Publications by authors named "Chen Cheng"

2,328 Publications

  • Page 1 of 1

Metal-organic frameworks/ hydrotalcite/graphene oxide sandwich composites derived [email protected] hierarchical materials as highly efficient catalysts for rechargeable Zn-air batteries.

J Colloid Interface Sci 2022 Jun 10;625:555-564. Epub 2022 Jun 10.

Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637000, PR China.

The fabrication of efficient bi-functional catalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) applied in energy storage and conversion devices like Zn-air batteries to solve the growing energy and environmental crises has attracted great attentions. In this work, the [email protected] catalysts have developed by first constructing the MOF/LDH/GO templates with multi-stage mixed growth method followed by calcining the template at high temperature. Fe-Ni-LDH (hydrotalcite) plays the role of linking the metal organic frameworks (Fe-Ce-MOF) and graphene oxides (GO), avoiding the separation of MOFs derivatives and GO sheets during pyrolysis process. Rare-earth metal oxide (CeO) featuring with abundant oxygen vacancies dispersed on the surface of transition-metal oxide can efficiently improve the stability of catalysts. The optimal [email protected] catalysts exhibit excellent ORR/OER performances with the potential gap between ORR (E = 0.87 V) and OER (E = 1.59 V) of 0.720 V. The aqueous Zn-air battery assembled with [email protected] catalysts exhibits outstanding performances with high open circuit voltage (1.56 V), large specific capacity (801.1 mAh/[email protected] mA.cm), and good charge-discharge cycle performances (>500 h). The [email protected] based solid-state Zn-air battery also delivers an excellent performance with high specific capacity (791.7 mAh/[email protected] mA.cm) and long cycle stability (>230 h).
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http://dx.doi.org/10.1016/j.jcis.2022.06.035DOI Listing
June 2022

High waist circumference is a risk factor for hypertension in normal-weight or overweight individuals with normal metabolic profiles.

J Clin Hypertens (Greenwich) 2022 Jun 23. Epub 2022 Jun 23.

Cardiovascular Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.

This study aims to investigate the relationship between waist circumference and hypertension risk in normal-weight/overweight individuals with normal cardiometabolic profiles. The authors included 7217 normal-weight and overweight individuals with normal cardiometabolic profiles from the 2001 to 2014 US National Health and Nutrition Examination Survey. The authors summarized demographic characteristics, cardiometabolic profiles, and behavioral factors across waist circumference quartiles. Then, in the logistic regression analysis, the authors observed a positive and significant association between waist circumference (as a continuous variable) and the prevalence of hypertension in all three models (nonadjusted, minimally adjusted, and fully adjusted), with odds ratios (95% confidence intervals) of 1.76 (1.65-1.86), 1.29 (1.20-1.39), and 1.24 (1.09-1.40), respectively. When analyzed as a categorical variable, individuals in the highest waist circumference group had a 1.48-fold increased risk of hypertension than the lowest group in the fully adjusted model. Moreover, the Cox regression analysis revealed a positive and significant association between waist circumference and all-cause mortality in individuals with hypertension in the nonadjusted model (HR, 1.27; 95% CI, 1.10-1.47) and the fully adjusted model (HR, 1.59; 95% CI, 1.22-2.06). In conclusions, our results showed that, even in those with normal metabolic profiles, high waist circumference was significantly associated with the increased prevalence of hypertension. And once hypertension has been established, patients with high waist circumference showed elevated all-cause mortality. Therefore, waist circumference should be routinely measured and controlled regardless of metabolic profiles.
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http://dx.doi.org/10.1111/jch.14528DOI Listing
June 2022

Generative Consistency for Semi-Supervised Cerebrovascular Segmentation from TOF-MRA.

IEEE Trans Med Imaging 2022 Jun 21;PP. Epub 2022 Jun 21.

Cerebrovascular segmentation from Time-of-flight magnetic resonance angiography (TOF-MRA) is a critical step in computer-aided diagnosis. In recent years, deep learning models have proved its powerful feature extraction for cerebrovascular segmentation. However, they require many labeled datasets to implement effective driving, which are expensive and professional. In this paper, we propose a generative consistency for semi-supervised (GCS) model. Considering the rich information contained in the feature map, the GCS model utilizes the generation results to constrain the segmentation model. The generated data comes from labeled data, unlabeled data, and unlabeled data after perturbation, respectively. The GCS model also calculates the consistency of the perturbed data to improve the feature mining ability. Subsequently, we propose a new model as the backbone of the GSC model. It transfers TOF-MRA into graph space and establishes correlation using Transformer. We demonstrated the effectiveness of the proposed model on TOF-MRA representations, and tested the GCS model with state-of-the-art semi-supervised methods using the proposed model as backbone. The experiments prove the important role of the GCS model in cerebrovascular segmentation. Code is available at https://github.com/MontaEllis/SSL-For-Medical-Segmentation.
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http://dx.doi.org/10.1109/TMI.2022.3184675DOI Listing
June 2022

Efficient Photoinduced Thermocatalytic Chemiluminescence System Based on the Z-Scheme Heterojunction AgPO/Ag/BiTiO for HS Sensing.

Anal Chem 2022 Jun 21. Epub 2022 Jun 21.

Analytical & Testing Center, Sichuan University, Chengdu 610064, China.

Cataluminescence as a highly efficient gas transduction principle has attracted wide attention among research in environmental monitoring and clinical diagnosis with increasing awareness of human safety. Nowadays, the development of innovation sensing systems and the construction of the sensing mechanism to improve the analytical performance of compounds remain a major challenge. Herein, we construct an advanced photoinduced thermocatalytic chemiluminescence (PI-TC-CL) gas-sensing system via the introduction of a Z-scheme heterojunction AgPO/Ag/BiTiO to achieve higher efficient detection of HS. The unique electron transport path of the Z-scheme heterojunction and the LSPR effect of Ag nanoparticles fascinate the generation of the photoinduced electron-hole pair on the surface of catalysts when stimulated by LED lamps and slow down the recombination of electron-hole pairs under thermal conditions. Thus, based on the cooperative effect of the Z-scheme heterojunction AgPO/Ag/BTO and PI-TC-CL system, we have successfully established an efficient HS CTL detection system, which has a response three times higher than that on the traditional CTL system and even 45 times higher than that on BTO and ranges among the best of the state-of-the-art CTL performance in HS detection with the linear range of 0.095-8.87 μg mL and a limit of detection of 0.0065 μg mL. Besides, to explore the gas-sensing mechanism, the synergetic effects of photoinduction and thermal catalysis are investigated thoroughly via conductivity and electrochemical experiments. This research provides a new perspective of engineering highly efficient catalysts and ingenious sensor systems through designing the nanostructure of materials and synergism catalytic mechanism.
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http://dx.doi.org/10.1021/acs.analchem.2c01586DOI Listing
June 2022

Tracheobronchial Foreign Bodies in Children: Experience From 1,328 Patients in China.

Front Pediatr 2022 26;10:873182. Epub 2022 May 26.

Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objective: To analyze the clinical characteristics of tracheobronchial foreign body (FB) cases in a pediatric Chinese population.

Methods: The clinical data of pediatric patients aged 0-18 years old diagnosed with a tracheobronchial FB in the Children's Hospital of Chongqing Medical University between September 2018 and August 2021 were analyzed retrospectively.

Results: Among 1,328 included cases, 92.09% of patients were <3 years old, the male to female ratio was 1.86:1. The prevalence of tracheobronchial FB was similar between patients living in rural and urban areas and tracheobronchial FBs were more common in winter. The most common presenting symptoms were cough and wheezing. The most common CT findings was local obstruction or tracheobronchial narrowing, followed by obstructive emphysema of lung and pneumonia. The 11.3% of cases that did not report FB aspiration on admission had a longer time to hospital admission and longer hospitalization time than cases reporting FB aspiration ( < 0.05). The most common FB type was nuts (81.17%). FBs were more frequently located in the right bronchus, and 64 (4.82%) cases involved multiple FBs. FBs were expelled by coughing in only 4.07% of cases. For the other cases, FB removal by first bronchoscopy in our hospital was successful and complete in 96.86% of cases. 1.51% of patients had hypoxic ischemic encephalopathy (HIE) and the location of FBs was a possible risk factor for HIE ( < 0.05).

Conclusions: Tracheobronchial FBs occurred most commonly in children <3 years old. If asphyxia occurs in children which FBs aspirated, emergency treatment is needed to reduce the occurrence of HIE. Rigid bronchoscopy remains the first-line method for FB removal in children.
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http://dx.doi.org/10.3389/fped.2022.873182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199421PMC
May 2022

Microplastics alter nitrous oxide production and pathways through affecting microbiome in estuarine sediments.

Water Res 2022 Jun 10;221:118733. Epub 2022 Jun 10.

Key Laboratory of Geographic Information Science (Ministry of Education), East China Normal University, Shanghai 200241, China; School of Geographic Sciences, East China Normal University, Shanghai 200241, China.

Increasing microplastics (MPs) pollution in estuaries profoundly impacts microbial ecosystems and biogeochemical processes. Nitrous oxide (NO), a powerful greenhouse gas, is an important intermediate product of microbial nitrogen cycling. However, how MPs regulate NO production and its pathways remain poorly understood. Here, impacts of traditional petroleum-based and emerging biodegradable MPs on microbial NO production and its pathways were studied through dual-isotope (N-O) labeling technique and molecular methods. Results indicated that both traditional petroleum-based and emerging biodegradable MPs promoted sedimentary NO production, whereas pathways varied. Biodegradable polylactic acid (PLA) MPs displayed greater promotion of NO production than petroleum-based MPs, polyvinyl chloride (PVC) and polyethylene (PE), of which PLA promoted through nitrifier nitrification (NN) and heterotrophic denitrification (HD), PE through nitrifier denitrification and HD, and PVC through NN. By combining the analysis of NO production rates with sediment chemical and microbiological properties, we demonstrated that the enrichment of nitrifying and denitrifying bacteria, as well as related functional genes directly and/or indirectly increased NO production primarily by interacting with carbon and nitrogen substrates. Different response of nitrogen cycling microbes to MPs led to the difference in NO increase pathways, of which nitrifying bacteria significantly enriched in all MPs treatments due to the niches provided by MPs. However, part of denitrifying bacteria significantly enriched in treatments containing PLA and PE MPs, which may serve as organic carbon substrates. This work highlights that the presence of MPs can promote sedimentary NO production, and the emerging biodegradable MPs represented by PLA may have a greater potential to enhance estuarine NO emissions and accelerate global climate change.
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http://dx.doi.org/10.1016/j.watres.2022.118733DOI Listing
June 2022

Antibiotics sulfamethoxazole alter nitrous oxide production and pathways in estuarine sediments: Evidenced by the N-O isotopes tracing.

J Hazard Mater 2022 Jun 3;437:129281. Epub 2022 Jun 3.

Key Laboratory of Geographic Information Science (Ministry of Education), East China Normal University, Shanghai 200241, China; School of Geographic Sciences, East China Normal University, Shanghai 200241, China.

Estuarine antibiotic residues are profoundly impacting microbial nitrogen (N) cycling and associated NO production, but the response of NO production pathways to antibiotics remains poorly understood. Here, N-O labeling technique combined with molecular methods were used to investigate the impacts of sulfamethoxazole on the contribution of ammonia oxidation (nitrifier nitrification, nitrifier denitrification, and nitrification-coupled denitrification) and heterotrophic denitrification (HD) to NO production in estuarine sediments. Results showed that environmental concentration of sulfamethoxazole (4 ng/g) promoted the total NO production by 17.1% through nitrifier denitrification. Environmentally relevant (40-4000 ng/g) and irrelevant (40,000 ng/g) concentration of sulfamethoxazole drove nitrification denitrification to gradually lose the dominant role in total NO production and ammonia oxidation-derived NO, replaced by HD and nitrifier nitrification, while total NO production were inhibited. Furthermore, when HD dominated the total NO production, the HD-derived NO increased by 63.6% with sulfamethoxazole concentration reaching 40,000 ng/g. The mechanistic investigation further showed that nitrifying bacteria were more susceptible to sulfamethoxazole than nitrifying archaea and denitrifiers. The increased expression of nirS gene carried by non-dominant denitrifiers improved the ratio of nirS:nosZ and hence increased HD-derived NO under high sulfamethoxazole stresses. Overall, our results provide a comprehensive view into how antibiotics regulate NO production and its pathways in estuarine sediments.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129281DOI Listing
June 2022

Realization of low-cross-talk half-wavelength pitch waveguide array on a silicon-on-insulator platform.

Opt Lett 2022 Jun;47(12):2955-2958

Realizing a densely packed waveguide antenna array is of great importance in light detection and ranging (LIDAR), owing to its suppressed grating lobes. In this work, a low-cross-talk half-wavelength pitch silicon waveguide array is proposed and experimentally demonstrated. It has a periodic arrangement of silicon strip nanophotonic waveguides, between which deep-subwavelength silicon strips are placed. Our experimental results show that this array's cross talk suppression is nearly 20 dB and has a bandwidth covering a wavelength range from 1500 nm to 1560 nm. Our realization of a half-wavelength pitch waveguide array may offer a promising platform for studying integrated optical phased arrays for solid-state LIDAR with a very low grating lobe and thus potentially a large field of view.
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http://dx.doi.org/10.1364/OL.455977DOI Listing
June 2022

Interfacial interaction-driven rheological properties of quartz nanofluids from molecular dynamics simulations and density functional theory calculations.

J Mol Model 2022 Jun 16;28(7):189. Epub 2022 Jun 16.

Institute of Atomic and Molecular Physics, Sichuan University, Chengdu, China.

Correlations of the shear viscosity of quartz nanofluids with particle concentration, particle size, and temperature were investigated with molecular dynamics simulations and density functional theory (DFT) calculations. A new understanding to the experimentally concluded correlations was addressed in terms of microscopic particle-water interfacial interaction in three aspects. First, the viscosity of quartz nanofluids at different particle concentrations, particle sizes, and temperatures were simulated using the equilibrium molecular dynamics simulations method to reproduce the experimental observations. At the same particle size, the nanofluid viscosity decreases significantly with temperature and increases with nanoparticle volume concentration, and at the same volume concentration, the nanofluid viscosity increases with the decrease of particle size. Second, DFT calculations confirm a stronger particle-water interaction than that among water molecules. The important role of particle-water interaction in the viscosity determination of nanofluids was revealed. Finally, a correlation was proposed to fit the simulated results and compared with earlier two-parameter correlations. One parameter in the correlation is indeed a constant, while the other is a function of SiO-water interaction energy. Our study proposes a physical basis for the experimentally concluded correlations on the viscosity of nanofluids.
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http://dx.doi.org/10.1007/s00894-022-05177-wDOI Listing
June 2022

Huge thymoma combined with pure red cell aplasia: a case report and literature review.

Gland Surg 2022 May;11(5):938-942

Department of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Background: Thymoma is the most common tumor of the anterior mediastinum, especially in adults, and accounts for 20-25% of all mediastinal tumors and 50% of anterior mediastinal tumors. Thymomas originating from thymus epithelial cells or lymphocytes are the most common, and account for 95% of thymomas. Thymoma is a relatively rare and inert disease of the chest, and many thymoma patients have a long survival period despite disease progression. Surgery is the first choice of treatment for thymoma, but controversy remains as to the best approach for treating giant thymoma. The incidence of large tumors in the thorax is low, surgical treatment is difficult, and surgical risk is high. A thymoma with myasthenia gravis is common, but a huge thymoma with pure red cell aplasia is rare.

Case Description: Our hospital (Liupanshui People's Hospital) admitted a patient with a large thymoma. The 37-year-old female patient had chest pain without obvious cause, accompanied by chest tightness and shortness of breath for 3 days. The patient appeared to have severe anemia. The patient's initial hemoglobin level was 51 g/L. A computed tomography (CT) scan after hospitalization revealed a large soft tissue mass in the left thoracic cavity, about 22.0 cm × 18.0 cm × 15.0 cm in size, of mixed density, with an intact boundary envelope, partial pulmonary atelectasis of the left lung, and pleural fluid on the left. The tumor was successfully removed by left anterolateral incision, and postoperatively, the patient s compression and anemia improved significantly, and a pathologic diagnosis of type A thymoma.

Conclusions: Through a literature review and case analysis, we extend understandings of thymoma. Clinical differential diagnosis should be made before surgery, which is very important for making treatment plan. Our results can provide a reference for the clinical treatment of thymoma, and strive to provide the best treatment for patients.
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http://dx.doi.org/10.21037/gs-22-218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177286PMC
May 2022

An exploration of the clinical progression models of osimertinib in the treatment of advanced EGFR-mutant non-small cell lung cancer.

Transl Lung Cancer Res 2022 May;11(5):817-831

Department of Oncology, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China.

Background: Classifying the progression pattern had been proved to be momentous for predicting efficacy and guiding treatment in the 1st/2nd generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), while lack evidence in the 3rd generation EGFR-TKIs. This study aimed to classify tumor progression of osimertinib in EGFR+ advanced non-small cell lung cancer (NSCLC), exploring the characteristics and the clinical significance of each progression pattern.

Methods: After screening 1,125 lung cancer patients, 168 EGFR T790M+ advanced patients using osimertinib were enrolled and divided into two groups and five clinical progression models according to the time course of the tumor progression. The prognosis and characteristics, such as gender, age, metastases, of each model were analyzed and compared by Kaplan-Meier method, test, and linear regression.

Results: Complete follow-up data were available for 117 of the 168 patients. Progressive disease (PD) occurred in 89 patients at an average onset of 6.59 months since using osimertinib, with 79.78% of patients experiencing enlargement of some preexisting lesions before PD. Among the five progression models, the 'Rapid Enlargement' (10.11%) model, the 'Rapid New Lesion' model (10.11%), the 'Delayed Enlargement' model (29.21%), the 'Delayed New Lesion' model (15.73%), and the 'Non-targeted Enlargement' model (34.83%), the 'Non-targeted Enlargement' model had the worst prognosis, with a median progression-free survival (mPFS) of 7.1 months (P=0.046). The mPFS of other models was similar, with the largest difference in the time interval between the beginning of osimertinib treatment to the first appearance of target lesion enlargement (T). Smoking history (P=0.046) and the location of the initial (P=0.048), enlarged (P=0.003), and progressive lesions (P=0.002) affected the progression models, while gender, age, and treatment lines had no effect. The T was related to the overall disease control time with a correlation coefficient of 0.667 (P=0.000). The appearance of a malignant pleural effusion had an impact on progression.

Conclusions: We tried to create a classification system for describing the failure of the third-generation EGFR-TKI osimertinib including two groups, subdivided into five progression models based on the time course of tumor lesion changes. The system might be conducive to predict the prognosis and be potential to assist in selecting subsequent treatment strategies.
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http://dx.doi.org/10.21037/tlcr-22-315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186173PMC
May 2022

Bioinformatic analysis of dysregulated circular RNAs in pediatric pulmonary hypertension linked congenital heart disease.

Transl Pediatr 2022 May;11(5):715-727

Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: Circular RNAs (circRNAs) may play important roles in the progression of pulmonary arterial hypertension. However, the potential roles they play in childhood pulmonary arterial hypertension associated congenital heart disease (CHD) progression remains unclear.

Methods: Thirteen human plasma samples including eight from pulmonary arterial hypertension secondary to CHD patients and five from a control group were analyzed using the Arraystar Human circRNA array. The relative expression levels of five differentially expressed circRNAs in pulmonary arterial hypertension were detected using real-time polymerase chain reaction (PCR) analysis. In parallel, these levels were also taken on control samples from 32 CHD patients. We used miRanda and TargetScan software packages to predict potential microRNA (miRNA)targets, which were then combined into a circRNA-miRNA-messenger RNA (mRNA) network.

Results: Twenty-seven circRNAs (three upregulated and 24 downregulated) were differentially expressed between the pulmonary arterial hypertension and control groups. Compared to control group levels, circ_003416 expression in the pulmonary arterial hypertension group was significantly downregulated, while circ_005372 expression, in contrast, was significantly upregulated. The differential expression of these circRNAs was mainly linked to variation in levels of oxidative phosphorylation and tight junction signaling.

Conclusions: We identified one overexpressed and one underexpressed circRNA in plasma samples from children with CHD associated pulmonary arterial hypertension. Bioinformatic analysis indicated these dysregulated circRNAs might be associated with the occurrence and regulation of pulmonary arterial hypertension.
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http://dx.doi.org/10.21037/tp-22-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173884PMC
May 2022

Optimization of the Heat Dissipation Performance of a Lithium-Ion Battery Thermal Management System with CPCM/Liquid Cooling.

Materials (Basel) 2022 May 27;15(11). Epub 2022 May 27.

School of Aeronautical Manufacturing Industry, Chengdu Aeronautic Polytechnic, Chengdu 610021, China.

In view of the harsh conditions of rapid charging and discharging of electric vehicles, a hybrid lithium-ion battery thermal management system combining composite phase change material (PCM) with liquid cooling was proposed. Based on the numerical heat transfer model, a simulation experiment for the battery thermal management system was carried out. Taking the maximum temperature and temperature difference of the battery module as the objectives, the effects of PCM thickness, the liquid flow rate and the cross-sectional area of the liquid channel on the temperature of the battery module were analyzed using response surface methodology (RSM). The results show that 31 groups of candidate parameter combinations can be obtained through response surface analysis, and phase change material (PCM) thickness should be minimized in order to improve space utilization in the battery module. The optimal parameter combination is a flow rate of 0.4 m/s and a PCM thickness of 5.58 mm, with the cross-sectional area of the liquid channel as 3.35 mm.
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http://dx.doi.org/10.3390/ma15113835DOI Listing
May 2022

Green Protective Geopolymer Coatings: Interface Characterization, Modification and Life-Cycle Analysis.

Materials (Basel) 2022 May 25;15(11). Epub 2022 May 25.

Key Laboratory for Resilient Infrastructures of Coastal Cities, Ministry of Education, Shenzhen University, Shenzhen 518060, China.

In the interest of solving the resource and environmental problems of the construction industry, low-carbon geopolymer coating ensures great durability and extends the service life of existing infrastructure. This paper presents a multidisciplinary assessment of the protective performance and environmental impacts of geopolymer coating. Various parameters, such as main substance, water-solid (W/S) ratio, activator type and curing time, were investigated for their effects on interface characterization in terms of contact angle, surface energy, mechanical properties and microstructure. These parameters had negligible effects on the amounts and types of hydrophilic functional groups of geopolymer surfaces. A combination of organic surface modifiers and geopolymer coatings was shown to ensure hydrophobic surface conditions and great durability. Silicon-based modifiers exhibited better wetting performance than capillary crystalline surfactants by eliminating hydroxyl groups and maintaining structural backbone Si-O-T (Si, Al) on geopolymers' surfaces. Finally, life-cycle analysis was conducted to investigate the environmental performance. Geopolymer coating yielded substantially lower environmental impacts (50-80% lower in most impact categories) than ordinary Portland cement (OPC) coating. Silicon-based modifiers had negligible influence due to their minimal usage. Increasing the W/S ratio diluted the geopolymer coating and decreased the environmental impacts, and slag-based geopolymer coating achieved lower environmental impacts than FA-based and MK-based varietie.
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http://dx.doi.org/10.3390/ma15113767DOI Listing
May 2022

Dual honeycomb-superlattice enables double-high activity and reversibility of anion redox for sodium-ion battery layered cathodes.

Angew Chem Int Ed Engl 2022 Jun 8. Epub 2022 Jun 8.

Nanjing University, Xianlin 168, Nanjing, CHINA.

Anion redox contributes to the anomalous capacity exceeding theoretical limit of layered oxides. However, double-high activity and reversibility is challenging due to the structural rearrangement and potential oxygen loss. Here, we propose a strategy of constructing dual honeycomb-superlattice structure in Na 2/3 [Li 1/7 Mn 5/14 ][Mg 1/7 Mn 5/14 ]O 2 to simultaneously realize high activity and reversibility of lattice O redox. Theoretical simulation and electrochemical tests show that [Li 1/7 Mn 5/14 ] superlattice units remarkably trigger the anion redox activity and enable to deliver a record capacity of 285.9 mA g -1 in layered sodium-ion battery cathodes. Nuclear magnetic resonance and in-situ X-ray diffraction reveal that [Mg 1/7 Mn 5/14 ] superlattice units are beneficial to the structure and anion redox reversibility , where Li + reversibly shuttles between Na layers and transition-metal slabs in contrast to the absence of [Mg 1/7 Mn 5/14 ] units. Our findings underline the importance of multifunctional units and provide a path to advanced battery materials.
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http://dx.doi.org/10.1002/anie.202206625DOI Listing
June 2022

Associations of Gut Microbiota and Fatty Metabolism With Immune Thrombocytopenia.

Front Med (Lausanne) 2022 19;9:810612. Epub 2022 May 19.

Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: To determine whether gut microbiota, fatty metabolism and cytokines were associated with immune thrombocytopenia (ITP).

Methods: In total, 29 preliminarily diagnosed ITP patients and 33 healthy volunteers were enrolled. Fecal bacterial were analyzed based on 16S rRNA sequencing. Plasma cytokines and motabolites were analyzed using flow cytometry and liquid chromatography-mass spectrometry (LC-MS), respectively.

Results: , , and were enriched at the genus level in ITP patients, while , , were depleted. At the phylum level, the relative abundance of and increased in ITP patients, while , , and the ratio decreased. Plasma levels of 5-hydroxyeicosatetraenoic acid (5-HETE), 6-trans-12-epi-leukotriene B4 (6t,12e-LTB), and resolvin D2 (RvD) were upregulated, and stachydrine, dowicide A, dodecanoylcarnitine were downregulated in ITP patients. Furthermore, RvD is positively correlated with order , 5-HETE is positively correlated with genus , and 6t,12e-LTB is positively correlated with genus . In addition, stachydrine is positively correlated with family , dowicide A is positively correlated with class , and dodecanoylcarnitine is positively correlated with order . Plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were upregulated in ITP patients.

Conclusion: Our study revealed a relationship between microbiota and fatty metabolism in ITP. Gut microbiota may participate in the pathogenesis of ITP through affecting cytokine secretion, interfering with fatty metabolism.
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http://dx.doi.org/10.3389/fmed.2022.810612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160917PMC
May 2022

Multi-Scale Feature Fusion Convolutional Neural Network for Indoor Small Target Detection.

Front Neurorobot 2022 19;16:881021. Epub 2022 May 19.

School of Energy and Electronic Engineering, University of Portsmouth, Portsmouth, United Kingdom.

The development of object detection technology makes it possible for robots to interact with people and the environment, but the changeable application scenarios make the detection accuracy of small and medium objects in the practical application of object detection technology low. In this paper, based on multi-scale feature fusion of indoor small target detection method, using the device to collect different indoor images with angle, light, and shade conditions, and use the image enhancement technology to set up and amplify a date set, with indoor scenarios and the SSD algorithm in target detection layer and its adjacent features fusion. The Faster R-CNN, YOLOv5, SSD, and SSD target detection models based on multi-scale feature fusion were trained on an indoor scene data set based on transfer learning. The experimental results show that multi-scale feature fusion can improve the detection accuracy of all kinds of objects, especially for objects with a relatively small scale. In addition, although the detection speed of the improved SSD algorithm decreases, it is faster than the Faster R-CNN, which better achieves the balance between target detection accuracy and speed.
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http://dx.doi.org/10.3389/fnbot.2022.881021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160233PMC
May 2022

Family of Nanoclusters, Ln (Ln = Sm/Eu) and Gd, Exhibiting Magnetocaloric Effects and Fluorescence Sensing for MnO.

Inorg Chem 2022 Jun 2;61(23):8861-8869. Epub 2022 Jun 2.

Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, China.

A family of nanoclusters, [Ln(EDTA)(OAc)(CO)(μ-OH)(μ-OH)(HO)]·OAc·HO ( ≈ 50, Ln = Sm for ; ≈ 70, Ln = Eu for ) and [Gd(EDTA)(OAc)(CO)(CO)(μ-OH)(μ-OH)(HO)]·(HO) ( ≈ 70 for ; HEDTA = ethylene diamine tetraacetic acid), was prepared through the assembly of repeating subunits under the action of an anion template. The analysis of the structures showed that compounds and containing 33 Ln ions were isostructural, which were constructed by three kinds of subunits in the presence of CO as an anion template, while compound had a slightly different structure. Compound containing 32 Gd ions was formed by three types of subunits in the presence of CO and CO as a mixed anion template. The CO anions came from the slow fixation of CO in the air. Meanwhile, one kind of high-nuclearity lanthanide clusters showed high chemical stability. The quantum Monte Carlo (QMC) calculation suggested that weak antiferromagnetic interactions were dominant between Gd ions in . Magnetocaloric studies showed that compound had a large entropy change of 43.0 J kg K at 2 K and 7 T. Surprisingly, compound showed excellent recognition and detection effects for permanganate in aqueous solvents based on the fluorescence quenching phenomenon.
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http://dx.doi.org/10.1021/acs.inorgchem.2c00898DOI Listing
June 2022

Microbial diversity response to geochemical gradient characteristics on AMD from abandoned Dashu pyrite mine in Southwest China.

Environ Sci Pollut Res Int 2022 Jun 1. Epub 2022 Jun 1.

State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu, 610059, China.

The formation and release of acid mine drainage (AMD) have caused extremely serious pollution in the environment around many mining areas. The biological oxidation of metal sulfide minerals causes the production and release of AMD. To understand the interaction mechanism between microbial and AMD, the study uses Southwest Dashu pyrite as an example to investigate the geochemical gradient characteristics and microbial diversity response on AMD from abandoned mine. Through collecting and testing the water samples, the geochemical parameters such as physical and chemical indexes, main ion composition and microbial community composition of seven mine drainage points were obtained. The results showed that the geochemical and microbial community structure the decrease of AMD pollution in the study area with the decrease of altitude has obvious gradient characteristics. Although AMD has the distribution of acid-resistant iron and sulfur bacteria oxidizing bacteria, the microbial community diversity has obvious gradient characteristics. The categories with a relative abundance of > 5% include Proteobacteria, Actinobacteriota, Firmicutes, WPS-2, Chloroflexi, Bacteroidota, and Acidobacteriota. Actinobacteriota, which was common in the AMD, was distributed throughout the samples. The correlation analysis between water quality parameters and microbial community showed that the microbial community structure was affected by environmental factors. With the increase of acidity and metal ion content, the diversity of microbial community decreased, and the content of acid-resistant iron and sulfur oxidizing bacteria increased. The results showed that pH, dissolved oxygen (Do), the total iron (Fe) content (TFe), SO, and Al were the five parameters that most affected microbiological diversity and interaction. Hydrogeochemistry and major ions analysis revealed that AMD in the study area mainly comes from the biological oxidation of metal sulfides and the dissolution and cation exchange of other minerals around the deposit. The degree of AMD pollution is related to the hydrogeochemical conditions in the mine. The higher the mine's water level, the lower the pollutants, and the less AMD is produced and released. The findings confirmed that geochemical gradients significantly changed the biota of the mine water and enriched the related microbial diversity adapted to different environmental factors. Therefore, the findings provide strong support for mine containment to inhibit oxidation and lay the foundation for prevention and control strategies of AMD pollution sources.
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http://dx.doi.org/10.1007/s11356-022-21031-1DOI Listing
June 2022

Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade.

Acta Pharm Sin B 2022 May 29;12(5):2533-2549. Epub 2021 Dec 29.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Induction of immunogenic cell death promotes antitumor immunity against cancer. However, majority of clinically-approved drugs are unable to elicit sufficient ICD. Here, our study revealed that mitochondria-targeted delivery of doxorubicin (DOX) massively amplified ICD substantial generation of reactive oxygen species (ROS) after mitochondrial damage. The underlying mechanism behind increased ICD was further demonstrated to be ascribed to two pathways: (1) ROS elevated endoplasmic reticulum (ER) stress, leading to surface exposure of calreticulin; (2) ROS promoted release of various mitochondria-associated damage molecules including mitochondrial transcription factor A. Nevertheless, adaptive upregulation of PD-L1 was found after such ICD-inducing treatment. To overcome such immunosuppressive feedback, we developed a tumor stimuli-responsive nano vehicle to simultaneously exert mitochondrial targeted ICD induction and PD-L1 blockade. The nano vehicle was self-assembled from ICD-inducing copolymer and PD-L1 blocking copolymer, and possessed long-circulating property which contributed to better tumor accumulation and mitochondrial targeting. As a result, the nano vehicle remarkably activated antitumor immune responses and exhibited robust antitumor efficacy in both immunogenic and non-immunogenic tumor mouse models.
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http://dx.doi.org/10.1016/j.apsb.2021.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136536PMC
May 2022

Sources and processes of organic aerosol in non-refractory PM and PM during foggy and haze episodes in an urban environment of the Yangtze River Delta, China.

Environ Res 2022 Sep 28;212(Pt D):113557. Epub 2022 May 28.

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China; State Environmental Protection Key Laboratory of Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environment Sciences, Shanghai, China. Electronic address:

Organic aerosol (OA) generally accounts for a large fraction of fine particulate matter (PM) in the urban atmosphere. Despite significant advances in the understanding their emission sources, transformation processes and optical properties in the submicron aerosol fraction (PM), larger size fractions - e.g., PM - still deserve complementary investigations. In this study, we conducted a comprehensive analysis on sources, formation process and optical properties of OA in PM and PM under haze and foggy environments in the Yangtze River Delta (eastern China), using two aerosol chemical speciation monitors, as well as a photoacoustic extinctiometer at 870 nm. Positive matrix factorization analysis - using multilinear engine (ME2) algorithm - was conducted on PM and PM organic mass spectra. Four OA factors were identified, including three primary OA (POA) factors, i.e., hydrocarbon-like OA (HOA), cooking OA (COA), and biomass burning OA (BBOA), and a secondary OA (SOA) factor, i.e., oxidized oxygenated OA (OOA). An enhanced PM COA concentration was clearly observed during cooking peak hours, suggesting important contribution of fresh cooking emissions on large-sized particles (i.e., PM). The oxidation state and concentration of PM HOA were higher than that in PM, suggesting that large-sized HOA particles might be linked to oxidized POA. High contribution (44%) of large-sized OOA to non-refractory PM mass was observed during haze episodes. During foggy episodes, PM and PM OOA concentrations increased as a positive relationship over time, along with an exponential increase in the PM-OOA to PM-OOA ratio. Meanwhile, OOA loadings increased with the aerosol liquid water content (ALWC) during foggy episodes. Random forest cross-validation analysis also supported the important influence of ALWC on OOA variations, supporting substantial impact of aqueous process on SOA formation during haze and/or foggy episodes. Obtained results also indicated high OOA contributions (21%-36%) and low POA contributions (6%-14%) to the PM scattering coefficient during haze and foggy episodes, respectively. Finally, we could illustrate that atmospheric vertical diffusion and horizontal transport have important but different effects on the concentrations of different primary and secondary OA factors in different particle size fractions.
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http://dx.doi.org/10.1016/j.envres.2022.113557DOI Listing
September 2022

Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing.

J Biomed Res 2022 May 28:167-180. Epub 2022 May 28.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Tuberculosis (TB), is an infectious disease caused by ( ), and presents with high morbidity and mortality. Alveolar macrophages play an important role in TB pathogenesis although there is heterogeneity and functional plasticity. This study aimed to show the characteristics of alveolar macrophages from bronchioalveolar lavage fluid (BALF) in active TB patients. Single-cell RNA sequencing (scRNA-seq) was performed on BALF cells from three patients with active TB and additional scRNA-seq data from three healthy adults were established as controls. Transcriptional profiles were analyzed and compared by differential geneexpression and functional enrichment analysis. We applied pseudo-temporal trajectory analysis to investigate correlations and heterogeneity within alveolar macrophage subclusters. Alveolar macrophages from active TB patients at the single-cell resolution are described. We found that TB patients have higher cellular percentages in five macrophage subclusters. Alveolar macrophage subclusters with increased percentages were involved in inflammatory signaling pathways as well as the basic macrophage functions. The TB-increased alveolar macrophage subclusters might be derived from M1-like polarization state, before switching to an M2-like polarization state with the development of infection. Cell-cell communications of alveolar macrophages also increased and enhanced in active TB patients. Overall, our study demonstrated the characteristics of alveolar macrophages from BALF in active TB patients by using scRNA-seq.
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http://dx.doi.org/10.7555/JBR.36.20220007DOI Listing
May 2022

Transcription Profiling of Rice Panicle in Response to Crude Toxin Extract of .

Front Microbiol 2022 12;13:701489. Epub 2022 May 12.

Institute of Plant Protection, Sichuan Academy of Agricultural Sciences, Chengdu, China.

infects rice, causing rice false smut disease and reduced yields. During its growth, can also produce some toxins but less is known about the response mechanisms of the plant to toxins. toxins can inhibit the accumulation of total sugar in rice panicles. We used RNA sequencing to analyze the differential expression profile induced by infiltrating crude toxins into early growth-stage rice panicles. We compared the transcriptomes of the control and crude toxin-treated rice panicles and determined variable transcriptional responses under the action of the crude toxins. A total of 6,127 differentially expressed genes (DEGs) were identified. Among these genes, 3,150 were upregulated and 2,977 were downregulated. Gene Ontology (GO) and metabolic pathway enrichment analyses indicated that toxins mainly influenced glycometabolism, amino acid metabolism, and secondary metabolism of rice panicles. DEG analysis showed that the gene expression levels of 10 transcription factor families were significantly changed. Genes involved in phenylpropanoid biosynthesis, flavonoid biosynthesis, sugar transporters, and starch synthesis-related were significantly downregulated, including cytochrome P450, beta-glucosidase, CHS1, sucrose transporters, SWEETs, starch-branching enzymes, and UDP-glucose pyrophosphorylase. However, genes involved in programmed cell death (PCD) were significantly upregulated and contained cytochrome c, metacaspase, and protein kinase genes. The results indicate that toxins may act as the pathogenic factors to reduce stress resistance, disrupt total sugar accumulation and starch formation, and induce PCD.
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http://dx.doi.org/10.3389/fmicb.2022.701489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135463PMC
May 2022

Comparing of Frequency Shift and Impedance Analysis Method Based on QCM Sensor for Measuring the Blood Viscosity.

Sensors (Basel) 2022 May 17;22(10). Epub 2022 May 17.

School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China.

Blood viscosity measurements are crucial for the diagnosis of cardiovascular and hematological diseases. Traditional blood viscosity measurements have obvious limitations because of their expensive equipment usage and large sample consumption. In this study, blood viscosity was measured by the oscillating circuit method and impedance analysis method based on single QCM. In addition, the effectiveness of two methods with high precision and less sample is proved by the experiments. Moreover, compared to the result from a standard rotational viscometer, the maximum relative errors of the proposed oscillating circuit method and impedance analysis method are ±5.2% and ±1.8%, respectively. A reliability test is performed by repeated measurement (N = 5), and the result shows that the standard deviation about 0.9% of impedance analysis is smaller than that of oscillating circuit method. Therefore, the impedance analysis method is superior. Further, the repeatability of impedance analysis method was evaluated by regression analysis method, and the correlation coefficient R > 0.965 demonstrated that it had excellent reproducibility.
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http://dx.doi.org/10.3390/s22103804DOI Listing
May 2022

An Opposition-Based Learning CRO Algorithm for Solving the Shortest Common Supersequence Problem.

Entropy (Basel) 2022 May 3;24(5). Epub 2022 May 3.

School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

As a non-deterministic polynomial hard (NP-hard) problem, the shortest common supersequence (SCS) problem is normally solved by heuristic or metaheuristic algorithms. One type of metaheuristic algorithms that has relatively good performance for solving SCS problems is the chemical reaction optimization (CRO) algorithm. Several CRO-based proposals exist; however, they face such problems as unstable molecular population quality, uneven distribution, and local optimum (premature) solutions. To overcome these problems, we propose a new approach for the search mechanism of CRO-based algorithms. It combines the opposition-based learning (OBL) mechanism with the previously studied improved chemical reaction optimization (IMCRO) algorithm. This upgraded version is dubbed OBLIMCRO. In its initialization phase, the opposite population is constructed from a random population based on OBL; then, the initial population is generated by selecting molecules with the lowest potential energy from the random and opposite populations. In the iterative phase, reaction operators create new molecules, where the final population update is performed. Experiments show that the average running time of OBLIMCRO is more than 50% less than the average running time of CRO_SCS and its baseline algorithm, IMCRO, for the desoxyribonucleic acid (DNA) and protein datasets.
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http://dx.doi.org/10.3390/e24050641DOI Listing
May 2022

Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty.

Diagnostics (Basel) 2022 May 11;12(5). Epub 2022 May 11.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Inflammatory arthritis affects the level of synovial inflammatory factors, which makes it more difficult to diagnose prosthetic joint infection (PJI) patients with inflammatory arthritis. The aim of this study was to analyze synovial interleukin levels to distinguish between PJI and active rheumatoid arthritis (RA) after a hip or knee arthroplasty. From September 2019 to September 2021, we prospectively enrolled patients with joint pain after arthroplasty due to aseptic prosthesis loosening (n = 39), acute RA (n = 26), and PJI (n = 37). Synovial fluid from the affected joint is obtained and tested with a standard enzyme-linked immunosorbent assay. Receiver operating characteristic curve (ROC) was analyzed for each biomarker. Interleukin (IL)-1β, IL-6, and IL-8 showed promising value in differentiating of aseptic loosening from PJI, with areas under the curves (AUCs) of 0.9590, 0.9506, and 0.9616, respectively. Synovial IL-1β, IL-6, and IL-8 showed limited value in distinguishing between PJI and acute episodes of RA after arthroplasty, with AUCs of 0.7507, 0.7069, and 0.7034, respectively. Interleukins showed satisfactory efficacy in differentiating aseptic loosening from PJI. However, when pain after arthroplasty results from an acute episode of RA, current synovial interleukin levels do not accurately rule out the presence of PJI.
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http://dx.doi.org/10.3390/diagnostics12051196DOI Listing
May 2022

Retraction notice to " LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury'" [J. Pharmacol. Sci. 145 (2021) 202-212].

J Pharmacol Sci 2022 07 13;149(3):172. Epub 2022 May 13.

Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China; Institute of Cardiothoracic Vascular Disease, Nanjing University, Nanjing, 210008, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2022.05.001DOI Listing
July 2022

Recovery of wolframite from tungsten mine tailings by the combination of shaking table and flotation with a novel "crab" structure sebacoyl hydroxamic acid.

J Environ Manage 2022 Sep 23;317:115372. Epub 2022 May 23.

Department of Chemical Engineering, Perm National Research Polytechnic University, Perm, 614990, Russia. Electronic address:

Tailings ponds for gangue mineral storage are widely recognized as a dangerous source of toxic minerals and heavy metal-bearing solution. Therefore, recovering valuable minerals and critical elements from tailings is an important means to protect the environment in an economic way. Wolframite tailings usually contain a considerable amount of tungsten resources, but the presence of high content of kaolinite sludge makes it very difficult to recycle wolframite. Herein, a novel sebacoyl hydroxamic acid (SHA) was synthesized and introduced as a novel wolframite collector to effectively utilize wolframite tailings, and its collection performance was compared with that of benzohydroxamic acid (BHA). Micro-flotation tests showed that SHA could still obtain 80% wolframite recovery in the presence of kaolinite slimes. Bench-scale flotation tests indicated that SHA can effectively recover wolframite concentrate with 55.64% WO grade and 75.28% WO recovery from wolframite tailings by the combined shaking table-flotation process. Polarized light microscope observations showed that SHA could promote the formation of hydrophobic agglomerates of wolframite particles. These results show that SHA can be used as an efficient collector for disposing of wolframite tailings, and provide an important reference for the development of efficient and comprehensive utilization of tailings.
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http://dx.doi.org/10.1016/j.jenvman.2022.115372DOI Listing
September 2022

Effects of nitric oxide synthase inhibitor on mitochondria apoptosis and meat quality in postmortem Gannan yak (Bos grunniens) meat.

J Food Biochem 2022 May 24:e14234. Epub 2022 May 24.

College of Food Science and Engineering, Gansu Agricultural University, Lanzhou, China.

This research aimed to explore the effects of the nitric oxide synthase (NOS) inhibitor (L-NAME) on mitochondria apoptosis in postmortem Gannan yak (Bos grunniens) longissimus dorsi (LD) muscle and to explore its effect on meat quality further. The Gannan yak meat samples were treated with the control group (0.9% NaCl) and L-NAME (20, 60, and 100 mM) for 24 h and then stored for 0, 1, 3, 5, and 7 days at 4°C. NOS activity and NO content were investigated, and the parameters of mitochondrial apoptosis of the postmortem Gannan yak meat were determined. Meanwhile, the meat quality such as the centrifugation loss, meat color, and myofibril fragmentation index (MFI) was evaluated. The results indicated that after treatment with L-NAME, NOS activity and NO content decreased, causing mitochondrial membrane damage, Bax protein, and Cyt-c levels increased, and resulted in increased activities of caspase-9 and -3, promoting the occurrence of mitochondrial apoptosis. Furthermore, it increased the tenderness and water retention of Gannan yak meat. The results indicated that NOS inhibitor played a regulatory role in postmortem Gannan yak meat quality by regulating mitochondria apoptosis during postmortem aging. PRACTICAL APPLICATIONS: The meat's tenderness is often considered the most important factor affecting consumers' willingness to repurchase. The relationship of caspases and MFI suggested that L-NAME played a regulatory role in postmortem Gannan yak meat quality by regulating mitochondria apoptosis during postmortem aging. This study provides valuable information for the development of the Gannan yak economy in Tibetan areas.
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http://dx.doi.org/10.1111/jfbc.14234DOI Listing
May 2022

A novel magnet-driven rotary mixing aerator for carbon dioxide fixation and microalgae cultivation: Focusing on bubble behavior and cultivation performance.

J Biotechnol 2022 Jun 21;352:26-35. Epub 2022 May 21.

Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400044, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, China.

A novel magnet-driven rotary mixing aerator (MDRMA) was proposed to reduce the diameter and rising rate of bubbles while improving CO mass transfer during microalgae growth in a column photobioreactor. Visualization results showed that the bubble number density increased significantly with the increasing rotation rate of MDRMA. As the rotation rate increased from 0 to 300 r min, the average bubble diameter decreased from 3.8 mm to 2.0 mm (47.4% reduction), while the corresponding average bubble rising rate decreased from 0.32 m s to 0.22 m s (31.3% reduction). Notably, when the rotation rate of MDRMA exceeded 300 r min, a significant number of microbubbles with diameters below 0.5 mm were generated. When synthetic flue gas containing 12% CO (v/v) was supplied for microalgae cultivation, a maximum biomass concentration of 1.75 g L was obtained with rotating MDRMA at 200 r min, showing a 57.7% increase compared to the control aerated with a silicone tube aerator. Meanwhile, the pigment content reached 14.48 mg L, 22.7% higher than that of the control.
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http://dx.doi.org/10.1016/j.jbiotec.2022.05.007DOI Listing
June 2022
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