Publications by authors named "Chen Zhang"

2,835 Publications

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Identification of the Early Steps in Herbicidin Biosynthesis Reveals an Atypical Mechanism of -Glycosylation.

J Am Chem Soc 2022 Aug 18. Epub 2022 Aug 18.

Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.

Herbicidins are adenosine-derived nucleoside antibiotics with an unusual tricyclic core structure. Deletion of the genes responsible for formation of the tricyclic skeleton in sp. L-9-10 reveals the o importance of Her4, Her5, and Her6 in the early stages of herbicidin biosynthesis. o characterization of Her4 and Her5 demonstrates their involvement in an initial, two-stage C-C coupling reaction that results in net C5'-glycosylation of ADP/ATP by UDP/TDP-glucuronic acid. Biochemical analyses and intermediate trapping experiments imply a noncanonical mechanism of -glycosylation reminiscent of NAD-dependent -adenosylhomocysteine (SAH)-hydrolase catalysis. Structural characterization of the isolated metabolites suggests possible reactions catalyzed by Her6 and Her7. An overall herbicidin biosynthetic pathway is proposed based on these observations.
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http://dx.doi.org/10.1021/jacs.2c05728DOI Listing
August 2022

Winning and losing in online gambling: Effects on within-session chasing.

PLoS One 2022 18;17(8):e0273359. Epub 2022 Aug 18.

Department of Experimental Psychology, Ghent University, Ghent, Belgium.

The tendency to continue or intensify gambling after losing (loss-chasing) is widely regarded as a defining feature of gambling disorder. However, loss-chasing in real gambling contexts is multifaceted, and some aspects are better understood than others. Gamblers may chase losses between multiple sessions or within a single session. Furthermore, within a session, loss-chasing can be expressed in the decision of (1) when to stop, (2) how much stake to bet, and (3) the speed of play after winning and losing. Using a large player-tracking data set (>2500 players, >10 million rounds) collected from the online commercial game Mystery Arena, we examined these three behavioral expressions of within-session loss-chasing. While the first two aspects (when to stop and how much stake to bet) have been examined previously, the current research is the first large-scale study to examine the effects of wins and losses on the speed of play in real gambling. The players were additionally assigned different involvement levels by the operator based on their gambling behavior on the operator's own platform, which further allowed us to examine group differences in loss-chasing. We found that after winning, both the high- and low-involvement groups were less likely to stop, and increased the stake amount, thus showing win-chasing instead of loss-chasing in these two facets. After losing, both groups played more quickly though, which may reflect an urge to continue gambling (as an expression of loss-chasing). Wins and losses had a smaller influence on the speed of play for the high-involvement players, suggesting that they might have reduced sensitivity to wins and/or losses. Future work can further examine chasing in different gambling products and in people with gambling problems to assess the generalizability of these findings.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273359PLOS
August 2022

Novel One-Dimensional Nanofiber MnSe/CMK-3 High-Performance Cathode Material for Aluminum Batteries.

ACS Appl Mater Interfaces 2022 Aug 15. Epub 2022 Aug 15.

Hebei Key Laboratory of Optic-Electronic Information and Materials, National & Local Joint Engineering Laboratory of New Energy Photoelectric Devices, College of Physics Science and Technology, Hebei University, Baoding 071002, China.

Transition metal selenides have shown outstanding performance as cathode materials for aluminum-ion batteries and have thus become a popular choice for cathode materials. Herein, Mn-based carbon fibers (Mn/CNFs) were first synthesized by electrospinning as a precursor, and then MnSe composites were prepared by a melt-diffusion method. However, due to polyselenides and selenides being generated during electrochemical reactions, the cycling stability of MnSe cathode materials is poor. After 200 cycles, the discharge specific capacity is only 176 mA h/g. To suppress the shuttle effect of selenides and polyselenides, a CMK-3-modified separator was used instead of a glass fiber separator. Compared with MnSe-800, the replaced MnSe-800/CMK-3 has a great capacity improvement; the initial discharge specific capacity is 1029.85 mA h/g, which after 3000 cycles, still remains at 297.84 mA h/g. The soft pack battery can still light up the LED normally under different degrees of folding, which proves the application of this material in wearable devices. This work provides a new way to improve the performance of transition metal selenides.
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http://dx.doi.org/10.1021/acsami.2c10170DOI Listing
August 2022

Discovery of antibacterial agents targeting biofilm formation: total synthesis and investigation of amycolasporins.

Org Biomol Chem 2022 Aug 15. Epub 2022 Aug 15.

Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.

Three monoterpene alkaloids amycolasporin A and (±) amycolasporins B and C have been synthesized for the first time from commercially available materials in yields of 31%, 14% and 21%, respectively. Their six analogues (18, 19, 30a and 30d-30f) were synthesized through a similar protocol. Meanwhile, the antibacterial activity of all synthesized molecules was evaluated, showing different levels of bioactivity. Among them, analogue 30d was screened as the most effective antibacterial candidate against (MIC value, 12.5 μg mL) and . (MIC value, 12.5 μg mL). Further investigation showed that 30d obviously inhibited biofilm formation and disrupted the preformed biofilm of . and . by promoting intracellular ROS release.
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http://dx.doi.org/10.1039/d2ob01166bDOI Listing
August 2022

Multidrug-resistant is predisposed to mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients.

Front Cell Infect Microbiol 2022 27;12:934439. Epub 2022 Jul 27.

Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Multidrug-resistant (MDR) is a frequent opportunistic pathogen that causes significant mortality in patients with non-cystic fibrosis bronchiectasis (NCFB). Although the quorum sensing (QS) system is a potential target for treatment, mutants that present with a QS-deficient phenotype have been frequently reported among clinical isolates. We aimed to investigate whether antibiotic resistance would select for mutants during chronic lung infection and determine the mechanism underlying the phenomenon.

Methods: We prospectively evaluated episodes of chronic lung infections in NCFB patients over a 2-year period at two centers of our institution. QS phenotypic assessments and whole-genome sequencing (WGS) of isolates were performed. Evolution experiments were conducted to confirm the emergence of mutants in clinical MDR cultures.

Results: We analyzed episodes of infection among 97 NCFB patients and found only prior carbapenem exposure independently predictive of the isolation of MDR strains. Compared with non-MDR isolates, MDR isolates presented significantly QS-deficient phenotypes, which could not be complemented by the exogenous addition of 3OC12-HSL. The paired isolates showed that their QS-phenotype deficiency occurred after MDR was developed. Whole-genome sequencing analysis revealed that nonsynonymous mutations were significantly more frequent in MDR isolates, and positive correlations of mutation frequencies were observed between genes of and negative-efflux-pump regulators ( and ). The addition of the efflux pump inhibitor PAβN could not only promote QS phenotypes of these MDR isolates but also delay the early emergence of mutants in evolution experiments.

Conclusions: Our data indicated that MDR was predisposed to mutation through the upregulated activity of efflux pumps. These findings suggest that anti-QS therapy combined with efflux pump inhibitors might be a potential strategy for NCFB patients in the challenge of MDR infections.
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http://dx.doi.org/10.3389/fcimb.2022.934439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363577PMC
August 2022

A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis.

Acta Pharm Sin B 2022 Aug 2;12(8):3367-3382. Epub 2022 Apr 2.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.

With the development of synthesis technology, modified messenger RNA (mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient delivery of IL-10 mRNA. IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment.
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http://dx.doi.org/10.1016/j.apsb.2022.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366313PMC
August 2022

Tracking of menstrual cycles and prediction of the fertile window via measurements of basal body temperature and heart rate as well as machine-learning algorithms.

Reprod Biol Endocrinol 2022 Aug 13;20(1):118. Epub 2022 Aug 13.

Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, No. 419, Fangxie Rd, Shanghai, 200011, China.

Background: Fertility awareness and menses prediction are important for improving fecundability and health management. Previous studies have used physiological parameters, such as basal body temperature (BBT) and heart rate (HR), to predict the fertile window and menses. However, their accuracy is far from satisfactory. Additionally, few researchers have examined irregular menstruators. Thus, we aimed to develop fertile window and menstruation prediction algorithms for both regular and irregular menstruators.

Methods: This was a prospective observational cohort study conducted at the International Peace Maternity and Child Health Hospital in Shanghai, China. Participants were recruited from August 2020 to November 2020 and followed up for at least four menstrual cycles. Participants used an ear thermometer to assess BBT and wore the Huawei Band 5 to record HR. Ovarian ultrasound and serum hormone levels were used to determine the ovulation day. Menstruation was self-reported by women. We used linear mixed models to assess changes in physiological parameters and developed probability function estimation models to predict the fertile window and menses with machine learning.

Results: We included data from 305 and 77 qualified cycles with confirmed ovulations from 89 regular menstruators and 25 irregular menstruators, respectively. For regular menstruators, BBT and HR were significantly higher during fertile phase than follicular phase and peaked in the luteal phase (all P < 0.001). The physiological parameters of irregular menstruators followed a similar trend. Based on BBT and HR, we developed algorithms that predicted the fertile window with an accuracy of 87.46%, sensitivity of 69.30%, specificity of 92.00%, and AUC of 0.8993 and menses with an accuracy of 89.60%, sensitivity of 70.70%, and specificity of 94.30%, and AUC of 0.7849 among regular menstruators. For irregular menstruators, the accuracy, sensitivity, specificity and AUC were 72.51%, 21.00%, 82.90%, and 0.5808 respectively, for fertile window prediction and 75.90%, 36.30%, 84.40%, and 0.6759 for menses prediction.

Conclusions: By combining BBT and HR recorded by the Huawei Band 5, our algorithms achieved relatively ideal performance for predicting the fertile window and menses among regular menstruators. For irregular menstruators, the algorithms showed potential feasibility but still need further investigation.

Trial Registration: ChiCTR2000036556. Registered 24 August 2020.
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http://dx.doi.org/10.1186/s12958-022-00993-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375297PMC
August 2022

Multi-omics analysis revealed the role of extracellular vesicles in hepatobiliary & pancreatic tumor.

J Control Release 2022 Aug 13;350:11-25. Epub 2022 Aug 13.

Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, PR China; Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Hubei, PR China. Electronic address:

Liquid biopsy is rapidly growing into a hot research field due to its unique advantages of minimal invasiveness, and extracellular vesicle (EVs) are also expected to become an important pillar in the diagnostic technology system as a newly discovered active substance carrier. More and more research has highlighted the important contribution of EVs in the progress of tumor. Molecular changes during disease progression could be detected in EVs. However, the diagnostic applications of EVs are not generally understood. Combined with the characteristics of hepatobiliary and pancreatic tumor, we summarized the recent developments in various omics analysis of EVs. Furtherly, we explored the role of EVs in the early diagnosis of hepatobiliary and pancreatic tumors by multi-omics analysis.
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http://dx.doi.org/10.1016/j.jconrel.2022.08.010DOI Listing
August 2022

Immune activation after intraventricular hemorrhage.

J Stroke Cerebrovasc Dis 2022 Aug 10;31(10):106696. Epub 2022 Aug 10.

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.

Objectives: Intraventricular hemorrhage (IVH) is a subtype of stroke which has high mortality and morbidity, while comprehensive mechanism investigations and effective therapies are still in great need. Plenty of studies have shown that inflammation after stroke plays a critical role in disease outcomes. However, the inflammation after IVH remains unclear. This study aims to observe the immune response after IVH, thus providing therapeutic targets for IVH treatments.

Materials And Methods: IVH was induced by autologous blood infusion model in SD rats. Totally 588 rats were assigned either in the sham or IVH group. T2* lesion and hemoglobin quantities, ventricular volume, brain edema, ventricular wall damage, blood-brain-barrier (BBB) continuity and immune response were observed by magnetic resonance image (MRI), hematoxylin-eosin staining (HE), Evans Blue, flow cytometry (FACS), and enzyme-linked immunosorbent assay (ELISA) at baseline, 6 h, 1 d, 3 d, 7 d, 14 d after surgery.

Results: We found that ventricular volume enlargement occurred hours after IVH and peaked at 3 d after IVH, then mildly reduced till 14 d. Similar changes happened in brain edema, ventricular wall damage and BBB leakage. Immune cells and cytokines in the central nervous system and peripheral blood also increased after IVH and experienced similar trends as ventricular enlargement. T2* lesion and hemoglobin degradation occurred 6 h after IVH and kept decreasing till 14 d after IVH.

Conclusions: Our investigation illustrates that immune response exists after IVH, which may have a close relationship with disease outcomes. These results may provide promising immune related clues for mechanism and intervention studies in IVH.
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2022.106696DOI Listing
August 2022

Extraction, purification, structural features and biological activities of longan fruit pulp (Longyan) polysaccharides: A review.

Front Nutr 2022 25;9:914679. Epub 2022 Jul 25.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

. (also called as longan) is a subtropical and tropical evergreen tree belonging to the Sapindaceae family and is widely distributed in China, Southeast Asia and South Asia. The pulp of longan fruit is a time-honored traditional medicinal and edible raw material in China and some Asian countries. With the advancement of food therapy in modern medicine, longan fruit pulp as an edible medicinal material is expected to usher in its rapid development as a functional nutrient. As one of the main constituents of longan fruit pulp, longan fruit pulp polysaccharides (LPs) play an indispensable role in longan fruit pulp-based functional utilization. This review aims to outline the extraction and purification methods, structural characteristics and biological activities (such as immunoregulatory, anti-tumor, prebiotic, anti-oxidant, anti-inflammatory and inhibition of AChE activity) of LPs. Besides, the structure-activity relationship, application prospect and patent application of LPs were analyzed and summarized. Through the systematic summary, this review attempts to provide a theoretical basis for further research of LPs, and promote the industrial development of this class of polysaccharides.
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http://dx.doi.org/10.3389/fnut.2022.914679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358249PMC
July 2022

Exploring organic micropollutant biodegradation under dynamic substrate loading in rapid sand filters.

Water Res 2022 Aug 7;221:118832. Epub 2022 Jul 7.

Environmental Technology, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. Electronic address:

Microbial removal of trace organic micropollutants (OMPs) from drinking water sources remains challenging. Nitrifying and heterotrophic bacteria in rapid sand filters (RSFs) are capable of biodegrading OMPs while growing on ammonia and dissolved organic matter (DOM). The loading patterns of ammonia and DOM may therefore affect microbial activities as well as OMP biodegradation. So far, there is very limited information on the effect of substrate loading on OMP biodegradation at environmentally relevant concentrations (∼ 1 µg/L) in RSFs. We investigated the biodegradation rates of 16 OMPs at various substrate loading rates and/or empty bed contact times (EBCT). The presence of DOM improved the biodegradation of paracetamol (41.8%) by functioning as supplementary carbon source for the heterotrophic degrader, while hindering the biodegradation of 2,4-D, mecoprop and benzotriazole due to substrate competition. Lower loading ratios of DOM/benzotriazole benefited benzotriazole biodegradation by reducing substrate competition. Higher ammonia loading rates enhanced benzotriazole removal by stimulating nitrification-based co-metabolism. However, stimulating nitrification inhibited heterotrophic activity, which in turn inhibited the biodegradation of paracetamol, 2,4-D and mecoprop. A longer EBCT promoted metformin biodegradation as it is a slowly biodegradable compound, but suppressed the biodegradation of paracetamol and benzotriazole due to limited substrate supply. Therefore, the optimal substrate loading pattern is contingent on the type of OMP, which can be chosen based on the priority compounds in practice. The overall results contribute to understanding OMP biodegradation mechanisms at trace concentrations and offer a step towards enhancing microbial removal of OMPs from drinking water by optimally using RSFs.
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http://dx.doi.org/10.1016/j.watres.2022.118832DOI Listing
August 2022

Serum complement C1q level is associated with left ventricular hypertrophy induced by coarctation of the aorta: A retrospective observational study.

BMC Cardiovasc Disord 2022 08 10;22(1):367. Epub 2022 Aug 10.

Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing, 100029, China.

Background: The complement system plays an important role in the development of left ventricular hypertrophy. Complement C1q is an initial component of the classical complement pathway and is related to many inflammatory diseases. We aimed to determine whether there was an association between serum complement C1q and left ventricular hypertrophy induced by coarctation of the aorta (CoA).

Methods: Based on whether CoA was combined with a large ventricular septal defect (VSD) or patent ductus arteriosus (PDA), the patients were divided into a simple CoA group (n = 15) and a complex CoA group (n = 13). Meanwhile, we selected simple large VSD (n = 14) patients and normal children (n = 28) as the control group. The serum complement C1q level was compared using immunity transmission turbidity among different groups.

Results: The preoperative content of C1q in the simple CoA group was significantly lower than that in the complex CoA group and normal group (96.97 ± 20.66 vs. 130.73 ± 35.78, 96.97 ± 20.66 vs. 156.21 ± 29.14, P < 0.05). There was no significant difference in the preoperative content of C1q between the complex CoA group and the large VSD group (P > 0.05). There was a negative correlation between the preoperative complement C1q content and the interventricular septal thickness and left ventricular posterior wall thickness (r = - 0.035, r = - 0.288, P < 0.05). The percentage of postoperative decrease in C1q in children with simple CoA or complex CoA was positively correlated with the time of cardiopulmonary bypass and aortic cross clamp, respectively (r = 0.797, r = 0.622, r = 0.898, r = 0.920, P < 0.05). There was no significant difference in the content of preoperative triglycerides (TG), total cholesterol (TCHO), high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) among the different groups (P > 0.05). In the simple CoA group and complex CoA group, the preoperative complement C1q, TG, TCHO, HDL-C and LDL-C levels were significantly higher than those after the operation (P < 0.05). There was no significant correlation between preoperative complement C1q and TG, TCHO, HDL-C or LDL-C (P > 0.05).

Conclusions: Complement C1q has an inhibitory effect on the formation of left ventricular hypertrophy, which may not be mediated by regulating lipid metabolism. During cardiac surgery, complement C1q may have a protective effect against myocardial injury.
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http://dx.doi.org/10.1186/s12872-022-02807-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364524PMC
August 2022

Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial.

JAMA Surg 2022 Aug 10. Epub 2022 Aug 10.

Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Importance: Older patients may benefit from the hemodynamic stability of etomidate for general anesthesia. However, it remains uncertain whether the potential for adrenocortical suppression with etomidate may increase morbidity.

Objective: To test the primary hypothesis that etomidate vs propofol for anesthesia does not increase in-hospital morbidity after abdominal surgery in older patients.

Design, Setting, And Participants: This multicenter, parallel-group, noninferiority randomized clinical trial (Etomidate vs Propofol for In-hospital Complications [EPIC]) was conducted between August 15, 2017, and November 20, 2020, at 22 tertiary hospitals in China. Participants were aged 65 to 80 years and were scheduled for elective abdominal surgery. Patients and outcome assessors were blinded to group allocation. Data analysis followed a modified intention-to-treat principle.

Interventions: Patients were randomized 1:1 to receive either etomidate or propofol for general anesthesia by target-controlled infusion.

Main Outcomes And Measures: Primary outcome was a composite of major in-hospital postoperative complications (with a noninferiority margin of 3%). Secondary outcomes included intraoperative hemodynamic measurements; postoperative adrenocortical hormone levels; self-reported postoperative pain, nausea, and vomiting; and mortality at postoperative months 6 and 12.

Results: A total of 1944 participants were randomized, of whom 1917 (98.6%) completed the trial. Patients were randomized to the etomidate group (n = 967; mean [SD] age, 70.3 [4.0] years; 578 men [59.8%]) or propofol group (n = 950; mean [SD] age, 70.6 [4.2] years; 533 men [56.1%]). The primary end point occurred in 90 of 967 patients (9.3%) in the etomidate group and 83 of 950 patients (8.7%) in the propofol group, which met the noninferiority criterion (risk difference [RD], 0.6%; 95% CI, -1.6% to 2.7%; P = .66). In the etomidate group, mean (SD) cortisol levels were lower at the end of surgery (4.8 [2.7] μg/dL vs 6.1 [3.4] μg/dL; P < .001), and mean (SD) aldosterone levels were lower at the end of surgery (0.13 [0.05] ng/dL vs 0.15 [0.07] ng/dL; P = .02) and on postoperative day 1 (0.14 [0.04] ng/dL vs 0.16 [0.06] ng/dL; P = .001) compared with the propofol group. No difference in mortality was observed between the etomidate and propofol groups at postoperative month 6 (2.2% vs 3.0%; RD, -0.8%; 95% CI, -2.2% to 0.7%) and 12 (3.3% vs 3.9%; RD, -0.6%; 95% CI, -2.3% to 1.0%). More patients had pneumonia in the etomidate group than in the propofol group (2.0% vs 0.3%; RD, 1.7%; 95% CI, 0.7% to 2.8%; P = .001). Results were consistent in the per-protocol population.

Conclusions And Relevance: Results of this trial showed that, compared with propofol, etomidate anesthesia did not increase overall major in-hospital morbidity after abdominal surgery in older patients, although it induced transient adrenocortical suppression.

Trial Registration: ClinicalTrials.gov Identifier: NCT02910206.
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http://dx.doi.org/10.1001/jamasurg.2022.3338DOI Listing
August 2022

A multi-strategy firefly algorithm based on rough data reasoning for power economic dispatch.

Math Biosci Eng 2022 06;19(9):8866-8891

School of Electronics and Information Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.

Dynamic economic dispatch (DED) is a multi constraint and nonlinear complex problem, which is embodied in the dynamic decision-making coupled with each other in time and space. It is generally transformed into a high-dimensional multi constraint optimization problem. In this paper, a multi Strategy firefly algorithm (MSRFA) is proposed to solve the DED problem. MSRFA puts forward three strategies through the idea of opposite learning strategy and rough data reasoning to optimize the initialization and iteration process of the algorithm, improve the convergence speed of the algorithm in medium and high dimensions, and improve the escape ability when the algorithm falls into local optimization; The performance of MSRFA is tested in the simulation experiment of DED problem. The experimental results show that MSRFA can search the optimal power generation cost and minimum load error in the experiment, which reflects MSRFA superior stability and ability to jump out of local optimization. Therefore, MSRFA is an efficient way to solve the DED problem.
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http://dx.doi.org/10.3934/mbe.2022411DOI Listing
June 2022

Quantum-assisted distortion-free audio signal sensing.

Nat Commun 2022 Aug 8;13(1):4637. Epub 2022 Aug 8.

3rd Institute of Physics, University of Stuttgart, Allmandring 13, 70569, Stuttgart, Germany.

Quantum sensors are known for their high sensitivity in sensing applications. However, this sensitivity often comes with severe restrictions on other parameters which are also important. Examples are that in measurements of arbitrary signals, limitation in linear dynamic range could introduce distortions in magnitude and phase of the signal. High frequency resolution is another important feature for reconstructing unknown signals. Here, we demonstrate a distortion-free quantum sensing protocol that combines a quantum phase-sensitive detection with heterodyne readout. We present theoretical and experimental investigations using nitrogen-vacancy centers in diamond, showing the capability of reconstructing audio frequency signals with an extended linear dynamic range and high frequency resolution. Melody and speech based signals are used for demonstrating the features. The methods could broaden the horizon for quantum sensors towards applications, e.g. telecommunication in challenging environment, where low-distortion measurements are required at multiple frequency bands within a limited volume.
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http://dx.doi.org/10.1038/s41467-022-32150-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360047PMC
August 2022

Robustness of Bilayer Hexagonal Ice against Surface Symmetry and Corrugation.

Phys Rev Lett 2022 Jul;129(4):046001

International Center for Quantum Materials, School of Physics, Peking University, Beijing 100871, China.

Two-dimensional (2D) bilayer hexagonal ice (BHI) is regarded as the first intrinsic 2D ice crystal. However, the robustness of such a structure or its derivatives against surface symmetry and corrugation is still unclear. Here, we report the formation of 2D BHI on gold surfaces with 1D corrugation, using noncontact atomic force microscopy. The hexagonal arrangement of the first wetting layer was visualized on the Au(110)-1×2 surface. Upon depositing more water molecules, the first layer would rearrange and shrink, resulting in the formation of buckled BHI. Such a buckled BHI is hydrophobic despite the appearance of dangling OH, due to the strong interlayer bonding. Furthermore, the BHI is also stable on the Au(100)-5×28 surface. This work reveals the unexpected generality of the BHI on corrugated surfaces with nonhexagonal symmetry, thus shedding new light on the microscopic understandings of the low-dimensional ice formation on solid surfaces or under confinement.
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http://dx.doi.org/10.1103/PhysRevLett.129.046001DOI Listing
July 2022

The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway.

Front Pharmacol 2022 22;13:895724. Epub 2022 Jul 22.

College of Life Sciences, Northeast Agricultural University, Harbin, China.

JinQi Jiangtang tablet (JQJTT) is a Chinese patent medicine that has been shown to be beneficial for patients with diabetes both preclinically and clinically; however, the molecular mechanism underlying the effects of JQJTT remains unclear. In this study, surface plasmon resonance fishing was employed to identify JQJTT constituent molecules that can specifically bind to fibroblast growth factor receptor 1 (FGFR1), leading to the retrieval of palmatine (PAL), a key active ingredient of JQJTT. and experiments demonstrated that PAL can significantly stimulate FGFR1 phosphorylation and upregulate glucose transporter type 1 (GLUT-1) expression, thereby facilitating glucose uptake in insulin resistance (IR) HepG2 cells as well as alleviating hyperglycemia in diabetic mice. Our results revealed that PAL functions as an FGFR1 activator and that the hypoglycemic effect of JQJTT is partially dependent on the PAL-induced activation of the FGFR1 pathway. In addition, this study contributed to the understanding the pharmacodynamic basis and mechanism of action of JQJTT and provided a novel concept for future research on PAL.
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http://dx.doi.org/10.3389/fphar.2022.895724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354937PMC
July 2022

Application of depithelized gracilis adipofascial flap for pelvic floor reconstruction after pelvic exenteration.

BMC Surg 2022 Aug 6;22(1):304. Epub 2022 Aug 6.

Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.

Background: Pelvic exenteration is a radical surgery performed in selected patients with locally advanced or recurrent pelvic malignancy. It involves radical en bloc resection of the adjacent anatomical structures affected by the tumor. The authors sought to evaluate the clinical application of a depithelized gracilis adipofascial flap for pelvic floor reconstruction after pelvic exenteration.

Methods: A total of 31 patients who underwent pelvic floor reconstruction with a gracilis adipofascial flap after pelvic exenterationat Peking University Third Hospital from 2014 to 2022 were enrolled in the study. The postoperative follow-up durations varied from 4 to 12 months.

Results: The survival rate of the flap was 96.77% with partial flap necrosis in one case. The total incidence of postoperative complications associated with the flap was 25.81%, with an incidence of 6.45% in the donor site and 19.35% in the recipient site. All complications were early complications, including postoperative infection and flap necrosis. All patients recovered after treatments, including anti-infectives, dressing change, debridement, and local flap repair. Long-term follow-up showed good outcomes without flap-related complications.

Conclusions: A depithelized gracilis adipofascial flap can be applied for pelvic floor reconstruction after pelvic exenteration. The flap is an ideal and reliable choice for pelvic floor reconstruction with few complications, an elevated survival rate, sufficient volume, and mild effects on the function of the donor site.
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http://dx.doi.org/10.1186/s12893-022-01755-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357311PMC
August 2022

Near-real-time MODIS-derived vegetation index data products and online services for CONUS based on NASA LANCE.

Sci Data 2022 08 4;9(1):477. Epub 2022 Aug 4.

Center for Spatial Information Science and Systems, George Mason University, Fairfax, VA, 22030, USA.

This paper describes a set of Near-Real-Time (NRT) Vegetation Index (VI) data products for the Conterminous United States (CONUS) based on Moderate Resolution Imaging Spectroradiometer (MODIS) data from Land, Atmosphere Near-real-time Capability for EOS (LANCE), an openly accessible NASA NRT Earth observation data repository. The data set offers a variety of commonly used VIs, including Normalized Difference Vegetation Index (NDVI), Vegetation Condition Index (VCI), Mean-referenced Vegetation Condition Index (MVCI), Ratio to Median Vegetation Condition Index (RMVCI), and Ratio to previous-year Vegetation Condition Index (RVCI). LANCE enables the NRT monitoring of U.S. cropland vegetation conditions within 24 hours of observation. With more than 20 years of observations, this continuous data set enables geospatial time series analysis and change detection in many research fields such as agricultural monitoring, natural resource conservation, environmental modeling, and Earth system science. The complete set of VI data products described in the paper is openly distributed via Web Map Service (WMS) and Web Coverage Service (WCS) as well as the VegScape web application ( https://nassgeodata.gmu.edu/VegScape/ ).
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http://dx.doi.org/10.1038/s41597-022-01565-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352751PMC
August 2022

Ketamine induces rapid antidepressant effects via the autophagy-NLRP3 inflammasome pathway.

Psychopharmacology (Berl) 2022 Aug 4. Epub 2022 Aug 4.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Sub-anesthetic ketamine has rapid-onset effects for the treatment of major depressive disorder (MDD). However, the mechanism underlying ketamine's antidepressant properties remains unclear. Recent studies have reported an interrelationship between autophagy and the inflammasome, both of which are involved in the pathophysiology of MDD. In this study, we assess whether ketamine exerts its antidepressant effects via an association with the autophagy-NLRP3 inflammasome pathway.

Methods: We established a depressive-like rat model by treating Wistar Kyoto rats with chronic restraint stress (CRS) for 28 days. Microglial cells from newborn Sprague-Dawley rats were used for in vitro experiments.

Results: We found sub-anesthetic ketamine treatment reversed depressive-like behavior in CRS rats. Ketamine triggered autophagy in the microglia of prefrontal cortex (PFC) and (hippocampus) HPC, with increased levels of LC3B, decreased levels of p62 protein, and elevated autophagosomes both in vivo and in vitro. Moreover, NLRP3 inflammasome activation was also inhibited by ketamine, with reduced expression of NLRP3-ASC-CASP1 assembly and decreased IL-1β levels in cerebrospinal fluid (CSF) as well as in the serum. Increased BDNF levels and synaptophysin levels were detected in the ketamine-treated group. The rapid anti-depressive effects, elevation of autophagy, reduction in NLRP3, and neuroplasticity-related factors induced by ketamine could be significantly blocked by the autophagy inhibitor Baf A1 (0.1 mg/kg).

Conclusions: Our findings demonstrate that sub-anesthetic doses of ketamine exert their antidepressant-like effects by inhibiting inflammation and initiating neuroprotection via autophagy activation. These data might help expand future investigations on the antidepressant properties of ketamine.
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http://dx.doi.org/10.1007/s00213-022-06201-wDOI Listing
August 2022

Observational and model studies on transport and inventory of microplastics from a leak accident on the beaches of Yantai.

Mar Pollut Bull 2022 Jul 31;182:113976. Epub 2022 Jul 31.

Research and Development Center for Efficient Utilization of Coastal Bioresources, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, PR China.

We investigated an unexpected microplastic (MP) leakage event that occurred along the coastline of Yantai in January 2021. Sediment samples were collected from three zones on 9 beaches. MPs were identified with an average abundance of 247.6 ± 125.6 items/m on 7 beaches. The total amount of MPs from the leak accident was estimated to be 1.50 × 10 items (514.67 kg). The MPs were identified as polyethylene (PE), polypropylene (PP), and PP/PE blends using μ-FT-IR analysis. By utilizing a numerical model, the transmission process and potential source of MPs were demonstrated. The modeling results showed that the MPs might originate from the central and western part of the Bohai Sea and be driven to the beaches of Yantai by northwest wind and wind-induced surface current. However, due to the absence of direct evidence, the simulation results might only indicate the range of the leaking source, which was the movement trajectory of MPs.
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http://dx.doi.org/10.1016/j.marpolbul.2022.113976DOI Listing
July 2022

Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway.

Metab Brain Dis 2022 Aug 3. Epub 2022 Aug 3.

The School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.

Background: Isofraxidin is a coumarin compound mainly isolated from several traditional and functional edible plants beneficial for neurodegenerative diseases, including Sarcandra glabra and Apium graveolens, and Siberian Ginseng.

Objective: This study aimed to assess effects of isofraxidin against memory impairments and cognition deficits in a scopolamine-induced mouse model.

Materials & Methods: Animals were randomly divided into 6 groups, control, vehicle, donepezil (10 mg/kg, p.o.), and isofraxidin (3, 10, and 30 mg/kg, p.o.). Isofraxidin or donepezil was administered for 44 days, once per day. The scopolamine insults (1 mg/kg, i.p.) was given from the 21st day, once per day. Morris water maze test and Y-maze test were used for the behavioral test. After that, brain samples were collected for analysis.

Results: Firstly, isofraxidin significantly improved scopolamine-induced behavioral impairments and cognition deficits in Morris water maze and Y-maze test. Then, isofraxidin facilitated cholinergic activity via inhibiting acetylcholinesterase (AChE) activity. Besides, isofraxidin decreased lipid peroxidation level but enhanced levels of glutathione, glutathione peroxidase, and superoxide dismutase. Moreover, isofraxidin suppressed the expression of inflammatory mediators and cytokines. Further investigations showed that isofraxidin up-regulated expression of brain-derived neurotrophic factor (BDNF), and promoted phosphorylation of tropomyosin-related kinase B (TrkB), cyclic AMP-response element-binding protein (CREB), and extracellular signal-regulated kinase (ERK).

Discussion & Conclusions: These results suggested that isofraxidin ameliorated scopolamine-induced cognitive and memory impairments, possibly through regulating AChE activity, suppressing oxidative stress and inflammatory response, and modulating BDNF-CREB-ERK pathways.
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http://dx.doi.org/10.1007/s11011-022-00980-zDOI Listing
August 2022

Antepartum sleep quality, mental status, and postpartum depressive symptoms: a mediation analysis.

BMC Psychiatry 2022 08 2;22(1):521. Epub 2022 Aug 2.

Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, 200011, China.

Background: Poor sleep quality and maternal mood disturbances are common during pregnancy and may play pivotal roles in the development of postpartum depression. We aim to examine the trajectories of sleep quality and mental health in women from early pregnancy to delivery and explore the mediating effects of sleep quality and mental status on the link between antepartum depressive symptoms and postpartum depressive symptoms.

Methods: In an ongoing prospective birth cohort, 1301 women completed questionnaires in the first, second and third trimesters and at 6 weeks postpartum. In each trimester, sleep quality was measured utilizing the Pittsburgh Sleep Quality Index (PSQI), and mental health was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D), the Self-Rating Anxiety Scale (SAS) and the Perceived Stress Scale (PSS). Postpartum depressive symptoms were evaluated by the Edinburgh Postnatal Depression Scale (EPDS). The bootstrap method was used to test the mediation effect.

Results: The PSQI, CES-D, and SAS scores presented U-shaped curves across the antenatal period while the PSS score followed a descending trend. Antenatal sleep quality, depressive symptoms, anxiety symptoms and perceived stress all predicted depressive symptoms at 6 weeks postpartum. The influence of antepartum depressive symptoms on postpartum depressive symptoms was mediated by antepartum sleep quality and anxiety symptoms, which accounted for 32.14%, 39.25% and 31.25% in the first, second and third trimesters (P = 0.002, P = 0.001, P = 0.001, respectively).

Conclusions: Poor sleep quality and anxiety symptoms in pregnancy mediated the relationship between antepartum depressive symptoms and postpartum depressive symptoms. Interventions aimed at detecting and managing sleep quality and elevated anxiety among depressed women in pregnancy warrant further investigation as preventative strategies for postpartum depression.
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http://dx.doi.org/10.1186/s12888-022-04164-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344627PMC
August 2022

Impact of economic growth target constraints on enterprise technological innovation: Evidence from China.

PLoS One 2022 2;17(8):e0272003. Epub 2022 Aug 2.

School of Business Administration, University of Science and Technology Liaoning, Anshan, Liaoning, China.

By using the data from Chinese listed companies in the Shanghai and Shenzhen A-share market for the period 2007 to 2019 and the Report on the Work of the Government, this paper investigates the impact of the local government's economic growth target constraints on enterprise technological innovation and its mechanism. It is found that the local government's economic growth target constraints significantly inhibit enterprise technological innovation, which is more obvious in the samples of SOEs, regulated industries, and enterprises at low marketization levels. The change of government officials' performance appraisal indicators from the quantity to quality of economic growth can alleviate the negative effect. The mechanism effect test indicates that the local government's economic growth target constraints will aggravate enterprise financing constraints and decrease the contribution of R&D investment to enterprise performance, and further inhibit enterprise technological innovation.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374057PMC
August 2022

Xanthotoxin (8-methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity.

Phytother Res 2022 Aug 1. Epub 2022 Aug 1.

College Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.

Xanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF-κB, MAPK, JAK/STAT, Nrf2/HO-1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in-depth studies are needed to determine the clinical efficacy of XAT.
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http://dx.doi.org/10.1002/ptr.7577DOI Listing
August 2022

Synthesis, Formation Mechanism, and Structure of K[BHS(CH)BH] and Its Application in Preparation of KBH.

Inorg Chem 2022 Aug 31;61(32):12828-12834. Epub 2022 Jul 31.

School of Chemistry and Chemical Engineering, Henan Key Laboratory of Boron Chemistry and Advanced Energy Materials, Henan Normal University, Xinxiang 453007, Henan, China.

The design, synthesis, and applications of new boranes are eternal topics in boron chemistry. A new bis(borane)alkanethiolate salt, K[BHS(CH)BH], was synthesized in high yield by the reaction of K with (CH)S·BH at room temperature. The formation mechanism was elucidated based on experimental and theoretical studies. The single-crystal structure of the K[BHS(CH)BH]·18-crown-6 adduct was determined in which the B-S-B bonding information of K[BHS(CH)BH] was illustrated for the first time. Using K[BHS(CH)BH] as a starting material, KBH was successfully synthesized.
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http://dx.doi.org/10.1021/acs.inorgchem.2c01912DOI Listing
August 2022

Study of the Effects on Mn, Pb, and Zn Solidification in Soil by a Mixed Curing Agent of Modified Diatomite.

ACS Omega 2022 Jul 18;7(29):25229-25238. Epub 2022 Jul 18.

School of Resources and Safety Engineering, Central South University, Changsha 410083, China.

In order to improve the application scale of diatomite in the remediation of heavy metal-contaminated soil in non-ferrous metal mining areas, the preparation of the modified diatomite-combined curing agent and its stabilizing effect on manganese (Mn), lead (Pb), and zinc (Zn) were systematically studied in non-ferrous metal tailing soil in this paper. The results showed that compared with that in natural diatomite (DE), the contents of available Mn in soil treated by acid- and alkali-modified diatomite samples (C-D and Na-D) were 18.82 and 25.93% lower, respectively, and the content of available Zn in Na-D was significantly lower, 6.71%, than that in DE. Further research showed that modified diatomite combined with quicklime (CaO) and hydroxyapatite (HAP) could significantly improve the solidification effect of soil heavy metals. Compared with that in single modified diatomite, the contents of available Mn, Pb, and Zn in the mixed curing agent-treated soil decreased by 23.59-46.32, 5.88-47.93, and 5.37-10.68%, respectively. The final pot test showed that the mixed curing agent of modified diatomite had no significant effect on the growth of plants, but it could reduce the Mn, Pb, and Zn accumulation in the upper and lower parts of plants, which is because the acid-soluble and reducible heavy metals in soil transform into an oxidizable and residual state, which reduces the mobility of heavy metals.
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http://dx.doi.org/10.1021/acsomega.2c02135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330184PMC
July 2022

CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma.

Cancer Gene Ther 2022 Jul 28. Epub 2022 Jul 28.

The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China.

Long-term alcohol use is a confirmed risk factor of liver cancer tumorigenesis and metastasis. Multiple mechanisms responsible for alcohol related tumorigenesis have been proposed, including toxic reactive metabolite production, oxidative stress and fat accumulation. However, mechanisms underlying alcohol-mediated liver cancer metastasis remain largely unknown. We have previously demonstrated that SIRT7 regulates chemosensitivity by altering a p53-dependent pathway in human HCC. In the current study, we further revealed that SIRT7 is a critical factor in promoting liver cancer metastasis. SIRT7 expression is associated with disease stage and high SIRT7 predicts worse overall and disease-free survival. Overexpression of SIRT7 promotes HCC cell migration and EMT while knockdown of SIRT7 showed opposite effects. Mechanistically, we found that SIRT7 suppresses E-Cadherin expression through FOXO3-dependent promoter binding and H3K18 deacetylation. Knockdown of FOXO3 abolished the suppressive effect of SIRT7 on E-cadherin transcription. More importantly, we identified that alcohol treatment upregulates SIRT7 and suppresses E-cadherin expression via a CYP2E/ROS axis in hepatocytes both in vitro and in vivo. Antioxidant treatment in primary hepatocyte or CYP2E1 mice fed with alcohol impaired those effects. Reducing SIRT7 activity completely abolished alcohol-mediated promotion of liver cancer metastasis in vivo. Taken together, our data reveal that SIRT7 is a pivotal regulator of alcohol-mediated HCC metastasis.
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http://dx.doi.org/10.1038/s41417-022-00512-yDOI Listing
July 2022

Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression.

Adv Sci (Weinh) 2022 Jul 28:e2200546. Epub 2022 Jul 28.

Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Extracellular matrix (ECM) remodeling is crucial in the regulation of gastric cancer (GC) progression. This work aims to reveal novel posttranslational modifications and their relevant mechanisms in GC. In 3D matrix culture and animal models, it is found that fibrillin 1 (FBN1) expression is increased in advanced GC and has succinylation modification. The succinylation modification of FBN1 blocks its degradation by matrix metalloproteinases (MMPs). The long-term accumulation and deposition of FBN1 enhance tumor progression by activating TGF-β1 and intracellular PI3K/Akt pathway. The FBN1 succinylation site monoclonal antibody can effectively intervene the effect of succinylation modification and inhibit GC progression. FBN1 is specifically upregulated in the progression of GC compared with other tumors. In conclusion, FBN1 is widely present in the form of K672-succinylated modifications in GC. Besides, the succinyl group of FBN1 blocks its binding to MMP2, inhibits its degradation by MMP2, and leads to the accumulation of FBN1, which poses a long-term risk to the poor prognosis of GC.
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http://dx.doi.org/10.1002/advs.202200546DOI Listing
July 2022

Tuning Zn-Ion Solvation Chemistry with Chelating Ligands toward Stable Aqueous Zn Anodes.

Adv Mater 2022 Jul 28:e2200677. Epub 2022 Jul 28.

Nanoyang Group, Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, 350207, China.

Changing the solvation sheath of hydrated Zn ions is an effective strategy to stabilize Zn anodes to obtain a practical aqueous Zn-ion battery. However, key points related to the rational design remain unclear including how the properties of the solvent molecules intrinsically regulate the solvated structure of the Zn ions. This study proposes the use of a stability constant (K), namely, the equilibrium constant of the complexation reaction, as a universal standard to make an accurate selection of ligands in the electrolyte to improve the anode stability. It is found that K greatly impacts the corrosion current density and nucleation overpotential. Following this, ethylene diamine tetraacetic acid with a superhigh K effectively suppresses Zn corrosion and induces uniform Zn-ion deposition. As a result, the anode has an excellent stability of over 3000 h. This work presents a general principle to stabilize anodes by regulating the solvation chemistry, guiding the development of novel electrolytes for sustainable aqueous batteries.
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http://dx.doi.org/10.1002/adma.202200677DOI Listing
July 2022
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