Publications by authors named "Charles Taieb"

70 Publications

Use of Complementary and Alternative Medicines by Patients with Psoriasis: Results from a Study with 2562 Patients.

Am J Clin Dermatol 2021 Feb 21. Epub 2021 Feb 21.

Department of Dermatology, Timone Hospital, University Hospital of Marseille, Marseille, France.

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http://dx.doi.org/10.1007/s40257-021-00587-7DOI Listing
February 2021

Influence of Skin Subjective Symptoms on Sleep Quality in Patients with Cutaneous Disorders: A Study of 2871 Subjects.

Clin Cosmet Investig Dermatol 2021 11;14:143-152. Epub 2021 Feb 11.

European Market Maintenance, Assessment, Patients Priority Department, Fontenay-sous-Bois, France.

Introduction: Previous studies showed more sleep disturbance (SD) in patients with cutaneous disorders (CD). During CD, unpleasant subjective symptoms [USS], such as itch, pain and others (tingling, burning, or tightness) have a negative influence on sleep quality. This study aims to evaluate the prevalence of SD in CD patients and to identify the influence of itch, pain and other unpleasant sensations on SD.

Materials And Methods: An international, anonymized real-life survey was conducted with individuals [18-75 years], with physician-confirmed CD, or without CD. The 25 items covered sociodemographic characteristics, feeling of overall sleep quality and skin unpleasant sensations. Severity of SD and unpleasant sensations were assessed using a 10-cm Visual Analogue Scale (VAS).

Results: From 3834 analyzed questionnaires, 2871 (67.3%) were in the CD group and 863 (32.7%) in the control group. Patients with CD had significantly more SD (71.2% vs 32.7% in the control group, p<0.0001). CD patients without any reported unpleasant sensation were at higher risk for SD than control subjects (OR 1,362 [95% CI 1.975-2.405] p=0.0013). SS were highly associated with SD (OR 1.641 [95% CI 1.393-1.933] p<0.0001). Pruritus, pain and intermediate sensations were significant predictors of SD, with odds ratios of 1.670, 1.625 and 1.326, respectively. VAS sleep scores were strongly associated with pruritus (r: 0.25, p<0.0001) and pain (r: 0.25 p<0.0001) severity ratings.

Discussion: SD is a common problem for patients with CD. Patients with subjective symptoms suffer more from SD, suggesting that they are aggravating factors, but are likely not the only reason for SD in CD patients. We found that during CD, intermediate sensations also contribute to SD. Despite some limitations and the potential bias due to the study design, our results confirm for the first time on an international level the influence of subjective symptoms on sleep quality in patients with CD.
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http://dx.doi.org/10.2147/CCID.S288557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886096PMC
February 2021

Allergy - Patients with Atopic Dermatitis Express Themselves Through a Questionnaire.

Clin Cosmet Investig Dermatol 2020 5;13:1075-1077. Epub 2021 Jan 5.

La Roche-Posay Dermatological Laboratories, Levallois Perret, France.

Introduction: Allergies are becoming more prevalent across the globe and can be linked to several skin diseases, particularly atopic dermatitis (AD). Disruption of the immune system in the skin can lead to inflammatory diseases such as atopic and contact dermatitis, skin infections, and allergies. This is especially evident in processes such as "atopic march", where in childhood, the development of atopic dermatitis can later lead to food allergies, allergic rhinitis and asthma.

Objective: The aim of this international online survey is to study the link between self-reported doctor-diagnosed AD and allergy prevalence.

Methodology: Our survey queried a representative sample of the general population over the age of 18 from five countries (Brazil, China, Russia, the USA and France).

Results: A total of 9399 participants answered the entire online questionnaire. Among them, 2483 (26.4%) had an allergy diagnosed by a doctor (1243 with food allergies (13.2%), 1564 with respiratory allergies (16.6%) and 1669 with skin allergies (17.7%)). There were 794 (31.9%) participants with current AD in the allergy group and 640 (9.25%) in the group without allergies (p<0.001), and there were 1299 (52.3%) participants with CAD in the allergy group versus 1368 (19.8%) in the group without allergies (p<0.001). Multivariate analysis showed ORs of 3.24 [2.98, 3.63] (p<0.001) for current AD and 2.4 [2.09, 2.74] (p<0.001) for CAD. There was no significant interaction between AD and CAD (p=0.6).

Conclusion: A total of 26.4% of survey respondents reported having doctor-diagnosed allergies. Among these patients, half reported having AD during childhood, and 1/3 reported having a current AD. CAD and AD patients clearly have a higher risk of having an allergy than patients without CAD or AD.
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http://dx.doi.org/10.2147/CCID.S285943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802332PMC
January 2021

Cost Effectiveness of Emollients in the Prevention of Relapses in Atopic Dermatitis.

Clin Cosmet Investig Dermatol 2020 21;13:987-996. Epub 2020 Dec 21.

La Roche-Posay Dermatological Laboratories, Levallois-Perret, France.

Introduction: Atopic dermatitis (AD) is chronic inflammatory skin condition, characterized by its remission-relapse cycles. This predominantly pediatric disease is becoming more and more prevalent. Emollients are part of the therapeutic management and particularly a way to increase time between relapses. The follow-up of AD and relapses have a great impact on patient's quality of life, expenditures and society costs. The aim of this study is to assess the cost-effectiveness of different emollients prescribed to AD patients.

Methods: A three-state Markov simulation model was developed over a six-year period with 28 days cycles. Two perspectives were adopted, a health care system perspective and a societal perspective. Four different emollients (A, B, C, D) were compared with no emollient use. Time without flare-up was the key endpoint of the study. quality adjusted life-years (QALYs) were assessed as a secondary outcome. Cost and effectiveness data were derived from (i) randomized clinical trials and literature review for the efficacy of treatments, (ii) resource utilization and quality of life data, and (iii) unit prices from official price lists.

Results: The six-year health care costs associated with emollient A amount to £1844.23 and generate 4.58 years-without flare-up. Compared to emollient B, emollient A is costlier (Δ £41) but more effective (0.097 years). The ICER is £428.30 per year without flare-up. Emollient A is the dominant strategy compared to no treatment (£2,251.01; 3.99 years without flare-ups). When accounting for the societal costs, emollient A is the dominant strategy.

Discussion: According to the analysis, treatment with preventive emollient was a cost-effective option compared with no treatment in adult AD patients. In this comparative study, emollient A is the most efficient strategy from a willingness to pay £200 with a probability of 49%.
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http://dx.doi.org/10.2147/CCID.S279233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762264PMC
December 2020

Self-Reported Skin Sensation by People Who Have Experienced Containment During COVID-19 Pandemic.

Clin Cosmet Investig Dermatol 2020 9;13:943-947. Epub 2020 Dec 9.

Patients Priority Department, European Market Maintenance Assessment [EMMA], Fontenay Sous Bois, France.

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http://dx.doi.org/10.2147/CCID.S280310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734043PMC
December 2020

Contraception, Sexuality and Pregnancy in Women with Psoriasis: Real-Life Experience of 235 Women.

Clin Cosmet Investig Dermatol 2020 11;13:817-823. Epub 2020 Nov 11.

FIMARAD, Hôpital Necker Enfants Malades, Paris, France.

Background: Little is known about how women of childbearing age with psoriasis experience contraception, sexuality and pregnancies through the lens of their skin condition.

Objective: To evaluate the experiences and expectations in this group of patients.

Materials And Methods: In total, 235 women aged between 18 and 45 years old completed an online survey. We collected the characteristics of psoriasis, contraception and pregnancy history. Psoriasis severity was measured using the Simplified Psoriasis Index. Patient quality of life was assessed using the Dermatology Life Quality Index (DLQI) and the Short Form-12.

Results: Psoriasis was mild in 78% of cases. The mean DLQI score was 8.8, highlighting a moderate impact of psoriasis. In total, 28% of the women had no current follow-ups, while at least two distinct physicians followed 21% of these patients. In total, 31.5% of the women felt that they could discuss sexuality during their consultations. In addition, 63% of respondents had a contraceptive method, but more than half of the women reported that contraception was rarely or never discussed during the consultations. In total, 63% had at least one pregnancy, and 61.5% reported that the doctor managing their psoriasis did not discuss their pregnancy during consultations. Psoriasis worsened during pregnancy for 21% of the respondents but improved in 34%. Among women who were not pregnant, less than 15% reported that the doctor in charge of their psoriasis discussed family planning and pregnancy possibilities.

Conclusion: Our study shows that the management of women of childbearing age with psoriasis must be improved with respect to sexuality, contraception and pregnancy planning.
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http://dx.doi.org/10.2147/CCID.S275512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666974PMC
November 2020

Prevalence and Characterization of Fatigue in Patients with Skin Diseases.

Acta Derm Venereol 2020 Nov 18;100(18):adv00327. Epub 2020 Nov 18.

Department of Dermatology and Venerology, University Hospital of Brest, FR-29200 Brest, France. E-mail:

The aim of this study was to examine the prevalence and nature of fatigue in patients with skin diseases by comparison with controls, using a survey of a large representative sample of the French population (n = 2,502). Of the respondents, 659 reported having a skin disease and 1,843 did not. Quality of life was decreased in people with skin diseases compared with controls, while levels of stress and sleep deprivation were higher in people with skin diseases. Level of fatigue was higher in people with skin diseases than in controls. The relative risk of fatigue was 4.71 (3.44-5.98, p < 0.001). Mediation analysis, adjusted according to sex, age and each skin disease, showed that the effects of skin diseases on fatigue were more commonly direct than indirect. To our knowledge, this is the first study to demonstrate that patients with skin diseases experience fatigue more frequently and more intensely. Hence, fatigue should be used as a new patient-related outcome in clinical trials.
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http://dx.doi.org/10.2340/00015555-3694DOI Listing
November 2020

Impact of Atopic Dermatitis in Adolescents and their Parents: A French Study.

Acta Derm Venereol 2020 Oct 20;100(17):adv00294. Epub 2020 Oct 20.

Department of Dermatology, Hôpital Henri Mondor, FR-94000 Creteil, France.

Atopic dermatitis has a negative impact on quality of life in patients and their families. However, there have been very few studies of the impact of atopic dermatitis on adolescents and their relatives. The objective of this study was to evaluate the impact of atopic dermatitis in the daily lives of adolescents between 12 and 17 years of age in the French population and to assess the burden of the disease on their families. Quality of life was measured in 399 parents of adolescents with atopic dermatitis and in the adolescents themselves. Impairment of quality of life in the adolescents was associated with disease severity. Moreover, in children aged 12-14 years, quality of life was worse with increasing age, with decreasing disease duration, and when parents had atopic dermatitis. In children aged 15-17 years quality of life was worse when the parent who answered the questionnaire was male and when the parent was < 45 years old. The burden of atopic dermatitis was higher in parents of older children, in parents with children with higher disease severity, with shorter disease duration, in male parents, and in parents aged <45 years. The burden of atopic dermatitis in adolescents and their parents is considerable and should be taken into account in the management of atopic dermatitis.
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http://dx.doi.org/10.2340/00015555-3653DOI Listing
October 2020

Self-reported allergies in Russia and impact on skin.

SAGE Open Med 2020 12;8:2050312120957916. Epub 2020 Sep 12.

Department of Allergology and Immunology Saint-Petersburg State Medical University, Saint-Petersburg, Russia.

Introduction: The rising prevalence of allergies can substantially impact the skin, which is one of the largest targets for allergic and immunologic responses.We present the results of an online survey assessing self-reported allergy prevalence in Russians, outline the populations who report allergies and characterize the skin conditions associated with allergy.

Methods: An online survey was conducted in Russia of 2010 adults as a representative sample of the general Russian population.

Results: A total of 34.9% of Russian adults (mean age: 41.3 ± 14.4 years old) reported having allergies. Reported allergies included skin allergies (73.3%), food allergies (53.9%) and respiratory allergies (43.4%), and 65.9% reported their allergies had been diagnosed by a doctor. In total, 75.1% of those who reported allergies also reported experiencing associated skin reactions, they were 1.5-5.5 times more likely to report a cutaneous disease and were 1.5 times to report sensitive skin compared to those who did not report allergies. In addition, those that reported allergies were also 2 times more likely to report experiencing skin reactions when using skincare products.

Conclusion: It is estimated that over 35 million Russian adults have allergies. These results will help raise awareness about the burden of allergies and the need to develop solutions to mitigate their impact on health.
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http://dx.doi.org/10.1177/2050312120957916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488871PMC
September 2020

A Method for Designing a Patient Burden Questionnaire in Dermatology.

Clin Cosmet Investig Dermatol 2020 6;13:521-528. Epub 2020 Aug 6.

Necker Enfants Malades Hospital, Paris, France.

Introduction: In recent years, the concept of "disease burden" has been given a central role in evaluating patient care, particularly in skin diseases. Measuring patient-reported outcomes (PRO) such as symptoms and disease burden may be useful.

Aim: To present a methodology that facilitates the development and validation of burden questionnaires for patients suffering from skin diseases.

Methodology: Based on past published burden questionnaires, a methodology for designing skin disease burden questionnaires was to be developed.

Results: Based on 16 burden questionnaires developed and published over the last 10 years, the authors propose a standardized methodology for the easy design and validation of disease burden questionnaires for patients with chronic skin diseases. The authors provide detailed guidance for the conception, development and validation of the questionnaires, including reliability, internal consistency, external validity, cognitive debriefing, testing-retesting, translation and cross-cultural adaptation, as well as for statistical analysis.

Conclusion: The proposed methodology enhances the design and validation of disease burden questionnaires in dermatology. Burden questionnaires may be used in clinical research as well as in daily clinical practice.
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http://dx.doi.org/10.2147/CCID.S260323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417926PMC
August 2020

Impact of the COVID-19 Pandemic on Chronic Inflammatory Dermatoses: Mixed Messages Regarding the Dermatologist's Point of View and the Patient's Concerns.

Acta Derm Venereol 2020 Aug 18;100(15):adv00248. Epub 2020 Aug 18.

Department of Dermatology, Military Teaching Hospital Bégin, 69 avenue de Paris, FR-94160 Saint Mandé, France. E-mail:

is missing (Short communication).
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http://dx.doi.org/10.2340/00015555-3610DOI Listing
August 2020

Psychological Consequences of the Most Common Dermatoses: Data from the Objectifs Peau Study.

Acta Derm Venereol 2020 Jun 11;100(13):adv00175. Epub 2020 Jun 11.

Department of Dermatology and Venereology, University Hospital of Brest, FR-29200 Brest, France. E-mail:

The prevalence of psychological disorders in patients with common skin diseases was assessed in a large representative sample of the French adult population. General health, as measured by the EQ5D score, was significantly lower if patients reported having rosacea, atopic dermatitis, urticaria, fungal infections, psoriasis or acne. The proportions of participants reporting being extremely anxious or depressed were higher in those who reported having rosacea, atopic dermatitis or contact dermatitis. Difficulties in sexual and conjugal life were frequently reported by people with psoriasis, atopic dermatitis, contact dermatitis, urticaria and, in particular, acne. Sleep disorders were present in 30-50% of those who reported having acne, rosacea, eczema, psoriasis or urticaria. Sleep disorders may be related not only to pruritus, but also to disfiguring skin diseases. Anxiety and depression complications were mainly reported by those with disfiguring diseases. Sexual and conjugal dysfunctions were associated with all dermatoses (with the exception of warts).
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http://dx.doi.org/10.2340/00015555-3531DOI Listing
June 2020

Individual Burden of Psoriasis (I-BOP): Building and Validation of a New Scoring Tool for Patients with Psoriasis.

Clin Cosmet Investig Dermatol 2020 4;13:325-332. Epub 2020 May 4.

Resopso, Paris, France.

Background: Psoriasis impacts independently of its severity on patients' lifestyle and quality of life (QoL).

Aim: To build a tool for assessing the patient-reported psoriasis burden.

Methods: An expert group created a questionnaire using a standardized methodology building questionnaires assessing quality of life issues. The questionnaire was translated from French into a cultural and linguistically validated US English version.

Results: A conceptual questionnaire of 54 questions was created. The confirmatory analyses resulted in a 10-feature questionnaire divided into 4 internally consistent domains with a Cronbach's alpha coefficient of 0.9. It was reproducible and highly reliable. It correlated well with the Dermatology Life Quality Index (DLQI), Perceived Stress Scale (PSS), and SF-12 mental and SF12 physical scores.

Conclusion: This tool allows for the first time to assess the burden of psoriasis patients. Its use may allow improving medical and nonmedical patient care, thus improving their daily life.
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http://dx.doi.org/10.2147/CCID.S249776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213973PMC
May 2020

Pain in Atopic Dermatitis: An Online Population-based Survey.

Acta Derm Venereol 2020 Jul 2;100(14):adv00198. Epub 2020 Jul 2.

Department of Dermatology, University Hospital of Brest, FR-29200 Brest, France.

Pruritus in atopic dermatitis has been studied extensively; however, evaluation of skin pain has been very limited. The aim of this study was to evaluate the presence, frequency and characteristics of skin pain in patients with atopic dermatitis. A survey was conducted of a representative sample of 5,000 18-80-year-old individuals selected from the French population according to sex, age, geographical area and socioprofessional status. Data on socio-demographic status and the presence of any skin disease were collected. Pain in the past month and health-related quality of life were evaluated. Average intensity of skin pain during the previous month was assessed with a horizontal visual analogue scale (0-10). Skin pain was reported by more than half of the patients with atopic dermatitis, at a pain intensity of almost 6/10. A neuropathic component was suggested by the Douleur Neuropathique - 4 questions (DN4) questionnaire (a tool for detection of neuropathic pain), as well as the presence of pain inside and outside of skin lesions. Severe alterations to health-related quality of life were assessed with the Dermatology Life Quality Index and Short Form 12 Health Survey (SF-12). Pain is reported frequently by patients with atopic dermatitis. Healthcare professionals should question patients about pain and provide effective treatments. Future clinical trials must take skin pain into account.
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http://dx.doi.org/10.2340/00015555-3521DOI Listing
July 2020

Self-Reported Prevalence of Allergies in the USA and Impact on Skin-An Epidemiological Study on a Representative Sample of American Adults.

Int J Environ Res Public Health 2020 05 12;17(10). Epub 2020 May 12.

Medical Dermatology Associates of Chicago, IL 60654 USA.

Background: The rising prevalence of allergies can substantially impact the skin, which is one of the largest targets for allergic and immunologic responses.

Objective: Here, we describe the results of an online survey assessing self-reported allergy prevalence in Americans, outline the populations who report allergies, and characterize the skin conditions associated with allergy.

Methods: An online survey was conducted in the USA of 2,008 adults as a representative sample of the general American population.

Results: 41.7% of American adults (mean age 44.7 ± 15.3 years old) reported having allergies. Reported allergies included respiratory allergies (45.2%), skin allergies (41.4) and food allergies (33.9%). 47.7% of those who reported allergies also reported experiencing associated skin reactions. In addition, those who reported allergies were 2 to 4.5 times more likely to report a cutaneous skin disease, 7 times more likely to report sensitive skin, and twice as likely to report experiencing skin reactions when using skincare products compared to those who did not report allergies.

Conclusions: It is estimated that over 100 million American adults have allergies. These results will help raise awareness about the burden of allergies and the need to develop solutions to mitigate their impact on health.
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http://dx.doi.org/10.3390/ijerph17103360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277149PMC
May 2020

Perceived clinical severity of atopic dermatitis in adolescents: Comparison between patients' and parents' evaluation.

J Am Acad Dermatol 2021 Jan 15;84(1):164-165. Epub 2020 Apr 15.

Public Health, Hôpital Necker Enfants Malades, Paris, France; European Market Maintenance Assessment, Vincennes, France; Maison de la Dermatologie, Société Française des Sciences Humaines sur la Peau (SFSHP), Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.037DOI Listing
January 2021

Skin pain and psoriasis.

J Am Acad Dermatol 2020 Jul 10;83(1):245-246. Epub 2020 Jan 10.

European Market Maintainance Assessment (EMMA), Fontenay sous Bois, France.

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http://dx.doi.org/10.1016/j.jaad.2019.12.066DOI Listing
July 2020

Incontinentia pigmenti burden scale: designing a family burden questionnaire.

Orphanet J Rare Dis 2019 11 26;14(1):271. Epub 2019 Nov 26.

French Rare Diseases Healthcare Network Department of Dermatology, Necker Enfants Malades Hospital Paris, APHP, Paris, France.

Background: Incontentia pigmenti (IP) is a rare multisystem disorder of ectodermal origin comprising skin, dental, ocular and central nervous system features. Symptomatic treatments are adapted to each family according to the patient's disability. Due to its rarity, the family IP burden in its broadest sense (psychological, social, economic and physical) has not yet been evaluated.

Aim: To design a questionnaire allowing assessing the family burden of IP (F'BoIP).

Method: A questionnaire was developed using a standardized methodology for designing quality of life questionnaires according to the following steps: conception, development, and validation. A multidisciplinary working group was designed, including experts in questionnaire development, dermatologists specialised in IP patient care and representatives of the French IP association. A cultural and linguistic validation into US English was conducted, based on the original French version.

Results: A 20-item conceptual questionnaire was generated. Subsequent confirmatory analyses produced a 20-item questionnaire grouped into four domains, demonstrating internal consistency (Cronbach's alpha: 0.93), reproducibility and high reliability. The F'BoIP questionnaire significantly correlated with other validated questionnaires: Family Dermatology Life Quality Index (F-DLQI), Perceived Stress Scale (PSS) and SF-12 mental and SF12 physical scores, indicating good external validity.

Conclusion: The F'BoIP questionnaire is the first specific tool to assess the family burden of IP and can be used by both family members of IP patients and by health care professionals. It is a valuable tool which evaluates medical and nonmedical strategies to improve the daily life of families affected by this orphan disease.
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http://dx.doi.org/10.1186/s13023-019-1234-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880510PMC
November 2019

Sensitive Skin in Children.

Acta Derm Venereol 2020 Jan 23;100(1):adv00039. Epub 2020 Jan 23.

Department of Dermatology and Venerology, University Hospital of Brest, FR-29200 Brest, France.

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http://dx.doi.org/10.2340/00015555-3376DOI Listing
January 2020

Burden of adult neurofibromatosis 1: development and validation of a burden assessment tool.

Orphanet J Rare Dis 2019 05 3;14(1):94. Epub 2019 May 3.

Department of Dermatology, Hôpital Henri Mondor, Créteil, France.

Background: Neurofibromatosis Type 1 (NF1) is a common genetic neurocutaneous disease, with an autosomal dominant inheritance mode. Quality of life has been shown impaired in NF1, due to severe complications, cosmetic features, and uncertainty about the disorder.

Methods: This study sought to develop a self-administered questionnaire in French to assess the burden of NF1 (BoN), then translate and linguistically and cross-culturally validate it into American English, standardized methodology applied, as outlined in the report.

Results: Based on several discussions with NF1 patients, a 17-item conceptual questionnaire was first produced. Of the 91 NF1 adult patients who responded to the conceptual questionnaire, 65 (64.6% females) were accessible. Subsequent confirmatory analyses generated a 15-item questionnaire grouped into four domains, demonstrating internal consistency (Cronbach's alpha: 091), discriminant validity, and high reliability. The BoN was likewise shown to significantly correlate with other validated questionnaires, such as Dermatology Life Quality Index, Perceived Stress Scale, and SF12 mental score, indicating good external validity.

Conclusions: BoN is a specific tool for assessing the burden that NF1 generates on many practical aspects of the patient daily activities, beyond the notion of quality of life". Given the increasing relevance that regulatory authorities attribute to patient-reported outcomes, the BoN questionnaire provides such supplementary information while accounting for the burden of NF1 patients in the broadest sense.
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http://dx.doi.org/10.1186/s13023-019-1067-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500066PMC
May 2019

Sensitive Skin in the Indian Population: An Epidemiological Approach.

Front Med (Lausanne) 2019 20;6:29. Epub 2019 Feb 20.

EMMA, Direction Scientifique, Fontenay sous Bois, France.

Sensitive skin is a very frequent condition, the prevalence of this syndrome has been studied in different countries in Europe, in United States and in Japan. The aim of the study was to evaluate the epidemiology of sensitive skin in the Indian population, like this has never been studied in this country. A representative nationwide sample of the Indian population aged 15 and over was selected. Individuals were selected as per the quota method (based on sex, age, householder profession, rural/urban location, and region). In total, 27.9% of men and 36.7% of women declared having "sensitive" or "very sensitive" skin. The difference between the 2 sexes was very significant. Of these, 5.1% of men and 7.2% of women reported having "very sensitive" skin. The subjects complaining about "sensitive" or "very sensitive" skin were 2-4 times more likely to declare suffering from atopic dermatitis, acne, psoriasis, or vitiligo. They were 2 to 3 times more reactive to climatic factors, environmental factors, cosmetics and food intake. In conclusion, although less frequently reported than in other countries, sensitive skin is a frequent condition in India, affecting about one third of the population.
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http://dx.doi.org/10.3389/fmed.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391320PMC
February 2019

Cross-cultural validation of a short-form of the Vitiligo Impact Patient scale (VIPs).

J Am Acad Dermatol 2019 Nov 11;81(5):1107-1114. Epub 2019 Feb 11.

FIMARAD, Hôpital Necker-Enfants Malades, Paris, France.

Background: There is a lack of short-form questionnaires evaluating the burden of vitiligo according to skin phototype.

Objective: To develop and validate a 12-item short-form of the Vitiligo Impact Patient scale (VIPs) that takes into account skin phototype.

Methods: Multicenter, prospective, cross-sectional study conducted in France (Créteil and Bordeaux) and the US (Worcester, Massachusetts, and Dallas, Texas).

Results: In total, 891 patients completed the questionnaire. Of these, 509 patients belonged to the French Development sample-313 with dark skin (DS) (phototypes IV to VI) and 196 with fair skin (FS) (phototypes I to III). The US validation sample comprised 382 patients-113 DS and 269 FS. There was a very high correlation between VIPs-FS and its 12-item short-form, VIPs-12-FS, in both the development and validation samples (respectively, rho = 0.96, P < .0001 and rho = 0.98, P < .0001). Similarly, the correlations between VIPs-DS and its short-form, VIPs-12-DS, in both the development and validation samples were very high (respectively, rho = 0.95, P < .0001 and rho = 0.96, P < .0001).

Limitations: Responsiveness of the 12-item short-forms should be confirmed.

Conclusions: These data enabled the development and validation of 12-item short-forms of the VIPs questionnaires for fair (VIPs-12-FS) and dark (VIPs-12-DS) skin.
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http://dx.doi.org/10.1016/j.jaad.2019.02.008DOI Listing
November 2019

Building a scale for measuring burden of hand eczema: BoHEM.

J Am Acad Dermatol 2019 06 23;80(6):1784-1785. Epub 2018 Dec 23.

FIMARAD (Filière de santé Maladies rares: maladies rares en dermatologie), Paris, France; European Market Maintenance Assessment, Fontenay sous-Bois, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.12.036DOI Listing
June 2019

Body Piercing: A National Survey in France.

Dermatology 2019 7;235(1):71-78. Epub 2018 Nov 7.

FIMARAD, Hôpital Necker Enfants Malades, Paris, France.

Background: There are no recent data available in France regarding body piercing (BP).

Objective: We examined the demographics, motivations, quality of life, cutaneous conditions, and cutaneous side effects after BP within the French population.

Methods: A representative sample of 5,000 individuals (aged 15 and over) from the general population responded to a survey online between April and August 2017. Data regarding demographics, BP characteristics (location, age at first piercing, hesitation, regrets, motivations, cutaneous side effects), tobacco, skin conditions (acne, contact eczema, atopic eczema, rosacea, psoriasis, vitiligo), and tattoos were collected. Respondents also filled an SF-12 quality of life questionnaire.

Results: Overall, 12% of the respondents reported at least one BP (women: 19.4%, men: 8.4%, p < 0.01). The prevalence was highest among those aged between 25 and 34 years (25.8%). Individuals with BP were more likely to smoke (p < 0.01). The most common body parts for piercings were the external part of the ear (42%), the navel (24%), the tongue (15%), and the nose (11%). Gender differences included localization (belly button and nose for women, eyebrows for men) and motivations (embellishment of the body for women, individuality and sexuality for men). A total of 33.6% of the study participants reported having skin problems after BP, primarily infection (44%). Individuals with BPs were more likely to report having contact eczema, atopic dermatitis, and acne. BP was associated with a lower mental quality of life score.

Conclusion: This is the largest epidemiological study on BP in France to date. It allows us to draw a precise current snapshot of French indi viduals with BP.
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http://dx.doi.org/10.1159/000494350DOI Listing
March 2019

Tattooing: A national survey in the general population of France.

J Am Acad Dermatol 2019 08 2;81(2):607-610. Epub 2018 Nov 2.

FIMARAD, Hopital Necker Enfants Malades, Paris, France; European Market Maintenance Assessment, France.

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http://dx.doi.org/10.1016/j.jaad.2018.10.059DOI Listing
August 2019

Development and Validation of a New Tool to Assess Burden of Dietary Sodium Restriction in Patients with Chronic Heart Failure: The BIRD Questionnaire.

Nutrients 2018 Oct 7;10(10). Epub 2018 Oct 7.

Heart Failure Unit, Department of Cardiology, INSERM U955, ARI, DHU ATVB, AP-HP Henri Mondor Hospital, University Paris Est Créteil (UPEC), 94000 Créteil, France.

(1) Background: Burden scales are useful in estimating the impact of interventions from patients' perspectives. This is overlooked in sodium diet/heart failure (HF). The aim of this study is to develop and validate a specific tool to assess the burden associated with low-sodium diets in HF: the Burden scale In Restricted Diets (BIRD). (2) Methods: Based on the literature and reports from patients, 14 candidate items were identified for the following dietary-related domains: organization, pleasure, leisure, social life, vitality, and self-rated health. The validation study was conducted prospectively. The questionnaire was refined via item reduction according to inter-item correlations and exploratory factor analysis. Internal consistency was determined using Cronbach's alpha (Cα) and convergent validity by assessing correlations between BIRD and the health-related quality of life (HRQoL) Minnesota Living with HF questionnaire (MLHF). (3) Results: Of the 152 invited patients, 96 (63%) returned the questionnaire. The median score was 6.5 (IQR 2.0⁻14.0). The results showed good acceptability (non-response rates/item from 2.0% to 12.1%), an excellent internal consistency (Cα = 0.903) and a good convergent validity (rhos = 0.37 (physical), 0.4 (mental), and 0.45 (global); all < 0.05). (4) Conclusions: BIRD demonstrates good psychometric properties and is useful to quantify the burden associated with sodium restriction. It may help optimize dietary interventions and improve the overall management of patients with HF.
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http://dx.doi.org/10.3390/nu10101453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213449PMC
October 2018

Burden of albinism: development and validation of a burden assessment tool.

Orphanet J Rare Dis 2018 09 18;13(1):162. Epub 2018 Sep 18.

EA EpiDermE, UPE-Université Paris-Est, Créteil, France.

Background: Albinism comprises a group of autosomal recessive diseases that are characterized by poor vision and a variable hypopigmentation phenotype. A comprehensive literature review showed that no tool can assess the burden experienced by individuals who present with albinism, although such a tool is needed and would be beneficial for clinicians and patients alike.

Method: The questionnaire was devised using standardized methodology for developing and validating questionnaires on the quality of life of subjects according to the following chronological structure: conceptual phase, development phase, and then validation phase. A multidisciplinary working group was assembled, including experts on questionnaire design and development, dermatologists specializing in care for patients with albinism, and representatives of the Genespoir association.

Results: Based on an initial verbatim report, the workgroup compiled a list of items that were transcribed and reformulated into questions. During the validation phase, principal component analysis (PCA) was conducted on the 24 items, which allowed the questionnaire to be reduced to 20 questions [Q]. The standardized regression coefficients were all greater than 0.5 for their corresponding factors. Based on their normalized regression coefficients, each group of questions was linked to one of the following four dimensions, with each dimension consisting of at least three questions: "Live with" (8 Q), "Daily life" (3 Q), "Resignation" (3 Q), and "Fear of the future" (6 Q). All dimensions correlated well with the overall BoA score. Cronbach's α was 0.92 for the entire BoA scale, confirming excellent internal coherence. Intradimensional coherences all demonstrated excellent reliability (α > 0.65). The BoA questionnaire was highly correlated with the SF12, RSES and DLQI validated questionnaires. This outcome confirmed the external validity.

Conclusion: This questionnaire represents the first specific assessment tool for evaluating the burden of albinism. It is easy to use and relatively quick to complete, which will allow the burden to be evaluated over time with a reproducible questionnaire. To ensure that this questionnaire can be used by as many people as possible, cultural and linguistic validation in US English was conducted with the original French version.
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http://dx.doi.org/10.1186/s13023-018-0894-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145119PMC
September 2018

Association between two painful and poorly understood conditions: Irritable bowel and sensitive skin syndromes.

Eur J Pain 2019 01 4;23(1):160-166. Epub 2018 Sep 4.

EMMA, Fontenay-sous-Bois, France.

Background: Irritable bowel and sensitive skin syndromes are common painful conditions that are poorly understood, with alterations of the peripheral (and possibly central) nervous system that lead to a lowering of perception thresholds as the main pathophysiological mechanism.

Methods: A cross-sectional epidemiological study was carried out on a representative sample of French people, according to the quota method using a questionnaire.

Results: Among the 5,000 respondents, 48.9% were men and 51.1% were women. According to the adapted Rome questionnaire, 14.6% suffered from irritable bowel syndrome. A total of 59.1% declared very sensitive or sensitive skin. A total of 73.1% of subjects had irritable bowel syndrome versus 52.3% in the other group without an irritable colon (p < 0.001). Similarly, the frequency of irritable bowel syndrome symptoms was associated with the severity of sensitive skin syndrome. The presence of sensitive skin was highly associated with the presence of abdominal pain or discomfort, with an OR of 1.93 after adjustment for sex and age.

Conclusions: This study is the first study showing an association between sensitive skin and irritable bowel syndromes. Sensory symptoms are predominant in these two syndromes and transit disorders in one case and vasomotor disorders in the other could probably be considered as pathophysiological equivalents.

Significance: The demonstration of the association between these two syndromes can open new pathophysiological or even therapeutic pathways, since dysfunctional nerve endings and/or increased release of some neurotransmitters are likely involved.
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http://dx.doi.org/10.1002/ejp.1296DOI Listing
January 2019

Patient Burden is Associated with Alterations in Quality of Life in Adult Patients with Atopic Dermatitis: Results from the ECLA Study.

Acta Derm Venereol 2018 Jul;98(7):713-714

Department of Dermatology, Brest University Hospital, FR-29200 Brest, France.

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http://dx.doi.org/10.2340/00015555-2940DOI Listing
July 2018