Publications by authors named "Charlie Lees"

46Publications

Environmental stimuli and gut inflammation via dysbiosis in mouse and man.

Authors:
Charlie W Lees

Nat Rev Gastroenterol Hepatol 2020 Oct 1. Epub 2020 Oct 1.

Centre for Genomics and Experimental Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41575-020-00373-6DOI Listing
October 2020

Normalization of Fecal Calprotectin Within 12 Months of Diagnosis Is Associated With Reduced Risk of Disease Progression in Patients With Crohn's Disease.

Clin Gastroenterol Hepatol 2020 Aug 13. Epub 2020 Aug 13.

Edinburgh IBD Unit, Western General Hospital, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital Campus, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2020.08.022DOI Listing
August 2020

Innovation in Inflammatory Bowel Disease Care During the COVID-19 Pandemic: Results of a Global Telemedicine Survey by the International Organization for the Study of Inflammatory Bowel Disease.

Gastroenterology 2020 09 29;159(3):805-808.e1. Epub 2020 May 29.

Division of Gastroenterology, University of California, San Francisco, San Francisco, California and, Member, International Organization for the study of Inflammatory Bowel Disease.

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http://dx.doi.org/10.1053/j.gastro.2020.05.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256529PMC
September 2020

Mobile Health in IBD: Enhancing Care, One Phone at a Time.

Inflamm Bowel Dis 2020 01;26(2):163-166

Mount Sinai Hospital, New York, New York, USA.

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http://dx.doi.org/10.1093/ibd/izz262DOI Listing
January 2020

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Gastroenterology 2020 01 7;158(1):189-199. Epub 2019 Oct 7.

Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.09.041DOI Listing
January 2020

Higher anti-tumor necrosis factor levels are associated with perianal fistula healing and fistula closure in Crohn's disease.

Eur J Gastroenterol Hepatol 2020 01;32(1):32-37

The Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1097/MEG.0000000000001561DOI Listing
January 2020

Reply.

Clin Gastroenterol Hepatol 2020 02 24;18(2):526. Epub 2019 Jul 24.

Gastrointestinal Unit, Western General Hospital, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2019.07.031DOI Listing
February 2020

Association Between Level of Fecal Calprotectin and Progression of Crohn's Disease.

Clin Gastroenterol Hepatol 2019 10 14;17(11):2269-2276.e4. Epub 2019 Feb 14.

Gastrointestinal Unit, Western General Hospital, Edinburgh, United Kingdom; Gastrointestinal Unit, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2019.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880783PMC
October 2019

Bilateral lower limb weakness in acute severe ulcerative colitis.

Lancet 2016 Jul;388(10039):101-2

Department of Gastroenterology, Western General Hospital, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)30857-1DOI Listing
July 2016

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Genetics of ulcerative colitis.

Inflamm Bowel Dis 2011 Mar 12;17(3):831-48. Epub 2010 Nov 12.

Gastrointestinal Unit, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1002/ibd.21375DOI Listing
March 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.

Expert Rev Gastroenterol Hepatol 2009 Oct;3(5):513-34

Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1586/egh.09.45DOI Listing
October 2009

Early combined immunosuppression in Crohn's disease.

Lancet 2008 Jun;371(9629):1995; author reply 1996-7

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http://dx.doi.org/10.1016/S0140-6736(08)60859-4DOI Listing
June 2008

The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, and disease.

Gastroenterology 2005 Nov;129(5):1696-710

Gastrointestinal Unit, School of Molecular and Clinical Medicine, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2005.05.010DOI Listing
November 2005

Pharmacogenetics and inflammatory bowel disease: progress and prospects.

Inflamm Bowel Dis 2004 Mar;10(2):148-58

Department of Gastroenterology, Western General Hospital, Edinburgh EH,4 2XU.

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http://dx.doi.org/10.1097/00054725-200403000-00014DOI Listing
March 2004