Charles Y Lin

Charles Y Lin

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Charles Y Lin

Charles Y Lin

Publications by authors named "Charles Y Lin"

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Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Circ Res 2019 Sep 14;125(7):662-677. Epub 2019 Aug 14.

From the Department of Medicine, Division of Cardiology (M.S.S., R.A.B., M.B.F., A.S.R., B.Y.E., K.A.K., M.A.C., K.S., M.P.Y.L., T.A.M.), University of Colorado Anschutz Medical Campus, Aurora.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315125DOI Listing
September 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Cell Chem Biol 2019 06 21;26(6):792-803.e10. Epub 2019 Mar 21.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biology Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588464PMC
June 2019

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.

Cell Chem Biol 2019 05 14;26(5):711-723.e14. Epub 2019 Mar 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.009DOI Listing
May 2019

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.

Cell Rep 2018 12;25(13):3693-3705.e6

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; VA Boston Healthcare System, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407615PMC
December 2018

Mutant NPM1 Maintains the Leukemic State through HOX Expression.

Cancer Cell 2018 09;34(3):499-512.e9

Stem Cell and Regenerative Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Texas Children's Hospital and Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159911PMC
September 2018

NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.

Cancer Cell 2018 03;33(3):435-449.e6

Institut Curie - Recherche, Laboratoire 110, Centre Universitaire, Orsay Cedex 91405, France; INSERM U1021, Centre Universitaire, Orsay 91405, France; CNRS UMR 3347, Centre Universitaire, Orsay 91405, France; Université Paris Sud-11, 91405 Orsay, France; PSL Research University, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183005
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http://dx.doi.org/10.1016/j.ccell.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368680PMC
March 2018

BET bromodomain proteins regulate enhancer function during adipogenesis.

Proc Natl Acad Sci U S A 2018 02 14;115(9):2144-2149. Epub 2018 Feb 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1711155115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834672PMC
February 2018

c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals.

Blood 2017 12 27;130(25):2739-2749. Epub 2017 Oct 27.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX; and.

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http://dx.doi.org/10.1182/blood-2017-02-769463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746163PMC
December 2017

Randomised controlled trial of early prophylactic feeding vs standard care in patients with head and neck cancer.

Br J Cancer 2017 Jun 23;117(1):15-24. Epub 2017 May 23.

Centre for Dietetics Research (C-DIET-R), School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1038/bjc.2017.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520203PMC
June 2017

Investigation of p16 status, chemotherapy regimen, and other nutrition markers for predicting gastrostomy in patients with head and neck cancer.

Head Neck 2017 05 23;39(5):868-875. Epub 2017 Feb 23.

Centre for Dietetic Research (C-DIET-R), School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1002/hed.24630DOI Listing
May 2017

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.

Cell Rep 2017 03;18(10):2359-2372

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston 02215, MA, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston 02215, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609449PMC
March 2017

Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes.

Proc Natl Acad Sci U S A 2016 12 1;113(51):14805-14810. Epub 2016 Dec 1.

Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1617793113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187723PMC
December 2016

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.

Cell Rep 2016 08 14;16(5):1366-1378. Epub 2016 Jul 14.

Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado Denver, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972677PMC
August 2016

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Cell Rep 2016 06 9;15(12):2692-704. Epub 2016 Jun 9.

Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094353PMC
June 2016

Models of human core transcriptional regulatory circuitries.

Genome Res 2016 Mar 3;26(3):385-96. Epub 2016 Feb 3.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

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http://dx.doi.org/10.1101/gr.197590.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772020PMC
March 2016

Taming of the beast: shaping Myc-dependent amplification.

Trends Cell Biol 2015 Apr 1;25(4):241-8. Epub 2014 Dec 1.

Laboratory of Pathology, 10 Center Drive, Bethesda, MD 20892-1500, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2014.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380620PMC
April 2015

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.

Mol Cell 2015 Apr 19;58(2):362-70. Epub 2015 Mar 19.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402134PMC
April 2015

BET bromodomains mediate transcriptional pause release in heart failure.

Cell 2013 Aug;154(3):569-82

Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://www.cell.com/cms/attachment/2021781429/2041682307/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741300884
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http://dx.doi.org/10.1016/j.cell.2013.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090947PMC
August 2013

SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.

Cell 2013 May;153(4):855-68

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

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http://dx.doi.org/10.1016/j.cell.2013.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103662PMC
May 2013

A probabilistic model for cell cycle distributions in synchrony experiments.

Cell Cycle 2007 Feb 12;6(4):478-88. Epub 2007 Feb 12.

Department of Biology, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.4161/cc.6.4.3859DOI Listing
February 2007