Publications by authors named "Chen Zhou"

652 Publications

Erratum to "Analysis of negative DSA findings in patients with acute nonvariceal gastrointestinal bleeding: A retrospective study of 133 patients" [J. Interv. Med. 2 (2019) 27-30].

J Interv Med 2019 May 24;2(2):99. Epub 2019 Oct 24.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

[This corrects the article DOI: 10.1016/j.jimed.2019.05.007.].
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http://dx.doi.org/10.1016/j.jimed.2019.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562262PMC
May 2019

Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model.

Sci Rep 2021 Nov 24;11(1):22846. Epub 2021 Nov 24.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.

Liver fibrosis plays a crucial role in promoting tumor immune escape and tumor aggressiveness for liver cancer. However, an interesting phenomenon is that the tumor size of liver cancer patients with liver fibrosis is smaller than that of patients without liver fibrosis. In this study, 16 SD rats were used to establish orthotopic liver tumor transplantation models with Walker-256 cell lines, respectively on the fibrotic liver (n = 8, LF group) and normal liver (n = 8, control group). MRI (magnetic resonance imaging) was used to monitor the size of the tumors. All rats were executed at the third week after modeling, and the immunohistochemical staining was used to reflect the changes in the tumor microenvironment. The results showed that, compared to the control group, the PD-L1 (programmed cell death protein receptor-L1) expression was higher, and the neutrophil infiltration increased while the effector (CD8+) T cell infiltration decreased in the LF group. Additionally, the expression of MMP-9 (matrix metalloproteinase-9) of tumor tissue in the LF group increased. Three weeks after modeling, the size of tumors in the LF group was significantly smaller than that in the control group (382.47 ± 195.06 mm vs. 1736.21 ± 657.25 mm, P < 0.001). Taken together, we concluded that liver fibrosis facilitated tumor immunity escape but limited the expansion of tumor size.
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http://dx.doi.org/10.1038/s41598-021-02155-9DOI Listing
November 2021

22R- but not 22S-hydroxycholesterol is recruited for diosgenin biosynthesis.

Plant J 2021 Nov 24. Epub 2021 Nov 24.

Shanghai Key Laboratory of Bio-Energy Crops, Research Center for Natural Products, School of Life Sciences, Shanghai University, Shanghai, 200444, China.

Diosgenin is an important compound in the pharmaceutical industry and it is biosynthesized in several eudicot and monocot species, herein represented by fenugreek (a eudicot), and Dioscorea zingiberensis (a monocot). Formation of diosgenin can be achieved by the early C22,16-oxidations of cholesterol followed by a late C26-oxidation. This study reveals that, in both fenugreek and D. zingiberensis, the early C22,16-oxygenase(s) show strict 22R-stereospecificity for hydroxylation of the substrates. Evidence against the recently proposed intermediacy of 16S,22S-dihydroxycholesterol in diosgenin biosynthesis was also found. Moreover, in contrast to the eudicot fenugreek, which utilizes a single multifunctional cytochrome P450 (TfCYP90B50) to perform the early C22,16-oxidations, the monocot D. zingiberensis has evolved two separate cytochrome P450 enzymes, with DzCYP90B71 being specific for the 22R-oxidation and DzCYP90G6 for the C16-oxidation. We suggest that the DzCYP90B71/DzCYP90G6 pair represent more broadly conserved catalysts for diosgenin biosynthesis in monocots.
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http://dx.doi.org/10.1111/tpj.15604DOI Listing
November 2021

Gastric oxyntic gland neoplasm: A case series.

Asian J Surg 2021 Nov 20. Epub 2021 Nov 20.

Department of Pathology, Jinhu County People's Hospital, Jiangsu Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2021.10.014DOI Listing
November 2021

Investigation on a Zr-based metal-organic framework (MOF-801) for the high-performance separation of light alkanes.

Chem Commun (Camb) 2021 Nov 22. Epub 2021 Nov 22.

Institute of New Energy Technology, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan Road, Ningbo 315201, P. R. China.

A Zr-based metal-organic framework (MOF-801) with high thermal and chemical stability was prepared by the solvothermal synthesis method. Notably, MOF-801 exhibits a high separation selectivity for CH/CH and CH/CH, making it a practical material for the storage and purification of light alkanes.
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http://dx.doi.org/10.1039/d1cc05306jDOI Listing
November 2021

A new choice of stent for transjugular intrahepatic portosystemic shunt creation: Viabahn ePTFE covered stent/bare metal stent combination.

J Interv Med 2021 Feb 13;4(1):32-38. Epub 2020 Oct 13.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objectives: To compare the clinical outcomes in terms of structure and function between the insertion of a transjugular intrahepatic portosystemic shunt (TIPS) created with the Viabahn ePTFE covered stent/bare metal stent (BMS) combination and the Fluency ePTFE covered stent/BMS combination.

Methods: A total of 101 consecutive patients who received a TIPS from February 2016 to August 2018 in our center were retrospectively analyzed. Sixty-four subjects were enrolled in the Viabahn group and 37 were enrolled in the Fluency group. The geometry characteristics of the TIPS were calculated, and the associated occurrence of shunt dysfunction, survival, overt hepatic encephalopathy, and variceal rebleeding were evaluated.

Results: The technical success rate was 100%. After the insertion of the TIPS, the rate of shunt dysfunction during the first 3 months was significantly different between the Viabahn and Fluency groups (1.6% and 13.5%, respectively; p ​= ​0.024). Multivariate analysis indicated that the angle of portal venous inflow (α) was the only independent risk factor for shunt dysfunction (hazard ratio ​= ​1.060, 95% confidence interval ​= ​1.009-1.112, p ​= ​0.020). In addition, 3 months after the TIPS insertion, the α angle distinctly increased from 20.9° ​± ​14.3°-26.9° ​± ​20.1° (p ​= ​0.005) in the Fluency group but did not change significantly in the Viabahn group (from 21.9° ​± ​15.1°-22.9° ​± ​17.6°, p ​= ​0.798).

Conclusions: Shunt dysfunction was related to the α angle owing to the slight effect on the α angle after the implantation of the TIPS. The Viabahn ePTFE covered stent/BMS combination was more stable in structure and promised higher short-term stent patency compared with the Fluency ePTFE covered stent/BMS combination.
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http://dx.doi.org/10.1016/j.jimed.2020.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562232PMC
February 2021

Transjugular intrahepatic portosystemic shunt for repeated bleeding of hemorrhoids caused by severe portal hypertension with ectopic varices: A case report.

J Interv Med 2020 Sep 9;3(3):157-160. Epub 2020 Jul 9.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Severe portal hypertension is life-threatening and can bring adverse complications such as ascites, gastroesophageal varices, and edema. It can, even cause variceal hemorrhage, which may lead to a high risk of death. There is a rare incidence in bleeding of hemorrhoids caused by severe ectopic varices.

Case Presentation: We report the case of a female patient with a 20-year history of hepatitis B virus infection who presented with repeated bleeding of hemorrhoids caused by severe portal hypertension with ectopic varices that is connection between the superior mesenteric vein and rectal venous plexus. Laboratory results revealed a hemoglobin level of 74 g/L. Finally, the patient was successfully treated with transjugular intrahepatic portosystemic shunt (TIPSS) placement without variceal embolization after a multidisciplinary comprehensive opinion. In the two-month follow-up period, the patient had failed to develop hepatic encephalopathy or hematochezia, and computed tomography venography (CTV) indicated that the stent was unobstructed and ascites disappeared.

Conclusions: TIPSS placement is effective for the case, and we hope this case can help improve clinicians' awareness of hemorrhoidal bleeding with severe portal hypertension. Portal hypertension should also be considered during the diagnosis and treatment, as opposed to hemorrhoidal bleeding alone. Moreover, abdominal CTV is recommended as an effective imaging examination method to determine the stent status after operation.
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http://dx.doi.org/10.1016/j.jimed.2020.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562226PMC
September 2020

Analysis of negative DSA findings in patients with acute nonvariceal gastrointestinal bleeding: A retrospective study of 133 patients.

J Interv Med 2019 Feb 27;2(1):27-30. Epub 2019 Jun 27.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Purpose: To analyze causes of acute nonvariceal gastrointestinal bleeding (GIB) with negative digital subtraction angiography (DSA) results.

Materials And Methods: The clinical and follow-up data of 133 patients - recruited between February 2008 and November 2016 - with acute nonvariceal GIB and negative DSA results were included in this study. DSA results, diagnoses, and clinical outcomes were recorded.

Results: The DSA results were negative in all 133 patients. Of the total, 55 patients (41.4%) chose to undergo surgery and 78 (58.6%) opted for conservative treatment. Within 30 days, there was no significant difference in the rebleeding or mortality rates between the two groups ( < .05). Of all 133 patients, 76 (57.1%) had upper GIB and 57 (42.9%) had lower GIB; within 30 days, the rebleeding rate in the upper GIB group (44.7%, 34/76) was significantly higher than that in the lower GIB group (26.3%, 15/57). There was no significant statistical difference ( < .05) within 30 days in the mortality rates between the two groups.Among patients with upper GIB, 26 (34.2%, 26/76) opted to undergo surgery and 50 (65.8%, 50/76) chose conservative treatment; within 30 days, the rebleeding rate in the group that chose surgery (61.5%, 16/26) was higher than that in the conservative treatment group (36%, 18/50). There was no significant difference ( < .05) within 30 days in the mortality rate between the two groups.Among the patients with lower GIB, 29 (50.9%, 29/57) chose to undergo surgery and 28 (49.1%, 28/57) opted for conservative treatment. Within 30 days, the rebleeding rate in the surgery group (13.8%, 4/29) was lower than that in conservative treatment group (39.3%, 11/28). There was no significant difference ( < .05) within 30 days in the mortality rate between the two groups.Sixteen patients underwent prophylactic arterial embolization; in 6 of these, bleeding was stopped for 30 days. DSA was then repeated in these 16 patients after a median interval of 1 day, and a positive bleeding site was found in 9 of the 16. Causes of bleeding were found in 111 patients by surgery or endoscopy, whereas the causes remained unknown in 22 patients.

Conclusions: Upper GIB with negative DSA results was stopped by conservative treatment, whereas lower GIB required surgery to detect the culprit bleeding site. Rare causes of GIB should be considered and appropriate management selected in a timely manner in order to detect unusual causes.
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http://dx.doi.org/10.1016/j.jimed.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562268PMC
February 2019

In situ formation of the loop snare technique for retrieval of foreign bodies from vessels.

J Interv Med 2018 Nov 30;1(4):247-251. Epub 2019 Apr 30.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

To investigate the feasibility and effectiveness of in situ formation of the loop snare technique for retrieval of foreign bodies from vessels. We retrospectively reviewed in situ formation of the loop snare technique for retrieval of foreign bodies in 6 patients. After placing the guide wire and the loop of the gooseneck snare on each side of the tubes, the soft tip of the guide wire was caught with the gooseneck snare to form a new loop structure. The foreign body was retrieved with the new loop snare by combining the gooseneck snare and the guide wire. We reviewed the application of this technique in 6 patients with fractured central venous catheters without free ends. With in situ formation of the loop snare technique, the internal ruptured catheter was successfully removed from all of the 6 patients in about 2 to 4 min. There were no complications such as arrhythmia or heart valve injury in the 6 patients with the distal end of the fragment in the pulmonary artery or right atrium. The in situ formation loop snare technique is an effective and fast means of retrieving tubular foreign bodies without free ends from vessels. Further research is needed to investigate the practical utility of the method for retrieval of all kinds of foreign bodies.
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http://dx.doi.org/10.19779/j.cnki.2096-3602.2018.04.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586705PMC
November 2018

Validation of risk assessment models predicting venous thromboembolism in inpatients with AECOPD: a multicenter cohort study.

Thromb Haemost 2021 Nov 10. Epub 2021 Nov 10.

Department of Respiratory and Critical Care Medicine, Sichuan University West China Hospital, Chengdu, China.

Background: As inpatients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are at increased risk for venous thromboembolism (VTE), identifying high-risk patients requiring thromboprophylaxis is critical to reduce the mortality and morbidity associated with VTE. This study aimed to evaluate and compare the validities of the Padua Prediction Score and Caprini risk assessment model (RAM) in predicting the risk of VTE in inpatients with AECOPD.

Methods: The inpatients with AECOPD were prospectively enrolled from seven medical centers of China between September 2017 and January 2020. Caprini and Padua scores were calculated on admission, and the incidence of 3-month VTE was investigated.

Results: Among the 3277 eligible patients with AECOPD, 128 patients (3.9%) developed VTE within 3 months after admission. The distribution of the study population by the Caprini risk level was as follows: high, 53.6%; moderate, 43.0%; and low, 3.5%. The incidence of VTE increased by risk level as high, 6.1%; moderate, 1.5%; and low, 0%. According to the Padua RAM, only 10.9% of the study population was classified as high risk and 89.1% as low risk, with the corresponding incidence of VTE 7.9% and 3.4%, respectively. The Caprini RAM had higher area under curve (AUC) compared with the Padua RAM (0.713  0.021 vs 0.644 ± 0.023, P = 0.029).

Conclusion: The Caprini RAM was superior to the Padua RAM in predicting the risk of VTE in inpatients with AECOPD and might better guide thromboprophylaxis in these patients.
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http://dx.doi.org/10.1055/a-1693-0063DOI Listing
November 2021

Towards high light conversion efficiency from photo-fermentative hydrogen production of Arundo donax L. By light-dark duration alternation strategy.

Bioresour Technol 2021 Nov 6:126302. Epub 2021 Nov 6.

Key Laboratory of New Materials and Facilities for Rural Renewable Energy of Ministry of Agriculture and Rural Affairs of China, Henan Agricultural University, Zhengzhou 450002, PR China. Electronic address:

Suitable illumination project would help in achieving high light conversion efficiency (LCE) for photo-fermentation. This study proposed an improvement strategy for LCE of photo-fermentative hydrogen production (PFHP) with a photosynthetic consortium by adopting light-dark duration alternation. For this purpose, 6 projects (continues light, 24 h light + 24 h dark, 24 h dark + 24 h light, 48 h light + 48 h light, 48 h dark + 48 h light, and continues dark) light disturbances were carried out to estimate the strategy. The fluctuation of cell growth (OD660) was corresponded to the light-dark alternation. 24 h dark + 24 h light alternation achieved the maximum hydrogen yield (HY) of 390.9 mL/g TS cell (6.7 % higher than continuous light) and maximum improvement of LCE of 114.7%. Moreover, heat map analysis revealed that the light period after inoculation had the closest relation (Pearson's r = 1) with the average hydrogen production rate (HPR) of photo-fermentation. Besides, decreased dark period after inoculation would increase the hydrogen yield of photo-fermentation.
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http://dx.doi.org/10.1016/j.biortech.2021.126302DOI Listing
November 2021

Optimization of Nanostructured Copper Sulfide to Achieve Enhanced Enzyme-Mimic Activities for Improving Anti-Infection Performance.

ACS Appl Mater Interfaces 2021 Nov 2;13(45):53659-53670. Epub 2021 Nov 2.

The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.

Advanced antibacterial methods are urgently needed to deal with possible infectious diseases. As promising alternatives to antibiotics, enzyme-mimic nanocatalysts face bottlenecks of low activities and indistinct catalytic mechanisms, which seriously restrict their development for anti-infection treatment. Herein, metastable copper sulfide (CuS) nanozymes with diversiform sizes and compositions were selected to adjust the electronic structure for enhancing enzyme-mimic activities. The as-synthesized large and thin nanoplates (L/TN nanoplates), with the stoichiometric ratio of CuS, were proven to possess the optimal peroxidase (POD)-mimic activity. Using quantum mechanics, it was theoretically revealed that the sulfur vacancies could alter the electronic structure of copper active sites and thus reduce the reaction energy barrier of HO to·OH to promote the POD-mimic performance. Moreover, through enhanced enzyme-mimic activities, L/TN nanoplates achieved efficient depletion of glutathione and ascorbic acid for improving antibacterial performances. Further, synergizing with the NIR irradiation, the satisfactory destruction capability for bacteria and biofilm was achieved for L/TN nanoplates under an inflammatory level of hydrogen peroxide (50 μM). Altogether, this work provides a deeper understanding of geometrical and electronic properties-dependent antibacterial performance, and paves the way toward precise compositions and structures engineering of nanozymes.
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http://dx.doi.org/10.1021/acsami.1c17985DOI Listing
November 2021

Direct copolymerization of ethylene with protic comonomers enabled by multinuclear Ni catalysts.

Nat Commun 2021 Nov 1;12(1):6283. Epub 2021 Nov 1.

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

Ethylene/polar monomer coordination copolymerization offers an attractive way of making functionalized polyolefins. However, ethylene copolymerization with industrially relevant short chain length alkenoic acid remain a big challenge. Here we report the efficient direct copolymerization of ethylene with vinyl acetic acid by tetranuclear nickel complexes. The protic monomer can be extended to acrylic acid, allylacetic acid, ω-alkenoic acid, allyl alcohol, and homoallyl alcohol. Based on X-ray analysis of precatalysts, control experiments, solvent-assisted electrospray ionization-mass spectrometry detection of key catalytic intermediates, and density functional theory studies, we propose a possible mechanistic scenario that involves a distinctive vinyl acetic acid enchainment enabled by Ni···Ni synergistic effects. Inspired by the mechanistic insights, binuclear nickel catalysts are designed and proved much more efficient for the copolymerization of ethylene with vinyl acetic acid or acrylic acid, achieving the highest turnover frequencies so far for both ethylene and polar monomers simultaneously.
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http://dx.doi.org/10.1038/s41467-021-26470-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560877PMC
November 2021

The effect of perioperative sustained-release opioid use on long-term opioid dispensing following total knee arthroplasty: a retrospective cohort study.

N Z Med J 2021 10 22;134(1544):57-68. Epub 2021 Oct 22.

MBChB, FANZCA, Consultant Anaesthetist, Department of Anaesthesia and Pain Medicine, Counties Manukau Health, Middlemore, New Zealand.

Aims: To determine the impact of perioperative sustained-release (SR) opioid use on total inpatient opioid consumption and longer-term outpatient dispensing for three months following elective total knee arthroplasty (TKA).

Methods: Patients who underwent primary unilateral TKA between 1 January and 31 December 2018 at Counties Manukau Health were retrospectively identified. Participants were stratified into two groups by inpatient use or avoidance of strong SR opioids (OxyContin or M-Eslon). The primary outcome was the percentage of patients receiving prescriptions for opioid medications at thirty-day intervals for three months after discharge.

Results: Two hundred and thirty-two patients were eligible for inclusion. The baseline demographics of both groups were similar. In the SR opioid use group, the majority (79%) received OxyContin. Overall, inpatient opioid use between postoperative days (POD) zero and three was lower in the SR opioid avoidance group, although this was not statistically significant (157.5 [IQR 110.0-220.0] vs 167.5mg OME [110.0-290.0], p=0.14). Outpatient postoperative opioid dispensing between 0-30 days was significantly greater in patients who received inpatient SR opioids (p=0.01). Dispensing of oxycodone was significantly higher in the SR opioid use group at one- and two- months (p=0.01 and 0.03 respectively).

Conclusion: The postoperative use of SR opioids is not routinely recommended following TKA. Their use is associated with greater overall inpatient opioid use, sustained opioid dispensing during and after the expected recovery period, and the potential for significant harm.
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October 2021

Gene Network Analysis of Alzheimer's Disease Based on Network and Statistical Methods.

Entropy (Basel) 2021 Oct 19;23(10). Epub 2021 Oct 19.

School of Mathematical Sciences, Tiangong University, Tianjin 300382, China.

Gene network associated with Alzheimer's disease (AD) is constructed from multiple data sources by considering gene co-expression and other factors. The AD gene network is divided into modules by Cluster one, Markov Clustering (MCL), Community Clustering (Glay) and Molecular Complex Detection (MCODE). Then these division methods are evaluated by network structure entropy, and optimal division method, MCODE. Through functional enrichment analysis, the functional module is identified. Furthermore, we use network topology properties to predict essential genes. In addition, the logical regression algorithm under Bayesian framework is used to predict essential genes of AD. Based on network pharmacology, four kinds of AD's herb-active compounds-active compound targets network and AD common core network are visualized, then the better herbs and herb compounds of AD are selected through enrichment analysis.
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http://dx.doi.org/10.3390/e23101365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535014PMC
October 2021

Eutectic Crystallization Activates Solid-State Zinc-Ion Conduction.

Angew Chem Int Ed Engl 2021 Oct 19. Epub 2021 Oct 19.

Qingdao Industrial Energy Storage Research Institute, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.

Solid-state zinc (Zn) batteries offer a new candidate for emerging applications sensitive to volume, safety and cost. However, current solid polymeric or ceramic electrolyte structures remain poorly conductive for the divalent Zn , especially at room temperature. Constructing a heterogeneous interface which allows Zn percolation is a viable option, but this is rarely involved in multivalent systems. Herein, we construct a solid Zn -ion conductor by inducing crystallization of tailored eutectic liquids formed by organic Zn salts and bipolar ligands. High-entropy eutectic-networks weaken the ion-association and form interfacial Zn -percolated channels on the nucleator surfaces, resulting in a solid crystal with exceptional selectivity for Zn transport (t =0.64) and appreciable Zn conductivity (σ =3.78×10  S cm at 30 °C, over 2 orders of magnitude higher than conventional polymers), and finally enabling practical ambient-temperature Zn/V O metal solid cells. This design principle leveraged by the eutectic solidification affords new insights on the multivalent solid electrochemistry suffering from slow ion migration.
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http://dx.doi.org/10.1002/anie.202113086DOI Listing
October 2021

First-in-Human, Single-Ascending Dose and Food Effect Studies to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Cetagliptin, a Dipeptidyl Peptidase-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus.

Clin Drug Investig 2021 Nov 16;41(11):999-1010. Epub 2021 Oct 16.

Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, #300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Background And Objectives: Cetagliptin is a highly selective dipeptidyl peptidase-4 inhibitor under development to treat type 2 diabetes mellitus. This first-in-human study was conducted to characterise the pharmacokinetics, pharmacodynamics and tolerability of single-ascending oral doses of cetagliptin in healthy subjects. In addition, the effect of food on pharmacokinetics was evaluated.

Methods: Study 1 enrolled 66 healthy subjects in a double-blind, randomised, placebo-controlled, single-dose escalation study; sitagliptin was employed as a positive open-label control. Forty-four subjects were assigned to seven cohorts (cetagliptin 12.5, 25, 50, 100, 200, 300 or 400 mg); 12 subjects were assigned to the placebo group. The remaining ten subjects received sitagliptin 100 mg as the positive control. Blood, urine and faeces were collected for the pharmacokinetic analysis and determination of plasma dipeptidyl peptidase-4 inhibition, active glucagon-like peptide-1, glucose and insulin levels. In Study 2, 14 healthy subjects were assigned to a randomised, open-label, two-period crossover study, and received a single oral dose of cetagliptin 100 mg in the fasted state or after a high-fat meal, with a 14-day washout period between treatments. Blood samples were collected to evaluate the effects of food on the pharmacokinetics of cetagliptin.

Results: Following administration of a single oral dose, cetagliptin was rapidly absorbed, presenting a median time to maximum concentration of 1.0-3.25 h. The terminal half-life ranged between 25.8 and 41.3 h, which was considerably longer than that of sitagliptin. The area under the plasma concentration-time curve was approximately dose proportional between 25 mg and 400 mg, and the increase in maximum concentration was greater than dose proportional. The unchanged drug was mainly excreted in the urine (27.2-46.2% of dose) and minimally via the faeces (1.4% of dose). Dipeptidyl peptidase-4 inhibition, an increase in active glucagon-like peptide-1 and a slight decrease in blood glucose were observed, whereas insulin was not significantly altered when compared with placebo. The weighted average dipeptidyl peptidase-4 inhibition by cetagliptin 100 mg was higher than that mediated by sitagliptin 100 mg. Cetagliptin was well tolerated up to a single oral dose of 400 mg. No food effects were noted.

Conclusions: Cetagliptin inhibited plasma dipeptidyl peptidase-4 activity, increased levels of active glucagon-like peptide-1 and was well tolerated at single doses up to 400 mg, eliciting no dose-limiting toxicity in healthy volunteers. Food did not affect the pharmacokinetics of cetagliptin.

Clinical Trial Registration: The studies were registered at http://www.chinadrugtrials.org.cn (Nos. CTR20180167 and CTR20181331).
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http://dx.doi.org/10.1007/s40261-021-01088-5DOI Listing
November 2021

Dietary Polysaccharide from Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-Producing Bacterium, , in Mice Fed a High-Fat Diet.

Polymers (Basel) 2021 Sep 26;13(19). Epub 2021 Sep 26.

Key Laboratory of Marine Drugs of Ministry of Education, and Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Previous studies have suggested that polysaccharide from (ECP) could be used as a potential prebiotic to treat dysbiosis-associated diseases. However, whether it has any therapeutic effects on obesity has not been investigated. In the present study, we explored the anti-obesity effect of ECP and illustrated that it can significantly reduce the body weight and decrease the serum levels of triacylglycerol and cholesterol in high-fat diet (HFD)-fed mice. As revealed by 16S rRNA high-throughput sequencing and bioinformatic analysis, HFD remarkably changed the composition of the gut microbiota and promoted the growth of opportunistic pathogens such as Mucispirillum, Desulfobacterota and Alphaproteobacteria in obese mice. Interestingly, ECP improved intestinal dysbiosis caused by HFD and reshaped the structure of the gut microbiota in diseased mice by increasing the abundance of butyrate-producing bacterium, , in the gut. Altogether, we demonstrate for the first time an anti-obesity effect of ECP and shed new light into its therapeutic mechanisms from the perspective of gut microbiota. Our study will pave the way for the development of ECP as new prebiotic for the treatment of obesity and its associated disorders.
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http://dx.doi.org/10.3390/polym13193286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512240PMC
September 2021

Comparison of three ionic liquids pretreatment of Arundo donax L. For enhanced photo-fermentative hydrogen production.

Bioresour Technol 2022 Jan 5;343:126088. Epub 2021 Oct 5.

Key Laboratory of New Materials and Facilities for Rural Renewable Energy of Ministry of Agriculture and Rural Affairs of China, Henan Agricultural University, Zhengzhou 450002, PR China. Electronic address:

Ionic liquids (ILs) pretreatment has been regarded as a promising green way to treat lignocellulosic biomass. 1-Butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF), 1-allyl-3-methylimidazolium chloride ([Amim]Cl), and 1-Butyl-3-methylimidazolium Hydrogen Sulfate ([Bmim]HSO) with different loadings (2, 4, 8, and 16 g/L) were adopted to pretreat the Arundo donax L.. 16 g/L [Bmim]HSO pretreated Arundo donax L. obtained the highest sugar yield of 7.9 g/L during the enzymatic hydrolysis and hydrogen yield of 106.1 mL/g TS during the photo-fermentation, which were 68.8 % and 35.3 % higher than those of untreated Arundo donax L., respectively. Moreover, volatile fatty acids (VFAs) distribution revealed that acetic acid was the main by-product during hydrogen production process with ILs pretreated Arundo donax L.. Besides, the relationship between sugar yield and hydrogen yield was the closest based on scatter matrix analysis. This study helps to understand of correlation between ILs pretreatment with the behavior of bioenergy production.
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http://dx.doi.org/10.1016/j.biortech.2021.126088DOI Listing
January 2022

-Body Reduced Density Matrix-Based Valence Bond Theory and Its Applications in Diabatic Electronic-Structure Computations.

Acc Chem Res 2021 10 6;54(20):3895-3905. Epub 2021 Oct 6.

Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, The State Key Laboratory of Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.

Valence bond (VB) theory, as a helpful complement to the more popular molecular orbital theory, is a fundamental electronic-structure theory that aims at interpreting molecular structure and chemical reactions in a lucid way. Both theoretical and experimental chemists have shown great interest in VB theory because of its capability of providing intuitive insight into the nature of chemical bonding and the mechanism of chemical reaction in a clear and comprehensible language rooted in Lewis structure. Therefore, there is a great call for the renaissance of VB theory. Nevertheless, this is possible only after a series of methods and algorithms were developed and efficiently implemented in user-friendly programs so as to serve computational chemists for general applications. In the past three decades, we have devoted a great amount of scientific enthusiasm toward this goal. In this Account, we will concisely summarize and briefly but insightfully discuss recent developments in VB theory, especially the -body reduced density matrices (RDM)-based approach and its applications in diabatic electronic-structure computations, which is very useful for the vivid interpretation of many fundamental chemical processes such as electron and energy transfers. Furthermore, because of the fundamentally important role that the diabatic state plays in electron and energy transfers, which are two frontier research topics in both molecular and biochemical sciences, there are a broad range of applications that VB theory can handle.We start by briefly reviewing the general feature of VB wave functions. In particular, we focus on the multistructural VB theory that uses strictly localized orbitals, including the fundamental VB self-consistent field (VBSCF) and two post-SCF methods, VBCI and VBPT2, that use the VBSCF wave function as reference. We then allot a section to describing the recent developments of the RDM-based VB approach in the second quantization language. In this section, the enhanced Wick theorem is first outlined, followed by a brief discussion of its applications in evaluating VBSCF energy gradients and a Hessian with respect to the orbital expansion coefficients, together with a short review of the implementation of an automatic formula and code generator (AFCG) designed for many-body methods with nonorthogonal orbitals. Then, we introduce the application of the RDM-based approach in implementing the post-SCF method that addresses dynamic electronic correlation via perturbation theory, viz., the icVBPT2 method that adopts an internal contraction technique naturally. We finish this section by incorporating VB theory with the concept of seniority number, in which the tensor analysis technique is carefully exploited with the RDM-based approach, resulting in significant improvements in both the number of the active electrons/orbitals and in the speedup of the computational efficiency, thus pushing VB theory to its new limit. With these achievements available, we present the applications of VB theory in diabatic electronic-structure computations by using the intuitive insight rendered by VB theory. Therefore, we believe that there is a bright future in VB theory with true opportunities and new challenges coexisting both for theoretical developments and computational applications.
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http://dx.doi.org/10.1021/acs.accounts.1c00421DOI Listing
October 2021

208-µs single-shot multi-molecular sensing with spectrum-encoded dual-comb spectroscopy.

Opt Express 2021 Aug;29(17):27600-27611

Dual-comb spectroscopy (DCS) is a powerful spectroscopic technique, which is developing for the detection of transient species in reaction kinetics on a short time scale. Conventionally, the simultaneous determination of multiple species is limited to the requirement of broadband spectral measurement at the cost of the measurement speed and spectral resolution owing to the inherent trade-off among these characteristics in DCS. In this study, a high-speed multi-molecular sensing is demonstrated and achieved through using a programmable spectrum-encoded DCS technique, where multiple narrow encoding spectral bands are reserved selectively and other comb lines are filtered out. As a dual-comb spectrometer with a repetition rate of 108 MHz is encoded spectrally over a spectral coverage range of 1520 to 1580 nm, the measurement speed is increased 6.15 times and single-shot absorption spectra of multiple molecules (CH, HCN, CO, CO) at a time scale of 208 µs are obtained. Compared to conventional single-shot dual-comb spectra, encoded dual-comb spectra have improved short-term signal-to-noise ratios (SNRs) by factors of 3.65 with four encoding bands and 5.68 with two encoding bands. Furthermore, a fiber-Bragg-grating-based encoded DCS is demonstrated, which reaches 17.1 times higher average SNR than that of the unencoded DCS. This spectrum-encoded technique can largely improve the DCS measurement speed, and thus is promising for use in studies on multi-species reaction kinetics.
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http://dx.doi.org/10.1364/OE.430026DOI Listing
August 2021

Two-step complete splenic artery embolization for the management of symptomatic sinistral portal hypertension.

Scand J Gastroenterol 2021 Sep 28:1-7. Epub 2021 Sep 28.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Sinistral portal hypertension (SPH) is a rare clinical syndrome. The purpose of this study was to assess the clinical outcomes and safety of splenic artery embolization (SAE) in the treatment of SPH.

Methods: This retrospective study included 39 SPH patients who underwent SAE treatment between August 2009 and May 2021. The cases had esophageal, gastric, or ectopic varices detected by endoscopy or enhanced CT, with symptoms or signs of upper gastrointestinal (GI) bleeding and/or postprandial fullness. Clinical symptom improvement rate, complications, and symptomatic recurrence rate were observed and analyzed after treatment.

Results: All the procedures were performed successfully. Of all patients, 17 received the 2-step complete SAE procedure, 19 received only the first step of the 2-step protocol (i.e., partial splenic embolization [PSE] procedure), and the remaining three received the 1-step complete SAE procedure. After the procedures, the symptoms completely disappeared in all patients, and the main complications were post-embolization syndromes, with 27 patients (69.2%) developing a low-grade fever, 24 (61.5%) developing abdominal pain and 4 (10.3%) developing nausea or mild vomiting. During the prolonged follow-up, varicose veins were gradually reduced as detected by enhanced CT; liver function parameters and platelet count remained in the normal range. Only one patient who underwent PSE treatment developed upper GI rebleeding 7 months after the procedure.

Conclusion: Two-step complete SAE is a safe and feasible procedure for the treatment of symptomatic SPH.
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http://dx.doi.org/10.1080/00365521.2021.1983641DOI Listing
September 2021

Differential Expression Pattern of Goat Uterine Fluids Extracellular Vesicles miRNAs during Peri-Implantation.

Cells 2021 09 3;10(9). Epub 2021 Sep 3.

College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Early pregnancy failure occurs when a mature embryo attaches to an unreceptive endometrium. During the formation of a receptive endometrium, extracellular vesicles (EVs) of the uterine fluids (UFs) deliver regulatory molecules such as small RNAs to mediate intrauterine communication between the embryo and the endometrium. However, profiling of small RNAs in goat UFs' EVs during pregnancy recognition (day 16) has not been carried out. In this study, EVs were isolated from UFs on day 16 of the estrous cycle or gestation. They were isolated by Optiprep™ Density G radient (ODG) and verified by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blotting. Immunostaining demonstrated that CD63 was present both in the endometrial epithelium and glandular epithelium, and stain intensity was greater in the pregnant endometrium compared to the non-pregnant endometrium. Small RNA sequencing revealed that UFs' EVs contained numerous sRNA families and a total of 106 differentially expressed miRNAs (DEMs). Additionally, 1867 target genes of the DEMs were obtained, and miRNA-mRNA interaction networks were constructed. GO and KEGG analysis showed that miRNAs were significantly associated with the formation of a receptive endometrium and embryo implantation. In addition, the fluorescence in situ hybridization assay (FISH) showed that chi-miR-451-5p was mainly expressed in stromal cells of the endometrium and a higher level was detected in the endometrial luminal epithelium in pregnant states. Moreover, the dual-luciferase reporter assay showed that chi-miR-451-5p directly binds to PSMB8 and may play an important role in the formation of a receptive endometrium and embryo implantation. In conclusion, these results reveal that UFs' EVs contain various small RNAs that may be vital in the formation of a receptive endometrium and embryo implantation.
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http://dx.doi.org/10.3390/cells10092308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470123PMC
September 2021

Endovascular repair of traumatic aortic dissection: a single-center experience.

Rev Cardiovasc Med 2021 Sep;22(3):1029-1035

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China.

The data on endovascular aortic repair (EVAR) for traumatic aortic dissection (TAD) are lacking. Hence, this study aimed to evaluate the efficacy of EVAR for TAD and report our experience based on patients from our medical center with a relatively long follow-up. A total of 25 consecutive patients with TAD underwent EVAR from October 2015 to October 2020. The demographics, imaging characteristics, clinical features, treatment details, and follow-up results were reviewed. Urgent EVAR was performed in 3 patients (12%), while the remaining 22 patients (88%) underwent delayed EVAR. Systematic heparinization was used in all patients during the endovascular procedure. The EVAR was technically successful in all patients, with no cases converted into open surgery. No death occurred during the perioperative period. One patient presented with a type II endoleak on postoperative 1-month CT images during a mean follow-up of 42.3 ± 17.7 months (5-67.5 months) and showed spontaneous regression of the endoleak without any intervention during the subsequent follow-up. All the patients survived until the time of writing, and none of them showed late endoleak, stent migration, paraplegia, and reintervention. The patients with left subclavian artery covered (n = 8) had no obvious ischemia of the arm and brain. The study results demonstrated that EVAR for TAD proved to be safe and effective, and most patients could undergo delayed EVAR. Systematically heparinization during EVAR under the setting of multi-trauma was safe.
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http://dx.doi.org/10.31083/j.rcm2203112DOI Listing
September 2021

Reductive destruction of multiple nitrated energetics over palladium nanoparticles in the H-based membrane catalyst-film reactor (MCfR).

J Hazard Mater 2022 Feb 31;423(Pt A):127055. Epub 2021 Aug 31.

Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, AZ, USA.

Nitrated energetics are widespread contaminants due to their improper disposal from ammunition facilities. Different classes of nitrated energetics commonly co-exist in ammunition wastewater, but co-removal of the classes has hardly been documented. In this study, we evaluated the catalytic destruction of three types of energetics using palladium (Pd) nano-catalysts deposited on H-transfer membranes in membrane catalyst-film reactors (MCfRs). This work documented nitro-reduction of 2,4,6-trinitrotoluene (TNT), as well as, for the first time, denitration of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and pentaerythritol tetranitrate (PETN) over Pd at ambient temperature. The catalyst-specific activity was 20- to 90-fold higher than reported for other catalyst systems. Nitrite (NO) released from RDX and PETN also was catalytically reduced to dinitrogen gas (N). Continuous treatment of a synthetic wastewater containing TNT, RDX, and PETN (5 mg/L each) for more than 20 hydraulic retention times yielded removals higher than 96% for all three energetics. Furthermore, the concentrations of NO and NH were below the detection limit due to subsequent NO reduction with > 99% selectivity to N. Thus, the MCfR provides a promising strategy for sustainable catalytic removal of co-existing energetics in ammunition wastewater.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127055DOI Listing
February 2022

Transcatheter Arterial Embolization Containing Donafenib Induces Anti-Angiogenesis and Tumoricidal CD8 T-Cell Infiltration in Rabbit VX2 Liver Tumor.

Cancer Manag Res 2021 7;13:6943-6952. Epub 2021 Sep 7.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.

Purpose: To evaluate the effect and immune response of transcatheter arterial embolization (TAE) combined with donafenib in rabbit VX2 liver tumor model.

Materials And Methods: Thirty-six New Zealand white rabbits with VX2 liver tumor were randomly divided into three groups. The LD group was treated with the emulsion of 0.5 mL lipiodol and 4 mg donafenib via hepatic arterial administration. The LE group was treated with the emulsion of 0.5 mL lipiodol and 4 mg epirubicin. The control group was treated with the equal volume of saline. Four rabbits were euthanized in each group on day 1, 3 and 7 after treatment. The tumor growth, histological markers associated with angiogenesis and immune response were assessed by imaging and histopathology. In addition, immune modulatory cytokines included interleukin (IL)-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and biochemical hepatorenal function were measured.

Results: Compared to other groups, LD group achieved lower tumor growth rate, fewer metastatic lesions, and higher tumor necrosis rate on day 7 after treatment. The percentage of CD31-positive area in the LD group was significantly lower than that in the LE group on day 3 and 7 after treatment. In addition, CD8 lymphocytes infiltration was more pronounced in LD group than in LE group on day 7 after treatment, regardless of in the tumor or adjacent liver tissue. Serum cytokines including IL-6, TNF-α and IFN-γ were strongly upregulated in the LD group on day 1 after treatment. And there was no significant difference in the hepatorenal function between LD group and LE group after treatment.

Conclusion: The combination of TAE and angiogenesis inhibitor donafenib resulted in a potentiated tumoricidal effect, anti-angiogenesis and antitumour T cell response in rabbit VX2 liver tumor model. This may provide a potential basis for exploring the immune-related mechanisms of embolization in liver cancer.
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http://dx.doi.org/10.2147/CMAR.S328294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434853PMC
September 2021

Increased Liquefactive Necrosis Formation After Transarterial Chemoembolization Combined with Molecular Targeted Agents Plus Immune Checkpoint Inhibitors for Hepatocellular Carcinoma.

Cancer Manag Res 2021 7;13:6935-6941. Epub 2021 Sep 7.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.

Purpose: In clinical practice, we found some of the patients who received transarterial chemoembolization (TACE) with molecular targeted agents (MTGs) plus immune checkpoint inhibitors (ICIs) for hepatocellular carcinoma (HCC) had obvious liquefactive necrosis formation within the tumor and some even progressed to a liver abscess, which seems more frequent than patients who received other treatments. Thus, we aim to identify this condition and analyze the potential risk factors.

Patients And Methods: Medical records of 72 consecutive patients with intermediate (BCLC B) and advanced (BCLC C) HCC who received TACE plus MTGs combined with (n=30) or without (n=42) ICIs were reviewed. Liquefactive necrosis formation was defined as the presence of obvious liquefactive necrosis within the tumor that required intervention.

Results: The liquefactive necrosis rate was higher in the TACE+MTGs+ICIs group than in the TACE+MTGs group (30% vs 4.8%, P=0.006). Moreover, 18.2% (2/11) of the patients with liquefactive necrosis within the tumor had a bacterial infection. We then take the binary logistic regression analysis model to identify the predictors of liquefactive necrosis formation, and which showed the tumor size (P=0.006, OR=1.355, 95% CI: 1.090-1.684), alpha-fetoprotein level (P=0.036, OR=6.745, 95% CI: 1.130-40.262) and treatment modality (P=0.015, OR=11.717, 95% CI: 1.617-84.887) were the independent risk factor for liquefactive necrosis formation within the tumor.

Conclusion: Patients with HCC who received TACE combined with MTGs plus ICIs have increased liquefactive necrosis formation, and the larger tumor size and higher alpha-fetoprotein level were associated with more liquefactive necrosis formation within the tumor.
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http://dx.doi.org/10.2147/CMAR.S328812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434848PMC
September 2021

Physiologically based pharmacokinetic/pharmacodynamic modeling to evaluate the absorption of midazolam rectal gel.

Eur J Pharm Sci 2021 Dec 11;167:106006. Epub 2021 Sep 11.

Phase I Clinical Trial Unit, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China; Department of Clinical Pharmacology, School of Pharmacy College, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Objective: We aimed to 1) develop physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models of a novel midazolam rectal gel in healthy adults, 2) assess the contribution of different physiologically relevant factors in rectal absorption, and 3) to provide supports for future clinical studies of midazolam rectal gel.

Methods: We developed the rectal PBPK model after built the intravenous and the oral PBPK model. Then, the physiological progress of rectal route was described in terms of the drug release, the rectal absorption and the particle first-pass elimination. Next, the validated PBPK model was combined with the sigmoid E PD model. This PBPK/PD model was used to identify the dose range and the critical parameters to ensure safety sedation.

Results: Based on the simulations, the recommended maximum dose for adults' sedation was 15 mg. And the retention time of midazolam rectal gel should be longer than 3 h to reach over 80% pharmacokinetics and pharmacodynamics effects.

Conclusion: We successfully developed a PBPK/PD model for the midazolam rectal gel, which accurately described the PK/PD behavior in healthy adults and indicated the transit time of rectum was the most sensitive parameter for absorption. This PBPK/PD model would be expected to support the future clinical studies and pediatric application.
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http://dx.doi.org/10.1016/j.ejps.2021.106006DOI Listing
December 2021

Decline of three farmland pest species in rapidly urbanizing landscapes.

iScience 2021 Sep 19;24(9):103002. Epub 2021 Aug 19.

Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, Institute of Biodiversity Science and Institute of Eco-Chongming, School of Life Sciences, Fudan University, Shanghai 200438, China.

Urbanization is a pressing challenge for earth's humans because it is changing not only natural environments but also agricultural lands. Yet, the consequences of cropland loss on pest insect populations that largely depend on these habitats remain largely unclear. We used a 17-year data set to investigate the dynamics of three moth pest species (i.e., striped stem borer, yellow stem borer, and pink stem borer) and their driving forces across the largest mega-urban region of China. Total abundance of three pest species is declined by about 80%, which was strongly associated with cropland loss during rapid urbanization. Our findings indicate that not only the increasing conversion of natural areas to human-dominated landscapes but also that of agricultural lands to urban landscapes can be critical to insect populations. It is therefore essential to monitor and understand the insect dynamics in rapidly urbanizing regions, which are currently found in many developing countries worldwide.
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http://dx.doi.org/10.1016/j.isci.2021.103002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411231PMC
September 2021

Current understanding of ferroptosis in the progression and treatment of pancreatic cancer.

Cancer Cell Int 2021 Sep 9;21(1):480. Epub 2021 Sep 9.

Department of General Surgery, Gansu Province, The First Hospital of Lanzhou University, No. 1, Donggang West Road, Chengguan District, Lanzhou City, 730000, China.

Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accumulation and lipid peroxidation. Recent studies have found that ferroptosis plays an important role in the development and treatment response of tumours, particularly pancreatic cancer. This article reviews the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer.
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http://dx.doi.org/10.1186/s12935-021-02166-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427874PMC
September 2021
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