.v19i.7195DOI Listing
June 2022

A direct link between BR and SA signaling: negative regulation of TGA4 by BIN2.

Mol Plant 2022 Jun 10. Epub 2022 Jun 10.

Department of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Gainesville, FL 32611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molp.2022.06.006DOI Listing
June 2022

Effects of Team-Based Learning on Students' Teamwork, Learning Attitude, and Health Care Competence for Older People in the Community to Achieve SDG-3.

Int J Environ Res Public Health 2022 May 29;19(11). Epub 2022 May 29.

Department of Nursing, College of Health, National Taichung University of Science and Technology, Taichung 40401, Taiwan.

Background: Team-based learning (TBL) was studied in several preclinical settings, but evidence for its effectiveness in community nursing education is scant. A community health care nursing course was developed, and nursing students engaged in TBL to achieve Sustainable Development Goal 3.

Purpose: This study aimed to examine the effect of TBL model integration on students' learning attitude, community understanding, and community care competence for achieving SDG 3 and determine the extent to which the TBL model altered students' nursing competence for providing community health care. We compared the effect of TBL and traditional learning (TL) in terms of community health care knowledge objectives.

Methods: TBL was employed as the teaching strategy to guide students' discussion of community care issues, allowing them to fully utilize the knowledge acquired in their community practice. We used an unblinded crossover design, and 99 students participated in the community health nursing course.

Results: The results demonstrated that TBL improved participants' community understanding and enhanced their skills for assessing and fulfilling community needs. The experimental and control groups differed significantly in their TBL performance, learning attitude, and nursing competencies. The performance of those who engaged in TBL was higher than that of those who engaged in TL on all community issues. TBL appears to be a more effective method than TL in terms of achieving nursing students' knowledge objectives.

Conclusions: Regarding practical application, the proposed intervention enables nursing students to acquire professional knowledge related to community aging health care and nursing skills, and establish partnerships with community residents. This facilitates the achievement of the United Nations' sustainable development goal of ensuring healthy living and promoting well-being at all ages.
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http://dx.doi.org/10.3390/ijerph19116632DOI Listing
May 2022

Robot-Assisted Laparoscopic IVC Treatment Strategy in Retroperitoneal Tumors.

Front Oncol 2022 20;12:908272. Epub 2022 May 20.

Department of Urology, Peking University Third Hospital, Haidian District, Beijing, China.

Objectives: To show the practice of robot-assisted laparoscopic inferior vena cava (IVC) treatment strategies in patients with retroperitoneal tumors.

Patients And Methods: From October 2020 to July 2021, 17 patients with retroperitoneal tumors successfully underwent robot-assisted laparoscopic tumor resection with IVC management. The patient details, tumor characteristics, intraoperative data, pathological features and severe complications were assessed. The IVC treatment strategies were divided into 4 ways: ①local resection and primary repair of the IVC; ②IVC ligation; ③ IVC reconstruction by bovine pericardial grafts; and ④ IVC transection and anastomosis.

Results: In terms of IVC management, 5 cases had conventional total occlusion of the IVC and its branches, 3 cases had delayed occlusion of the proximal IVC technique, 2 cases had IVC resection by Satinsky clamp, 5 cases had IVC ligation, 1 case had IVC reconstruction by bovine pericardial grafts and 1 case had IVC transection and anastomosis. The median operation time was 151 min, and blood loss was 500 ml. There was no severe complication perioperatively. The follow-up time of 17 patients was 8 to 17 months (median: 12 months). No local recurrence or overall death was found during follow-up.

Conclusions: These robot-assisted laparoscopic IVC treatment strategies were considered to be safe and feasible in experienced centers, as well as helpful to completely remove the tumor for better oncological prognosis and restore the blood reflux of IVC as much as possible to ensure fewer postoperative complications.
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http://dx.doi.org/10.3389/fonc.2022.908272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166303PMC
May 2022

Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4.

Exp Mol Med 2022 Jun 3. Epub 2022 Jun 3.

Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

Liver fibrosis occurs during wound healing after repeated liver injury and is characterized by extensive extracellular matrix deposition. We previously identified hyaluronan synthase 2 (HAS2) as a driver of liver fibrosis and hepatic stellate cell (HSC) activation. Developing strategies to suppress HSC activation is key to alleviating liver fibrosis, and HAS2 is an attractive candidate for intervention. To gain insight into the molecular function of HAS2, we investigated its posttranscriptional regulation. We found that miR-200c directly targets the 3' untranslated regions of HAS2. Moreover, miR-200c and HAS2 were inversely expressed in fibrotic human and mouse livers. After establishing the direct interaction between miR-200c and HAS2, we investigated the functional outcome of regulating HAS2 expression in three murine models: CCl-induced acute liver injury, CCl-induced chronic liver fibrosis, and bile duct ligation-induced liver fibrosis. Hepatic Has2 expression was induced by acute and chronic CCl treatment. In contrast, miR-200c expression was decreased after CCl treatment. HSC-specific Has2 deletion reduced the expression of inflammatory markers and infiltration of macrophages in the models. Importantly, hyaluronidase-2 (HYAL2) but not HYAL1 was overexpressed in fibrotic human and murine livers. HYAL2 is an enzyme that can cleave the extracellular matrix component hyaluronan. We found that low-molecular-weight hyaluronan stimulated the expression of inflammatory genes. Treatment with the HA synthesis inhibitor 4-methylumbelliferone alleviated bile duct ligation-induced expression of these inflammatory markers. Collectively, our results suggest that HAS2 is negatively regulated by miR-200c and contributes to the development of acute liver injury and chronic liver inflammation via hyaluronan-mediated immune signaling.
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http://dx.doi.org/10.1038/s12276-022-00781-5DOI Listing
June 2022

Current-Volt Biosensing "Cystatin C" on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta.

J Anal Methods Chem 2022 23;2022:8160502. Epub 2022 May 23.

Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), Kangar 01000, Perlis, Malaysia.

A carbon nanowire-modified surface with interdigitated electrode (IDE) sensing system was introduced to identify abdominal aortic aneurysm biomarker "papain," also known as cysteine protease, used as the capture probe to identify Cystatin C. Papain was immobilized through the covalent integration of amine group on papain and the carboxyl group with carbon nanowire. This papain-modified electrode surface was utilized to detect the different concentrations of Cystatin C (100 pg/mL to 3.2 ng/mL). The interaction between papain and Cystatin C was monitored using a picoammeter, and the response curves were compared. With increasing Cystatin C concentrations, the total current levels were gradually increased with a linear range from 200 pg/mL to 3.2 ng/mL, and the current differences were plotted and the detection limit of Cystatin C was calculated as 200 pg/mL. The averaging of three independent experiments ( = ) was made with 3 estimation, and the determination coefficient was  = 1.8477 × 0.7303 and  = 0.9878. Furthermore, control experiments with creatinine and gliadin failed to bind the immobilized papain, indicating the specific detection of Cystatin C.
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http://dx.doi.org/10.1155/2022/8160502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152415PMC
May 2022

Boosting the performance of single-atom catalysts via external electric field polarization.

Nat Commun 2022 Jun 2;13(1):3063. Epub 2022 Jun 2.

Key Laboratory of Mesoscopic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 210023, Nanjing, Jiangsu, China.

Single-atom catalysts represent a unique catalytic system with high atomic utilization and tunable reaction pathway. Despite current successes in their optimization and tailoring through structural and synthetic innovations, there is a lack of dynamic modulation approach for the single-atom catalysis. Inspired by the electrostatic interaction within specific natural enzymes, here we show the performance of model single-atom catalysts anchored on two-dimensional atomic crystals can be systematically and efficiently tuned by oriented external electric fields. Superior electrocatalytic performance have been achieved in single-atom catalysts under electrostatic modulations. Theoretical investigations suggest a universal "onsite electrostatic polarization" mechanism, in which electrostatic fields significantly polarize charge distributions at the single-atom sites and alter the kinetics of the rate determining steps, leading to boosted reaction performances. Such field-induced on-site polarization offers a unique strategy for simulating the catalytic processes in natural enzyme systems with quantitative, precise and dynamic external electric fields.
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http://dx.doi.org/10.1038/s41467-022-30766-xDOI Listing
June 2022

Transformation mechanism and fate of dissolved organic nitrogen (DON) in a full-scale drinking water treatment.

J Environ Sci (China) 2022 Nov 1;121:122-135. Epub 2022 Feb 1.

College of Environment, Hohai University, Nanjing 210098, China.

Dissolved organic nitrogen (DON) has attracted much attention in drinking water treatment due to its potential to produce nitrogenous disinfection by-products (N-DBPs). This work was designed to explore the transformation and fate of DON and dissolved inorganic nitrogen (DIN) in drinking water treatment. The changes of DON and formation of N-DBPs were evaluated along the water treatment route (i.e., pre-ozonation and biological-contact oxidation, delivery pipes' transportation, coagulation-sedimentation, sand filtration, post-ozonation, biological activated carbon, ultrafiltration and disinfection) of drinking water treatment plant (DWTP). The transformation mechanism of DON was comprehensively investigated by molecular weight fractionation, three-dimensional fluorescence, LC-OCD (Liquid Chromatography-Organic Carbon Detection), total free amino acids. A detailed comparison was made between concentrations and variations of DON and DIN affected by seasons in the drinking water treatment. Regardless of seasonal variation in raw water concentration, the DON removal trends between different treatment processes remain constant in the present study. Compared to other treatment processes, pre-ozonation and coagulation-sedimentation exhibited the dominant DON removal in different seasons, i.e., 11.13%-14.45% and 14.98%-22.49%, respectively. Contrary, biological-contact oxidation and biological activated carbon negatively impacted the DON removal, in which DON increased by 1.76%-6.49% in biological activated carbon. This may be due to the release of soluble microbial products (SMPs) from bacterial metabolism, which was further validated by the rise of biopolymers in LC-OCD.
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http://dx.doi.org/10.1016/j.jes.2021.09.007DOI Listing
November 2022

Water-Enhanced and Remote Self-Healing Elastomers in Various Harsh Environments.

ACS Appl Mater Interfaces 2022 Jun 2. Epub 2022 Jun 2.

Key Laboratory of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.

The development of underwater remote stimulus-responsive self-healing polymer materials for applications in inaccessible and urgent situations is very challenging because water can readily disturb traditional noncovalent bonds and absorb heat, UV light, IR light, and electromagnetic wave energy at the wave band of micrometers and millimeters. Herein, visible-light-responsive diselenide bonds are employed as the healing moieties to produce a water-enhanced and remote self-healing elastomer triggered by a blue laser, which possesses excellent underwater transmission capability. During healing, the strain at break reaches ∼200% in 5 min and its toughness almost fully recovers within 1 h, which is estimated to be the fastest reported to date for healing silicone elastomers with a healing efficiency above 90%. The remote underwater pipeline sealing is instantly accomplished with the diselenide-containing elastomers by a blue laser 3 m away, thereby providing a direction for future emergent healing applications.
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http://dx.doi.org/10.1021/acsami.2c05570DOI Listing
June 2022

Chitosan-Heparin Polyelectrolyte Multilayer-Modified Poly(vinyl alcohol) Vascular Patches based on a Decellularized Scaffold for Vascular Regeneration.

ACS Appl Bio Mater 2022 Jun 27;5(6):2928-2934. Epub 2022 May 27.

Medical School, Nanjing University, Nanjing 210093, P. R. China.

Vascular patches play an important role in vascular reparation and cardiovascular diseases therapy. Recently, decellularized scaffold (DCS)-based vascular patches have drawn attention for their good biocompatibility and blood compatibility. In this work, we developed a poly(vinyl alcohol)-coated DCS as a vascular patch for vascular regeneration. Polyelectrolyte multilayers (PEMs) were further decorated on the surface via layer-by-layer (LbL) self-assembly to improve the biocompatibility of the vascular patch. According to the in vitro experiment, the vascular patch exhibited rapid endothelialization and good hemocompatibility. Compared with unmodified poly(vinyl alcohol)/DCS, the PEM-modified vascular patch possesses improved hemocompatibility, for example, enhanced anti-platelet adhesion ability, prolonged in vitro coagulation time, and decreased hemolysis rate. Therefore, this vascular patch is conducive to the proliferation and attachment of endothelial progenitor cells. Meanwhile, the in vivo performance in a porcine model was investigated with the in vivo computed tomography angiography and B ultrasound was used to further confirm the vascular regeneration. Excitedly, the porcine artery could remain unblocked for 5 months after implantation. Our current research provides a potential strategy for treating diseased blood vessels in clinical surgery.
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http://dx.doi.org/10.1021/acsabm.2c00266DOI Listing
June 2022

Improved Singlet Oxygen Production by Synergistic Effect a Dual-Core Photosensitizer Doped Polymer Fibrous Films: Synthesis and Performance.

Front Chem 2022 9;10:890545. Epub 2022 May 9.

CNOOC (Tianjin) Pipeline Engineering Technology Ltd., Tianjin, China.

Singlet oxygen (O) is a common reactive oxygen species that has found wide application in wastewater processing, photochemical synthesis, and photodynamic therapy. In this paper, a dual-core metal [a Re(I)-based component and a Gd(III)-based component] photosensitizer was synthesized and doped into polymer fibrous films for O generation. Here the Re(I)-based component is responsible for the photosensitizing reaction which directly transformed O to O, while the Gd(III)-based component served as an auxiliary part that assisted the transformation from O to O synergistic effect by its triplet excited ligands. The photophysical parameters of this photosensitizer (denoted as Re-Gd) and its fibrous films (denoted as [email protected]) were carefully recorded, discussed, and compared. It was found that the excited state lifetime and photostability of Re-Gd were both improved after being doped into fibrous films, favoring O generation. The O generation performance comparison between Re-Gd in the solid state, in solution, and fibrous films suggested that O generation performance was indeed improved by the electrospinning films. In addition, the positive factor of synergistic effect on improving O-producing efficiency was confirmed by comparing [email protected] films with reference films with a single-core metal photosensitizer having no synergistic effect.
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http://dx.doi.org/10.3389/fchem.2022.890545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124785PMC
May 2022

Spatiotemporal neural network for estimating surface NO concentrations over north China and their human health impact.

Environ Pollut 2022 Aug 20;307:119510. Epub 2022 May 20.

Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei, 230031, China.

Atmospheric nitrogen dioxide (NO) is an important reactive gas pollutant harmful to human health. The spatiotemporal coverage provided by traditional NO monitoring methods is insufficient, especially in the suburban and rural areas of north China, which have a high population density and experience severe air pollution. In this study, we implemented a spatiotemporal neural network (STNN) model to estimate surface NO from multiple sources of information, which included satellite and in situ measurements as well as meteorological and geographical data. The STNN predicted NO with high accuracy, with a coefficient of determination (R) of 0.89 and a root mean squared error of 5.8 μg/m for sample-based 10-fold cross-validation. Based on the surface NO concentration determined by the STNN, we analyzed the spatial distribution and temporal trends of NO pollution in north China. We found substantial drops in surface NO concentrations ranging between 9.1% and 33.2% for large cities during the 2020 COVID-19 lockdown when compared to those in 2019. Moreover, we estimated the all-cause deaths attributed to NO exposure at a high spatial resolution of about 1 km, with totals of 6082, 4200, and 18,210 for Beijing, Tianjin, and Hebei Provinces in 2020, respectively. We observed remarkable regional differences in the health impacts due to NO among urban, suburban, and rural areas. Generally, the STNN model could incorporate spatiotemporal neighboring information and infer surface NO concentration with full coverage and high accuracy. Compared with machine learning regression techniques, STNN can effectively avoid model overfitting and simultaneously consider both spatial and temporal correlations of input variables using deep convolutional networks with residual blocks. The use of the proposed STNN model, as well as the surface NO dataset, can benefit air quality monitoring, forecasting, and health burden assessments.
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http://dx.doi.org/10.1016/j.envpol.2022.119510DOI Listing
August 2022

Genetic Incorporation of the Favorable Alleles for Three Genes Associated With Spikelet Development in Wheat.

Front Plant Sci 2022 3;13:892642. Epub 2022 May 3.

State Key Laboratory of Sustainable Dryland Agriculture (in Preparation), College of Agronomy, Shanxi Agricultural University, Taiyuan, China.

The number of spikelets per spike is an important trait that directly affects grain yield in wheat. Three quantitative trait loci (QTLs) associated with spikelet nodes per spike (SNS) were mapped in a population of recombinant inbred lines generated from a cross between two advanced breeding lines of winter wheat based on the phenotypic variation evaluated over six locations/years. Two of the three QTLs are at the () loci and at the () loci. The allele with a 14-bp deletion at was associated with increased spikelets per spike. , as a novel allele at , were regulated at the transcript level that was associated with the SNS trait. The third SNS QTL, on chromosome 7D, was not associated with homoeologous or any other genes known to regulate SNS. The favorable alleles for each of , , and are identified and incorporated to increase up to 3.4 spikelets per spike in the RIL lines. Molecular markers for the alleles were developed. This study has advanced our understanding of the genetic basis of natural variation in spikelet development in wheat.
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http://dx.doi.org/10.3389/fpls.2022.892642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111956PMC
May 2022

Magnetic phenolic resin core-shell structure derived carbon microspheres for ultrafast magnetic solid-phase extraction of triazine herbicides.

J Sep Sci 2022 May 17. Epub 2022 May 17.

Guangxi Colleges and Universities Key Laboratory of Food Safety and Detection, College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, P. R. China.

In this study, monodisperse magnetic carbon microspheres were successfully synthesized through the carbonization of phenolic resin encapsulated Fe O core-shell structures. The magnetic carbon microspheres showed high performance in ultrafast extraction and separation of trace triazine herbicides from environmental water samples. Under optimized conditions, both the adsorption and desorption processes could be achieved in 2 min, and the maximum adsorption capacity for simazine and prometryn were 387.6 and 448.5 μg/g. Coupled with high-performance liquid chromatography-ultraviolet detection technology, the detection limit of triazine herbicides was in the range of 0.30-0.41 ng/ml. The mean recoveries ranged from 81.44 to 91.03% with relative standard deviations lower than 7.47%. The excellent magnetic solid-phase extraction performance indicates that magnetic carbon microspheres are promising candidate adsorbents for the fast analysis of environmental contaminants.
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http://dx.doi.org/10.1002/jssc.202200283DOI Listing
May 2022

Association of marital status with cardiovascular outcome in patients with breast cancer.

J Thorac Dis 2022 Apr;14(4):841-850

Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Background: The influences of marital status on cardiovascular death risk in patients with breast cancer remained unclear. This study aimed to evaluate the associations of different marital status with cardiovascular death risk in patients with breast cancer.

Methods: A total of 182,666 female breast cancer patients were enrolled in this study from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2014, and was divided into two groups: married (N=107,043) and unmarried (N=75,623). A 1:1 propensity score matching (PSM) was applied to reduce inter-group bias between the two groups. Competing-risks model was used to assess the associations between different marital status and cardiovascular death risk in patients with breast cancer.

Results: After PSM, marital status was an independent predictor for cardiovascular death in patients with breast cancer. Unmarried condition was associated with increased cardiovascular death risk than married condition among breast cancer patients [unadjusted model: hazard ratio (HR) =2.012, 95% confidence interval (CI): 1.835-2.208, P<0.001; Model 1: HR =1.958, 95% CI: 1.785-2.148, P<0.001; Model 2: HR =1.954, 95% CI: 1.781-2.144, P<0.001; Model 3: HR =1.920, 95% CI: 1.748-2.107, P<0.001]. With the exception of separated condition (adjusted HR =0.886, 95% CI: 0.474-1.658, P=0.705), further unmarried subgroups analysis showed that the other three unmarried status were associated with increased cardiovascular death risk as follows: single (adjusted HR =1.623, 95% CI: 1.421-1.853, P<0.001), divorced (adjusted HR =1.394, 95% CI: 1.209-1.608, P<0.001), and widowed (adjusted HR =2.460, 95% CI: 2.227-2.717, P<0.001). In particularly, widowed condition showed the highest cardiovascular death risk in all 4 unmarried subgroups.

Conclusions: Unmarried condition (e.g., single, divorced and widowed) was associated with elevated cardiovascular death risk compared with their married counterparts in patients with breast cancer, suggesting that more attention and humanistic care should be paid to unmarried breast cancer patients (especially the widowed patients) in the management of female breast cancer patients.
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http://dx.doi.org/10.21037/jtd-21-1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096314PMC
April 2022

Free-Spin Dominated Magnetocaloric Effect in Dense Gd Double Perovskites.

Chem Mater 2022 Apr 29;34(7):3440-3450. Epub 2022 Mar 29.

Department of Physics, University of Cambridge, Cambridge CB3 0HE, United Kingdom.

Frustrated lanthanide oxides with dense magnetic lattices are of fundamental interest for their potential in cryogenic refrigeration due to a large ground state entropy and suppressed ordering temperatures but can often be limited by short-range correlations. Here, we present examples of frustrated oxides, BaGdSbO and SrGdSbO, and the new site-disordered analogue CaGdSbO ([CaGd] [CaSb] O), in which the magnetocaloric effect is influenced by minimal superexchange ( ∼ 10 mK). We report on the crystal structures using powder X-ray diffraction and the bulk magnetic properties through low-field susceptibility and isothermal magnetization measurements. The Gd compounds exhibit a magnetic entropy change of up to -15.8 J/K/mol in a field of 7 T at 2 K, a 20% excess compared to the value of -13.0 J/K/mol for a standard in magnetic refrigeration, GdGaO. Heat capacity measurements indicate a lack of magnetic ordering down to 0.4 K for BaGdSbO and SrGdSbO, suggesting cooling down through the liquid 4-He regime. A mean-field model is used to elucidate the role of primarily free-spin behavior in the magnetocaloric performance of these compounds in comparison to other top-performing Gd-based oxides. The chemical flexibility of the double perovskites raises the possibility of further enhancement of the magnetocaloric effect in the Gd lattices.
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http://dx.doi.org/10.1021/acs.chemmater.2c00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098179PMC
April 2022

Oncostatin M promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the NF-κB pathway in THP-1 macrophages and promotes the progression of atherosclerosis.

Ann Transl Med 2022 Apr;10(8):456

Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

Background: Oncostatin M (OSM) is reported to be involved in many stages of atherosclerosis, including endothelial dysfunction, chronic inflammation, and smooth muscle cell migration. This study explored the effects of OSM on foam cell formation and its corresponding molecular mechanisms.

Methods: THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA) to induce macrophage differentiation and were then exposed to oxidized low-density lipoprotein (ox-LDL). OSM expression was analyzed by quantitative reverse transcription-polymerase chain reaction, Western blotting, and enzyme-linked immunosorbent assay (ELISA). OSM-specific small interfering RNAs (siRNAs) were transfected into THP-1 macrophages. The effects of OSM silencing were evaluated by Oil Red O staining, ELISA, and Western blotting. Moreover, the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasomes was detected by western blotting and immunofluorescence.

Results: OSM was highly expressed in THP-1 macrophages in a time- and dose-dependent fashion. Silencing OSM significantly reduced the total cholesterol content and Oil Red O staining levels in ox-LDL-treated macrophages. Silencing OSM significantly inhibited ox-LDL-induced cytokine release, including TNF-α, IL-1β, IL-6, and IL-18. Ox-LDL activated p65 and NLRP3, which further induced caspase-1 cleavage, apoptosis-associated, speck-like protein containing a caspase-1 recruitment domain (ASC) upregulation, and gasdermin-D (GSDMD)-N fragmentation. Overexpression of NLRP3 significantly reversed the effects of OSM silencing on ox-LDL-induced foam cell formation and inflammation.

Conclusions: OSM was highly expressed in the cell model of atherosclerosis. OSM has a promoting role in ox-LDL-induced foam cell formation and inflammation via the activation of p65-NLRP3 signaling pathways. Silencing OSM may be has benefit in treating atherosclerosis.
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http://dx.doi.org/10.21037/atm-22-560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096425PMC
April 2022

Reduction-Induced Crystallization-Driven Self-Assembly of Main-Chain-Type Alternating Copolymers: Transformation from 1D Lines to 2D Platelets.

ACS Macro Lett 2021 May 21;10(5):564-569. Epub 2021 Apr 21.

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials; Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

In recent years, crystalline-driven self-assembly (CDSA) has received enormous attention, but almost only for block copolymers (BCPs). Herein, we introduced perfluorocarbon chains into main-chain-type liquid crystalline alternating copolymers (ACPs) to obtain perfluoroalkane-containing ACPs with periodic C-I bonds in polymer backbones via step transfer-addition and radical-termination (START) polymerization, followed by an iodine reduction reaction of C-I bonds to induce CDSA of ACPs and put forward a novel concept of "reduction-induced crystallization-driven self-assembly" (RI-CDSA) of main-chain-type ACPs for the first time. Finally, we proposed the folded-chain model and mechanism to explain the novel RI-CDSA behavior, and its rationality has been proved by the corresponding experimental results.
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http://dx.doi.org/10.1021/acsmacrolett.1c00109DOI Listing
May 2021

Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia.

Gene 2022 Aug 13;834:146565. Epub 2022 May 13.

School of Basic Medicine, Ningxia Medical University, 1160 Shengli South Street, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region, China. Electronic address:

Background: Hypoxia is a primary inducer of cardiomyocyte injury, its significant marker being hypoxia-induced cardiomyocyte apoptosis. Nuclear respiratory factor-1 (NRF-1) and hypoxia-inducible factor-1α (HIF-1α) are transcriptional regulatory elements implicated in multiple biological functions, including oxidative stress response. However, their roles in hypoxia-induced cardiomyocyte apoptosis remain unknown. The effect HIF-1α, together with NRF-1, exerts on cardiomyocyte apoptosis also remains unclear.

Methods: We established a myocardial hypoxia model and investigated the effects of these proteins on the proliferation and apoptosis of rat cardiomyocytes (H9C2) under hypoxia. Further, we examined the association between NRF-1 and HIF-1α to improve the current understanding of NRF-1 anti-apoptotic mechanisms.

Results: The results show that NRF-1 and HIF-1α are important anti-apoptotic molecules in H9C2 cells under hypoxia, although their regulatory mechanisms differ. NRF-1 could bind to the promoter region of Hif1a and negatively regulate its expression. Additionally, HIF-1β exhibited competitive binding with NRF-1 and HIF-1α, demonstrating a synergism between NRF-1 and the peroxisome proliferator-activated receptor-gamma coactivator-1α.

Conclusion: These results indicate that cardiomyocytes can regulate different molecular patterns to tolerate hypoxia, providing a novel methodological framework for studying cardiomyocyte apoptosis under hypoxia.
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http://dx.doi.org/10.1016/j.gene.2022.146565DOI Listing
August 2022

Cerium-based nanoparticles triggered catalytic reaction for the colorimetric and ratiometric fluorimetric dual-signal sensing of vitamin C.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Oct 30;278:121324. Epub 2022 Apr 30.

College of Biological and Environmental Engineering, Changsha University, Changsha 410022, China; College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China. Electronic address:

The construction of multi-modal detection methods has attracted widespread attention in the field of biosensing due to their high sensitivity and strong anti-interference ability. In this manuscript, we developed colorimetric and ratiometric fluorescence dual-signal optical methods based on cerium-based nanoparticles (Ce NPs) for the sensitive detection of vitamin C (VC). The catalysis of Ce NPs with excellent peroxidase-like activity upon the reaction of HO with OPD was occurred, promoting the oxidation of o-phenylenediamine (OPD) to generate 2,3-diaminophennazine (OPDox) with an obvious absorption peak at 420 nm and an emission peak at 565 nm. In the presence of VC, VC not only inhibited the generation of OPDox, but also induced the formation of quinoxaline with an obvious absorption peak at 336 nm and an emission peak at 430 nm. This can be visually observed and monitored by measuring the absorbance of peak at 336 nm (A) and the ratiometric fluorescence intensity (F/F). Therefore, the dual-signal methods are constructed for the detection of VC. The detection lower detection limits are 8.0 μM and 8.4 μM when using the fluorescence and colorimetric signals, respectively. Furthermore, the proposed methods are successfully applied to the detection of VC in practical samples with satisfactory results.
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http://dx.doi.org/10.1016/j.saa.2022.121324DOI Listing
October 2022

Epidemiologic characteristics and differential management strategies of seven case series with COVID-19 outbreaks caused by asymptomatic carriers from June 2020 to May 2021 in China.

Am J Transl Res 2022 15;14(4):2244-2255. Epub 2022 Apr 15.

School of Public Health, Rutgers University New Brunswick, New Jersey 08854, USA.

With the COVID-19 epidemic quickly under control in China in the early stage of 2020, global cooperation/communications may pose great challenges to epidemic control and prevention in the country. Large-scale spread by asymptomatic carriers was a concern. We obtained data on new cluster outbreak regions with COVID-19 caused by asymptomatic carriers from June 2020 to May 2021 in China, and reported the epidemiological characteristics, the possible routes of viral transmission and infection, and different control strategies. These results show the importance of regular screening for high-risk populations and differential management strategies for epidemic control, which provide an objective basis for suppressing the spread of the SARS-CoV-2 virus. These experiences can be used as a reference to minimize the subsequent spread of virus mutants in various places.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091077PMC
April 2022

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma.

J Exp Clin Cancer Res 2022 May 12;41(1):173. Epub 2022 May 12.

Department of Medicine, Division of Hematology, Bioclinicum and Center for Molecular Medicine, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden.

Background: The ETS transcription factor GABPA has long been thought of as an oncogenic factor and recently suggested as a target for cancer therapy due to its critical effect on telomerase activation, but the role of GABPA in clear cell renal cell carcinoma (ccRCC) is unclear. In addition, ccRCC is characterized by metabolic reprograming with aberrant accumulation of L-2-hydroxyglurate (L-2HG), an oncometabolite that has been shown to promote ccRCC development and progression by inducing DNA methylation, however, its downstream effectors remain poorly defined.

Methods: siRNAs and expression vectors were used to manipulate the expression of GABPA and other factors and to determine cellular/molecular and phenotypic alterations. RNA sequencing and ChIP assays were performed to identify GABPA target genes. A human ccRCC xenograft model in mice was used to evaluate the effect of GABPA overexpression on in vivo tumorigenesis and metastasis. ccRCC cells were incubated with L-2-HG to analyze GABPA expression and methylation. We carried out immunohistochemistry on patient specimens and TCGA dataset analyses to assess the effect of GABPA on ccRCC survival.

Results: GABPA depletion, although inhibiting telomerase expression, robustly enhanced proliferation, invasion and stemness of ccRCC cells, whereas GABPA overexpression exhibited opposite effects, strongly inhibiting in vivo metastasis and carcinogenesis. TGFBR2 was identified as the GABPA target gene through which GABPA governed the TGFβ signaling to dictate ccRCC phenotypes. GABPA and TGFBR2 phenocopies each other in ccRCC cells. Higher GABPA or TGFBR2 expression predicted longer survival in patients with ccRCC. Incubation of ccRCC cells with L-2-HG mimics GABPA-knockdown-mediated phenotypic alterations. L-2-HG silenced the expression of GABPA in ccRCC cells by increasing its methylation.

Conclusions: GABPA acts as a tumor suppressor by stimulating TGFBR2 expression and TGFβ signaling, while L-2-HG epigenetically inhibits GABPA expression, disrupting the GABPA-TGFβ loop to drive ccRCC aggressiveness. These results exemplify how oncometabolites erase tumor suppressive function for cancer development/progression. Restoring GABPA expression using DNA methylation inhibitors or other approaches, rather than targeting it, may be a novel strategy for ccRCC therapy.
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http://dx.doi.org/10.1186/s13046-022-02382-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097325PMC
May 2022

Bioisosterism and Scaffold Hopping in Modern Nematicide Research.

J Agric Food Chem 2022 May 12. Epub 2022 May 12.

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.

The application of agrochemicals is critical to global food safety. Nowadays, environmentally friendly green agrochemicals are the trend in field crop protection. The research and development of nematicides absorbed more attention as a typical representation of agrochemicals. This review describes the origin of recently commercialized nematicides, the application of bioisosterism and scaffold hopping in the discovery and optimization of agrochemicals, especially nematicides, and novel bioisosteric design strategies for the identification of fluensulfone analogues. Pesticide repurposing, high-throughput screening, computer-aided drug design, and incorporation of known pharmacophoric fragments have been the most successful approach for the discovery of new nematicides. As outlined, the strategies of bioisosteric replacements and scaffold hopping have been very successful approaches in the search for new nematicides for sustainable crop protection. In the exploration of novel fluensulfone analogues with nematicidal activity, bioisosteric replacement of sulfone by amide, chain extension by insertion of a methylene group, and reversal of the amide group have proven to be successful approaches and yielded new and highly active fluensulfone analogues. These attempts might result in compounds with an optimal balance of steric, hydrophobic, electronic, and hydrogen-bonding properties and contribute to deal with the complex problem during the research and development of new nematicides. Further ideas are also put forward to provide new approaches for the molecular design of nematicides.
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http://dx.doi.org/10.1021/acs.jafc.2c00785DOI Listing
May 2022
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