Publications by authors named "Cheng He"

605 Publications

Influence of continuing nursing care team mode on the rehabilitation of patients with pancreatic cancer after postoperative daily chemotherapy.

Support Care Cancer 2022 Aug 9. Epub 2022 Aug 9.

Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Objective: This study aimed to investigate the effect of continuing nursing care team mode on postoperative outpatient chemotherapy patients with pancreatic cancer.

Methods: One-hundred patients receiving postoperative outpatient chemotherapy for pancreatic cancer between September 2019 and December 2020 were enrolled in this study and divided into two groups, an intervention group and a control group (n = 50 each), by random number table method or coin tossing method. The patients in the intervention group were followed up using continuing nursing care team mode, while those in the control group were followed up using the traditional telephone follow-up mode. The effects of the two modes on patients' self-care ability, quality of life, anxiety, hospital waiting time, and the nurses' communication ability and self-efficacy were compared and analyzed.

Results: The self-care ability and quality of life of the patients in the intervention group were better than those of the control group (p < 0.05), the anxiety score and hospital waiting times were lower than those in the control group (p < 0.05), and the communication ability and general self-efficacy of the nurses were also significantly stronger than those in the control group (p < 0.05).

Conclusion: The application of the continuing nursing care team mode for follow-up can improve the self-care ability and quality of life of patients, effectively reduce the anxiety and hospital waiting time of outpatient chemotherapy patients, and improve the nurses' communication ability and general self-efficacy. Therefore, this practice is worthy of clinical popularization.
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http://dx.doi.org/10.1007/s00520-022-07308-8DOI Listing
August 2022

The effects of night-time warming on mortality burden under future climate change scenarios: a modelling study.

Lancet Planet Health 2022 Aug;6(8):e648-e657

School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China. Electronic address:

Background: The health impacts of climate warming are usually quantified based on daily average temperatures. However, extra health risks might result from hot nights. We project the future mortality burden due to hot nights.

Methods: We selected the hot night excess (HNE) to represent the intensity of night-time heat, which was calculated as the excess sum of high temperature during night time. We collected historical mortality data in 28 cities from three east Asian countries, from 1981 to 2010. The associations between HNE and mortality in each city were firstly examined using a generalised additive model in combination with a distributed lag non-linear model over lag 0-10 days. We then pooled the cumulative associations using a univariate meta-regression model at the national or regional levels. Historical and future hourly temperature series were projected under two scenarios of greenhouse-gas emissions from 1980-2099, with ten general circulation models. We then projected the attributable fraction of mortality due to HNE under each scenario.

Findings: Our dataset comprised 28 cities across three countries (Japan, South Korea, and China), including 9 185 598 deaths. The time-series analyses showed the HNE was significantly associated with increased mortality risks, the relative mortality risk on days with hot nights could be 50% higher than on days with non-hot nights. Compared with the rise in daily mean temperature (lower than 20%), the frequency of hot nights would increase more than 30% and the intensity of hot night would increase by 50% by 2100s. The attributable fraction of mortality due to hot nights was projected to be 3·68% (95% CI 1·20 to 6·17) under a strict emission control scenario (SSP126). Under a medium emission control scenario (SSP245), the attributable fraction of mortality was projected to increase up to 5·79% (2·07 to 9·52), which is 0·95% (-0·39 to 2·29) more than the attributable fraction of mortality due to daily mean temperature.

Interpretation: Our study provides evidence for significant mortality risks and burden in association with night-time warming across Japan, South Korea, and China. Our findings suggest a growing role of night-time warming in heat-related health effects in a changing climate.

Funding: The National Natural Science Foundation of China, Shanghai International Science and Technology Partnership Project.
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http://dx.doi.org/10.1016/S2542-5196(22)00139-5DOI Listing
August 2022

Binding of Dual-Function Hybridized MetalOrganic Capsules to Enzymes for Cascade Catalysis.

JACS Au 2022 Jul 6;2(7):1736-1746. Epub 2022 Jul 6.

State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, People's Republic of China.

The combination of chemo- and biocatalysis for multistep syntheses provides attractive advantages in terms of evolvability, promiscuity, and sustainability striving for desirable catalytic performance. Through the encapsulation of flavin analogues by both NADH and heme mimics codecorated heteroleptic metalorganic capsules, herein, we report a progressive hostguest strategy to imitate cytochrome P450s catalysis for cascade oxidative coupling catalysis. Besides the construction of stable dual-function metalorganic capsules and the modification of cofactor-decorated capsules at the domain of enzymes, this supramolecular strategy involves multistage directional electron flow, affording reactive ferric peroxide species for inducing oxygenation. Under light irradiation, the metalorganic capsule selectively converts stilbene to oxidative coupling products (including 2-oxo-1,2-diphenylethyl formate, 2-alkoxy-1,2-diphenylethanone) in tandem with enzymatic reactions respectively, at the domain of natural enzymes. The ingenious combination of capsules and enzymes with the in situ-regenerated capsule-loaded NADH cofactor promises non-native coupling reactions by forming regional cooperation and division. This abiotic-biotic conjugated hostguest strategy is conducive to the de novo creation of multifunctional components approaching active enzymatic sites for reinforced matter and energy transporting, demonstrating a key role of multicomponent supramolecular catalysts for one-pot integrated catalytic conversions.
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http://dx.doi.org/10.1021/jacsau.2c00322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327082PMC
July 2022

Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma.

J Immunol Res 2022 21;2022:7353572. Epub 2022 Jul 21.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Background: Pancreatic ductal adenocarcinoma (PDAC) displays a typical mucin expression pattern which is characterized by MUC1 positive, MUC2 negative, and MUC5AC positive. More and more evidences show that mucins are involved in the development of pancreatic diseases. However, the relationship between mucin expression and prognosis of PDAC patients has been controversial in the past decades; therefore, we aim to figure out the association of mucin expression with survival in PDAC patients who underwent radical resection.

Methods: We performed immunohistochemistry (IHC) to detect the expression of MUC1, MUC2, and MUC5AC in resected PDAC specimens from Shanghai Cancer Center, Fudan University (FUSCC, = 427) and obtained the corresponding clinical statistical data for retrospective study. Kaplan-Meier methods and Mantel-Cox tests were used to compare the survival curves, and the Cox regression model was employed for multivariate analyses to determine the independent risk factors. Survival analysis was also performed in the Queensland Centre for Medical Genomics (QCMG, = 70) PDAC cohort to verify the conclusion.

Results: Both the FUSCC cohort and the QCMG cohort demonstrated that MUC1 absence was significantly correlated with worse overall survival (OS). The presence of MUC2 showed marginal significance in predicting shorter OS of PDAC patients, while MUC5AC had no prognostic value. In the FUSCC cohort, MUC1 absence was associated with increased proportion of stage III PDAC ( = 0.011), and MUC1 absence and MUC2 presence were associated with tumour perineural aggression ( = 0.011 and = 0.030, respectively). Multivariable adjusted hazard ratios (HRs) for mortality of MUC1 and MUC2 were 0.492 (95% CI: 0.274-0.883, = 0.017) and 1.596 (95% CI: 1.061-2.401, = 0.025), respectively.

Conclusions: MUC1 absence or MUC2 presence is independently associated with poor OS among patients with resectable PDAC. MUC5AC absence tended to be associated with short-term death.
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http://dx.doi.org/10.1155/2022/7353572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334048PMC
August 2022

MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics.

Int J Mol Sci 2022 Jul 15;23(14). Epub 2022 Jul 15.

Department of Pathology, National University Hospital, National University Health System, Singapore 119074, Singapore.

Adipocytic tumors are the most common subtype of soft tissue tumors. In current clinical practice, distinguishing benign lipomas from well-differentiated liposarcomas (WDLPS), as well as dedifferentiated liposarcomas (DDLPS) from their morphologic mimics, remains a significant diagnostic challenge. This is especially so when examining small biopsy samples and without the aid of additional ancillary tests. Recognizing the important role that microRNAs (miRNAs) play in tumorigenesis and their potential utility in tumor classification, we analyzed routine clinical tissue samples of benign and malignant lipomatous tumors, as well as other sarcoma mimics, to identify distinguishing miRNA-based signatures that can aid in the differential diagnosis of these entities. We discovered a 6-miRNA signature that separated lipomas from WDLPS with high confidence (AUC of 0.963), as well as a separate 6-miRNA signature that distinguished DDLPS from their more aggressive histologic mimics (AUC of 0.740). Functional enrichment analysis unveiled possible mechanistic involvement of these predictive miRNAs in adipocytic cancer-related biological processes and pathways such as PI3K/AKT/mTOR and MAPK signaling, further supporting the relevance of these miRNAs as biomarkers for adipocytic tumors. Our results demonstrate that miRNA expression profiling may potentially be used as an adjunctive tool for the diagnosis of benign and malignant adipocytic tumors. Further validation studies are warranted.
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http://dx.doi.org/10.3390/ijms23147804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322088PMC
July 2022

Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression.

Front Neurol 2022 8;13:828612. Epub 2022 Jul 8.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Mental health has become a new challenge in cancer treatment, with a high prevalence of depression in patients with cancer. Albiflorin (AF) and paeoniflorinn (PF) are isomers extracted from the root of Alba (Baishao in Chinese), belonging to the monoterpene glycosides, and multiple studies have been conducted on their antidepression and anti-cancer effects. However, the effects of AF and PF on cancer-related depression are unclear. Therefore, the current study aims to investigate whether the two isomers are able to exert antidepressant-like effects and understand the underlying mechanisms in a rat model, established by combining irradiation with chronic restraint stress and solitary confinement. Our results demonstrate a significant regulation of AF and PF in the pharmacodynamic index, including the peripheral blood, organ index, behavioral traits, and HPA axis, relative to control rats. In serum and cerebral cortex metabonomics analysis, AF and PF showed a significantly restorative trend in abnormal biomarkers and regulating ether lipid metabolism, alanine, aspartate, glutamate metabolism, tryptophan metabolism, carnitine metabolism, arachidonic acid metabolism, arginine and proline metabolism pathway. Eight potential biomarkers were further screened by means of receiver operating characteristic (ROC) analysis. The data indicate that AF and PF could effectively ameliorate a depression-like state in the model rats, and the mechanism may be associated with the regulation of the neuroendocrine immune system and disrupted metabolic pathways. Further experiments are warranted to comprehensively evaluate the antidepressant effects of AF and PF in cancer-related depression. This study provides a better insight into the action mechanisms of antidepression of TCM, and provides a new perspective for the therapy of cancer-related depression.
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http://dx.doi.org/10.3389/fneur.2022.828612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304767PMC
July 2022

cis-Regulatory variation affecting gene expression contributes to the improvement of maize kernel size.

Plant J 2022 Jul 21. Epub 2022 Jul 21.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

cis-Regulatory variations contribute to trait evolution and adaptation during crop domestication and improvement. As the most important harvested organ in maize (Zea mays L.), kernel size has undergone intensive selection for size. However, the associations between maize kernel size and cis-regulatory variations remain unclear. We chose two independent association populations to dissect the genetic architecture of maize kernel size together with transcriptomic and genotypic data. The resulting phenotypes reflected a strong influence of population structure on kernel size. Compared with genome-wide association studies (GWASs), which accounted for population structure and relatedness, GWAS based on a naïve or simple linear model revealed additional associated single-nucleotide polymorphisms significantly involved in the conserved pathways controlling seed size in plants. Regulation analyses through expression quantitative trait locus mapping revealed that cis-regulatory variations likely control kernel size by fine-tuning the expression of proximal genes, among which ZmKL1 (GRMZM2G098305) was transgenically validated. We also proved that the pyramiding of the favorable cis-regulatory variations has contributed to the improvement of maize kernel size. Collectively, our results demonstrate that cis-regulatory variations, together with their regulatory genes, provide excellent targets for future maize improvement.
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http://dx.doi.org/10.1111/tpj.15910DOI Listing
July 2022

An ALBI- and Ascites-Based Model to Predict Survival for BCLC Stage B Hepatocellular Carcinoma.

Evid Based Complement Alternat Med 2022 7;2022:1801230. Epub 2022 Jul 7.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, Hunan, China.

Background: We aimed to develop a predictive model constituted with the ALBI grade, the ascites, and tumor burden related parameters in patients with BCLC stage B HCC.

Methods: Patients diagnosed as the BCLC stage B HCC were collected from a retrospective database. Construction and validation of the predictive model were performed based on multivariate Cox regression analysis. Predictive accuracy, discrimination (c-index), and fitness performance (calibration curve) of the model were compared with the other eight models. The decision curve analysis (DCA) was used to evaluate the clinical utility.

Results: A total of 1773 patients diagnosed as BCLC stage B HCC between 2007 and 2016 were included in the present study. The ALBI-AS grade, the AFP level, and the 8-and-14 grade were used for the development of a prognostic prediction model after multivariate analysis. The area under the receiver operator characteristic curve (AUROC) for overall survival at 1, 2, and 3 years predicted by the present model were 0.73, 0.69, and 0.67 in the training cohort. The concordance index (c-index) and the Aiken information criterion (AIC) were 0.68 and 6216.3, respectively. In the internal and external validation cohorts, the present model still revealed excellent predictive accuracy, discrimination, and fitness performance. Then the ALBI-AS based model was evaluated to be superior to other prognostic models with the highest AUROC, c-index, and lowest AIC values. Moreover, DCA also demonstrated that the present model was clinically beneficial.

Conclusion: The ALBI-AS grade is a novel predictor of survival for patients with BCLC stage B HCC.
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http://dx.doi.org/10.1155/2022/1801230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283054PMC
July 2022

NOTCH1 signaling regulates the latent neurogenic program in adult reactive astrocytes after spinal cord injury.

Theranostics 2022 27;12(10):4548-4563. Epub 2022 May 27.

Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science, Naval Medical University, Shanghai 200433, China.

Direct reprogramming of astrocytes into neurons opens up a new avenue for neuroregenerative medicine. However, the poor understanding of the molecular mechanisms underpinning the latent neurogenic program in astrocytes has largely restricted this strategy towards safe and effective clinical therapies. Immunocytochemistry, immunohistochemistry, western blotting, qRT-PCR, gene knockdown and fate-mapping are performed to analyze the role of NOTCH1 signaling in regulation of the latent neurogenic program in reactive astrocytes after spinal cord injury. Western blotting analysis highlights that NOTCH1 is a key signaling mediating Ascl1- and Neurog2-driven astrocyte-to-neuron conversion. Inhibition of NOTCH1 signaling in cultured astrocytes by shRNA or DAPT (a NOTCH1 inhibitor) is sufficient to reprogram them into neurons by upregulating the expression of pro-neural transcription factors, including NeuroD1, NeuroD2, Pax6, Lmx1a and Lhx6. In the spinal cord of adult mouse, the expression of Notch1 is detected in resident astrocytes, which was significantly increased after spinal cord injury (SCI). Genetical knockdown of NOTCH1 signaling alone successfully triggers endogenous reactive astrocytes reprogramming into neurons in the injured adult spinal cord. Importantly, pharmacologically blocking NOTCH1 signaling with small molecule DAPT alone can also induce astrocyte-to-neuron conversion after SCI. We identify NOTCH1 as a key common signaling pathway in reactive astrocyte that provides a barrier for cell fate conversion. This proof-of-principle study will significantly expand our molecular understanding of astroglial-lineage reprogramming and overcoming the NOTCH1 gatekeeper with small molecules may provide a transgene-free approach for chemical neuronal reprogramming with potential clinical application in neuroregeneration.
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http://dx.doi.org/10.7150/thno.71378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254256PMC
May 2022

The inequality labor loss risk from future urban warming and adaptation strategies.

Nat Commun 2022 Jul 6;13(1):3847. Epub 2022 Jul 6.

School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, 200032, China.

Heat-induced labor loss is a major economic cost related to climate change. Here, we use hourly heat stress data modeled with a regional climate model to investigate the heat-induced labor loss in 231 Chinese cities. Results indicate that future urban heat stress is projected to cause an increase in labor losses exceeding 0.20% of the total account gross domestic product (GDP) per year by the 2050s relative to the 2010s. In this process, certain lower-paid sectors could be disproportionately impacted. The implementation of various urban adaptation strategies could offset 10% of the additional economic loss per year and help reduce the inequality-related impact on lower-paid sectors. So future urban warming can not only damage cities as a whole but can also contribute to income inequality. The implication of adaptation strategies should be considered in regard to not only cooling requirements but also environmental justice.
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http://dx.doi.org/10.1038/s41467-022-31145-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259578PMC
July 2022

A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells.

Curr Med Sci 2022 Jul 5. Epub 2022 Jul 5.

Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, 210000, China.

Objective: The ataxia telangiectasia mutated (ATM) gene is a master regulator in cellular DNA damage response. The dysregulation of ATM expression is frequent in breast cancer, and is known to be involved in the carcinogenesis and prognosis of cancer. However, the underlying mechanism remains unclear. The bioinformatic analysis predicted a potential antisense transcript ATM-antisense (AS) from the opposite strand of the ATM gene. The purpose of this study was to identify ATM-AS and investigate the possible effect of ATM-AS on the ATM gene regulation.

Methods: Single strand-specific RT-PCR was performed to verify the predicted antisense transcript ATM-AS within the ATM gene locus. qRT-PCR and Western blotting were used to detect the expression levels of ATM-AS and ATM in normal and breast cancer cell lines as well as in tissue samples. Luciferase reporter gene assays, biological mass spectrometry, ChIP-qPCR and RIP were used to explore the function of ATM-AS in regulating the ATM expression. Immunofluorescence and host-cell reactivation (HCR) assay were performed to evaluate the biological significance of ATM-AS in ATM-mediated DNA damage repair. Breast cancer tissue samples were used for evaluating the correlation of the ATM-AS level with the ATM expression as well as prognosis of the patients.

Results: The ATM-AS significantly upregulated the ATM gene activity by recruiting KAT5 histone acetyltransferase to the gene promoter. The reduced ATM-AS level led to the abnormal downregulation of ATM expression, and impaired the ATM-mediated DNA damage repair in normal breast cells in vitro. The ATM-AS level was positively correlated with the ATM expression in the examined breast cancer tissue samples, and the patient prognosis.

Conclusion: The present study demonstrated that ATM-AS, an antisense transcript located within the ATM gene body, is an essential positive regulator of ATM expression, and functions by mediating the binding of KAT5 to the ATM promoter. These findings uncover the novel mechanism underlying the dysregulation of the ATM gene in breast cancer, and enrich our understanding of how an antisense transcript regulates its host gene.
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http://dx.doi.org/10.1007/s11596-022-2585-5DOI Listing
July 2022

Lobaplatin-based neoadjuvant chemotherapy for triple-negative breast cancer: a 5-year follow-up of a randomized, open-label, phase II trial.

Ther Adv Med Oncol 2022 24;14:17588359221107111. Epub 2022 Jun 24.

Department of Breast and Thyroid Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Gaotanyan Street 29, Chongqing 400038, China.

Purpose: We report the 5-year follow-up findings of a randomized, open-label, phase II trial of lobaplatin-based neoadjuvant chemotherapy plus adjuvant therapy for triple-negative breast cancer (TNBC).

Patients And Methods: This study included patients aged ⩾18 years with untreated, operable stage I-III TNBC and an Eastern Cooperative Oncology Group performance status of 0 or 1. One group of patients (TE group,  = 99) received four cycles of docetaxel (T, 75 mg/m²) plus epirubicin (E, 80 mg/m²) every 3 weeks, and another group (TEL group,  = 101) received the same treatment with the addition of lobaplatin (L, 30 mg/m). Two cycles of the corresponding treatments were administered after surgery in both groups. The primary endpoints were total pathological complete response (tpCR) rate and overall response rate (ORR), and the secondary endpoints were disease-free survival, overall survival, and long-term safety. This trial is registered with the Chinese Clinical Trial Registry (ChiCTR-TRC-14005019).

Results: The median follow-up was 48.2 months (interquartile range: 31.1-60.0). The tpCR rate was 41.4% and 17.8% in the TEL group and TE group, respectively ( < 0.001). The HR for comparison of DFS between the TEL group and TE group was 0.44 (95% CI: 0.21-0.90, P  = 0.028). The addition of lobaplatin resulted in an HR of 0.44 (95% CI: 0.18-1.02,  = 0.061) for the difference in OS between the two groups. The ORR, which included complete response and partial response, was 92.9% in the TEL group and 74.3% in the TE group ( = 0.001). The TEL group patients were more likely to develop grade III-IV anemia and thrombocytopenia. No lobaplatin-related deaths or increased risk of long-term toxicity was observed.

Conclusion: Neoadjuvant lobaplatin therapy can improve the tpCR and ORR rates of TNBC with tolerable side effects and have a tendency to improve the long-term survival.
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http://dx.doi.org/10.1177/17588359221107111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234826PMC
June 2022

Design of Novel Transition-Metal-Doped CN with High-Efficiency Polysulfide Anchoring and Catalytic Performances toward Application in Lithium-Sulfur Batteries.

ACS Appl Mater Interfaces 2022 Jun 15;14(25):29120-29130. Epub 2022 Jun 15.

School of Materials Science and Engineering, Chang'an University, Xi'an 710064, China.

Lithium-sulfur (Li-S) batteries are highly expected because of their high theoretical specific capacity and energy density. However, its application still faces challenges, including the shuttle effect affecting the sulfur reduction reaction, the high decomposition energy barrier of LiS during charging, the volume change of sulfur, and the poor conductivity during charging and discharging. Here, combined with density functional theory and particle swarm optimization algorithm for the nitrogen carbide monolayer structural search (CN, = 1-8), the surprising discovery is that a single metal-atom-doped CN monolayer could effectively accelerate the conversion of lithium polysulfide and anchor lithium polysulfide during discharging and decrease the decomposition energy barrier of LiS during charging. This "anchoring and catalyzing" mechanism effectively reduces the shuttle effect and greatly improves the reaction kinetics. Among a series of metal atoms, Cr is the best doping element, and it exhibits suitable adsorption energy for polysulfides and the lowest decomposition energy barrier for LiS. This work opens up a new way for the development of transition-metal-doped carbon-nitrogen materials with an excellent catalytic activity for lithium polysulfide as cathode materials for Li-S batteries.
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http://dx.doi.org/10.1021/acsami.2c07285DOI Listing
June 2022

Microglia Regulate Blood-Brain Barrier Integrity via MiR-126a-5p/MMP9 Axis during Inflammatory Demyelination.

Adv Sci (Weinh) 2022 Jun 27:e2105442. Epub 2022 Jun 27.

Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science, SMMU, Shanghai, 200433, China.

Blood-brain barrier (BBB) impairment is an early prevalent feature of multiple sclerosis (MS), and remains vital for MS progression. Microglial activation precedes BBB disruption and cellular infiltrates in the brain of MS patients. However, little is known about the function of microglia in BBB impairment. Here, microglia acts as an important modulator of BBB integrity in inflammatory demyelination. Microglial depletion profoundly ameliorates BBB impairment in experimental autoimmune encephalomyelitis (EAE). Specifically, miR-126a-5p in microglia is positively correlated with BBB integrity in four types of MS plaques. Mechanistically, microglial deletion of miR-126a-5p exacerbates BBB leakage and EAE severity. The protective effect of miR-126a-5p is mimicked and restored by specific inhibition of MMP9 in microglia. Importantly, Auranofin, an FDA-approved drug, is identified to protect BBB integrity and mitigate EAE progression via a microglial miR-126a-5p dependent mechanism. Taken together, microglia can be manipulated to protect BBB integrity and ameliorate inflammatory demyelination. Targeting microglia to regulate BBB permeability merits consideration in therapeutic interventions in MS.
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http://dx.doi.org/10.1002/advs.202105442DOI Listing
June 2022

Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma.

Oncogenesis 2022 Jun 24;11(1):35. Epub 2022 Jun 24.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.

Pancreatic ductal adenocarcinoma (PDAC) is a well-known lethal and heterogeneous disease. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) is an important mutagenic driver that has seldom been investigated in PDAC. Therefore, this study investigated the significance of APOBEC3C in PDAC. First, cytosine deamination-associated mutation signatures were identified in the PDAC cohorts from TCGA and Fudan University Shanghai Cancer Center (FUSCC) datasets, and C > X-enriched kataegis regions were identified in the FUSCC cohort (12 to 27 counts per sample). Patients were stratified according to APOBEC3C expression, and high APOBEC3C expression was found to correlate with a higher motif enrichment score of 5'-CC-3' and an elevated kataegis count within PCSK5 and NES genes. Second, we compared APOBEC expression in PDAC and normal pancreatic tissues and found that APOBEC3C was substantially upregulated in PDAC. APOBEC3C-overexpressing cell lines were generated to substantiate the effects of APOBEC3C on PDAC genome, including alterations in single-nucleotide variant (SNV) classes (higher proportion of C > T conversions) and the formation of kataegis regions (newly occurring kataegis regions detected in ACHE and MUC6 genes). Three different PDAC cohorts (FUSCC, TCGA, and QCMG) were analysed to evaluate the prognostic value of APOBEC3C, and APOBEC3C overexpression predicted shorter survival. Finally, the APOBEC3C overexpression correalted with the PDAC tumour microenvironment (TME) remodelling, APOBEC3C expression was associated with the invasion of CD4 + T lymphocytes and CD8 + T lymphocytes (cytotoxic T lymphocytes, CTLs), indicating enhanced immune activity and validating the practicality of APOBEC3C for guiding immunotherapy.
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http://dx.doi.org/10.1038/s41389-022-00411-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232547PMC
June 2022

Anthraquinone-Based Metal-Organic Frameworks as a Bifunctional Photocatalyst for C-H Activation.

Inorg Chem 2022 Jun 13;61(25):9493-9503. Epub 2022 Jun 13.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. China.

Metal-organic frameworks (MOFs) have gained attention as multifunctional catalytic platforms, allowing us to gain important insights into synergistically activating both C-H bonds and oxygen for improving oxidation. Herein, by ingenious incorporation of anthraquinone, we report an anthraquinone-based MOF as a bifunctional heterogeneous photocatalytic platform to simultaneously activate inert C(sp)-H bonds and oxygen for C-H bond oxidation. Making use of the rigid framework with the fixation and isolation effect, both a great chemical stability and bifunctional synergistic photocatalytic effects were obtained through the immobilization of anthraquinone into a MOF. Importantly, while decorating two carboxyl groups on anthraquinone, the carbonyl groups of anthraquinone photosensitizers were not involved in coordinating the self-assembly and orderly arranged on the wall of channels that were constructed through a π-π interaction between the anthraquinone moieties in the adjacent layers, which was beneficial to form and stabilize the excited-state radical intermediates in the molecule-fenced channels, and the close proximity between the catalytic sites and the substrates to abstract a hydrogen atom from the substrate through the hydrogen atom transfer process aimed at activating the inertness of C-H bonds. Moreover, high-density-distributed anthraquinone dyes in the confined channels would activate oxygen to form singlet oxygen (O) through an energy transfer pathway, further promoting inert C(sp)-H bond oxidation efficiency. Under visible light irradiation, this anthraquinone-based MOF was successfully applied to explore activation and oxidation of a series of substrates containing benzylic C(sp)-H bonds in the presence of air or oxygen to produce the corresponding carbonyl products. This bifunctional photocatalytic platform based on a heterogeneous MOF provides an available catalytic avenue to develop a scalable and sustainable synthetic strategy using green and sustainable oxygen as the potent oxidant.
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http://dx.doi.org/10.1021/acs.inorgchem.2c00441DOI Listing
June 2022

Neutron Total Scattering Investigation of the Dissolution Mechanism of Trehalose in Alkali/Urea Aqueous Solution.

Molecules 2022 May 25;27(11). Epub 2022 May 25.

Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China.

The atomic picture of cellulose dissolution in alkali/urea aqueous solution is still not clear. To reveal it, we use trehalose as the model molecule and total scattering as the main tool. Three kinds of alkali solution, i.e., LiOH, NaOH and KOH are compared. The most probable all-atom structures of the solution are thus obtained. The hydration shell of trehalose has a layered structure. The smaller alkali ions can penetrate into the glucose rings around oxygen atoms to form the first hydration layer. The larger urea molecules interact with hydroxide groups to form complexations. Then, the electronegative complexation can form the second hydration layer around alkali ions via electrostatic interaction. Therefore, the solubility of alkali aqueous solution for cellulose decreases with the alkali cation radius, i.e., LiOH > NaOH > KOH. Our findings are helpful for designing better green solvents for cellulose.
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http://dx.doi.org/10.3390/molecules27113395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182545PMC
May 2022

Application of Multi-Criteria Decision-Making Analysis to Rural Spatial Sustainability Evaluation: A Systematic Review.

Int J Environ Res Public Health 2022 05 27;19(11). Epub 2022 May 27.

School of Architecture and Planning, Hunan University, Changsha 410082, China.

The rational allocation of spatial resources is an important factor to ensure the sustainable development of rural areas, and effective pre-emptive spatial evaluation is the prerequisite for identifying the predicament of rural resource allocation. Multi-criteria decision-making analysis has advantages in solving multi-attribute and multi-objective decision-making problems, and has been used in sustainability evaluation research in various disciplines in recent years. Previous studies have proved the value of spatial evaluation using multi-criteria decision analysis in guiding rural incremental development and inventory updates, but systematic reviews of the previous literature from a multidisciplinary perspective and studies of the implementation steps of the evaluation framework are lacking. In the current paper, the research is reviewed from the two levels of quantitative statistics and research content, and through vertical and horizontal comparisons based on three common operating procedures: standard formulation, weight distribution, and ranking and verification. Through the results, the application status and characteristics of the MCDA method in related research are determined, and five research foci in the future are proposed.
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http://dx.doi.org/10.3390/ijerph19116572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180611PMC
May 2022

Corrigendum: A Novel Intranasal Vaccine With PmpGs + MOMP Induces Robust Protections Both in Respiratory Tract and Genital System Post Infection.

Front Vet Sci 2022 11;9:928489. Epub 2022 May 11.

College of Life Science and Engineering, Foshan University, Foshan, China.

[This corrects the article DOI: 10.3389/fvets.2022.855447.].
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http://dx.doi.org/10.3389/fvets.2022.928489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131106PMC
May 2022

Research Advancement in Grassland Ecosystem Vulnerability and Ecological Resilience and Its Inspiration for Improving Grassland Ecosystem Services in the Karst Desertification Control.

Plants (Basel) 2022 May 11;11(10). Epub 2022 May 11.

School of Karst Science, Guizhou Normal University, Guiyang 550001, China.

Karst desertification control of grasslands balances the ecological and economic benefits of ecological restoration and rural ecological animal husbandry development. In the context of global changes and intensified human activities, the fragility of grassland ecosystems under karst desertification control is becoming increasingly evident, and enhancing the ecological resilience and ecosystem services of grasslands is an issue that urgently needs to be addressed. In this paper, the CNKI literature, WOS core databases and Goolgle scholar were used as search sources, identifying 179 articles related to the study of grassland ecosystem vulnerability and ecological resilience. This research systematically reviewed the progress of grassland ecosystem vulnerability research and analyzed the relationship between grassland ecosystem services (GESs) and grassland ecosystem vulnerability and resilience. The direction of enhancing GESs in karst areas is indicated in terms of the reciprocal feedback, synergistic relationship, and mechanism of action of GESs, vulnerability, and resilience. It is also emphasized that the karst desertification area should provide an ecological foundation for the sustainable development of the regional environment around the supply-and-demand relationship of GESs, the trade-off synergy of service flow, and the enhancement of ecological resilience, thereby consolidating the effectiveness of karst desertification control, enhancing GESs, and helping rural revitalization.
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http://dx.doi.org/10.3390/plants11101290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145024PMC
May 2022

"Capture-Backdonation-Recapture" Mechanism for Promoting N Reduction by Heteronuclear Metal-Free Double-Atom Catalysts.

J Am Chem Soc 2022 Jun 20;144(21):9344-9353. Epub 2022 May 20.

School of Materials Science and Engineering, Chang'an University, Xi'an 710064, China.

Facing the increasingly serious energy and environmental crisis, the development of heteronuclear metal-free double-atom catalysts is a potential strategy to realize efficient catalytic nitrogen reduction with low energy consumption and no pollution because it could combine the advantages of flexible active sites in double-atom catalysts while also being pollution-free and have high Faraday efficiency in metal-free catalysts simultaneously. However, according to the existing mechanism, the finite orbits of other nonmetallic atoms, except the boron atom, reduce the possibility of metal-free catalysis and hinder the development of heteronuclear metal-free double-atom catalysts. Herein, we propose a new "capture-backdonation-recapture" mechanism, which skillfully uses the electron capture-backdonation-recapture between boron, the substrate, and other nonmetallic elements to solve the above problems. Based on this mechanism, by means of the first-principle calculations, the material structure, adsorption energy, catalytic activity, and selectivity of 36 catalysts are systematically investigated to evaluate their catalytic performance. [email protected] and [email protected] are selected for their good catalytic performance and low limiting potentials of -0.14 and -0.10 V, respectively. Meanwhile, the "capture-backdonation-recapture" mechanism is also verified by analyzing the results of adsorption energy and electron transfer. Our work broadens the ideas and lays the theoretical foundation for the development of heteronuclear metal-free double-atom catalysts in the future.
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http://dx.doi.org/10.1021/jacs.2c01245DOI Listing
June 2022

Transcriptome analysis of Aedes albopictus midguts infected by dengue virus identifies a gene network module highly associated with temperature.

Parasit Vectors 2022 May 19;15(1):173. Epub 2022 May 19.

Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.

Background: Dengue is prevalent worldwide and is transmitted by Aedes mosquitoes. Temperature is a strong driver of dengue transmission. However, little is known about the underlying mechanisms.

Methods: Aedes albopictus mosquitoes exposed or not exposed to dengue virus serotype 2 (DENV-2) were reared at 23 °C, 28 °C and 32 °C, and midguts and residual tissues were evaluated at 7 days after infection. RNA sequencing of midgut pools from the control group, midgut breakthrough group and midgut nonbreakthrough group at different temperatures was performed. The transcriptomic profiles were analyzed using the R package, followed by weighted gene correlation network analysis (WGCNA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis to identify the important molecular mechanisms regulated by temperature.

Results: The midgut infection rate and midgut breakthrough rate at 28 °C and 32 °C were significantly higher than those at 23 °C, which indicates that high temperature facilitates DENV-2 breakthrough in the Ae. albopictus midgut. Transcriptome sequencing was performed to investigate the antiviral mechanism in the midgut. The midgut gene expression datasets clustered with respect to temperature, blood-feeding and midgut breakthrough. Over 1500 differentially expressed genes were identified by pairwise comparisons of midguts at different temperatures. To assess key molecules regulated by temperature, we used WGCNA, which identified 28 modules of coexpressed genes; the ME3 module correlated with temperature. KEGG analysis indicated that RNA degradation, Toll and immunodeficiency factor signaling and other pathways are regulated by temperature.

Conclusions: Temperature affects the infection and breakthrough of Ae. albopictus midguts invaded by DENV-2, and Ae. albopictus midgut transcriptomes change with temperature. The candidate genes and key pathways regulated by temperature provide targets for the prevention and control of dengue.
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http://dx.doi.org/10.1186/s13071-022-05282-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118615PMC
May 2022

Acupuncture for chronic sciatica: protocol for a multicenter randomised controlled trial.

BMJ Open 2022 05 17;12(5):e054566. Epub 2022 May 17.

International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

Background: Chronic Sciatica is a disabling condition causing considerable medical, social and financial implications. Currently, there is no recognised long-term effective treatment to alleviate sciatica. Acupuncture has been widely used for treating chronic pains with persistent analgesic effects. We aim to evaluate the efficacy and safety of acupuncture for chronic sciatica with follow-up in 52 weeks.

Methods And Analysis: This is a multicenter randomised sham-controlled trial. A total of 216 patients with chronic sciatica will be enrolled and randomly assigned to the acupuncture or sham acupuncture group. There will be 10 treatment sessions applied in 4 weeks with frequency decreased over time. Patients will complete follow-ups during 52 weeks. The primary outcomes are changes in leg pain intensity and disability from baseline to week 4. Secondary outcomes include back pain intensity, frequency and bothersomeness, quality of life, and global perceived effect. Adverse events will be recorded in detail.

Ethics And Dissemination: Ethical approval of this trial was granted from the ethics committee of Beijing University of Chinese Medicine and all study centres (No. 2020BZYLL0803). Written informed consent will be obtained from enrolled patients. Trial results will be disseminated in peer-reviewed publications.

Trial Registration Number: ChiCTR2100044585 (Chinese Clinical Trial Registry, http://www.chictr.org.cn, registered on 24 March 2021); preresults.
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http://dx.doi.org/10.1136/bmjopen-2021-054566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114849PMC
May 2022

TGF-β1-induced RAP2 regulates invasion in pancreatic cancer.

Acta Biochim Biophys Sin (Shanghai) 2022 Mar;54(3):361-369

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Pancreatic cancer is highly lethal due to its aggressive invasive properties and capacity for metastatic dissemination. Additional therapeutic targets and effective treatment options for patients with tumours of high invasive capacity are required. Ras-related protein-2a (RAP2) is a member of the GTP-binding proteins. RAP2 has been reported to be widely upregulated in many types of cancers via regulating cytoskeleton reorganization, cell proliferation, migration, and adhesion, as well as inflammation. As a member of the RAS oncogene family, which has been demonstrated to drive pancreatic cancer oncogenesis and many other malignancies, the physiological roles of RAP2 in pancreatic cancer have seldom been discussed. In the present study, we explored the correlation between RAP2 expression and the prediction of overall survival of pancreatic cancer patients. Mechanistic studies were carried out to shed light on the role of RAP2 in pancreatic cancer invasion and how RAP2 is regulated in the invasive process. Our results demonstrated that patients with higher RAP2 expression showed unfavourable prognoses. studies demonstrated that silencing of inhibited the invasion of pancreatic cancer cells. Moreover, our results demonstrated that transforming growth factor-β1 (TGF-β1), an inducer of the metastatic potential of pancreatic cancer cells, regulates the expression of RAP2 via the transcription factor c-Myc. In conclusion, the present study uncovered RAP2 as a novel predictive marker and therapeutic target for pancreatic cancer.
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http://dx.doi.org/10.3724/abbs.2022015DOI Listing
March 2022

A Novel Intranasal Vaccine With PmpGs + MOMP Induces Robust Protections Both in Respiratory Tract and Genital System Posting Infection.

Front Vet Sci 2022 22;9:855447. Epub 2022 Apr 22.

College of Life Science and Engineering, Foshan University, Foshan, China.

() is a crucial zoonotic pathogen that causes severe respiratory and reproductive system disease in humans and animals. In our pioneer study, polymorphic membrane protein G (PmpG) mediated attachment to host cells as the adhesions and induced immunity against infection. We hypothesize that multiple PmpG antigens adjuvanted with ghost (VCG) and chitosan gel might trigger full protection the intranasal route (i.n). In the present study, 40 SPF chickens were randomly divided into four groups, including the PmpGs + MOMP group (i.n), major outer membrane protein (MOMP) group (i.n), PmpGs (Pmp17G + Pmp20G + Pmp21G) group (i.n), and control groups (VCG + chitosan gel) (i.n). Post twice immunizations, the PmpGs + MOMP group yielded highly level-specific IgG, IgA antibodies, and lymphocyte proliferation. As for cytokines, IFN-γ expression was upregulated significantly, while IL-10 concentration was downregulated in the PmpGs + MOMP group compared with other groups. Post challenge, exudate inflammations in air sacs, bacterial loads in lungs, and bacterial shedding in throat swabs were reduced significantly in the PmpGs + MOMP group. In the second experiment, 100 breeder ducks were divided into the PmpGs + MOMP group (i.n), the commercial MOMP group ( intramuscular injection, i.m), the inactivated EBs group (i.n), and the control group (i.n), 25 ducks per group. Post challenge, the reduced egg production recovered soon in the inactivated EBs group and the PmpGs + MOMP group. Moreover, the aforementioned two groups induced higher robust IgG antibodies, lymphocyte proliferation, and IFN-γ secretions than the commercial MOMP vaccine did. Postmortem, lower bacterial loads of spleens were determined in the PmpGs + MOMP group and the inactivated EBs group. However, bacterial clearance of follicular membranes and shedding from the vaginal tract were not significant differences among the three tested groups. Furthermore, the PmpGs + MOMP group induced lower inflammations in the follicles and oviducts. Based on the above evidence, the combination of PmpGs and MOMP adjuvanted with chitosan gel and VCG intranasal route could induce full protection both in the respiratory system and genital tract post infection. More importantly, the combination antigens are superior to the inactivated EBs antigen due to no contamination to the environment and less genital inflammation. The combination of PmpGs + MOMP adjuvanted with VCG and chitosan gel might be a promising novel vaccine by blocking infection from animals to human beings.
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http://dx.doi.org/10.3389/fvets.2022.855447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072866PMC
April 2022

Universal dynamical onset in water at distinct material interfaces.

Chem Sci 2022 Apr 28;13(15):4341-4351. Epub 2022 Mar 28.

School of Physics and Astronomy, Institute of Natural Sciences, Shanghai National Center for Applied Mathematics (SJTU Center), MOE-LSC, Shanghai Jiao Tong University Shanghai 200240 China

Interfacial water remains liquid and mobile much below 0 °C, imparting flexibility to the encapsulated materials to ensure their diverse functions at subzero temperatures. However, a united picture that can describe the dynamical differences of interfacial water on different materials and its role in imparting system-specific flexibility to distinct materials is lacking. By combining neutron spectroscopy and isotope labeling, we explored the dynamics of water and the underlying substrates independently below 0 °C across a broad range of materials. Surprisingly, while the function-related anharmonic dynamical onset in the materials exhibits diverse activation temperatures, the surface water presents a universal onset at a common temperature. Further analysis of the neutron experiment and simulation results revealed that the universal onset of water results from an intrinsic surface-independent relaxation: switching of hydrogen bonds between neighboring water molecules with a common energy barrier of ∼35 kJ mol.
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http://dx.doi.org/10.1039/d1sc04650kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006901PMC
April 2022

Eosin Y-Containing Metal-Organic Framework as a Heterogeneous Catalyst for Direct Photoactivation of Inert C-H Bonds.

Inorg Chem 2022 May 4;61(19):7256-7265. Epub 2022 May 4.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. China.

Xanthene dyes as a class of ideal organic homogeneous photocatalyst have received significant attention in C-H bond activation; however, the inherent nature of fast carrier recombination/deactivation and low stability limits their practical applications. Herein, by the ingenious decoration of eosin Y into a porous metal-organic framework (MOF), a high-performance heterogeneous MOF-based photocatalyst was prepared to efficiently activate inert C-H bonds on the reactants via the hydrogen atom transfer pathway for the functionalization of the C-H bonds. Taking advantage of the fixation effect of a rigid framework, the incorporation of eosin Y into MOF leads to great enhancement of their chemical durability. More importantly, by the introduction of the second auxiliary ligand, the carbonyl groups of xanthene on the eosin Y dyes were perfectly retained and periodically aligned within the confined channels of this rigid framework, which could effectively form excited state radicals to prompt inert C-H bond activation, promoting reaction efficiency by the host-guest supramolecular interaction. New eosin Y-based MOFs were recyclable for six times without reducing photocatalytic activity. This eosin Y functionalized MOF-based heterogeneous photocatalytic system provides an availably catalytic avenue to develop a scalable and sustainable synthetic strategy for the practical application of organic dyes.
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http://dx.doi.org/10.1021/acs.inorgchem.1c03813DOI Listing
May 2022

A novel 3D terbium metal-organic framework as a heterogeneous Lewis acid catalyst for the cyanosilylation of aldehyde.

RSC Adv 2021 Oct 27;11(55):34779-34787. Epub 2021 Oct 27.

State Key Laboratory of Fine Chemicals, Dalian University of Technology Dalian 116024 P. R. China

A novel 3D lanthanide(iii) metal-organic framework (MOF) (namely Tb-MOF), was synthesized by self-assembly from Tb(iii) ion nitrate and the rigid organic ligand Hsbdc (Hsbdc = 5,5-dioxo-5-dibenzo[,]thiophene-3,7-dicarboxylic acid), and could work as an efficient heterogeneous catalyst for the cyanosilylation of aromatic aldehydes at room temperature. The obtained Tb-MOF has been characterized and analysed in detail by single crystal X-ray diffraction, powder X-ray diffraction, thermogravimetric analysis and so on. The pores of Tb-MOF provided a microenvironment that was beneficial for the substrates to be close to the Lewis acid catalytic sites. The IR spectrogram and the fluorescence titration proved that the substrates could be activated inside the channel of Tb-MOF. The heterogeneous Tb-MOF catalyst with fine catalytic efficiency exhibited a high TON (TON = 460), and could be recycled at least three times without significantly reducing its activity.
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http://dx.doi.org/10.1039/d1ra06533eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042712PMC
October 2021

Single photon imaging based on a photon driven sparse sampling.

Opt Express 2022 Apr;30(8):12521-12532

Single photon three-dimensional (3D) imager can capture 3D profile details and see through obscuring objects with high sensitivity, making it promising in sensing and imaging applications. The key capabilities of such 3D imager lie on its depth resolution and multi-return discrimination. For conventional pulsed single photon lidar, these capabilities are limited by transmitter bandwidth and receiver bandwidth simultaneously. A single photon imager is proposed and experimentally demonstrated to implement time-resolved and multi-return imaging. Time-to-frequency conversion is performed to achieve millimetric depth resolution. Experimental results show that the depth resolution is better than 4.5 mm, even though time jitter of the SPAD reaches 1 ns and time resolution of the TCSPC module reaches 10 ns. Furthermore, photon driven sparse sampling mechanism allows us to discriminate multiple near surfaces, no longer limited by the receiver bandwidth. The simplicity of the system hardware enables low-cost and compact 3D imaging.
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http://dx.doi.org/10.1364/OE.455544DOI Listing
April 2022

New Pyroptosis -Associated Gene Signature for Overall Survival Forecast among Patients Suffering from Hepatocellular Carcinoma.

Authors:
Cheng He Ke You

J Healthc Eng 2022 15;2022:6365485. Epub 2022 Apr 15.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Due to the heterogeneity of tumors, we do not understand the given effect of pyroptosis on hepatocellular carcinoma (HCC) fully, particularly its influences on prognosis. The paper aims at exploring the prognostic value of pyroptosis-associated genes and its role in immune status in HCC. A multigene prognostic signature is set up by utilizing the least absolute shrinkage and choosing operator Cox exploration. The comparison of survival between different risk groups is made with the Kaplan-Meier exploration and Cox regression. LASSO Cox regression analysis is adopted to set up a pyroptosis-associated gene signature ( and ). By comparing with the group at low risks, the high-risk group displayed greatly decreased OS. The fatidic ability of the prognostic gene signature is confirmed by the receiver-running feature curve analysis. According to multivariate Cox exploration, the risk mark is an independent predicting agent for OS. A new signature established with two pyroptosis-associated genes can be adopted for prognostic forecast and influence the immune situation in HCC.
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http://dx.doi.org/10.1155/2022/6365485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033384PMC
April 2022
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