Charlotte M Niemeyer

Charlotte M Niemeyer

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Charlotte M Niemeyer

Charlotte M Niemeyer

Publications by authors named "Charlotte M Niemeyer"

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Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia.

Authors:
Saman K Hashmi Jyotinder N Punia Andrea N Marcogliese Amos S Gaikwad Kevin E Fisher Angshumoy Roy Pulivarthi Rao Dolores H Lopez-Terrada Jo Ringrose Mignon L Loh Charlotte M Niemeyer Rachel E Rau

Pediatr Blood Cancer 2019 Oct 28;66(10):e27905. Epub 2019 Jun 28.

Department of Pediatrics, Section of Hematology Oncology, Texas Children's Hospital/Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.27905DOI Listing
October 2019

Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial.

Authors:
Martin G Sauer Peter J Lang Michael H Albert Peter Bader Ursula Creutzig Matthias Eyrich Johann Greil Bernd Gruhn Wolfgang Holter Thomas Klingebiel Bernhard Kremens Heiko von der Leyen Christine Mauz-Körholz Roland Meisel Kirsten Mischke Ingo Müller Charlotte M Niemeyer Christina Peters Christine Pohler Dirk Reinhardt Birgit Burkhardt Paul G Schlegel Ansgar S Schulz Johanna Schrum Petr Sedlacek Brigitte Strahm Wilhelm Woessmann Rupert Handgretinger Martin Zimmermann Arndt Borkhardt

Leukemia 2019 Oct 2. Epub 2019 Oct 2.

Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41375-019-0584-8DOI Listing
October 2019

Next-generation reference intervals for pediatric hematology.

Authors:
Jakob Zierk Johannes Hirschmann Dennis Toddenroth Farhad Arzideh Rainer Haeckel Alexander Bertram Holger Cario Michael C Frühwald Hans-Jürgen Groß Arndt Groening Stefanie Grützner Thomas Gscheidmeier Torsten Hoff Reinhard Hoffmann Rainer Klauke Alexander Krebs Ralf Lichtinghagen Sabine Mühlenbrock-Lenter Michael Neumann Peter Nöllke Charlotte M Niemeyer Oliver Razum Hans-Georg Ruf Udo Steigerwald Thomas Streichert Antje Torge Wolfgang Rascher Hans-Ulrich Prokosch Manfred Rauh Markus Metzler

Clin Chem Lab Med 2019 Sep;57(10):1595-1607

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-1236DOI Listing
September 2019

Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.

Authors:
Christopher F Krombholz Lorena Gallego-Villar Sushree S Sahoo Pritam K Panda Marcin W Wlodarski Konrad Aumann Mark Hartmann Daniel B Lipka Michael Daskalakis Christoph Plass Charlotte M Niemeyer Miriam Erlacher Christian Flotho

Leukemia 2019 07 24;33(7):1805-1810. Epub 2019 Jan 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0343-2DOI Listing
July 2019

Impaired human hematopoiesis due to a cryptic intronic splicing mutation.

Authors:
Nour J Abdulhay Claudia Fiorini Jeffrey M Verboon Leif S Ludwig Jacob C Ulirsch Barbara Zieger Caleb A Lareau Xiaoli Mi Anindita Roy Esther A Obeng Miriam Erlacher Namrata Gupta Stacey B Gabriel Benjamin L Ebert Charlotte M Niemeyer Rami N Khoriaty Philip Ancliff Hanna T Gazda Marcin W Wlodarski Vijay G Sankaran

J Exp Med 2019 May 26;216(5):1050-1060. Epub 2019 Mar 26.

Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

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http://www.jem.org/lookup/doi/10.1084/jem.20181625
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http://dx.doi.org/10.1084/jem.20181625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504223PMC
May 2019

Juvenile myelomonocytic leukemia: who's the driver at the wheel?

Authors:
Charlotte M Niemeyer Christian Flotho

Blood 2019 Mar 22;133(10):1060-1070. Epub 2019 Jan 22.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2018-11-844688DOI Listing
March 2019

GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML.

Authors:
Ahad F Al Seraihi Ana Rio-Machin Kiran Tawana Csaba Bödör Jun Wang Ai Nagano James A Heward Sameena Iqbal Steven Best Nicholas Lea Donal McLornan Emilia J Kozyra Marcin W Wlodarski Charlotte M Niemeyer Hamish Scott Chris Hahn Alicia Ellison Hemanth Tummala Shirleny Romualdo Cardoso Tom Vulliamy Inderjeet Dokal Tom Butler Matthew Smith Jamie Cavenagh Jude Fitzgibbon

Leukemia 2018 11 19;32(11):2502-2507. Epub 2018 Apr 19.

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/s41375-018-0134-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224398PMC
November 2018

JMML genomics and decisions.

Authors:
Charlotte M Niemeyer

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):307-312

Department of Pediatrics and Adolescent Medicine, University Children's Hospital, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/asheducation-2018.1.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245977PMC
November 2018

Monosomy 7 in Pediatric Myelodysplastic Syndromes.

Authors:
Marcin W Wlodarski Sushree S Sahoo Charlotte M Niemeyer

Hematol Oncol Clin North Am 2018 Aug;32(4):729-743

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center, University of Freiburg, Mathildenstr.1, Freiburg 79106, Germany; German Cancer Consortium (DKTK), Freiburg, Germany.

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http://dx.doi.org/10.1016/j.hoc.2018.04.007DOI Listing
August 2018

Molecular profile of inflammatory and megakaryocytic factors in pediatric myelodysplastic syndrome with acute myelofibrosis.

Authors:
Kais Hussein Meinolf Suttorp Angelika Stucki-Koch Irith Baumann Charlotte M Niemeyer Hans Kreipe

Pediatr Blood Cancer 2018 07 18;65(7):e27048. Epub 2018 Apr 18.

Institute of Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/pbc.27048DOI Listing
July 2018

Recurring mutations in are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia.

Authors:
Marcin W Wlodarski Lydie Da Costa Marie-Françoise O'Donohue Marc Gastou Narjesse Karboul Nathalie Montel-Lehry Ina Hainmann Dominika Danda Amina Szvetnik Victor Pastor Nahuel Paolini Franca M di Summa Hannah Tamary Abed Abu Quider Anna Aspesi Riekelt H Houtkooper Thierry Leblanc Charlotte M Niemeyer Pierre-Emmanuel Gleizes Alyson W MacInnes

Haematologica 2018 06 29;103(6):949-958. Epub 2018 Mar 29.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands

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http://dx.doi.org/10.3324/haematol.2017.177980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058779PMC
June 2018

Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche.

Authors:
Friedrich G Kapp Julie R Perlin Elliott J Hagedorn John M Gansner Daniel E Schwarz Lauren A O'Connell Nicholas S Johnson Chris Amemiya David E Fisher Ute Wölfle Eirini Trompouki Charlotte M Niemeyer Wolfgang Driever Leonard I Zon

Nature 2018 06 13;558(7710):445-448. Epub 2018 Jun 13.

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-018-0213-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093292PMC
June 2018

Constitutional mutations cause familial myelodysplastic syndrome and transient monosomy 7.

Authors:
Victor B Pastor Sushree S Sahoo Jessica Boklan Georg C Schwabe Ebru Saribeyoglu Brigitte Strahm Dirk Lebrecht Matthias Voss Yenan T Bryceson Miriam Erlacher Gerhard Ehninger Marena Niewisch Brigitte Schlegelberger Irith Baumann John C Achermann Akiko Shimamura Jochen Hochrein Ulf Tedgård Lars Nilsson Henrik Hasle Melanie Boerries Hauke Busch Charlotte M Niemeyer Marcin W Wlodarski

Haematologica 2018 03 7;103(3):427-437. Epub 2017 Dec 7.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2017.180778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830370PMC
March 2018

Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation.

Authors:
Matthias Kollek Gesina Voigt Christian Molnar Fabronia Murad Daniela Bertele Christopher Felix Krombholz Sheila Bohler Verena Labi Stefan Schiller Mirjam Kunze Stephan Geley Charlotte M Niemeyer Ana Garcia-Saez Miriam Erlacher

J Exp Med 2017 Oct 7;214(10):2967-2983. Epub 2017 Sep 7.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.1084/jem.20161721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626392PMC
October 2017

Heterogeneity of GATA2-related myeloid neoplasms.

Authors:
Shinsuke Hirabayashi Marcin W Wlodarski Emilia Kozyra Charlotte M Niemeyer

Int J Hematol 2017 Aug 22;106(2):175-182. Epub 2017 Jun 22.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s12185-017-2285-2DOI Listing
August 2017

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia.

Authors:
Silvia Fluhr Christopher Felix Krombholz Angelina Meier Thomas Epting Oliver Mücke Christoph Plass Charlotte M Niemeyer Christian Flotho

Epigenetics 2017 08 27;12(8):715-723. Epub 2017 Jul 27.

a Department of Pediatrics and Adolescent Medicine , Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/15592294.2017.1356959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687323PMC
August 2017

Deferasirox for managing iron overload in people with thalassaemia.

Authors:
Claudia Bollig Lisa K Schell Gerta Rücker Roman Allert Edith Motschall Charlotte M Niemeyer Dirk Bassler Joerg J Meerpohl

Cochrane Database Syst Rev 2017 08 15;8:CD007476. Epub 2017 Aug 15.

Cochrane Germany, Medical Center - Univ. of Freiburg, Faculty of Medicine, Univ. of Freiburg, Breisacher Straße 153, Freiburg, Germany, 79110.

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http://dx.doi.org/10.1002/14651858.CD007476.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483623PMC
August 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.

Authors:
Federica Buonocore Peter Kühnen Jenifer P Suntharalingham Ignacio Del Valle Martin Digweed Harald Stachelscheid Noushafarin Khajavi Mohammed Didi Angela F Brady Oliver Blankenstein Annie M Procter Paul Dimitri Jerry K H Wales Paolo Ghirri Dieter Knöbl Brigitte Strahm Miriam Erlacher Marcin W Wlodarski Wei Chen George K Kokai Glenn Anderson Deborah Morrogh Dale A Moulding Shane A McKee Charlotte M Niemeyer Annette Grüters John C Achermann

J Clin Invest 2017 May 27;127(5):1700-1713. Epub 2017 Mar 27.

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http://dx.doi.org/10.1172/JCI91913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409795PMC
May 2017

Sirolimus is highly effective for lymph leakage in microcystic lymphatic malformations with skin involvement.

Authors:
Jochen Rössler Julia Geiger Etelka Földi Denise M Adams Charlotte M Niemeyer

Int J Dermatol 2017 04 5;56(4):e72-e75. Epub 2016 Oct 5.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/ijd.13419DOI Listing
April 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Authors:
Tim Ripperger Stefan S Bielack Arndt Borkhardt Ines B Brecht Birgit Burkhardt Gabriele Calaminus Klaus-Michael Debatin Hedwig Deubzer Uta Dirksen Cornelia Eckert Angelika Eggert Miriam Erlacher Gudrun Fleischhack Michael C Frühwald Astrid Gnekow Gudrun Goehring Norbert Graf Helmut Hanenberg Julia Hauer Barbara Hero Simone Hettmer Katja von Hoff Martin Horstmann Juliane Hoyer Thomas Illig Peter Kaatsch Roland Kappler Kornelius Kerl Thomas Klingebiel Udo Kontny Uwe Kordes Dieter Körholz Ewa Koscielniak Christof M Kramm Michaela Kuhlen Andreas E Kulozik Britta Lamottke Ivo Leuschner Dietmar R Lohmann Andrea Meinhardt Markus Metzler Lüder H Meyer Olga Moser Michaela Nathrath Charlotte M Niemeyer Rainer Nustede Kristian W Pajtler Claudia Paret Mareike Rasche Dirk Reinhardt Olaf Rieß Alexandra Russo Stefan Rutkowski Brigitte Schlegelberger Dominik Schneider Reinhard Schneppenheim Martin Schrappe Christopher Schroeder Dietrich von Schweinitz Thorsten Simon Monika Sparber-Sauer Claudia Spix Martin Stanulla Doris Steinemann Brigitte Strahm Petra Temming Kathrin Thomay Andre O von Bueren Peter Vorwerk Olaf Witt Marcin Wlodarski Willy Wössmann Martin Zenker Stefanie Zimmermann Stefan M Pfister Christian P Kratz

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Introduction: Genetic syndromes predisposing to myeloid neoplasia.

Authors:
Marcin W Wlodarski Charlotte M Niemeyer

Semin Hematol 2017 04 4;54(2):57-59. Epub 2017 May 4.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology; Medical Center; Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1053/j.seminhematol.2017.05.001DOI Listing
April 2017

Practical considerations for diagnosis and management of patients and carriers.

Authors:
Charlotte M Niemeyer Cristina Mecucci

Semin Hematol 2017 04 6;54(2):69-74. Epub 2017 Apr 6.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2017.04.002DOI Listing
April 2017

A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.

Authors:
Gudrun Göhring Kathrin Thomay Gunnar Schmidt Tim Ripperger Michael Xu Nicole Wittner Mwe Mwe Chao Irith Baumann Marena Niewisch Dirk Reinhardt Thomas Klingebiel Felicitas Thol Brigitte Schlegelberger Charlotte M Niemeyer

Leuk Lymphoma 2017 03 28;58(3):718-721. Epub 2016 Nov 28.

e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1207765DOI Listing
March 2017

Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia.

Authors:
Thomas Wilhelm Daniel B Lipka Tania Witte Justyna A Wierzbinska Silvia Fluhr Monika Helf Oliver Mücke Rainer Claus Carolin Konermann Peter Nöllke Charlotte M Niemeyer Christian Flotho Christoph Plass

Epigenetics 2016 18;11(2):110-9. Epub 2016 Feb 18.

a Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center , Heidelberg , Germany.

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http://dx.doi.org/10.1080/15592294.2016.1145327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846096PMC
December 2016

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Authors:
Silvia Fluhr Melanie Boerries Hauke Busch Aikaterini Symeonidi Tania Witte Daniel B Lipka Oliver Mücke Peter Nöllke Christopher Felix Krombholz Charlotte M Niemeyer Christoph Plass Christian Flotho

Clin Epigenetics 2016 5;8:50. Epub 2016 May 5.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Mathildenstrasse 1, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1186/s13148-016-0216-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858931PMC
December 2016

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia.

Authors:
Daniel A Lichtenstein Andrew W Crispin Anoop K Sendamarai Dean R Campagna Klaus Schmitz-Abe Cristovao M Sousa Martin D Kafina Paul J Schmidt Charlotte M Niemeyer John Porter Alison May Mrinal M Patnaik Matthew M Heeney Alec Kimmelman Sylvia S Bottomley Barry H Paw Kyriacos Markianos Mark D Fleming

Blood 2016 10 3;128(15):1913-1917. Epub 2016 Aug 3.

Department of Pathology and.

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http://dx.doi.org/10.1182/blood-2016-05-719062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064715PMC
October 2016

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Authors:
Christopher Felix Krombholz Konrad Aumann Matthias Kollek Daniela Bertele Silvia Fluhr Mirjam Kunze Charlotte M Niemeyer Christian Flotho Miriam Erlacher

Haematologica 2016 05 17;101(5):597-606. Epub 2016 Feb 17.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center, Freiburg, Germany The German Cancer Consortium, Heidelberg, Germany

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http://dx.doi.org/10.3324/haematol.2015.138545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004370PMC
May 2016

Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents.

Authors:
Marcin W Wlodarski Shinsuke Hirabayashi Victor Pastor Jan Starý Henrik Hasle Riccardo Masetti Michael Dworzak Markus Schmugge Marry van den Heuvel-Eibrink Marek Ussowicz Barbara De Moerloose Albert Catala Owen P Smith Petr Sedlacek Arjan C Lankester Marco Zecca Victoria Bordon Susanne Matthes-Martin Jonas Abrahamsson Jörn Sven Kühl Karl-Walter Sykora Michael H Albert Bartlomiej Przychodzien Jaroslaw P Maciejewski Stephan Schwarz Gudrun Göhring Brigitte Schlegelberger Annámaria Cseh Peter Noellke Ayami Yoshimi Franco Locatelli Irith Baumann Brigitte Strahm Charlotte M Niemeyer

Blood 2016 Mar 23;127(11):1387-97; quiz 1518. Epub 2015 Dec 23.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium, Freiburg, Germany, and German Cancer Research Center, Heidelberg, Germany;

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http://www.bloodjournal.org/content/bloodjournal/early/2015/
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-09-66
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http://dx.doi.org/10.1182/blood-2015-09-669937DOI Listing
March 2016

Therapy with low-dose azacitidine for MDS in children and young adults: a retrospective analysis of the EWOG-MDS study group.

Authors:
Annamaria M Cseh Charlotte M Niemeyer Ayami Yoshimi Albert Catala Michael C Frühwald Henrik Hasle Mary M van den Heuvel-Eibrink Melchior Lauten Barbara De Moerloose Owen P Smith Toralf Bernig Bernd Gruhn Andreas E Kulozik Markus Metzler Lale Olcay Meinolf Suttorp Ingrid Furlan Brigitte Strahm Christian Flotho

Br J Haematol 2016 Mar 13;172(6):930-6. Epub 2016 Jan 13.

Division of Paediatric Haematology-Oncology, Department of Paediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/bjh.13915DOI Listing
March 2016

Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.

Authors:
Klaus Schmitz-Abe Szymon J Ciesielski Paul J Schmidt Dean R Campagna Fedik Rahimov Brenda A Schilke Marloes Cuijpers Klaus Rieneck Birgitte Lausen Michael L Linenberger Anoop K Sendamarai Chaoshe Guo Inga Hofmann Peter E Newburger Dana Matthews Akiko Shimamura Pieter J L M Snijders Meghan C Towne Charlotte M Niemeyer Henry G Watson Morten H Dziegiel Matthew M Heeney Alison May Sylvia S Bottomley Dorine W Swinkels Kyriacos Markianos Elizabeth A Craig Mark D Fleming

Blood 2015 Dec 21;126(25):2734-8. Epub 2015 Oct 21.

Harvard Medical School, Boston, MA; Department of Pathology, Boston Children's Hospital, Boston, MA;

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http://dx.doi.org/10.1182/blood-2015-09-659854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683334PMC
December 2015

Unmistakable Morphology? Infantile Malignant Osteopetrosis Resembling Juvenile Myelomonocytic Leukemia in Infants.

Authors:
Anne Strauss Ingrid Furlan Sandra Steinmann Bernd Buchholz Bernhard Kremens Claudia Rossig Selim Corbacioglu Revathi Rajagopal Georgia Lahr Ayami Yoshimi Brigitte Strahm Charlotte M Niemeyer Ansgar Schulz

J Pediatr 2015 Aug 15;167(2):486-8. Epub 2015 May 15.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.jpeds.2015.04.064DOI Listing
August 2015

Bridging to transplant with azacitidine in juvenile myelomonocytic leukemia: a retrospective analysis of the EWOG-MDS study group.

Authors:
Annamaria Cseh Charlotte M Niemeyer Ayami Yoshimi Michael Dworzak Henrik Hasle Marry M van den Heuvel-Eibrink Franco Locatelli Riccardo Masetti Markus Schmugge Ute Groß-Wieltsch Andrea Candás Andreas E Kulozik Lale Olcay Meinolf Suttorp Ingrid Furlan Brigitte Strahm Christian Flotho

Blood 2015 Apr;125(14):2311-3

Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2015-01-619734DOI Listing
April 2015

Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood.

Authors:
Anna M Aalbers Marry M van den Heuvel-Eibrink Irith Baumann Michael Dworzak Henrik Hasle Franco Locatelli Barbara De Moerloose Markus Schmugge Ester Mejstrikova Michaela Nováková Marco Zecca C Michel Zwaan Jeroen G Te Marvelde Anton W Langerak Jacques J M van Dongen Rob Pieters Charlotte M Niemeyer Vincent H J van der Velden

Haematologica 2015 Mar 25;100(3):315-23. Epub 2014 Nov 25.

Department of Immunology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands

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http://dx.doi.org/10.3324/haematol.2014.107706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349269PMC
March 2015

An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults.

Authors:
Michael R Savona Luca Malcovati Rami Komrokji Ramon V Tiu Tariq I Mughal Attilio Orazi Jean-Jacques Kiladjian Eric Padron Eric Solary Raoul Tibes Raphael Itzykson Mario Cazzola Ruben Mesa Jaroslaw Maciejewski Pierre Fenaux Guillermo Garcia-Manero Aaron Gerds Guillermo Sanz Charlotte M Niemeyer Francisco Cervantes Ulrich Germing Nicholas C P Cross Alan F List

Blood 2015 Mar 26;125(12):1857-65. Epub 2015 Jan 26.

H. Lee Moffitt Cancer Center, Tampa, FL;

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http://dx.doi.org/10.1182/blood-2014-10-607341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915792PMC
March 2015

How I treat juvenile myelomonocytic leukemia.

Authors:
Franco Locatelli Charlotte M Niemeyer

Blood 2015 Feb 6;125(7):1083-90. Epub 2015 Jan 6.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Freiburg, Freiburg, Germany; German Cancer Consortium, Heidelberg, Germany; and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2014-08-550483DOI Listing
February 2015

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia.

Authors:
Charlotte M Niemeyer Mignon L Loh Annamaria Cseh Todd Cooper Christopher C Dvorak Rebecca Chan Blanca Xicoy Ulrich Germing Seiji Kojima Atsushi Manabe Michael Dworzak Barbara De Moerloose Jan Starý Owen P Smith Riccardo Masetti Albert Catala Eva Bergstraesser Marek Ussowicz Oskana Fabri André Baruchel Hélène Cavé Michel Zwaan Franco Locatelli Henrik Hasle Marry M van den Heuvel-Eibrink Christian Flotho Ayami Yoshimi

Haematologica 2015 Jan;100(1):17-22

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology University of Freiburg, Germany.

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http://dx.doi.org/10.3324/haematol.2014.109892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281308PMC
January 2015

Internal tandem duplication of the FLT3 gene confers poor overall survival in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukemia study.

Authors:
Antonio R Lucena-Araujo Haesook T Kim Rafael H Jacomo Raul A Melo Rosane Bittencourt Ricardo Pasquini Katia Pagnano Evandro M Fagundes Maria de Lourdes Chauffaille Carlos S Chiattone Ana Silvia Lima Guillermo Ruiz-Argüelles Maria Soledad Undurraga Lem Martinez Hau C Kwaan Robert Gallagher Charlotte M Niemeyer Stanley L Schrier Martin S Tallman David Grimwade Arnold Ganser Nancy Berliner Raul C Ribeiro Francesco Lo-Coco Bob Löwenberg Miguel A Sanz Eduardo M Rego

Ann Hematol 2014 Dec 2;93(12):2001-10. Epub 2014 Jul 2.

Medical School of Ribeirão Preto, Ribeirao Preto, Brazil.

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http://dx.doi.org/10.1007/s00277-014-2142-9DOI Listing
December 2014

Monitoring of hematopoietic chimerism after transplantation for pediatric myelodysplastic syndrome: real-time or conventional short tandem repeat PCR in peripheral blood or bone marrow?

Authors:
Andre M Willasch Hermann Kreyenberg Nona Shayegi Eva Rettinger Vida Meyer Marion Zabel Peter Lang Bernhard Kremens Roland Meisel Brigitte Strahm Claudia Rossig Bernd Gruhn Thomas Klingebiel Charlotte M Niemeyer Peter Bader

Biol Blood Marrow Transplant 2014 Dec 31;20(12):1918-25. Epub 2014 Jul 31.

Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2014.07.030DOI Listing
December 2014

RAS diseases in children.

Authors:
Charlotte M Niemeyer

Haematologica 2014 Nov;99(11):1653-62

Department of Pediatric Hematology and Oncology, Universitätsklinikum Freiburg, Germany

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http://dx.doi.org/10.3324/haematol.2014.114595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222471PMC
November 2014

Deferasirox for managing iron overload in people with myelodysplastic syndrome.

Authors:
Joerg J Meerpohl Lisa K Schell Gerta Rücker Nigel Fleeman Edith Motschall Charlotte M Niemeyer Dirk Bassler

Cochrane Database Syst Rev 2014 Oct 28(10):CD007461. Epub 2014 Oct 28.

German Cochrane Centre, Medical Center - University of Freiburg, Berliner Allee 29, Freiburg, Germany, 79110.

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http://dx.doi.org/10.1002/14651858.CD007461.pub3DOI Listing
October 2014

RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia.

Authors:
Anna R Poetsch Daniel B Lipka Tania Witte Rainer Claus Peter Nöllke Manuela Zucknick Christiane Olk-Batz Silvia Fluhr Michael Dworzak Barbara De Moerloose Jan Starý Marco Zecca Henrik Hasle Markus Schmugge Marry M van den Heuvel-Eibrink Franco Locatelli Charlotte M Niemeyer Christian Flotho Christoph Plass

Epigenetics 2014 Sep 31;9(9):1252-60. Epub 2014 Jul 31.

Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany; The German Cancer Consortium; Heidelberg, Germany.

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http://dx.doi.org/10.4161/epi.29941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169017PMC
September 2014

Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.

Authors:
Antonio R Lucena-Araujo Haesook T Kim Rafael H Jacomo Raul A Melo Rosane Bittencourt Ricardo Pasquini Katia Pagnano Evandro M Fagundes Maria de Lourdes Chauffaille Carlos S Chiattone Ana S Lima Hau C Kwaan Robert Gallagher Charlotte M Niemeyer Stanley L Schrier Martin S Tallman David Grimwade Arnold Ganser Nancy Berliner Raul C Ribeiro Francesco Lo-Coco Bob Löwenberg Miguel A Sanz Eduardo M Rego

Br J Haematol 2014 Aug 3;166(4):540-9. Epub 2014 May 3.

Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Centre for Cell Based Therapy, University of São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.1111/bjh.12921DOI Listing
August 2014

Deferasirox for managing transfusional iron overload in people with sickle cell disease.

Authors:
Joerg J Meerpohl Lisa K Schell Gerta Rücker Edith Motschall Nigel Fleeman Charlotte M Niemeyer Dirk Bassler

Cochrane Database Syst Rev 2014 May 27;5:CD007477. Epub 2014 May 27.

German Cochrane Centre, Medical Center - University of Freiburg, Berliner Allee 29, Freiburg, Germany, 79110.

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http://dx.doi.org/10.1002/14651858.CD007477.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489379PMC
May 2014

Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood.

Authors:
Ayami Yoshimi Marry M van den Heuvel-Eibrink Irith Baumann Stephan Schwarz Ingrid Simonitsch-Klupp Pascale de Paepe Vit Campr Gitte Birk Kerndrup Maureen O'Sullivan Rita Devito Roos Leguit Miguel Hernandez Michael Dworzak Barbara de Moerloose Jan Stary Henrik Hasle Owen P Smith Marco Zecca Albert Catala Markus Schmugge Franco Locatelli Monika Führer Alexandra Fischer Anne Guderle Peter Nöllke Brigitte Strahm Charlotte M Niemeyer

Haematologica 2014 Apr 25;99(4):656-63. Epub 2013 Oct 25.

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http://dx.doi.org/10.3324/haematol.2013.095786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971075PMC
April 2014

X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations.

Authors:
Dean R Campagna Charlotte I de Bie Klaus Schmitz-Abe Marion Sweeney Anoop K Sendamarai Paul J Schmidt Matthew M Heeney Helger G Yntema Caroline Kannengiesser Bernard Grandchamp Charlotte M Niemeyer Nine V A M Knoers Sonia Swart Gordon Marron Richard van Wijk Reinier A Raymakers Alison May Kyriacos Markianos Sylvia S Bottomley Dorine W Swinkels Mark D Fleming

Am J Hematol 2014 Mar 20;89(3):315-9. Epub 2013 Nov 20.

Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943703PMC
March 2014

Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myelogenous leukemia after aplastic anemia.

Authors:
Ayami Yoshimi Brigitte Strahm Irith Baumann Ingrid Furlan Stephan Schwarz Andrea Teigler-Schlegel Joachim-Ulrich Walther Brigitte Schlegelberger Gudrun Göhring Peter Nöllke Monika Führer Charlotte M Niemeyer

Biol Blood Marrow Transplant 2014 Mar 5;20(3):425-9. Epub 2013 Dec 5.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791130056
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http://dx.doi.org/10.1016/j.bbmt.2013.11.031DOI Listing
March 2014

Tracing the development of acute myeloid leukemia in CBL syndrome.

Authors:
Heiko Becker Kenichi Yoshida Nadja Blagitko-Dorfs Rainer Claus Milena Pantic Mahmoud Abdelkarim Christoph Niemöller Christine Greil Björn Hackanson Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Satoru Miyano Konstanze Döhner Susanne Schnittger Philipp Henneke Charlotte M Niemeyer Christian Flotho Dietmar Pfeifer Seishi Ogawa Michael Lübbert

Blood 2014 Mar 3;123(12):1883-6. Epub 2014 Feb 3.

Department of Medicine I, Medical Center-University of Freiburg, Freiburg, Germany;

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http://dx.doi.org/10.1182/blood-2013-10-533844DOI Listing
March 2014

Coping in long-term survivors of childhood cancer: relations to psychological distress.

Authors:
Kerstin Wenninger Almut Helmes Jürgen Bengel Melchior Lauten Susanne Völkel Charlotte M Niemeyer

Psychooncology 2013 Apr 28;22(4):854-61. Epub 2012 Mar 28.

University Medical Center, Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Freiburg, Germany.

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http://dx.doi.org/10.1002/pon.3073DOI Listing
April 2013

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL.

Authors:
Eduardo M Rego Haesook T Kim Guillermo J Ruiz-Argüelles Maria Soledad Undurraga Maria del Rosario Uriarte Rafael H Jacomo Homero Gutiérrez-Aguirre Raul A M Melo Rosane Bittencourt Ricardo Pasquini Katia Pagnano Evandro M Fagundes Maria de Lourdes Chauffaille Carlos S Chiattone Lem Martinez Luis A Meillón David Gómez-Almaguer Hau C Kwaan Javier Garcés-Eisele Robert Gallagher Charlotte M Niemeyer Stanley L Schrier Martin Tallman David Grimwade Arnold Ganser Nancy Berliner Raul C Ribeiro Francesco Lo-Coco Bob Löwenberg Miguel A Sanz

Blood 2013 Mar 14;121(11):1935-43. Epub 2013 Jan 14.

Hematology/Oncology Division, Department of Internal Medicine, Medical School of Ribeirão Preto and Center for Cell Based Therapy, University of São Paulo, Ribeirão Preto, Brazil.

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http://www.bloodjournal.org/content/early/2013/01/11/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-08-44
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http://dx.doi.org/10.1182/blood-2012-08-449918DOI Listing
March 2013

Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf.

Authors:
Verena Labi Daniela Bertele Claudia Woess Denise Tischner Florian J Bock Sven Schwemmers Heike L Pahl Stephan Geley Mirjam Kunze Charlotte M Niemeyer Andreas Villunger Miriam Erlacher

EMBO Mol Med 2013 01 24;5(1):122-36. Epub 2012 Nov 24.

Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1002/emmm.201201235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569658PMC
January 2013

Comparison of the efficacy of rabbit and horse antithymocyte globulin for the treatment of severe aplastic anemia in children.

Authors:
Ayami Yoshimi Charlotte M Niemeyer Monika M Führer Brigitte Strahm

Blood 2013 Jan;121(5):860-1

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http://dx.doi.org/10.1182/blood-2012-10-461509DOI Listing
January 2013

Classification of childhood aplastic anemia and myelodysplastic syndrome.

Authors:
Charlotte M Niemeyer Irith Baumann

Hematology Am Soc Hematol Educ Program 2011 ;2011:84-9

Department of Pediatric Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/asheducation-2011.1.84DOI Listing
April 2012

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.

Authors:
Felicitas Thol Sofia Kade Carola Schlarmann Patrick Löffeld Michael Morgan Jürgen Krauter Marcin W Wlodarski Britta Kölking Martin Wichmann Kerstin Görlich Gudrun Göhring Gesine Bug Oliver Ottmann Charlotte M Niemeyer Wolf-Karsten Hofmann Brigitte Schlegelberger Arnold Ganser Michael Heuser

Blood 2012 Apr 2;119(15):3578-84. Epub 2012 Mar 2.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1182/blood-2011-12-399337DOI Listing
April 2012

The impact of medical education and networking on the outcome of leukemia treatment in developing countries. The experience of International Consortium on Acute Promyelocytic Leukemia (IC-APL).

Authors:
Eduardo M Rego Haesook T Kim Guillermo J Ruiz-Argüelles Maria del Rosario Uriarte Rafael H Jacomo Homero Gutiérrez-Aguirre Raul A M Melo Rosane Bittencourt Ricardo Pasquini Katia Pagnano Evandro M Fagundes Maria de Lourdes Chauffaille Carlos Chiattone Lem Martinez Luis A Meillón David Gómez-Almaguer Hau Kwaan Javier Garcés-Eisele Robert Gallagher Charlotte M Niemeyer Bob Lowenberg Raul Ribeiro Francesco LoCoco Miguel A Sanz

Hematology 2012 Apr;17 Suppl 1:S36-8

Hematology Service, Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.1179/102453312X13336169155376DOI Listing
April 2012

Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML.

Authors:
Shinsuke Hirabayashi Christian Flotho Jessica Moetter Michael Heuser Henrik Hasle Bernd Gruhn Thomas Klingebiel Felicitas Thol Brigitte Schlegelberger Irith Baumann Brigitte Strahm Jan Stary Franco Locatelli Marco Zecca Eva Bergstraesser Michael Dworzak Marry M van den Heuvel-Eibrink Barbara De Moerloose Seishi Ogawa Charlotte M Niemeyer Marcin W Wlodarski

Blood 2012 Mar 11;119(11):e96-9. Epub 2012 Jan 11.

Pediatric Hematology and Oncology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2011-12-395087DOI Listing
March 2012

Deferasirox for managing iron overload in people with thalassaemia.

Authors:
Joerg J Meerpohl Gerd Antes Gerta Rücker Nigel Fleeman Edith Motschall Charlotte M Niemeyer Dirk Bassler

Cochrane Database Syst Rev 2012 Feb 15(2):CD007476. Epub 2012 Feb 15.

German Cochrane Centre, Institute of Medical Biometry & Medical Informatics and Pediatric Hematology & Oncology, Center forPediatrics & Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/14651858.CD007476.pub2DOI Listing
February 2012

Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.

Authors:
Tim Ripperger Marcel Tauscher Inka Praulich Brigitte Pabst Andrea Teigler-Schlegel Allen Yeoh Gudrun Göhring Brigitte Schlegelberger Christian Flotho Charlotte M Niemeyer Doris Steinemann

Br J Haematol 2011 Oct 18;155(2):209-17. Epub 2011 Aug 18.

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://doi.wiley.com/10.1111/j.1365-2141.2011.08817.x
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http://dx.doi.org/10.1111/j.1365-2141.2011.08817.xDOI Listing
October 2011

Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.

Authors:
Marcin W Wlodarski Jessica Mötter Thomas A Gorr Christiane Olk-Batz Henrik Hasle Michael Dworzak Charlotte M Niemeyer Christian Flotho

Blood 2011 Oct;118(16):4490-1

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http://dx.doi.org/10.1182/blood-2011-07-370684DOI Listing
October 2011

Advances in the prognostication and management of advanced MDS in children.

Authors:
Henrik Hasle Charlotte M Niemeyer

Br J Haematol 2011 Jul 9;154(2):185-95. Epub 2011 May 9.

Department of Paediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08724.xDOI Listing
July 2011

Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome.

Authors:
Christiane Olk-Batz Anna R Poetsch Peter Nöllke Rainer Claus Manuela Zucknick Inga Sandrock Tania Witte Brigitte Strahm Henrik Hasle Marco Zecca Jan Stary Eva Bergstraesser Barbara De Moerloose Monika Trebo Marry M van den Heuvel-Eibrink Dorota Wojcik Franco Locatelli Christoph Plass Charlotte M Niemeyer Christian Flotho

Blood 2011 May 15;117(18):4871-80. Epub 2011 Mar 15.

Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2010-08-298968DOI Listing
May 2011

Sequential acquisition of IgH and TCR rearrangements during the preleukemic phase of acute lymphoblastic leukemia in an adolescent patient.

Authors:
Tobias Linden Ingrid Furlan Stephan Schwarz Robert Stoehr Charlotte M Niemeyer Claudia Rossig

Pediatr Blood Cancer 2011 Feb;56(2):301-3

Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.

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http://dx.doi.org/10.1002/pbc.22734DOI Listing
February 2011

Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome.

Authors:
Gudrun Göhring Kyra Michalova H Berna Beverloo David Betts Jochen Harbott Oskar A Haas Gitte Kerndrup Laura Sainati Eva Bergstraesser Henrik Hasle Jan Stary Monika Trebo Marry M van den Heuvel-Eibrink Marco Zecca Elisabeth R van Wering Alexandra Fischer Peter Noellke Brigitte Strahm Franco Locatelli Charlotte M Niemeyer Brigitte Schlegelberger

Blood 2010 Nov 27;116(19):3766-9. Epub 2010 Aug 27.

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1182/blood-2010-04-280313DOI Listing
November 2010

Deferasirox for managing iron overload in people with myelodysplastic syndrome.

Authors:
Joerg J Meerpohl Gerd Antes Gerta Rücker Nigel Fleeman Edith Motschall Charlotte M Niemeyer Dirk Bassler

Cochrane Database Syst Rev 2010 Nov 10(11):CD007461. Epub 2010 Nov 10.

German Cochrane Centre, Institute of Medical Biometry & Medical Informatics and Pediatric Hematology & Oncology, Center for Pediatrics & Adolescent Medicine, University Medical Center Freiburg, Berliner Allee 29, Freiburg, Germany, 79110.

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http://dx.doi.org/10.1002/14651858.CD007461.pub2DOI Listing
November 2010

Clonal heterogeneity in childhood myelodysplastic syndromes--challenge for the detection of chromosomal imbalances by array-CGH.

Authors:
Inka Praulich Marcel Tauscher Gudrun Göhring Stefanie Glaser Winfried Hofmann Simone Feurstein Christian Flotho Peter Lichter Charlotte M Niemeyer Brigitte Schlegelberger Doris Steinemann

Genes Chromosomes Cancer 2010 Oct;49(10):885-900

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/gcc.20797DOI Listing
October 2010

Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia?

Authors:
Doris Steinemann Marcel Tauscher Inka Praulich Charlotte M Niemeyer Christian Flotho Brigitte Schlegelberger

Haematologica 2010 Sep 11;95(9):1616. Epub 2010 May 11.

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http://dx.doi.org/10.3324/haematol.2010.024984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930968PMC
September 2010

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.

Authors:
Charlotte M Niemeyer Michelle W Kang Danielle H Shin Ingrid Furlan Miriam Erlacher Nancy J Bunin Severa Bunda Jerry Z Finklestein Thomas A Gorr Parinda Mehta Irene Schmid Gabriele Kropshofer Selim Corbacioglu Peter J Lang Christoph Klein Paul-Gerhard Schlegel Andrea Heinzmann Michaela Schneider Jan Starý Marry M van den Heuvel-Eibrink Henrik Hasle Franco Locatelli Debbie Sakai Sophie Archambeault Leslie Chen Ryan C Russell Stephanie S Sybingco Michael Ohh Benjamin S Braun Christian Flotho Mignon L Loh

Nat Genet 2010 Sep 8;42(9):794-800. Epub 2010 Aug 8.

Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.

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http://dx.doi.org/10.1038/ng.641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297285PMC
September 2010

Molecular diagnosis of Shwachman-Diamond syndrome in a child with incomplete clinical disease phenotype.

Authors:
Tobias Linden Karoline Ehlert Charlotte M Niemeyer Gudrun Fleischhack Heribert Jürgens Claudia Rossig

Pediatr Blood Cancer 2010 Jul;55(1):177-9

University Children's Hospital Muenster, Department of Pediatric Hematology and Oncology, Albert-Schweitzer-Strasse 33, 48149 Muenster, Germany.

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http://dx.doi.org/10.1002/pbc.22424DOI Listing
July 2010

Mutations of the Shwachman-Bodian-Diamond syndrome gene in patients presenting with refractory cytopenia--do we have to screen?

Authors:
Axel Karow Christian Flotho Michaela Schneider Manfred Fliegauf Charlotte M Niemeyer

Haematologica 2010 Apr 30;95(4):689-90. Epub 2009 Nov 30.

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http://dx.doi.org/10.3324/haematol.2009.015008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857206PMC
April 2010

Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia.

Authors:
Silvia Bresolin Marco Zecca Christian Flotho Luca Trentin Andrea Zangrando Laura Sainati Jan Stary Barbara de Moerloose Henrik Hasle Charlotte M Niemeyer Geertruy Te Kronnie Franco Locatelli Giuseppe Basso

J Clin Oncol 2010 Apr 15;28(11):1919-27. Epub 2010 Mar 15.

Laboratory of Oncohematology, Department of Pediatrics, University of Padova, Pavia, Italy.

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http://dx.doi.org/10.1200/JCO.2009.24.4426DOI Listing
April 2010

Editorial policies of pediatric journals: survey of instructions for authors.

Authors:
Joerg J Meerpohl Robert F Wolff Charlotte M Niemeyer Gerd Antes Erik von Elm

Arch Pediatr Adolesc Med 2010 Mar;164(3):268-72

German Cochrane Center, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan-Meier-Strasse 26, Freiburg, Germany.

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http://dx.doi.org/10.1001/archpediatrics.2009.287DOI Listing
March 2010

Does SPRED1 contribute to leukemogenesis in juvenile myelomonocytic leukemia (JMML)?

Authors:
Christiane Batz Henrik Hasle Eva Bergsträsser Marry M van den Heuvel-Eibrink Marco Zecca Charlotte M Niemeyer Christian Flotho

Blood 2010 Mar;115(12):2557-8

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http://dx.doi.org/10.1182/blood-2009-12-260901DOI Listing
March 2010

Mitotic recombination and compound-heterozygous mutations are predominant NF1-inactivating mechanisms in children with juvenile myelomonocytic leukemia and neurofibromatosis type 1.

Authors:
Doris Steinemann Larissa Arning Inka Praulich Manfred Stuhrmann Henrik Hasle Jan Stary Brigitte Schlegelberger Charlotte M Niemeyer Christian Flotho

Haematologica 2010 Feb 16;95(2):320-3. Epub 2009 Dec 16.

Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.3324/haematol.2009.010355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817036PMC
February 2010

Mutational analysis of SHOC2, a novel gene for Noonan-like syndrome, in JMML.

Authors:
Christian Flotho Christiane Batz Henrik Hasle Eva Bergsträsser Marry M van den Heuvel-Eibrink Marco Zecca Charlotte M Niemeyer Martin Zenker

Blood 2010 Jan;115(4):913

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http://dx.doi.org/10.1182/blood-2009-10-250779DOI Listing
January 2010

Methylation of the PTEN gene CpG island is infrequent in juvenile myelomonocytic leukemia: Comments on "PTEN deficiency is a common defect in juvenile myelomonocytic leukemia" [Leuk. Res. 2009;33:671-677 (Epub 2008 November 17)].

Authors:
Christiane Batz Inga Sandrock Charlotte M Niemeyer Christian Flotho

Leuk Res 2009 Nov 31;33(11):1578-9; author reply 1580. Epub 2009 May 31.

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http://dx.doi.org/10.1016/j.leukres.2009.04.040DOI Listing
November 2009

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.

Authors:
Zhenyun Yang Takako Kondo Cara S Voorhorst Sarah C Nabinger Leila Ndong Fuqin Yin Edward M Chan Menggang Yu Oliver Würstlin Christian P Kratz Charlotte M Niemeyer Christian Flotho Eri Hashino Rebecca J Chan

Mol Cell Biol 2009 Aug 15;29(16):4376-93. Epub 2009 Jun 15.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1128/MCB.01330-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725726PMC
August 2009

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.

Authors:
Mignon L Loh Debbie S Sakai Christian Flotho Michelle Kang Manfred Fliegauf Sophie Archambeault Charles G Mullighan Leslie Chen Eva Bergstraesser Carlos E Bueso-Ramos Peter D Emanuel Henrik Hasle Jean-Pierre Issa Marry M van den Heuvel-Eibrink Franco Locatelli Jan Stary Monica Trebo Marcin Wlodarski Marco Zecca Kevin M Shannon Charlotte M Niemeyer

Blood 2009 Aug 1;114(9):1859-63. Epub 2009 Jul 1.

Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, California, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-01-19
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http://dx.doi.org/10.1182/blood-2009-01-198416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738571PMC
August 2009

Mutation analysis of the HAX1 gene in childhood myelodysplastic syndrome.

Authors:
Doris Steinemann Inka Praulich Noreen Otto Gudrun Göhring Charlotte M Niemeyer Brigitte Schlegelberger

Br J Haematol 2009 May;145(4):533-4

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07634.xDOI Listing
May 2009

Morphologic differential diagnosis of juvenile myelomonocytic leukemia--pitfalls apart from viral infection.

Authors:
Axel Karow Irith Baumann Charlotte M Niemeyer

J Pediatr Hematol Oncol 2009 May;31(5):380

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http://dx.doi.org/10.1097/MPH.0b013e31819ed260DOI Listing
May 2009

Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7.

Authors:
Ingrid Furlan Christiane Batz Christian Flotho Brigitte Mohr Michael Lübbert Meinolf Suttorp Charlotte M Niemeyer

Blood 2009 Mar;113(12):2867-8

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-12-19
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http://dx.doi.org/10.1182/blood-2008-12-195693DOI Listing
March 2009

HLA-identical umbilical cord blood transplantation from a sibling donor in juvenile myelomonocytic leukemia.

Authors:
Andrica C H de Vries Robbert G M Bredius Arjan C Lankester Marc Bierings Monika Trebo Petr Sedlacek Charlotte M Niemeyer Marco Zecca Franco Locatelli Marry M van den Heuvel-Eibrink

Haematologica 2009 Feb 23;94(2):302-4. Epub 2008 Dec 23.

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http://dx.doi.org/10.3324/haematol.2008.000216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635404PMC
February 2009

Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts.

Authors:
Ghulam J Mufti John M Bennett Jean Goasguen Barbara J Bain Irith Baumann Richard Brunning Mario Cazzola Pierre Fenaux Ulrich Germing Eva Hellström-Lindberg Itsuro Jinnai Atsushi Manabe Akira Matsuda Charlotte M Niemeyer Guillermo Sanz Masao Tomonaga Teresa Vallespi Ayami Yoshimi

Haematologica 2008 Nov 6;93(11):1712-7. Epub 2008 Oct 6.

Department of Haematology, King's College Hospital, Denmark Hill, London, SE5 9RS United Kingdom.

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http://www.haematologica.org/cgi/doi/10.3324/haematol.13405
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http://dx.doi.org/10.3324/haematol.13405DOI Listing
November 2008

Epidemiology, classification and prognosis of adults and children with myelodysplastic syndromes.

Authors:
Ulrich Germing Carlo Aul Charlotte M Niemeyer Rainer Haas John M Bennett

Ann Hematol 2008 Sep 25;87(9):691-9. Epub 2008 Jun 25.

Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstr. 5, 40225 Düsseldorf, Germany.

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http://link.springer.com/10.1007/s00277-008-0499-3
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September 2008

Angiogenesis as a target in neuroblastoma.

Authors:
Jochen Rössler Melissa Taylor Birgit Geoerger Francoise Farace Jeanette Lagodny Regine Peschka-Süss Charlotte M Niemeyer Gilles Vassal

Eur J Cancer 2008 Aug 7;44(12):1645-56. Epub 2008 Jul 7.

Pharmacology and New Treatments in Cancer, Institut Gustave Roussy, University of Paris-Sud, UPRES EA3535, Villejuif, France.

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http://dx.doi.org/10.1016/j.ejca.2008.05.015DOI Listing
August 2008

Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma.

Authors:
Sebastian Werner Arnulfo Mendoza Ralf A Hilger Miriam Erlacher Wilfried Reichardt Andrej Lissat Claudia Konanz Marcus Uhl Charlotte M Niemeyer Chand Khanna Udo Kontny

Cancer Chemother Pharmacol 2008 Jun 1;62(1):19-31. Epub 2007 Sep 1.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Albert-Ludwigs-University, Mathildenstr. 1, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00280-007-0566-9DOI Listing
June 2008

Differentiation of EBV-induced post-transplant Hodgkin lymphoma from Hodgkin-like post-transplant lymphoproliferative disease.

Authors:
Jan C Rohr Hans J Wagner Melchior Lauten Hans H Wacker Eva Jüttner Christof Hanke Martin Pohl Charlotte M Niemeyer

Pediatr Transplant 2008 Jun;12(4):426-31

Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1399-3046.2007.00816.xDOI Listing
June 2008

JAK2 mutations other than V617F: a novel mutation and mini review.

Authors:
Axel Karow Cornelius Waller Christian Reimann Charlotte M Niemeyer Christian P Kratz

Leuk Res 2008 Feb 26;32(2):365-6. Epub 2007 Apr 26.

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http://dx.doi.org/10.1016/j.leukres.2007.02.018DOI Listing
February 2008

Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia.

Authors:
Sophie Archambeault Nikki J Flores Ayami Yoshimi Christian P Kratz Miriam Reising Alexandra Fischer Peter Noellke Franco Locatelli Petr Sedlacek Christian Flotho Marco Zecca Peter D Emanuel Robert P Castleberry Charlotte M Niemeyer Peter Bader Mignon L Loh

Blood 2008 Feb 13;111(3):1124-7. Epub 2007 Nov 13.

Department of Pediatrics, University of California, San Francisco, CA 94143, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-09
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http://dx.doi.org/10.1182/blood-2007-06-093302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214753PMC
February 2008

Concomitant EBV-related B-cell proliferation and juvenile myelomonocytic leukemia in a 2-year-old child.

Authors:
Anna Janik-Moszant Małgorzata Barć-Czarnecka Mirjam van der Burg Anton W Langerak Nico G Hartwig Ann C T M Vossen Charlotte M Niemeyer Jacek Wachowiak Danuta Sońta-Jakimczyk Tomasz Szczepański

Leuk Res 2008 Jan 5;32(1):181-4. Epub 2007 Jul 5.

Department of Pediatric Hematology and Oncology, Silesian Medical Academy, Zabrze, Poland.

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http://dx.doi.org/10.1016/j.leukres.2007.05.017DOI Listing
January 2008

Myelodysplastic syndrome in children and adolescents.

Authors:
Charlotte M Niemeyer Irith Baumann

Semin Hematol 2008 Jan;45(1):60-70

Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1053/j.seminhematol.2007.10.006DOI Listing
January 2008

Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations.

Authors:
Christian Flotho Christian P Kratz Eva Bergsträsser Henrik Hasle Jan Starý Monika Trebo Marry M van den Heuvel-Eibrink Dorota Wójcik Marco Zecca Franco Locatelli Charlotte M Niemeyer

Blood 2008 Jan;111(2):966-7; author reply 967-8

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http://dx.doi.org/10.1182/blood-2007-09-111831DOI Listing
January 2008

Mesenteric chloroma with t(16;16) followed by acute myelomonocytic leukemia with clonal evolution.

Authors:
Gudrun Göhring Miriam Erlacher Miriam van Buiren Eva Jüttner Charlotte M Niemeyer Brigitte Schlegelberger

Cancer Genet Cytogenet 2007 Dec;179(2):162-4

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http://dx.doi.org/10.1016/j.cancergencyto.2007.08.016DOI Listing
December 2007

Biochemical and functional characterization of germ line KRAS mutations.

Authors:
Suzanne Schubbert Gideon Bollag Natalya Lyubynska Hoa Nguyen Christian P Kratz Martin Zenker Charlotte M Niemeyer Anders Molven Kevin Shannon

Mol Cell Biol 2007 Nov 17;27(22):7765-70. Epub 2007 Sep 17.

Department of Pediatrics, University of California, 513 Parnassus Avenue, HSE 302, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1128/MCB.00965-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169154PMC
November 2007

How a rare pediatric neoplasia can give important insights into biological concepts: a perspective on juvenile myelomonocytic leukemia.

Authors:
Christian Flotho Christian P Kratz Charlotte M Niemeyer

Haematologica 2007 Nov;92(11):1441-6

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http://dx.doi.org/10.3324/haematol.11280DOI Listing
November 2007

Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia.

Authors:
Andrica C H de Vries Ronald W Stam Pauline Schneider Charlotte M Niemeyer Elisabeth R van Wering Oskar A Haas Christian P Kratz Monique L den Boer Rob Pieters Marry M van den Heuvel-Eibrink

Haematologica 2007 Nov;92(11):1557-60

ErasmusMC-Sophia Children's Hospital, Department of Pediatric Hematology/Oncology, Room Sp 2568, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.11201DOI Listing
November 2007

Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia.

Authors:
Andrica C H de Vries Ronald W Stam Christian P Kratz Martin Zenker Charlotte M Niemeyer Marry M van den Heuvel-Eibrink

Haematologica 2007 Nov;92(11):1574-5

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http://dx.doi.org/10.3324/haematol.11493DOI Listing
November 2007

AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies.

Authors:
Christian Flotho Annika Paulun Christiane Batz Charlotte M Niemeyer

Br J Haematol 2007 Sep;138(5):644-50

Division of Paediatric Haematology-Oncology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06709.xDOI Listing
September 2007

Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study.

Authors:
Henrik Hasle Todd A Alonzo Anne Auvrignon Catherine Behar Myron Chang Ursula Creutzig Alexandra Fischer Erik Forestier Alcira Fynn Oskar A Haas Jochen Harbott Christine J Harrison Nyla A Heerema Marry M van den Heuvel-Eibrink Gertjan J L Kaspers Franco Locatelli Peter Noellke Sophia Polychronopoulou Yaddanapudi Ravindranath Bassem Razzouk Dirk Reinhardt Natalia N Savva Batia Stark Stefan Suciu Ichiro Tsukimoto David K Webb Dorora Wojcik William G Woods Martin Zimmermann Charlotte M Niemeyer Susana C Raimondi

Blood 2007 Jun 13;109(11):4641-7. Epub 2007 Feb 13.

Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark.

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http://dx.doi.org/10.1182/blood-2006-10-051342DOI Listing
June 2007

Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity.

Authors:
Andrej Lissat Thomas Vraetz Maria Tsokos Ruth Klein Matthias Braun Nino Koutelia Paul Fisch Maria E Romero Lauren Long Peter Noellke Crystal L Mackall Charlotte M Niemeyer Udo Kontny

Am J Pathol 2007 Jun;170(6):1917-30

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Albert-Ludwigs-University, Mathildenstrasse 1, 79106 Freiburg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899433PMC
http://dx.doi.org/10.2353/ajpath.2007.060993DOI Listing
June 2007

Targeting RAS signaling pathways in juvenile myelomonocytic leukemia.

Authors:
Christian Flotho Christian Kratz Charlotte M Niemeyer

Curr Drug Targets 2007 Jun;8(6):715-25

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Germany.

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http://dx.doi.org/10.2174/138945007780830773DOI Listing
June 2007

An unexpected new role of mutant Ras: perturbation of human embryonic development.

Authors:
Christian P Kratz Charlotte M Niemeyer Martin Zenker

J Mol Med (Berl) 2007 Mar 9;85(3):227-35. Epub 2007 Jan 9.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00109-006-0135-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820751PMC
March 2007