Chas Bountra

Chas Bountra

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Chas Bountra

Chas Bountra

Publications by authors named "Chas Bountra"

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Organizational Innovation for Developing New Medicines That Target Aging and Age-Related Conditions.

J Gerontol A Biol Sci Med Sci 2020 Jan;75(1):87-88

Charles Perkins Centre, Centre for Education and Research on Ageing and ANZAC Research Institute, University of Sydney and Concord Hospital, Australia.

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/glz062DOI Listing
January 2020

Establishing a reliable framework for harnessing the creative power of the scientific crowd.

PLoS Biol 2017 02 15;15(2):e2001387. Epub 2017 Feb 15.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.2001387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331949PMC
February 2017

Open Access Could Transform Drug Discovery: A Case Study of JQ1.

Expert Opin Drug Discov 2016 ;11(3):321-32

c Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1517/17460441.2016.1144587DOI Listing
October 2016

Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1.

Biochem Pharmacol 2016 10 9;117:35-45. Epub 2016 Aug 9.

Center for Phytochemical Epigenome Studies, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031540PMC
October 2016

Accelerating target discovery using pre-competitive open science-patients need faster innovation more than anyone else.

Ecancermedicalscience 2016 3;10:ed57. Epub 2016 Aug 3.

Structural Genomics Consortium, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.3332/ecancer.2016.ed57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990051PMC
September 2016

Animal models of epigenetic regulation in neuropsychiatric disorders.

Curr Top Behav Neurosci 2011 ;7:281-322

Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK,

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http://dx.doi.org/10.1007/7854_2010_104DOI Listing
April 2016

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Sci Adv 2015 Nov 13;1(10):e1500723. Epub 2015 Nov 13.

Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ, UK. ; Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.1126/sciadv.1500723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681344PMC
November 2015

21(st) Century Cures Act: An Act of Cure or Diagnosis?

Rejuvenation Res 2015 Aug;18(4):295-8

2 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford, United Kingdom .

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http://dx.doi.org/10.1089/rej.2015.1757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554930PMC
August 2015

Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies.

Mol Pain 2015 Jun 26;11:38. Epub 2015 Jun 26.

Peripheral Neuropathy Unit, Centre for Clinical Translation, Hammersmith Hospital, Imperial College London, Area A, Ground Floor, Du Cane Rd, London, W12 ONN, UK.

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http://journals.sagepub.com/doi/10.1186/s12990-015-0038-x
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http://dx.doi.org/10.1186/s12990-015-0038-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482278PMC
June 2015

Preclinical target validation using patient-derived cells.

Nat Rev Drug Discov 2015 Mar 20;14(3):149-50. Epub 2015 Feb 20.

Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrd4565DOI Listing
March 2015

Lost but making progress--Where will new analgesic drugs come from?

Sci Transl Med 2014 Aug;6(249):249sr3

Center for Pain and the Brain and Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319979PMC
August 2014

Mutant prolactin receptor and familial hyperprolactinemia.

N Engl J Med 2013 Nov 6;369(21):2012-2020. Epub 2013 Nov 6.

Academic Endocrine Unit, Radcliffe Department of Medicine (P.J.N., C.M.G., R.V.T.), Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine (C.B.W., P.K.), Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology (M.B., P.A.M.), and the Structural Genomics Consortium (C.B.), University of Oxford, Oxford, and Glasgow Royal Infirmary, Glasgow (S.J.C., M.A., R.S.D.) - all in the United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa1307557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209110PMC
November 2013

Epigenetic protein families: a new frontier for drug discovery.

Nat Rev Drug Discov 2012 Apr 13;11(5):384-400. Epub 2012 Apr 13.

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/nrd3674DOI Listing
April 2012

The precompetitive space: time to move the yardsticks.

Sci Transl Med 2011 Mar;3(76):76cm10

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3002399DOI Listing
March 2011

Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders.

Therap Adv Gastroenterol 2010 Sep;3(5):291-305

Neurogastroenterology Group, Wingate Institute of Neurogastroenterology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

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http://dx.doi.org/10.1177/1756283X10369922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002590PMC
September 2010

Open access chemical and clinical probes to support drug discovery.

Nat Chem Biol 2009 Jul;5(7):436-40

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nchembio0709-436DOI Listing
July 2009

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

Pain 2008 Sep 9;138(3):667-80. Epub 2008 Aug 9.

Peripheral Neuropathy Unit, Department of Clinical Neuroscience, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W120NN, UK.

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http://dx.doi.org/10.1016/j.pain.2008.06.007DOI Listing
September 2008

Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons.

J Neurooncol 2008 Aug 15;89(1):1-7. Epub 2008 Apr 15.

Peripheral Neuropathy Unit, Department of Clinical Neurosciences, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London, UK.

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http://dx.doi.org/10.1007/s11060-008-9585-6DOI Listing
August 2008

The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation.

Eur J Pain 2008 Apr 25;12(3):385-94. Epub 2007 Sep 25.

Department of Oral and Maxillofacial Medicine and Surgery, School of Clinical Dentistry, Claremont Crescent, University of Sheffield, Sheffield, South Yorkshire S10 2TA, United Kingdom.

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http://dx.doi.org/10.1016/j.ejpain.2007.07.010DOI Listing
April 2008

Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).

Neurosci Lett 2007 Nov 20;427(2):77-82. Epub 2007 Sep 20.

Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1016/j.neulet.2007.09.027DOI Listing
November 2007

Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.

Eur J Pain 2007 Apr 11;11(3):283-9. Epub 2006 May 11.

Pain Research Department, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Ltd., New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom.

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http://dx.doi.org/10.1016/j.ejpain.2006.03.006DOI Listing
April 2007

The effect of inflammation on Fos expression in the ferret trigeminal nucleus.

Eur J Oral Sci 2007 Feb;115(1):40-7

Department of Oral and Maxillofacial Medicine and Surgery, School of Clinical Dentistry, University of Sheffield, UK.

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http://dx.doi.org/10.1111/j.1600-0722.2007.00411.xDOI Listing
February 2007

Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy.

J Neurosci Methods 2007 Jan 2;159(1):26-34. Epub 2006 Aug 2.

Imperial College Faculty of Medicine, London Centre for Nanotechnology, Division of Medicine, 5th floor MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.jneumeth.2006.06.018DOI Listing
January 2007

Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.

BMC Urol 2006 Dec 27;6:31. Epub 2006 Dec 27.

Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK.

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http://dx.doi.org/10.1186/1471-2490-6-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766360PMC
December 2006

Changes in sodium channel expression following trigeminal nerve injury.

Exp Neurol 2006 Nov 14;202(1):207-16. Epub 2006 Aug 14.

Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK.

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http://dx.doi.org/10.1016/j.expneurol.2006.05.035DOI Listing
November 2006

Pharmacological FMRI in the development of new analgesic compounds.

NMR Biomed 2006 Oct;19(6):702-11

Pain Imaging Neuroscience Group, Department Physiology, Anatomy and Genetics, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1002/nbm.1076DOI Listing
October 2006

An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.

Eur J Pain 2006 Aug 30;10(6):537-49. Epub 2005 Sep 30.

Department of Pain Research, Neurology and Gastrointestinal CEDD, GlaxoSmithKline Research and Development Ltd., Harlow, Essex, UK.

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http://dx.doi.org/10.1016/j.ejpain.2005.08.003DOI Listing
August 2006

An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients.

Neuroimage 2006 Aug 5;32(1):256-65. Epub 2006 May 5.

Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 1QX, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S105381190600192
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http://dx.doi.org/10.1016/j.neuroimage.2006.03.024DOI Listing
August 2006

Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain.

BMC Womens Health 2005 Mar 8;5(1). Epub 2005 Mar 8.

Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1186/1472-6874-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554997PMC
March 2005

nNOS expression following inferior alveolar nerve injury in the ferret.

Brain Res 2004 Nov;1027(1-2):11-7

Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, The University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1016/j.brainres.2004.08.062DOI Listing
November 2004

Allodynia in rats infected with varicella zoster virus--a small animal model for post-herpetic neuralgia.

Brain Res Brain Res Rev 2004 Oct;46(2):234-42

Center for Infectious Disease, School of Veterinary Medicine, Division of Veterinary Biomedical Sciences, University of Edinburgh, Edinburgh EH9 1QH, UK.

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http://dx.doi.org/10.1016/j.brainresrev.2004.07.008DOI Listing
October 2004

Expression of the sodium channel beta3 subunit in injured human sensory neurons.

Neuroreport 2004 Jul;15(10):1629-32

Peripheral Neuropathy Unit, Imperial College London, Area A, Ground Floor, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK.

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http://dx.doi.org/10.1097/01.wnr.0000134927.02776.aeDOI Listing
July 2004

Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury.

J Peripher Nerv Syst 2004 Mar;9(1):15-25

Peripheral Neuropathy Unit,Imperial College, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/j.1085-9489.2004.09104.xDOI Listing
March 2004

Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.

Spine (Phila Pa 1976) 2002 Jan;27(2):135-40

Department of Musculoskeletal Surgery, Imperial College School of Medicine, Charing Cross Campus, London, UK.

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http://dx.doi.org/10.1097/00007632-200201150-00003DOI Listing
January 2002