Charles Whittaker

Charles Whittaker

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Charles Whittaker

Charles Whittaker

Publications by authors named "Charles Whittaker"

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Aneuploidy drives lethal progression in prostate cancer.

Proc Natl Acad Sci U S A 2019 Jun 13;116(23):11390-11395. Epub 2019 May 13.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1902645116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561291PMC
June 2019

The Population Biology and Transmission Dynamics of Loa loa.

Trends Parasitol 2018 04 10;34(4):335-350. Epub 2018 Jan 10.

Department of Infectious Disease Epidemiology, London Centre for Neglected Tropical Disease Research and MRC Centre for Outbreak Analysis and Modelling, Faculty of Medicine (St Mary's Campus), Imperial College London, London W2 1PG, UK; Joint last authors. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2017.12.003DOI Listing
April 2018

The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation.

Annu Rev Cell Dev Biol 2017 10 10;33:555-575. Epub 2017 Jul 10.

John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-cellbio-100616-060546DOI Listing
October 2017

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Biomaterials 2017 06 7;128:147-159. Epub 2017 Mar 7.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.03.008DOI Listing
June 2017

The algal pyrenoid: key unanswered questions.

J Exp Bot 2017 06;68(14):3739-3749

Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.

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http://dx.doi.org/10.1093/jxb/erx178DOI Listing
June 2017

Erratum to: Comparative genomics and transcriptomics of Pichia pastoris.

BMC Genomics 2016 09 28;17(1):762. Epub 2016 Sep 28.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 76-253, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039785PMC
http://dx.doi.org/10.1186/s12864-016-3109-0DOI Listing
September 2016

Comparative genomics and transcriptomics of Pichia pastoris.

BMC Genomics 2016 08 5;17:550. Epub 2016 Aug 5.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 76-253, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1186/s12864-016-2876-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974788PMC
August 2016

The extracellular matrix: Tools and insights for the "omics" era.

Matrix Biol 2016 Jan 8;49:10-24. Epub 2015 Jul 8.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X150012
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http://dx.doi.org/10.1016/j.matbio.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013529PMC
January 2016

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Genes Dev 2015 Sep;29(17):1850-62

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.267393.115
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http://dx.doi.org/10.1101/gad.267393.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573857PMC
September 2015

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues.

Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13409-14. Epub 2014 Sep 2.

Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1415287111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169915PMC
September 2014

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

BMC Cancer 2014 Jul 18;14:518. Epub 2014 Jul 18.

David H, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-14-518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223627PMC
July 2014

Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.

Genes Dev 2013 Jul;27(14):1557-67

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.222745.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731545PMC
July 2013

Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.

Mol Cell 2013 Apr 21;50(2):185-99. Epub 2013 Mar 21.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721642PMC
April 2013

Stage-specific sensitivity to p53 restoration during lung cancer progression.

Nature 2010 Nov;468(7323):572-5

Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/doifinder/10.1038/nature09535
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http://dx.doi.org/10.1038/nature09535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003305PMC
November 2010

Identification of aneuploidy-tolerating mutations.

Cell 2010 Oct 16;143(1):71-83. Epub 2010 Sep 16.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2010.08.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993244PMC
October 2010

Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):16940-5. Epub 2010 Sep 13.

Department of Biology and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1011548107
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http://dx.doi.org/10.1073/pnas.1011548107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947874PMC
September 2010

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development.

Development 2010 Jul;137(14):2439-49

Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/dev.049551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889609PMC
July 2010

Conservation and divergence of ADAM family proteins in the Xenopus genome.

BMC Evol Biol 2010 Jul 14;10:211. Epub 2010 Jul 14.

Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1186/1471-2148-10-211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055250PMC
July 2010

Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors.

J Immunol 2010 Jan 16;184(2):702-12. Epub 2009 Dec 16.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.4049/jimmunol.0902360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226722PMC
January 2010

Genomic predictors of interindividual differences in response to DNA damaging agents.

Genes Dev 2008 Oct 19;22(19):2621-6. Epub 2008 Sep 19.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.1688508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559901PMC
October 2008

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.

Science 2008 Oct;322(5902):703-9

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1160058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701511PMC
October 2008

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations.

Proc Natl Acad Sci U S A 2008 Jul 18;105(30):10408-13. Epub 2008 Jul 18.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1073/pnas.0805036105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492501PMC
July 2008

Protein 4.1B suppresses prostate cancer progression and metastasis.

Proc Natl Acad Sci U S A 2007 Jul 18;104(31):12784-9. Epub 2007 Jul 18.

Howard Hughes Medical Institute, Massachusetts Institute of Technology Center for Cancer Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0705499104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924789PMC
July 2007

The echinoderm adhesome.

Dev Biol 2006 Dec 7;300(1):252-66. Epub 2006 Aug 7.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565218PMC
December 2006

The genome of the sea urchin Strongylocentrotus purpuratus.

Authors:
Erica Sodergren George M Weinstock Eric H Davidson R Andrew Cameron Richard A Gibbs Robert C Angerer Lynne M Angerer Maria Ina Arnone David R Burgess Robert D Burke James A Coffman Michael Dean Maurice R Elphick Charles A Ettensohn Kathy R Foltz Amro Hamdoun Richard O Hynes William H Klein William Marzluff David R McClay Robert L Morris Arcady Mushegian Jonathan P Rast L Courtney Smith Michael C Thorndyke Victor D Vacquier Gary M Wessel Greg Wray Lan Zhang Christine G Elsik Olga Ermolaeva Wratko Hlavina Gretchen Hofmann Paul Kitts Melissa J Landrum Aaron J Mackey Donna Maglott Georgia Panopoulou Albert J Poustka Kim Pruitt Victor Sapojnikov Xingzhi Song Alexandre Souvorov Victor Solovyev Zheng Wei Charles A Whittaker Kim Worley K James Durbin Yufeng Shen Olivier Fedrigo David Garfield Ralph Haygood Alexander Primus Rahul Satija Tonya Severson Manuel L Gonzalez-Garay Andrew R Jackson Aleksandar Milosavljevic Mark Tong Christopher E Killian Brian T Livingston Fred H Wilt Nikki Adams Robert Bellé Seth Carbonneau Rocky Cheung Patrick Cormier Bertrand Cosson Jenifer Croce Antonio Fernandez-Guerra Anne-Marie Genevière Manisha Goel Hemant Kelkar Julia Morales Odile Mulner-Lorillon Anthony J Robertson Jared V Goldstone Bryan Cole David Epel Bert Gold Mark E Hahn Meredith Howard-Ashby Mark Scally John J Stegeman Erin L Allgood Jonah Cool Kyle M Judkins Shawn S McCafferty Ashlan M Musante Robert A Obar Amanda P Rawson Blair J Rossetti Ian R Gibbons Matthew P Hoffman Andrew Leone Sorin Istrail Stefan C Materna Manoj P Samanta Viktor Stolc Waraporn Tongprasit Qiang Tu Karl-Frederik Bergeron Bruce P Brandhorst James Whittle Kevin Berney David J Bottjer Cristina Calestani Kevin Peterson Elly Chow Qiu Autumn Yuan Eran Elhaik Dan Graur Justin T Reese Ian Bosdet Shin Heesun Marco A Marra Jacqueline Schein Michele K Anderson Virginia Brockton Katherine M Buckley Avis H Cohen Sebastian D Fugmann Taku Hibino Mariano Loza-Coll Audrey J Majeske Cynthia Messier Sham V Nair Zeev Pancer David P Terwilliger Cavit Agca Enrique Arboleda Nansheng Chen Allison M Churcher F Hallböök Glen W Humphrey Mohammed M Idris Takae Kiyama Shuguang Liang Dan Mellott Xiuqian Mu Greg Murray Robert P Olinski Florian Raible Matthew Rowe John S Taylor Kristin Tessmar-Raible D Wang Karen H Wilson Shunsuke Yaguchi Terry Gaasterland Blanca E Galindo Herath J Gunaratne Celina Juliano Masashi Kinukawa Gary W Moy Anna T Neill Mamoru Nomura Michael Raisch Anna Reade Michelle M Roux Jia L Song Yi-Hsien Su Ian K Townley Ekaterina Voronina Julian L Wong Gabriele Amore Margherita Branno Euan R Brown Vincenzo Cavalieri Véronique Duboc Louise Duloquin Constantin Flytzanis Christian Gache François Lapraz Thierry Lepage Annamaria Locascio Pedro Martinez Giorgio Matassi Valeria Matranga Ryan Range Francesca Rizzo Eric Röttinger Wendy Beane Cynthia Bradham Christine Byrum Tom Glenn Sofia Hussain Gerard Manning Esther Miranda Rebecca Thomason Katherine Walton Athula Wikramanayke Shu-Yu Wu Ronghui Xu C Titus Brown Lili Chen Rachel F Gray Pei Yun Lee Jongmin Nam Paola Oliveri Joel Smith Donna Muzny Stephanie Bell Joseph Chacko Andrew Cree Stacey Curry Clay Davis Huyen Dinh Shannon Dugan-Rocha Jerry Fowler Rachel Gill Cerrissa Hamilton Judith Hernandez Sandra Hines Jennifer Hume Laronda Jackson Angela Jolivet Christie Kovar Sandra Lee Lora Lewis George Miner Margaret Morgan Lynne V Nazareth Geoffrey Okwuonu David Parker Ling-Ling Pu Rachel Thorn Rita Wright

Science 2006 Nov;314(5801):941-52

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http://dx.doi.org/10.1126/science.1133609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159423PMC
November 2006

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.

Mol Biol Cell 2002 Oct;13(10):3369-87

Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e02-05-0259
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http://dx.doi.org/10.1091/mbc.e02-05-0259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129952PMC
October 2002