Charles W M Roberts

Charles W M Roberts

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Charles W M Roberts

Charles W M Roberts

Publications by authors named "Charles W M Roberts"

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell 2019 02;35(2):204-220.e9

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.006DOI Listing
February 2019

High Frequency of Ovarian Cyst Development in Vhl;Snf5 Mice.

Am J Pathol 2018 07 22;188(7):1510-1516. Epub 2018 Apr 22.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024179PMC
July 2018

Renal Medullary Carcinoma: Establishing Standards in Practice.

J Oncol Pract 2017 07;13(7):414-421

Vanderbilt University Medical Center, Nashville; St Jude Children's Research Hospital, Memphis, TN; University of Texas MD Anderson Cancer Center; Baylor College of Medicine, Houston, TX; American University of Beirut Medical Center, Beirut, Lebanon; Université Paris-Est Créteil, Créteil; Institut Curie; University Pierre and Marie Curie, Paris, France; University of North Carolina at Chapel Hill, Chapel Hill, NC; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA; Johns Hopkins University, Baltimore, MD; Memorial Sloan Kettering Cancer Center, New York, NY; and University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1200/JOP.2017.020909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508447PMC
July 2017

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers.

Nat Commun 2017 03 6;8:14648. Epub 2017 Mar 6.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms14648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343482PMC
March 2017

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.

Nat Genet 2017 Feb 12;49(2):296-302. Epub 2016 Dec 12.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285448PMC
February 2017

Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.

Neuro Oncol 2016 06 10;18(6):764-78. Epub 2016 Jan 10.

Children's Hospital and Swabian Children's Cancer Center, Augsburg, Germany (M.C.F.); Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California (J.A.B.); INSERM U830, Laboratory of Genetics and Biology of Cancers, and Department of Pediatric Oncology, Curie Institute, Paris, France (F.B.); Comprehensive Cancer Center and Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee (C.W.M.R.); Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.N.C.); Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts (S.N.C.); Department of Pediatrics, Harvard Medical School, Boston, Massachusetts (S.N.C.).

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http://dx.doi.org/10.1093/neuonc/nov264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864253PMC
June 2016

Targeting EZH2 in cancer.

Nat Med 2016 Feb;22(2):128-34

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918227PMC
February 2016

Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia.

Epigenetics Chromatin 2015 2;8:53. Epub 2015 Dec 2.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 281, Memphis, TN 38105 USA.

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http://dx.doi.org/10.1186/s13072-015-0046-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667523PMC
December 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proc Natl Acad Sci U S A 2015 Dec 14;112(52):15988-93. Epub 2015 Dec 14.

Department of Cell Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Laboratory of Epigenetics in Development and Tumorigenesis, Tianjin Research Center of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China;

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http://dx.doi.org/10.1073/pnas.1521740112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702963PMC
December 2015

Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.

Cancer Genet 2014 Sep 13;207(9):365-72. Epub 2014 Apr 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Hematology/Oncology, Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2014.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195815PMC
September 2014

Vulnerabilities of mutant SWI/SNF complexes in cancer.

Cancer Cell 2014 Sep;26(3):309-317

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159614PMC
September 2014

The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond.

Nucleus 2013 Sep-Oct;4(5):374-8. Epub 2013 Sep 30.

Department of Pediatric Oncology; Dana-Farber Cancer Institute; Boston, MA USA; Division of Hematology/Oncology; Boston Children's Hospital; Boston, MA USA; Department of Pediatrics; Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/nucl.26654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899127PMC
August 2014

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.

Mol Cell Biol 2014 Mar 13;34(6):1136-44. Epub 2014 Jan 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01372-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958034PMC
March 2014

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

Nat Med 2014 Mar 23;20(3):251-4. Epub 2014 Feb 23.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. [4] Broad Institute of Harvard and MIT, Boston, Massachusetts, USA. [5] Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954704PMC
March 2014

Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.

Clin Cancer Res 2014 Jan 11;20(1):21-7. Epub 2013 Oct 11.

Authors' Affiliations: Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Children's Hospital Boston; and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/content/clincanres/20/
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http://clincancerres.aacrjournals.org/content/clincanres/ear
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-0280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947303PMC
January 2014

CARMA: CARM1 methylation of SWI/SNF in breast cancer.

Cancer Cell 2014 Jan;25(1):3-4

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954702PMC
January 2014

Linking the SWI/SNF complex to prostate cancer.

Nat Genet 2013 Nov;45(11):1268-9

Department of Pediatric Oncology, Dana-Farber Cancer Institute, the Division of Hematology-Oncology, Boston Children's Hospital and the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2805DOI Listing
November 2013

CHD7 in charge of neurogenesis.

Cell Stem Cell 2013 Jul;13(1):1-2

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.stem.2013.06.010DOI Listing
July 2013

Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer.

Brain Pathol 2013 Mar;23(2):200-5

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1111/bpa.12021DOI Listing
March 2013

ARID1A mutations in cancer: another epigenetic tumor suppressor?

Cancer Discov 2013 Jan 3;3(1):35-43. Epub 2012 Dec 3.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546152PMC
January 2013

Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

Pediatr Blood Cancer 2012 Dec 19;59(7):1155-7. Epub 2012 Sep 19.

Director, Pediatric Medical Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Pediatric Hematology/Oncology, Boston, MA 02215, USA.

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http://dx.doi.org/10.1002/pbc.24315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538080PMC
December 2012

Cancer-fighting Smurf.

Nat Med 2012 Feb 6;18(2):204-5. Epub 2012 Feb 6.

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http://dx.doi.org/10.1038/nm.2655DOI Listing
February 2012

SWI/SNF nucleosome remodellers and cancer.

Nat Rev Cancer 2011 Jun 9;11(7):481-92. Epub 2011 Jun 9.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nrc3068DOI Listing
June 2011

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.

Cancer Cell 2010 Oct;18(4):316-28

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957473PMC
October 2010

The role of SMARCB1/INI1 in development of rhabdoid tumor.

Cancer Biol Ther 2009 Mar 29;8(5):412-6. Epub 2009 Mar 29.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709499PMC
http://dx.doi.org/10.4161/cbt.8.5.8019DOI Listing
March 2009

Epigenetics and cancer without genomic instability.

Cell Cycle 2009 Jan 30;8(1):23-6. Epub 2009 Jan 30.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.4161/cc.8.1.7290DOI Listing
January 2009

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

Mol Cell Biol 2008 Oct 18;28(20):6223-33. Epub 2008 Aug 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1128/MCB.00658-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577431PMC
October 2008

Metagene projection for cross-platform, cross-species characterization of global transcriptional states.

Proc Natl Acad Sci U S A 2007 Apr 27;104(14):5959-64. Epub 2007 Mar 27.

Eli and Edythe L. Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02141, USA.

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http://dx.doi.org/10.1073/pnas.0701068104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838404PMC
April 2007

Tumor-specific cooperation of retinoblastoma protein family and Snf5 inactivation.

Cancer Res 2007 Apr;67(7):3002-9

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4207DOI Listing
April 2007

Genetic causes of familial risk in rhabdoid tumors.

Pediatr Blood Cancer 2006 Sep;47(3):235-7

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/pbc.20672DOI Listing
September 2006

Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation.

Cell Cycle 2006 Mar 15;5(6):621-4. Epub 2006 Mar 15.

Department of Pediatric Oncology, Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cc.5.6.2579DOI Listing
March 2006

The SWI/SNF complex--chromatin and cancer.

Nat Rev Cancer 2004 Feb;4(2):133-42

Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nrc1273
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http://dx.doi.org/10.1038/nrc1273DOI Listing
February 2004

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.

Cancer Cell 2002 Nov;2(5):415-25

Division of Hematology-Oncology, Dana-Farber Cancer Institute and Children's Hospital, Department of Pediatrics, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00185-xDOI Listing
November 2002

The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors.

Cancer Res 2002 Jan;62(1):323-8

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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January 2002